{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:54:31Z","timestamp":1785549271113,"version":"3.56.0"},"reference-count":182,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Application of mesenchymal stem cells (MSC) in regenerative therapeutic procedures is becoming an increasingly important topic in medicine. Since the first isolation of dental tissue-derived MSC, there has been an intense investigation on the characteristics and potentials of these cells in regenerative dentistry. Their multidifferentiation potential, self-renewal capacity, and easy accessibility give them a key role in stem cell-based therapy. So far, several different dental stem cell types have been discovered and their potential usage is found in most of the major dental medicine branches. These cells are also researched in multiple fields of medicine for the treatment of degenerative and inflammatory diseases. In this review, we summarized dental MSC sources and analyzed their treatment modalities with particular emphasis on temporomandibular joint osteoarthritis (TMJ OA).<\/jats:p>","DOI":"10.3390\/ijms23031662","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T09:59:21Z","timestamp":1643709561000},"page":"1662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mesenchymal Stem Cells Based Treatment in Dental Medicine: A Narrative Review"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1024-5509","authenticated-orcid":false,"given":"Igor","family":"Smojver","sequence":"first","affiliation":[{"name":"St. Catherine Specialty Hospital, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Katalini\u0107","sequence":"additional","affiliation":[{"name":"St. Catherine Specialty Hospital, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-8045","authenticated-orcid":false,"given":"Roko","family":"Bjelica","sequence":"additional","affiliation":[{"name":"St. Catherine Specialty Hospital, 10000 Zagreb, Croatia"},{"name":"Department of Oral Surgery, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-1170","authenticated-orcid":false,"given":"Dragana","family":"Gabri\u0107","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, School of Dental Medicine, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-285X","authenticated-orcid":false,"given":"Vid","family":"Mati\u0161i\u0107","sequence":"additional","affiliation":[{"name":"St. Catherine Specialty Hospital, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-6499","authenticated-orcid":false,"given":"Vilim","family":"Molnar","sequence":"additional","affiliation":[{"name":"St. Catherine Specialty Hospital, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-080X","authenticated-orcid":false,"given":"Dragan","family":"Primorac","sequence":"additional","affiliation":[{"name":"St. Catherine Specialty Hospital, 10000 Zagreb, Croatia"},{"name":"Eberly College of Science, The Pennsylvania State University, University Park, State College, PA 16802, USA"},{"name":"The Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT 06516, USA"},{"name":"Medical School, University of Split, 21000 Split, Croatia"},{"name":"Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Medical School, University of Rijeka, 51000 Rijeka, Croatia"},{"name":"Medical School REGIOMED, 96450 Coburg, Germany"},{"name":"Medical School, University of Mostar, 88000 Mostar, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: Facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol. 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/iej.12606","article-title":"Clinical procedures for revitalization: Current knowledge and considerations","volume":"49","author":"Galler","year":"2016","journal-title":"Int. Endod. J."},{"key":"ref_3","unstructured":"Walton, R.E., and Torabinejad, M. (2002). Principles and Practice of Endodontics, W.B. Saunders Company."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/iej.13471","article-title":"Clinical cell-based versus cell-free regenerative endodontics: Clarification of concept and term","volume":"54","author":"Lin","year":"2021","journal-title":"Int. Endod. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.22203\/eCM.v041a17","article-title":"Therapeutic potential of mesenchymal stem cellderived extrac Ellular vesicles in regenerat Ive endodontics","volume":"41","author":"Ivica","year":"2021","journal-title":"Eur. Cells Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.11607\/jomi.te20","article-title":"Temporomandibular Disorders: A Review of Etiology, Clinical Management, and Tissue Engineering Strategies","volume":"28","author":"Murphy","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s00018-017-2473-5","article-title":"Interactions between mesenchymal stem cells and the immune system","volume":"74","author":"Li","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/628767","article-title":"Adult Mesenchymal Stem Cells: When, Where, and How","volume":"2015","author":"Caplan","year":"2015","journal-title":"Stem Cells Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1038\/emm.2013.94","article-title":"Mesenchymal stem cells: Environmentally responsive therapeutics for regenerative medicine","volume":"45","author":"Murphy","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.arcmed.2020.08.006","article-title":"Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review","volume":"52","author":"Caplan","year":"2021","journal-title":"Arch. Med. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Primorac, D., Molnar, V., Rod, E., Jele\u010d, \u017d., \u010cukelj, F., Mati\u0161i\u0107, V., Vrdoljak, T., Hudetz, D., Hajsok, H., and Bori\u0107, I. (2020). Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations. Genes, 11.","DOI":"10.3390\/genes11080854"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3325\/cmj.2021.62.288","article-title":"Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: A case report","volume":"62","author":"Primorac","year":"2021","journal-title":"Croat. Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Primorac, D., Molnar, V., Mati\u0161i\u0107, V., Hudetz, D., Jele\u010d, \u017d., Rod, E., \u010cukelj, F., Vidovi\u0107, D., Vrdoljak, T., and Dobri\u010di\u0107, B. (2021). Comprehensive Review of Knee Osteoarthritis Pharmacological Treatment and the Latest Professional Societies\u2019 Guidelines. Pharmaceuticals, 14.","DOI":"10.3390\/ph14030205"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Fageeh, H.N. (2021). Preliminary Evaluation of Proliferation, Wound Healing Properties, Osteogenic and Chondrogenic Potential of Dental Pulp Stem Cells Obtained from Healthy and Periodontitis Affected Teeth. Cells, 10.","DOI":"10.3390\/cells10082118"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/23202068211010768","article-title":"Isolation, Characterization, and Differentiation of Stem Cells From Various Dental Sources: An In Vitro Study","volume":"12","author":"Katti","year":"2021","journal-title":"J. Adv. Oral Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/5584_2018_333","article-title":"Stem Cells Derived from Dental Tissues","volume":"1144","author":"Aydin","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/ten.tec.2016.0519","article-title":"Cryopreservation Method for the Effective Collection of Dental Pulp Stem Cells","volume":"23","author":"Takebe","year":"2017","journal-title":"Tissue Eng.-Part C Methods"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00418-009-0646-5","article-title":"Isolation and in vitro characterisation of dental pulp stem cells from natal teeth","volume":"133","author":"Aksoy","year":"2010","journal-title":"Histochem. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2217\/rme-2019-0005","article-title":"Current evidence of tissue engineering for dentine regeneration in animal models: A systematic review","volume":"15","author":"Moreira","year":"2020","journal-title":"Regen. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1177\/0022034515608128","article-title":"The role of ORAI1 in the odontogenic differentiation of human dental pulp stem cells","volume":"94","author":"Sohn","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8864572","article-title":"Dental Tissue-Derived Human Mesenchymal Stem Cells and Their Potential in Therapeutic Application","volume":"2020","author":"Gan","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1096\/fj.201902482R","article-title":"Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth","volume":"34","author":"Pagella","year":"2020","journal-title":"FASEB J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1155\/2017\/2582080","article-title":"The Angiogenic Potential of DPSCs and SCAPs in an in Vivo Model of Dental Pulp Regeneration","volume":"2017","author":"Hilkens","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0506-5","article-title":"Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: A pilot clinical study","volume":"8","author":"Nakashima","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"204173141775276","DOI":"10.1177\/2041731417752766","article-title":"The use of human dental pulp stem cells for in vivo bone tissue engineering: A systematic review","volume":"9","author":"Junior","year":"2018","journal-title":"J. Tissue Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jcyt.2017.12.011","article-title":"Progress in the use of dental pulp stem cells in regenerative medicine","volume":"20","author":"Anitua","year":"2018","journal-title":"Cytotherapy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.joen.2016.09.005","article-title":"Human Dental Pulp Stem Cells Suppress Alloantigen-induced Immunity by Stimulating T Cells to Release Transforming Growth Factor Beta","volume":"43","author":"Kwack","year":"2017","journal-title":"J. Endod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: Stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000099617","article-title":"Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers","volume":"184","author":"Kerkis","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0022034509340867","article-title":"Critical reviews in oral biology & medicine: Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in Regenerative Medicine","volume":"88","author":"Huang","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.joen.2009.07.024","article-title":"Stem Cell Proliferation Pathways Comparison between Human Exfoliated Deciduous Teeth and Dental Pulp Stem Cells by Gene Expression Profile from Promising Dental Pulp","volume":"35","author":"Nakamura","year":"2009","journal-title":"J. Endod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1089\/scd.2009.0258","article-title":"Stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells","volume":"19","author":"Wang","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.joen.2008.04.009","article-title":"Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth","volume":"34","author":"Cordeiro","year":"2008","journal-title":"J. Endod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/scrt5","article-title":"Immunomodulatory properties of stem cells from human exfoliated deciduous teeth","volume":"1","author":"Yamaza","year":"2010","journal-title":"Stem Cell Res. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1089\/ten.tea.2018.0016","article-title":"Immunomodulatory Role of Stem Cells from Human Exfoliated Deciduous Teeth on Periodontal Regeneration","volume":"24","author":"Gao","year":"2018","journal-title":"Tissue Eng.-Part A"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0000079","article-title":"Mesenchymal stem cell-mediated functional tooth regeneration in Swine","volume":"1","author":"Sonoyama","year":"2006","journal-title":"PLoS ONE"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joen.2007.11.021","article-title":"Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth: A Pilot Study","volume":"34","author":"Sonoyama","year":"2008","journal-title":"J. Endod."},{"key":"ref_39","first-page":"1","article-title":"Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy","volume":"2019","author":"Kang","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yexcr.2013.10.005","article-title":"Multilineage potential and proteomic profiling of human dental stem cells derived from a single donor","volume":"320","author":"Patil","year":"2014","journal-title":"Exp. Cell Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1348-8643(07)80011-5","article-title":"Multilineage Cells from Apical Pulp of Human Tooth with Immature Apex","volume":"4","author":"Abe","year":"2007","journal-title":"Oral Sci. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1016\/j.yexcr.2013.07.008","article-title":"Depletion of histone demethylase KDM2A enhanced the adipogenic and chondrogenic differentiation potentials of stem cells from apical papilla","volume":"319","author":"Dong","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jcp.22050","article-title":"Effect of cryopreservation on biological and immunological properties of stem cells from apical papilla","volume":"223","author":"Ding","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/scd.2019.0025","article-title":"Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives","volume":"28","author":"Trubiani","year":"2019","journal-title":"Stem Cells Dev."},{"key":"ref_46","first-page":"1","article-title":"Dose-Dependent Effects of Zoledronic Acid on Human Periodontal Ligament Stem Cells: An In Vitro Pilot Study","volume":"29","author":"Chiarella","year":"2020","journal-title":"Cell Transplant."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.cellsig.2016.07.012","article-title":"Nuclear translocation of PKC\u03b1 isoenzyme is involved in neurogenic commitment of human neural crest-derived periodontal ligament stem cells","volume":"28","author":"Trubiani","year":"2016","journal-title":"Cell. Signal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5051\/jpis.2010.40.6.265","article-title":"Immunomodulatory effect of canine periodontal ligament stem cells on allogenic and xenogenic peripheral blood mononuclear cells","volume":"40","author":"Kim","year":"2010","journal-title":"J. Periodontal Implant Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/stem.1909","article-title":"Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells","volume":"33","author":"Liu","year":"2015","journal-title":"Stem Cells"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Giudice, A., Antonelli, A., Chiarella, E., Baudi, F., Barni, T., and Di Vito, A. (2020). The case of medication-related osteonecrosis of the jaw addressed from a pathogenic point of view. innovative therapeutic strategies: Focus on the most recent discoveries on oral mesenchymal stem cell-derived exosomes. Pharmaceuticals, 13.","DOI":"10.3390\/ph13120423"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1089\/scd.2019.0031","article-title":"Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium","volume":"28","author":"Tomokiyo","year":"2019","journal-title":"Stem Cells Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/ten.tea.2016.0274","article-title":"Conditioned Medium from Periodontal Ligament Stem Cells Enhances Periodontal Regeneration","volume":"23","author":"Nagata","year":"2017","journal-title":"Tissue Eng. Part A"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1359\/JBMR.041117","article-title":"Alveolar bone marrow as a cell source for regenerative medicine: Differences between alveolar and iliac bone marrow stromal cells","volume":"20","author":"Matsubara","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4058656","article-title":"Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA\/Collagen\/PLA Scaffold","volume":"2016","author":"Wang","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1600-051X.2012.01865.x","article-title":"Acquisition of human alveolar bone-derived stromal cells using minimally irrigated implant osteotomy: In vitro and in vivo evaluations","volume":"39","author":"Park","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01605-x","article-title":"Characterization of the immunomodulatory properties of alveolar bone-derived mesenchymal stem cells","volume":"11","author":"Cao","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.4049\/jimmunol.0990118","article-title":"Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis","volume":"184","author":"Zhang","year":"2010","journal-title":"J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1089\/scd.2010.0523","article-title":"Gingiva-derived mesenchymal stem cell-mediated therapeutic approach for bone tissue regeneration","volume":"20","author":"Wang","year":"2011","journal-title":"Stem Cells Dev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-0850-0","article-title":"Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: A new tool for bone defect repair","volume":"9","author":"Diomede","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0751-7","article-title":"Treatment of gingival defects with gingival mesenchymal stem cells derived from human fetal gingival tissue in a rat model","volume":"9","author":"Li","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1089\/scd.2011.0252","article-title":"Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis","volume":"21","author":"Zhang","year":"2012","journal-title":"Stem Cells Dev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.matbio.2004.12.004","article-title":"Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth","volume":"24","author":"Morsczeck","year":"2005","journal-title":"Matrix Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2016\/4682875","article-title":"The comparison of the immunologic properties of stem cells isolated from human exfoliated deciduous teeth, dental pulp, and dental follicles","volume":"2016","author":"Yildirim","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2217\/rme.15.21","article-title":"Comparison of human dental follicle cells and human periodontal ligament cells for dentin tissue regeneration","volume":"10","author":"Tian","year":"2015","journal-title":"Regen. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1089\/scd.2009.0277","article-title":"Periapical follicle stem cell: A promising candidate for cementum\/periodontal ligament regeneration and bio-root engineering","volume":"19","author":"Han","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00441-007-0397-3","article-title":"Human dental follicle cells acquire cementoblast features under stimulation by BMP-2\/-7 and enamel matrix derivatives (EMD) in vitro","volume":"329","author":"Rue","year":"2007","journal-title":"Cell Tissue Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/scd.2010.0145","article-title":"Immunomodulatory properties of mesenchymal stem cells derived from dental pulp and dental follicle are susceptible to activation by toll-like receptor agonists","volume":"20","author":"Tomic","year":"2011","journal-title":"Stem Cells Dev."},{"key":"ref_68","first-page":"105","article-title":"Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: Implications in neo-vascularization, osteo-, adipo-and neurogenesis","volume":"10","author":"Yalvac","year":"2010","journal-title":"Pharm. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/term.1975","article-title":"Cartilage tissue engineering on macroporous scaffolds using human tooth germ stem cells","volume":"11","author":"Ramazanoglu","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1007\/s12010-013-0706-0","article-title":"Bmp 2 and Bmp 7 induce odonto- and osteogenesis of human tooth germ stem cells","volume":"172","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10561-015-9498-5","article-title":"Effect of uncontrolled freezing on biological characteristics of human dental pulp stem cells","volume":"16","author":"Kumar","year":"2015","journal-title":"Cell Tissue Bank."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bj.2020.02.003","article-title":"Banking on teeth\u2013Stem cells and the dental office","volume":"43","author":"Zeitlin","year":"2020","journal-title":"Biomed. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/cbin.11626","article-title":"Dental stem cell banking: Techniques and protocols","volume":"45","author":"Khaseb","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref_74","first-page":"412","article-title":"Guidelines for the management of traumatic dental injuries: 2. avulsion of permanent teeth","volume":"39","author":"Andersson","year":"2017","journal-title":"Pediatr. Dent."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.joms.2009.06.011","article-title":"Tooth Replantation After Use of Euro-Collins Solution or Bovine Milk as Storage Medium: A Histomorphometric Analysis in Dogs","volume":"68","author":"Sottovia","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cryobiol.2015.07.003","article-title":"Mesenchymal stromal cells derived from various tissues: Biological, clinical and cryopreservation aspects","volume":"71","author":"McGann","year":"2015","journal-title":"Cryobiology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-3-319-45457-3_17","article-title":"Cryopreservation and banking of dental stem cells","volume":"951","author":"Hilkens","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/CTTT.S11249","article-title":"Cryopreservation and Cell Banking for Autologous Mesenchymal Stem Cell-Based Therapies","volume":"5","author":"Harel","year":"2013","journal-title":"Cell Tissue Transplant. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4103\/1735-3327.192266","article-title":"Scaffolds in regenerative endodontics: A review","volume":"13","author":"Gathani","year":"2016","journal-title":"Dent. Res. J."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Tatullo, M., Codispoti, B., Paduano, F., Nuzzolese, M., and Makeeva, I. (2019). Strategic Tools in Regenerative and Translational Dentistry. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081879"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/5584_2020_505","article-title":"A current overview of scaffold-based bone regeneration strategies with dental stem cells","volume":"1288","author":"Ercal","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/BOT.0000000000000978","article-title":"Size Matters: Defining Critical in Bone Defect Size!","volume":"31","author":"Schemitsch","year":"2017","journal-title":"J. Orthop. Trauma"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000469704","article-title":"Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?","volume":"204","author":"Oryan","year":"2017","journal-title":"Cells Tissues Organs"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Pina, S., Ribeiro, V.P., Marques, C.F., Maia, F.R., Silva, T.H., Reis, R.L., and Oliveira, J.M. (2019). Regenerative Medicine Applications. Materials, 12.","DOI":"10.3390\/ma12111824"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tice.2018.04.004","article-title":"Development of a novel biomaterial with an important osteoinductive capacity for hard tissue engineering","volume":"52","author":"Simu","year":"2018","journal-title":"Tissue Cell"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Zein, N., Harmouch, E., Lutz, J., De Grado, G.F., Kuchler-Bopp, S., Clauss, F., Offner, D., Hua, G., Benkirane-Jessel, N., and Fioretti, F. (2019). Polymer-Based Instructive Scaffolds for Endodontic Regeneration. Materials, 12.","DOI":"10.3390\/ma12152347"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.joen.2016.07.019","article-title":"Triple Antibiotic Polymer Nanofibers for Intracanal Drug Delivery: Effects on Dual Species Biofilm and Cell Function","volume":"42","author":"Pankajakshan","year":"2016","journal-title":"J. Endod."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cden.2017.06.009","article-title":"Advanced Scaffolds for Dental Pulp and Periodontal Regeneration","volume":"61","author":"Bottino","year":"2017","journal-title":"Dent. Clin. N. Am."},{"key":"ref_89","first-page":"3328","article-title":"The recent advances in scaffolds for integrated periodontal regeneration","volume":"6","author":"Woo","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40634-017-0118-0","article-title":"Scaffold-free tissue engineering for injured joint surface restoration","volume":"5","author":"Shimomura","year":"2018","journal-title":"J. Exp. Orthop."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Shoushrah, S.H., Transfeld, J.L., Tonk, C.H., B\u00fcchner, D., Witzleben, S., Sieber, M.A., Schulze, M., and Tobiasch, E. (2021). Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126387"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10439-014-1161-y","article-title":"Emergence of Scaffold-Free Approaches for Tissue Engineering Musculoskeletal Cartilages","volume":"43","author":"DuRaine","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Cicci\u00f9, M. (2020). Growth factor applied to oral and regenerative surgery. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207752"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/00000658-199406000-00012","article-title":"Determination of Endogenous Cytokines in Chronic Wounds","volume":"219","author":"Cooper","year":"1994","journal-title":"Ann. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/iej.12954","article-title":"Regenerative endodontics: A comprehensive review","volume":"51","author":"Kim","year":"2018","journal-title":"Int. Endod. J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joen.2014.11.021","article-title":"Influence of root canal disinfectants on growth factor release from dentin","volume":"41","author":"Galler","year":"2015","journal-title":"J. Endod."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cden.2016.08.005","article-title":"Biological Molecules for the Regeneration of the Pulp-Dentin Complex","volume":"61","author":"Kim","year":"2017","journal-title":"Dent. Clin. N. Am."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.joen.2015.08.026","article-title":"Regenerative Endodontic Treatment of an Immature Necrotic Molar with Arrested Root Development by Using Recombinant Human Platelet-derived Growth Factor: A Case Report","volume":"42","author":"Zhujiang","year":"2016","journal-title":"J. Endod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coms.2016.08.006","article-title":"Maxillofacial Defects and the Use of Growth Factors","volume":"29","author":"Herford","year":"2017","journal-title":"Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S1079-2104(98)90029-4","article-title":"Platelet-rich plasma: Growth factor enhancement for bone grafts","volume":"85","author":"Marx","year":"1998","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/SCS.0000000000002560","article-title":"Histologic and histomorphometric comparison of bone regeneration between bone morphogenetic protein-2 and platelet-derived growth factor-bb in experimental groups","volume":"27","author":"Guven","year":"2016","journal-title":"J. Craniofac. Surg."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1016\/j.biomaterials.2011.08.047","article-title":"The use of injectable sonication-induced silk hydrogel for VEGF165 and BMP-2 delivery for elevation of the maxillary sinus floor","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"key":"ref_103","first-page":"573","article-title":"Expression of four growth factors during fracture repair","volume":"37","author":"Bourque","year":"1993","journal-title":"Int. J. Dev. Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jcms.2009.10.010","article-title":"Effects of osteoinduction on bone regeneration in distraction: Results of a pilot study","volume":"38","author":"Kroczek","year":"2010","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3109\/00016356109043395","article-title":"The Role of the Blood Clot in Endodontic Therapy an Experimental Histologic Study","volume":"19","year":"1961","journal-title":"Acta Odontol. Scand."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1600-0722.1971.tb02019.x","article-title":"Tissue formation in the root canal following pulp removal","volume":"79","author":"Hjortdal","year":"1971","journal-title":"Eur. J. Oral Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-9657.2010.00963.x","article-title":"Revascularization of an immature permanent tooth with periradicular abscess after luxation","volume":"27","author":"Iwaya","year":"2011","journal-title":"Dent. Traumatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.joen.2006.09.013","article-title":"Regenerative Endodontics: A Review of Current Status and a Call for Action","volume":"33","author":"Murray","year":"2007","journal-title":"J. Endod."},{"key":"ref_109","unstructured":"(2021, September 29). Regenerative Endodontics-American Association of Endodontists. Available online: https:\/\/www.aae.org\/specialty\/clinical-resources\/regenerative-endodontics\/."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1177\/0022034515596527","article-title":"Delivery of apical mesenchymal stem cells into root canals of mature teeth","volume":"94","author":"Chrepa","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.joen.2015.09.015","article-title":"Treatment of Mature Permanent Teeth with Necrotic Pulps and Apical Periodontitis Using Regenerative Endodontic Procedures: A Case Series","volume":"42","author":"Saoud","year":"2016","journal-title":"J. Endod."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.joen.2013.04.029","article-title":"Regenerative endodontic treatment of permanent teeth after completion of root development: A report of 2 cases","volume":"39","author":"Paryani","year":"2013","journal-title":"J. Endod."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1177\/0022034514537829","article-title":"Missing concepts in de novo pulp regeneration","volume":"93","author":"Huang","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.3727\/096368914X683502","article-title":"Trophic effects and regenerative potential of mobilized mesenchymal stem cells from bone marrow and adipose tissue as alternative cell sources for pulp\/dentin regeneration","volume":"24","author":"Murakami","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Krupi\u0144ska, A.M., Sko\u015bkiewicz-Malinowska, K., and Staniowski, T. (2021). Different Approaches to the Regeneration of Dental Tissues in Regenerative Endodontics. Appl. Sci., 11.","DOI":"10.3390\/app11041699"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1089\/ten.tea.2010.0615","article-title":"Complete pulp regeneration after pulpectomy by transplantation of CD105+ stem cells with stromal cell-derived factor-1","volume":"17","author":"Iohara","year":"2011","journal-title":"Tissue Eng.-Part A"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.joen.2018.11.009","article-title":"Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells and Leukocyte Platelet-rich Fibrin: A Case Report","volume":"45","author":"Meza","year":"2019","journal-title":"J. Endod."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/tan.12614","article-title":"Allogenic benefit in stem cell therapy: Cardiac repair and regeneration","volume":"86","author":"Charron","year":"2015","journal-title":"Tissue Antigens"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/j.joen.2016.04.029","article-title":"Release of Growth Factors into Root Canal by Irrigations in Regenerative Endodontics","volume":"42","author":"Zeng","year":"2016","journal-title":"J. Endod."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00264-014-2664-8","article-title":"Growth factors and platelet-rich plasma: Promising biological strategies for early intervertebral disc degeneration","volume":"39","author":"Wang","year":"2015","journal-title":"Int. Orthop."},{"key":"ref_121","first-page":"1","article-title":"The influence of platelet-derived products on angiogenesis and tissue repair: A concise update","volume":"6","author":"Smith","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4103\/0972-0707.120932","article-title":"Comparative outcome of revascularization in bilateral, non-vital, immature maxillary anterior teeth supplemented with or without platelet rich plasma: A case series","volume":"16","author":"Jadhav","year":"2013","journal-title":"J. Conserv. Dent."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40824-016-0061-7","article-title":"Biomimetic microenvironments for regenerative endodontics","volume":"20","author":"Kaushik","year":"2016","journal-title":"Biomater. Res."},{"key":"ref_124","first-page":"51","article-title":"Stem Cell in Modern Dentistry: A Review Article","volume":"3","author":"Vyas","year":"2017","journal-title":"Int. J. Res. Health Allied Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.34172\/jlms.2020.73","article-title":"Photobiomodulation Therapy in the Proliferation and Differentiation of Human Umbilical Cord Mesenchymal Stem Cells: An In Vitro Study","volume":"11","author":"Miranda","year":"2020","journal-title":"J. Lasers Med. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10103-017-2414-4","article-title":"Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source","volume":"33","author":"Vatansever","year":"2018","journal-title":"Lasers Med. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s10103-013-1436-9","article-title":"Effects of laser therapy on the proliferation of human periodontal ligament stem cells","volume":"30","author":"Soares","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1089\/scd.2016.0332","article-title":"Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells","volume":"26","author":"Yin","year":"2017","journal-title":"Stem Cells Dev."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Iohara, K., Utsunomiya, S., Kohara, S., and Nakashima, M. (2018). Allogeneic transplantation of mobilized dental pulp stem cells with the mismatched dog leukocyte antigen type is safe and efficacious for total pulp regeneration. Stem Cell Res. Ther., 9.","DOI":"10.1186\/s13287-018-0855-8"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1096\/fj.05-5211com","article-title":"Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement","volume":"20","author":"Gnecchi","year":"2006","journal-title":"FASEB J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/stem.2575","article-title":"Concise Review: MSC-Derived Exosomes for Cell-Free Therapy","volume":"35","author":"Phinney","year":"2017","journal-title":"Stem Cells"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10571-016-0366-z","article-title":"Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake","volume":"36","author":"Abels","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1089\/cell.2017.0047","article-title":"Lipid, Protein, and MicroRNA Composition Within Mesenchymal Stem Cell-Derived Exosomes","volume":"20","author":"Deng","year":"2018","journal-title":"Cell. Reprogram."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","article-title":"Exosome Theranostics: Biology and Translational Medicine","volume":"8","author":"He","year":"2018","journal-title":"Theranostics"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1002\/stem.1771","article-title":"HucMSc-exosome mediated-Wnt4 signaling is required for cutaneous wound healing","volume":"33","author":"Zhang","year":"2015","journal-title":"Stem Cells"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.scr.2008.02.002","article-title":"Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium","volume":"1","author":"Timmers","year":"2008","journal-title":"Stem Cell Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.febslet.2015.03.031","article-title":"Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration","volume":"589","author":"Nakamura","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood-2011-02-338004","article-title":"Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes","volume":"119","author":"Montecalvo","year":"2012","journal-title":"Blood"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/sci.2017.09.06","article-title":"Clinical potential of mesenchymal stem\/stromal cell-derived extracellular vesicles","volume":"4","author":"Giebel","year":"2017","journal-title":"Stem Cell Investig."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1038\/s41467-019-12321-3","article-title":"CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity","volume":"10","author":"Fu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Gurunathan, S., Kang, M., Jeyaraj, M., Qasim, M., and Kim, J. (2019). Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes. Cells, 8.","DOI":"10.3390\/cells8040307"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Codispoti, B., Marrelli, M., Paduano, F., and Tatullo, M. (2018). NANOmetric BIO-Banked MSC-Derived Exosome (NANOBIOME) as a Novel Approach to Regenerative Medicine. J. Clin. Med., 7.","DOI":"10.3390\/jcm7100357"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s12015-020-10117-3","article-title":"Stem Cell-based Dental Pulp Regeneration: Insights From Signaling Pathways","volume":"17","author":"Liang","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adhm.201800457","article-title":"Tissue Engineered Constructs for Periodontal Regeneration: Current Status and Future Perspectives","volume":"7","author":"Vaquette","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jre.12275","article-title":"Tissue engineered periodontal products","volume":"51","author":"Bartold","year":"2016","journal-title":"J. Periodontal Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fphys.2017.00197","article-title":"Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/1574888X15666200726224132","article-title":"Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives","volume":"16","author":"Gong","year":"2021","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11914-016-0327-y","article-title":"Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders","volume":"14","author":"Aryaei","year":"2016","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11914-018-0462-8","article-title":"Part II: Temporomandibular Joint (TMJ)\u2014Regeneration, Degeneration, and Adaptation","volume":"16","author":"Roberts","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"ref_152","first-page":"295","article-title":"Temporomandibular disorders: Osteoarthritis","volume":"13","author":"Zarb","year":"1999","journal-title":"J. Orofac. Pain"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jdsr.2016.04.004","article-title":"The usefulness of diagnostic imaging for the assessment of pain symptoms in temporomandibular disorders","volume":"52","author":"Suenaga","year":"2016","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"De Souza, R.F., da Silva, C.H.L., Nasser, M., Fedorowicz, Z., and Al-Muharraqi, M.A. (2012). Interventions for managing temporomandibular joint osteoarthritis. Cochrane Database Syst. Rev., 2012.","DOI":"10.1002\/14651858.CD007261.pub2"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Hudetz, D., Bori\u0107, I., Rod, E., Jele\u010d, \u017d., Radi\u0107, A., Vrdoljak, T., Skelin, A., Lauc, G., Trbojevi\u0107-Akma\u010di\u0107, I., and Ple\u010dko, M. (2017). The effect of intra-articular injection of autologous microfragmented fat tissue on proteoglycan synthesis in patients with knee osteoarthritis. Genes, 8.","DOI":"10.3390\/genes8100270"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Bori\u0107, I., Hudetz, D., Rod, E., Jele\u010d, \u017d., Vrdoljak, T., Skelin, A., Pola\u0161ek, O., Ple\u010dko, M., Trbojevi\u0107-Akma\u010di\u0107, I., and Lauc, G. (2019). A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis. Genes, 10.","DOI":"10.3390\/genes10121051"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fgene.2016.00213","article-title":"Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair","volume":"7","author":"Fellows","year":"2016","journal-title":"Front. Genet."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1177\/0022034515604621","article-title":"RANTES and SDF-1 Are Keys in Cell-based Therapy of TMJ Osteoarthritis","volume":"94","author":"Lu","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s00167-018-5118-9","article-title":"Injective mesenchymal stem cell-based treatments for knee osteoarthritis: From mechanisms of action to current clinical evidences","volume":"27","author":"Lopa","year":"2019","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s13287-015-0240-9","article-title":"The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy","volume":"6","author":"Zhang","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.joca.2017.05.007","article-title":"Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandibular joint cartilage","volume":"25","author":"Zhang","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.joca.2012.06.003","article-title":"Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture","volume":"20","author":"Villafuertes","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1801236","DOI":"10.1002\/adhm.201801236","article-title":"Tissue Engineering for the Temporomandibular Joint","volume":"8","author":"Acri","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0278-2391(87)90303-X","article-title":"CT evaluation of TMJ disc replacement with a proplast-teflon laminate","volume":"45","author":"Heffez","year":"1987","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/0278-2391(95)90577-4","article-title":"A protocol for the management of failed alloplastic temporomandibular joint disc implants","volume":"53","author":"Kearns","year":"1995","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2485\/jhtb.24.211","article-title":"Experimental Study on In Situ Tissue Engineering of the Temporomandibular Joint Disc using Autologous Bone Marrow and Collagen Sponge Scaffold","volume":"24","author":"Kobayashi","year":"2015","journal-title":"J. Hard Tissue Biol."},{"key":"ref_167","first-page":"1","article-title":"The Pilot Study of Fibrin with Temporomandibular Joint Derived Synovial Stem Cells in Repairing TMJ Disc Perforation","volume":"2014","author":"Wu","year":"2014","journal-title":"Biomed Res. Int."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1016\/j.joms.2011.02.130","article-title":"Extracellular Matrix as an Inductive Template for Temporomandibular Joint Meniscus Reconstruction: A Pilot Study","volume":"69","author":"Brown","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/0278-2391(94)90538-X","article-title":"Temporomandibular joint disc replacement made by tissue-engineered growth of cartilage","volume":"52","author":"Puelacher","year":"1994","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"20130287","DOI":"10.1098\/rsif.2013.0287","article-title":"Autologous adipose stem cells and polylactide discs in the replacement of the rabbit temporomandibular joint disc","volume":"10","author":"Ahtiainen","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1177\/0022034516642404","article-title":"Engineering Human TMJ Discs with Protein-Releasing 3D-Printed Scaffolds","volume":"95","author":"Legemate","year":"2016","journal-title":"J. Dent. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0952-3278(89)90154-3","article-title":"Influence of propranolol on platelet aggregation and thromboxane B2 production from platelet-rich plasma and whole blood","volume":"36","author":"Anfossi","year":"1989","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1537-2995.1990.30790385523.x","article-title":"Platelet activation during preparation of platelet concentrates: A comparison of the platelet-rich plasma and the buffy coat methods","volume":"30","author":"Fijnheer","year":"1990","journal-title":"Transfusion"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00784-020-03420-3","article-title":"Evaluation of local hemostatic efficacy after dental extractions in patients taking antiplatelet drugs: A randomized clinical trial","volume":"25","author":"Brancaccio","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12903-019-0824-3","article-title":"Impact of platelet-rich fibrin on mandibular third molar surgery recovery: A systematic review and meta-analysis","volume":"19","author":"Xiang","year":"2019","journal-title":"BMC Oral Health"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"13","DOI":"10.22203\/eCM.v020a02","article-title":"A recently developed bifacial platelet-rich fibrin matrix","volume":"20","author":"Lucarelli","year":"2010","journal-title":"Eur. Cells Mater."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/2231-0746.83158","article-title":"Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons","volume":"1","author":"Saluja","year":"2011","journal-title":"Ann. Maxillofac. Surg."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00784-016-1719-1","article-title":"Comparative release of growth factors from PRP, PRF, and advanced-PRF","volume":"20","author":"Kobayashi","year":"2016","journal-title":"Clin. Oral Investig."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1089\/ten.tea.2010.0327","article-title":"Platelet-Rich Fibrin is a Bioscaffold and Reservoir of Growth Factors for Tissue Regeneration","volume":"17","author":"Kang","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"ref_180","first-page":"e1051","article-title":"The role of Leucocyte-rich and platelet-rich fibrin (L-PRF) in the treatment of the medication-related osteonecrosis of the jaws (MRONJ)","volume":"9","year":"2017","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"813","DOI":"10.4103\/ijdr.IJDR_689_19","article-title":"Usefulness of advanced-platelet rich fibrin (A-PRF) and injectable-platelet rich fibrin (i-PRF) in the management of a massive medication-related osteonecrosis of the jaw (MRONJ): A 5-years follow-up case report","volume":"31","author":"Giudice","year":"2020","journal-title":"Indian J. Dent. Res."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Van Bellinghen, X., Idoux-Gillet, Y., Pugliano, M., Strub, M., Bornert, F., Clauss, F., Schwint\u00e9, P., Keller, L., Benkirane-Jessel, N., and Kuchler-Bopp, S. (2018). Temporomandibular Joint Regenerative Medicine. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020446"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/3\/1662\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:12:02Z","timestamp":1760134322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/3\/1662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":182,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["ijms23031662"],"URL":"https:\/\/doi.org\/10.3390\/ijms23031662","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,31]]}}}