{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:59:03Z","timestamp":1793444343061,"version":"4.5.0"},"reference-count":106,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T00:00:00Z","timestamp":1644105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic radiation cystitis (CRC) is a consequence of pelvic radiotherapy and affects 5\u201310% of patients. The pathology of CRC is without curative treatment and is characterized by incontinence, pelvic pain and hematuria, which severely degrades patients\u2019 quality of life. Current management strategies rely primarily on symptomatic measures and have certain limitations. Thanks to a better understanding of the pathophysiology of radiation cystitis, studies targeting key manifestations such as inflammation, neovascularization and cell atrophy have emerged and are promising avenues for future treatment. However, the mechanisms of CRC are still better described in animal models than in human models. Preclinical studies conducted to elucidate the pathophysiology of CRC use distinct models and are most often limited to specific processes, such as fibrosis, vascular damage and inflammation. This review presents a synthesis of experimental studies aimed at improving our understanding of the molecular mechanisms at play and identifying key processes in CRC.<\/jats:p>","DOI":"10.3390\/ijms23031836","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T20:36:47Z","timestamp":1644179807000},"page":"1836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Understanding Molecular Mechanisms and Identifying Key Processes in Chronic Radiation Cystitis"],"prefix":"10.3390","volume":"23","author":[{"given":"Cl\u00e9ment","family":"Brossard","sequence":"first","affiliation":[{"name":"Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 31 Avenue de la Division Leclerc, Fontenay-aux-Roses, 92260 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Charlotte","family":"Lefranc","sequence":"additional","affiliation":[{"name":"Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 31 Avenue de la Division Leclerc, Fontenay-aux-Roses, 92260 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Simon","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Universitaire Piti\u00e9-Salp\u00eatri\u00e8re, Radiotherapy-Oncology Department, 47-83 Boulevard de l\u2019H\u00f4pital, CEDEX 13, 75651 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Benderitter","sequence":"additional","affiliation":[{"name":"Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 31 Avenue de la Division Leclerc, Fontenay-aux-Roses, 92260 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Milliat","sequence":"additional","affiliation":[{"name":"Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 31 Avenue de la Division Leclerc, Fontenay-aux-Roses, 92260 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-4120","authenticated-orcid":false,"given":"Alain","family":"Chapel","sequence":"additional","affiliation":[{"name":"Service de Recherche en Radiobiologie et en M\u00e9decine R\u00e9g\u00e9n\u00e9rative (SERAMED), Laboratoire de Radiobiologie des Expositions M\u00e9dicales (LRMED), Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), 31 Avenue de la Division Leclerc, Fontenay-aux-Roses, 92260 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,6]]},"reference":[{"key":"ref_1","unstructured":"The Global Cancer Observatory: International Agency for Research on Cancer: World Health Organization 2020 (Globocan) (2021, December 25). 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