{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:15:04Z","timestamp":1770272104819,"version":"3.49.0"},"reference-count":74,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiwan Ministry of Science and Technology","award":["MOST-108-2314-B-075B-001-MY3"],"award-info":[{"award-number":["MOST-108-2314-B-075B-001-MY3"]}]},{"name":"Taiwan Ministry of Science and Technology","award":["MOST-110-2314-B-037-095"],"award-info":[{"award-number":["MOST-110-2314-B-037-095"]}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH 111-094"],"award-info":[{"award-number":["KSVGH 111-094"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Hospital","doi-asserted-by":"publisher","award":["KMUH110-0R31"],"award-info":[{"award-number":["KMUH110-0R31"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Peripheral nerve injury involves divergent alterations within dorsal root ganglia (DRG) neurons sensitized by persistent inflammation. Thymic stromal lymphopoietin (TSLP) production is crucial in the development of chronic inflammatory responses. Herein, we investigate the changes of TSLP expression in rats\u2019 DRG neurons between injured and uninjured sides in the same rat. Linalyl acetate (LA) was served as a TSLP inhibitor and given intraperitoneally. Rats were assigned to be group of chronic constriction injury (CCI) of the sciatic nerve and the group of CCI of the sciatic nerve administrated with LA. Over 14 days, the rats were measured for paw withdrawal thresholds. DRGs were collected to assess morphological changes via immunofluorescence study. After receiving CCI, the rats rapidly developed mechanical hyperalgesia. TSLP expression at DRG, on the ipsilateral injured side, was consistent with changes in pain behaviors. TSLP appeared in nerve fibers with both small diameters and large diameters. Additionally, TSLP was expressed mostly in transient receptor potential vanilloid-1 (TRPV1)-positive nociceptive neurons. Administration with LA can attenuate the pain behaviors and expression of TSLP in DRG neurons, and in apoptotic neurons at the injured side, but not in the contra-lateral uninjured side. Overall, these results imply that altered expressions of TSLP in nociceptive DRG neurons contributed to mechanical hyperalgesia in a CCI rat model.<\/jats:p>","DOI":"10.3390\/ijms23042012","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T21:08:43Z","timestamp":1644786523000},"page":"2012","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Contribution of TSLP Activation to Hyperalgesia in Dorsal Root Ganglia Neurons of a Rat"],"prefix":"10.3390","volume":"23","author":[{"given":"Chun-Ching","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Department of Orthopaedics, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-2345","authenticated-orcid":false,"given":"Ying-Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung 821, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Pei","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh-Hsin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"},{"name":"Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/14728222.2017.1328057","article-title":"Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain","volume":"21","author":"Berta","year":"2017","journal-title":"Expert Opin. 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