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Our previous work suggests that the DNA repair activity of APE1\/Ref-1, the rate-limiting enzyme of the base excision repair (BER) pathway, is critical for neuroprotection against cisplatin. A specific role for 8-oxoguanine DNA glycosylase-1 (OGG1), the glycosylase that removes the most common oxidative DNA lesion, and putative coordination of OGG1 with APE1\/Ref-1 in sensory neurons, has not been investigated. We investigated whether inhibiting OGG1 glycosylase activity with the small molecule inhibitor, TH5487, and\/or APE1\/Ref-1 endonuclease activity with APE Repair Inhibitor III would alter the neurotoxic effects of cisplatin in sensory neuronal cultures. Sensory neuron function was assessed by calcitonin gene-related peptide (CGRP) release, as a marker of sensitivity and by neurite outgrowth. Cisplatin altered neuropeptide release in an inverse U-shaped fashion, with low concentrations enhancing and higher concentrations diminishing CGRP release. Pretreatment with BER inhibitors exacerbated the functional effects of cisplatin and enhanced 8oxo-dG and adduct lesions in the presence of cisplatin. Our studies demonstrate that inhibition of OGG1 and APE1 endonuclease activity enhances oxidative DNA damage and exacerbates neurotoxicity, thus limiting oxidative DNA damage in sensory neurons that might alleviate cisplatin-induced neuropathy.<\/jats:p>","DOI":"10.3390\/ijms23031909","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T23:37:48Z","timestamp":1644363468000},"page":"1909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4700-2428","authenticated-orcid":false,"given":"Adib","family":"Behrouzi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric L.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-1826","authenticated-orcid":false,"given":"Mark R.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"},{"name":"Department of Pediatrics, Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0730-9644","authenticated-orcid":false,"given":"Jill C.","family":"Fehrenbacher","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Stark Neuroscience Research Institute, Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis","volume":"155","author":"Seretny","year":"2014","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","article-title":"The resurgence of platinum-based cancer chemotherapy","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nbd.2016.10.003","article-title":"Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve","volume":"97","author":"Podratz","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.nbd.2010.11.017","article-title":"Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons","volume":"41","author":"Podratz","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s12035-016-0364-7","article-title":"Depletion of Mitofusin-2 Causes Mitochondrial Damage in Cisplatin-Induced Neuropathy","volume":"55","author":"Bobylev","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Leo, M., Schmitt, L.I., Kusterarent, P., Kutritz, A., Rassaf, T., Kleinschnitz, C., Hendgen-Cotta, U.B., and Hagenacker, T. (2020). Platinum-Based Drugs Cause Mitochondrial Dysfunction in Cultured Dorsal Root Ganglion Neurons. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228636"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kelley, M.R., Jiang, Y., Guo, C., Reed, A., Meng, H., and Vasko, M.R. (2014). Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106485"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1523\/JNEUROSCI.0523-07.2007","article-title":"Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy","volume":"27","author":"Dzagnidze","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1007\/s12035-016-0273-9","article-title":"Cisplatin Toxicity in Dorsal Root Ganglion Neurons Is Relieved by Meclizine via Diminution of Mitochondrial Compromise and Improved Clearance of DNA Damage","volume":"54","author":"Gorgun","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_10","first-page":"215","article-title":"Differences in the inhibition of neuritic outgrowth in organotypic cultures of rat foetal dorsal root ganglia treated with cisplatin and carboplatin: A comparative study","volume":"35","author":"Jirsova","year":"1997","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/ijc.2910570614","article-title":"Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle","volume":"57","author":"Donaldson","year":"1994","journal-title":"Int. J. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/taap.1997.8252","article-title":"Effects of antioxidants and Ca2+ in cisplatin-induced cell injury in rabbit renal cortical slices","volume":"146","author":"Kim","year":"1997","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1002\/ijc.22088","article-title":"Severe oxidatively damaged DNA after cisplatin treatment of cancer patients","volume":"119","author":"Siomek","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mrfmmm.2006.06.007","article-title":"DNA repair in neurons: So if they don\u2019t divide what\u2019s to repair?","volume":"614","author":"Fishel","year":"2007","journal-title":"Mutat. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/jnc.13355","article-title":"Role of platinum DNA damage-induced transcriptional inhibition in chemotherapy-induced neuronal atrophy and peripheral neurotoxicity","volume":"135","author":"Yan","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nchembio0706-348","article-title":"One-electron oxidation of DNA and inflammation processes","volume":"2","author":"Cadet","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nchembio796","article-title":"Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation","volume":"2","author":"Margolin","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1021\/ja962255b","article-title":"How Easily Oxidizable Is DNA? One-Electron Reduction Potentials of Adenosine and Guanosine Radicals in Aqueous Solution","volume":"119","author":"Steenken","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1006\/bbrc.1999.0649","article-title":"Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells","volume":"258","author":"Monden","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1074\/jbc.270.2.949","article-title":"DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract","volume":"270","author":"Singhal","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.dnarep.2011.06.004","article-title":"The repair function of the multifunctional DNA repair\/redox protein APE1 is neuroprotective after ionizing radiation","volume":"10","author":"Vasko","year":"2011","journal-title":"DNA Repair"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1158\/0008-5472.CAN-08-1173","article-title":"Implications of apurinic\/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons","volume":"68","author":"Jiang","year":"2008","journal-title":"Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dnarep.2017.01.002","article-title":"Differential role of base excision repair proteins in mediating cisplatin cytotoxicity","volume":"51","author":"Sawant","year":"2017","journal-title":"DNA Repair"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9761","DOI":"10.1021\/bi034546k","article-title":"Oxidized guanine lesions as modulators of gene transcription. Altered p50 binding affinity and repair shielding by 7,8-dihydro-8-oxo-2\u2032-deoxyguanosine lesions in the NF-kappaB promoter element","volume":"42","author":"Kotler","year":"2003","journal-title":"Biochemistry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/10715769900300781","article-title":"Effects of 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine on the binding of the transcription factor Sp1 to its cognate target DNA sequence (GC box)","volume":"31","author":"Ramon","year":"1999","journal-title":"Free Radic. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.dnarep.2013.10.002","article-title":"DNA modifications repaired by base excision repair are epigenetic","volume":"12","author":"Moore","year":"2013","journal-title":"DNA Repair"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.dnarep.2004.01.003","article-title":"Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II","volume":"3","author":"Tornaletti","year":"2004","journal-title":"DNA Repair"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.aar8048","article-title":"Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation","volume":"362","author":"Visnes","year":"2018","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11409","DOI":"10.1073\/pnas.1912355117","article-title":"Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome","volume":"117","author":"Roychoudhury","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/00005537-200107000-00005","article-title":"L-n-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity","volume":"111","author":"Feghali","year":"2001","journal-title":"Laryngoscope"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ctrv.2006.04.011","article-title":"Future opportunities in preventing cisplatin induced ototoxicity","volume":"32","author":"Beijnen","year":"2006","journal-title":"Cancer Treat. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/carcin\/bgm072","article-title":"Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells","volume":"28","author":"Haihong","year":"2007","journal-title":"Carcinogenesis"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nature05978","article-title":"Base-excision repair of oxidative DNA damage","volume":"447","author":"David","year":"2007","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.expneurol.2013.12.011","article-title":"Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture","volume":"253","author":"Pittman","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_35","first-page":"883","article-title":"Cisplatin-induced DNA-platination in experimental dorsal root ganglia neuronopathy","volume":"20","author":"Meijer","year":"1999","journal-title":"Neurotoxicology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nbd.2004.09.013","article-title":"Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: A potential mechanism for neurotoxicity","volume":"18","author":"McDonald","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mrfmmm.2015.06.010","article-title":"APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER","volume":"779","author":"Kim","year":"2015","journal-title":"Mutat. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jpain.2011.04.008","article-title":"Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients","volume":"12","author":"Cata","year":"2011","journal-title":"J. Pain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1002\/jnr.22465","article-title":"Different effects of erythropoietin in cisplatin- and docetaxel-induced neurotoxicity: An in vitro study","volume":"88","author":"Maggioni","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0165-0270(94)90151-1","article-title":"Image analysis of neuritic regeneration by adult rat dorsal root ganglion neurons in culture: Quantification of the neurotoxicity of anticancer agents and of its prevention by nerve growth factor or basic fibroblast growth factor but not brain-derived neurotrophic factor or neurotrophin-3","volume":"53","author":"Malgrange","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.expneurol.2016.02.010","article-title":"Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons","volume":"279","author":"Pittman","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuro.2006.04.010","article-title":"Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding","volume":"27","author":"Ta","year":"2006","journal-title":"NeuroToxicology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1021\/bi034264k","article-title":"Nucleotide excision repair from site-specifically platinum-modified nucleosomes","volume":"42","author":"Wang","year":"2003","journal-title":"Biochemistry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1073\/pnas.71.7.2777","article-title":"The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria","volume":"71","author":"Clayton","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrm3439","article-title":"Minimizing the damage: Repair pathways keep mitochondrial DNA intact","volume":"13","author":"Kazak","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1158\/0008-5472.177.65.1","article-title":"Glycolytic enzymes can modulate cellular life span","volume":"65","author":"Kondoh","year":"2005","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fnmol.2017.00108","article-title":"Inhibition of Mitochondrial p53 Accumulation by PFT-mu Prevents Cisplatin-Induced Peripheral Neuropathy","volume":"10","author":"Maj","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S.S., and Doetsch, P.W. (2013). Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081162"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1158\/1535-7163.MCT-08-0929","article-title":"Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2\u2032-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs","volume":"8","author":"Preston","year":"2009","journal-title":"Mol. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8559","DOI":"10.1093\/nar\/gkt620","article-title":"Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence","volume":"41","author":"Allgayer","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"25553","DOI":"10.1074\/jbc.M116.751453","article-title":"Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor kappaB-driven Gene Expression","volume":"291","author":"Pan","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20769","DOI":"10.1074\/jbc.C112.364620","article-title":"Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine","volume":"287","author":"Boldogh","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.freeradbiomed.2014.03.030","article-title":"8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and alpha-smooth muscle actin polymerization","volume":"73","author":"Luo","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41580-020-0236-x","article-title":"The regulation and functions of DNA and RNA G-quadruplexes","volume":"21","author":"Varshney","year":"2020","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1021\/acs.biochem.0c00387","article-title":"Cruciform DNA Sequences in Gene Promoters Can Impact Transcription upon Oxidative Modification of 2\u2032-Deoxyguanosine","volume":"59","author":"Fleming","year":"2020","journal-title":"Biochemistry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.2174\/0929867325666171229132619","article-title":"The Interplay between G-quadruplex and Transcription","volume":"26","author":"Kim","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_57","first-page":"151","article-title":"APE1\/Ref-1\u2014One Target with Multiple Indications: Emerging Aspects and New Directions","volume":"2","author":"Mijit","year":"2021","journal-title":"J. Cell Signal."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103133","DOI":"10.1016\/j.dnarep.2021.103133","article-title":"Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing\/decay","volume":"104","author":"Malfatti","year":"2021","journal-title":"DNA Repair"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/bmc-2020-0019","article-title":"Role of phase partitioning in coordinating DNA damage response: Focus on the Apurinic Apyrimidinic Endonuclease 1 interactome","volume":"11","author":"Tosolini","year":"2020","journal-title":"Biomol. Concepts"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1124\/jpet.116.235283","article-title":"Identification and Characterization of New Chemical Entities Targeting Apurinic\/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy","volume":"359","author":"Kelley","year":"2016","journal-title":"J. Pharm. Exp."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2008.01.076","article-title":"Specificity of stimulation of human 8-oxoguanine-DNA glycosylase by AP endonuclease","volume":"368","author":"Sidorenko","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/nar\/29.2.430","article-title":"Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: Potential coordination of the initial steps in base excision repair","volume":"29","author":"Hill","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"14564","DOI":"10.1074\/jbc.M111.225375","article-title":"Novel role of base excision repair in mediating cisplatin cytotoxicity","volume":"286","author":"Kothandapani","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.dnarep.2017.06.007","article-title":"BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management","volume":"56","author":"Limpose","year":"2017","journal-title":"DNA Repair"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.1093\/nar\/gkt479","article-title":"Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity","volume":"41","author":"Kothandapani","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1093\/nar\/gkm404","article-title":"Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates","volume":"35","author":"Wong","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbi.2020.12.011","article-title":"Nasal administration of mesenchymal stem cells reverses chemotherapy-induced peripheral neuropathy in mice","volume":"93","author":"Boukelmoune","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Tan, D., Zhang, H., Deng, J., Liu, J., Wen, J., Li, L., Wang, X., Pan, M., Hu, X., and Guo, J. (2020). RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. Cells, 9.","DOI":"10.3390\/cells9010230"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/neuonc\/noaa151","article-title":"Cisplatin-induced peripheral neuropathy is associated with neuronal senescence-like response","volume":"23","author":"Calls","year":"2021","journal-title":"Neuro-Oncology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1038\/s41598-020-71042-6","article-title":"Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice","volume":"10","author":"Acklin","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"646924","DOI":"10.3389\/fnagi.2021.646924","article-title":"Cellular Senescence in Brain Aging","volume":"13","author":"Sikora","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: The dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1093\/nar\/gky326","article-title":"APE1 deficiency promotes cellular senescence and premature aging features","volume":"46","author":"Li","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Hanna, B.M.F., Helleday, T., and Mortusewicz, O. (2020). OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions. Biomolecules, 10.","DOI":"10.3390\/biom10111483"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1021\/jm201537d","article-title":"Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic\/apyrimidinic endonuclease 1 inhibitors","volume":"55","author":"Rai","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/3\/1909\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:16:17Z","timestamp":1760134577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/3\/1909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["ijms23031909"],"URL":"https:\/\/doi.org\/10.3390\/ijms23031909","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,8]]}}}