{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:53:43Z","timestamp":1760151223909,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Role of HIV-1 and HHV-8 in Kaposi's sarcoma and AIDS-associated serous lymphomas"],"award-info":[{"award-number":["Role of HIV-1 and HHV-8 in Kaposi's sarcoma and AIDS-associated serous lymphomas"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Kaposi\u2019s sarcoma (KS) is an angioproliferative tumor showing an increased frequency and aggressiveness in HIV-infected subjects (AIDS-KS), due to the combined effects of inflammatory cytokines (IC), angiogenic factors, and the HIV-1 Tat protein. While the introduction of effective combined antiretroviral regimens greatly improved AIDS-KS incidence and course, it continues to be an incurable disease and the development of new rational targeted therapies is warranted. We used the BKV\/Tat transgenic mouse model to evaluate the effects of IC and anti-Tat antibodies (Abs) treatment on KS-like lesions arising in BKV\/Tat mice. We demonstrated here that IC-treatment increases the severity and delays the regression of KS-like lesions. Further, anti-Tat Abs reduced KS-like lesion severity developing in IC-treated mice when anti-Tat Abs were administered at an early-stage of lesion development as compared to more advanced lesions. Early anti-Tat Abs treatment also accelerated KS-like lesion regression and reduced the rate of severe-grade lesions. This effect was more evident in the first weeks after Ab treatment, suggesting that a longer treatment with anti-Tat Abs might be even more effective, particularly if administered just after lesion development. Although preliminary, these results are encouraging, and the approach deserves further studies for the development of anti-Tat Ab-based therapies for AIDS-KS. Clinical studies specifically addressing the effect of anti-Tat antibodies in treating AIDS-KS are not yet available. Nevertheless, the effectiveness of anti-Tat antibodies in controlling HIV\/AIDS progression, likely due to the neutralization of extracellular Tat activities, is suggested by several cross-sectional and longitudinal clinical studies, indicating that anti-Tat Ab treatment or Tat-based vaccines may be effective to treat AIDS-KS patients or prevent the tumor in individuals at risk.<\/jats:p>","DOI":"10.3390\/ijms23042081","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T03:46:00Z","timestamp":1644810360000},"page":"2081","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kaposi\u2019s Sarcoma Lesion Progression in BKV-Tat Transgenic Mice Is Increased by Inflammatory Cytokines and Blocked by Treatment with Anti-Tat Antibodies"],"prefix":"10.3390","volume":"23","author":[{"given":"Egidio","family":"Brocca-Cofano","sequence":"first","affiliation":[{"name":"Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara 64B, 44121 Ferrara, Italy"},{"name":"BlueSphereBio, University of Pittsburgh, 350 Technology Drive, Suite 520, Pittsburgh, PA 15219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-4912","authenticated-orcid":false,"given":"Cecilia","family":"Sgadari","sequence":"additional","affiliation":[{"name":"National HIV\/AIDS Research Center, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orietta","family":"Picconi","sequence":"additional","affiliation":[{"name":"National HIV\/AIDS Research Center, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-5863","authenticated-orcid":false,"given":"Clelia","family":"Palladino","sequence":"additional","affiliation":[{"name":"National HIV\/AIDS Research Center, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1241-0299","authenticated-orcid":false,"given":"Antonella","family":"Caputo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara 64B, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-8737","authenticated-orcid":false,"given":"Barbara","family":"Ensoli","sequence":"additional","affiliation":[{"name":"National HIV\/AIDS Research Center, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0959-8049(01)00121-6","article-title":"Biology of Kaposi\u2019s sarcoma","volume":"37","author":"Ensoli","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/hiv.12584","article-title":"The world-wide incidence of Kaposi\u2019s sarcoma in the HIV\/AIDS era","volume":"19","author":"Liu","year":"2018","journal-title":"HIV Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000455971","article-title":"HIV-Associated Kaposi\u2019s Sarcoma","volume":"40","author":"Hoffmann","year":"2017","journal-title":"Oncol. Res. Treat."},{"key":"ref_4","first-page":"240","article-title":"Human immunodeficiency virus-associated oral Kaposi\u2019s sarcoma. A heterogeneous population dominated by spindle shaped endothelial cells","volume":"143","author":"Regezi","year":"1993","journal-title":"Am. J. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"744","DOI":"10.7326\/0003-4819-103-5-744","article-title":"The natural history of Kaposi\u2019s sarcoma in the acquired immunodeficiency syndrome","volume":"103","author":"Safai","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"ref_6","first-page":"329","article-title":"Production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) in patients with AIDS. Enhanced level of TNF- alpha is related to a higher cytotoxic activity","volume":"78","author":"Hober","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"ref_7","first-page":"158","article-title":"Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1","volume":"2","author":"Fuchs","year":"1989","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1172\/JCI114678","article-title":"Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes","volume":"86","author":"Emilie","year":"1990","journal-title":"J. Clin. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00002030-199001000-00003","article-title":"Tumour necrosis factors (alpha, beta) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication","volume":"4","author":"Vyakarnam","year":"1990","journal-title":"AIDS"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/00002030-199611000-00012","article-title":"Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals","volume":"10","author":"Rizzardini","year":"1996","journal-title":"AIDS"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/eji.1830230950","article-title":"Increased cytokine production in mononuclear cells of healthy elderly people","volume":"23","author":"Fagiolo","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1182\/blood.V91.3.968","article-title":"g-Interferon production in peripheral blood mononuclear cells (PBMC) and tumour infiltrating lymphocytes from Kaposi\u2019s sarcoma patients: Correlation with the presence of human herpesvirus-8 in PBMC and lesional macrophages","volume":"91","author":"Sirianni","year":"1998","journal-title":"Blood"},{"key":"ref_13","first-page":"956","article-title":"g-Interferon produced by CD81 T cells infiltrating Kaposi\u2019s sarcoma induces spindle cells with angiogenic phenotype and synergy with HIV-1 Tat protein: An immune response to HHV-8 infection?","volume":"91","author":"Fiorelli","year":"1998","journal-title":"Blood"},{"key":"ref_14","first-page":"4044","article-title":"Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi\u2019s sarcoma","volume":"93","author":"Monini","year":"1999","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0065-230X(01)81005-8","article-title":"Reactivation and role of HHV-8 in Kaposi\u2019s sarcoma initiation","volume":"81","author":"Ensoli","year":"2001","journal-title":"Adv. Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1056\/NEJM198512263132609","article-title":"Spontaneous regression of Kaposi\u2019s sarcoma in patients with AIDS","volume":"313","author":"Real","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0140-6736(86)91436-4","article-title":"Kaposi\u2019s sarcoma: A reversible hyperplasia","volume":"328","author":"Brooks","year":"1986","journal-title":"Lancet"},{"key":"ref_18","first-page":"825","article-title":"Cytogenetic study of Kaposi\u2019s sarcoma associated with acquired immunodeficiency syndrome","volume":"112","author":"Saikevyc","year":"1988","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_19","first-page":"201","article-title":"Flow cytometric DNA content in Kaposis\u2019s sarcoma by histologic stage: Comparison with angiosarcoma","volume":"13","author":"Dictor","year":"1991","journal-title":"Anal. Quant. Cytol. Histol."},{"key":"ref_20","first-page":"257","article-title":"AIDS-related Kaposi\u2019s Sarcoma is a clonal neoplasm","volume":"1","author":"Rabkin","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1056\/NEJM199704033361403","article-title":"Monoclonal origin of multicentric Kaposi\u2019s sarcoma lesions","volume":"336","author":"Rabkin","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/jvi.67.1.277-287.1993","article-title":"Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation","volume":"67","author":"Ensoli","year":"1993","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1097\/00002030-199712000-00006","article-title":"HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region","volume":"11","author":"Chang","year":"1997","journal-title":"AIDS"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/345084a0","article-title":"Tat protein of HIV-1 stimulates growth of cells derived from Kaposi\u2019s sarcoma lesions of AIDS patients","volume":"345","author":"Ensoli","year":"1990","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7941","DOI":"10.1073\/pnas.90.17.7941","article-title":"The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi\u2019s sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence","volume":"90","author":"Barillari","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1073\/pnas.92.11.4838","article-title":"Angiogenic properties of human immunodeficiency virus type 1 Tat protein","volume":"92","author":"Albini","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1182\/blood-2002-07-2130","article-title":"Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma","volume":"101","author":"Aoki","year":"2003","journal-title":"Blood"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1128\/JVI.77.10.5759-5773.2003","article-title":"Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat","volume":"77","author":"Pati","year":"2003","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9336","DOI":"10.1128\/JVI.78.17.9336-9342.2004","article-title":"Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat","volume":"78","author":"Guo","year":"2004","journal-title":"J. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhou, F., Xue, M., Qin, D., Zhu, X., Wang, C., Zhu, J., Hao, T., Cheng, L., Chen, X., and Bai, Z. (2013). HIV-1 Tat promotes Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K\/PTEN\/AKT\/GSK-3\u03b2 signaling pathway. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053145"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1093\/nar\/gkv988","article-title":"MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-\u03baB signaling","volume":"43","author":"Yao","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1593\/neo.09494","article-title":"Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice","volume":"11","author":"Chen","year":"2009","journal-title":"Neoplasia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/335606a0","article-title":"The HIV tat gene induces dermal lesions resembling Kaposi\u2019s sarcoma in transgenic mice","volume":"335","author":"Vogel","year":"1988","journal-title":"Nature"},{"key":"ref_34","first-page":"5569","article-title":"Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes","volume":"53","author":"Corallini","year":"1993","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0002-9440(10)65375-8","article-title":"Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus\/tat transgenic mice","volume":"154","author":"Altavilla","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/00002030-199609000-00006","article-title":"Spindle cells isolated from Kaposi\u2019s sarcoma-like lesions of BKV\/tat-transgenic mice co-express markers of different cell types","volume":"10","author":"Cavallaro","year":"1996","journal-title":"AIDS"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.2643161","article-title":"AIDS-Kaposi\u2019s sarcoma derived cells express cytokines with autocrine and paracrine growth effects","volume":"243","author":"Ensoli","year":"1989","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1172\/JCI117849","article-title":"Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi\u2019s sarcoma spindle cells","volume":"95","author":"Fiorelli","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.4049\/jimmunol.158.4.1887","article-title":"Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi\u2019s sarcoma-like lesions in nude mice","volume":"158","author":"Samaniego","year":"1997","journal-title":"J. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.4049\/jimmunol.154.7.3582","article-title":"Inflammatory cytokines induce AIDS-Kaposi\u2019s sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi\u2019s sarcoma-like lesion formation in nude mice","volume":"154","author":"Samaniego","year":"1995","journal-title":"J. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00002030-199801000-00003","article-title":"Inflammatory cytokines induce the expression of basic fibroblast growth factor (bFGF) isoforms required for the growth of Kaposi\u2019s sarcoma and endothelial cells through the activation of AP-1 response elements in the bFGF promoter","volume":"12","author":"Faris","year":"1998","journal-title":"AIDS"},{"key":"ref_42","first-page":"1851","article-title":"Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi\u2019s sarcoma","volume":"149","author":"Cornali","year":"1996","journal-title":"Am. J. Pathol."},{"key":"ref_43","first-page":"1433","article-title":"Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi\u2019s sarcoma are induced by inflammatory cytokines and synergize to induce vascular permeability and KS lesion development","volume":"152","author":"Samaniego","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.4049\/jimmunol.163.4.1929","article-title":"Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi\u2019s sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin","volume":"163","author":"Barillari","year":"1999","journal-title":"J. Immunol."},{"key":"ref_45","first-page":"663","article-title":"The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging alpha5beta1 and alphavbeta3 integrins by mobilizing sequestered basic fibroblast growth factor","volume":"94","author":"Barillari","year":"1999","journal-title":"Blood"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/371674a0","article-title":"Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi\u2019s sarcoma","volume":"371","author":"Ensoli","year":"1994","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.4049\/jimmunol.162.2.1165","article-title":"IFN-gamma induces endothelial cells to proliferate and to invade the extracellular matrix in response to the HIV-1 Tat protein: Implications for AIDS-Kaposi\u2019s sarcoma pathogenesis","volume":"162","author":"Fiorelli","year":"1999","journal-title":"J. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.4049\/jimmunol.149.11.3727","article-title":"Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression. Implications for AIDS-Kaposi\u2019s sarcoma pathogenesis","volume":"149","author":"Barillari","year":"1992","journal-title":"J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Monini, P., Cafaro, A., Srivastava, I.K., Moretti, S., Sharma, V.A., Andreini, C., Chiozzini, C., Ferrantelli, F., Pavone Cossut, M.R., and Tripiciano, A. (2012). HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0048781"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cafaro, A., Barillari, G., Moretti, S., Palladino, C., Tripiciano, A., Falchi, M., Picconi, O., Pavone Cossut, M.R., Campagna, M., and Arancio, A. (2020). HIV-1 Tat Protein Enters Dysfunctional Endothelial Cells via Integrins and Renders Them Permissive to Virus Replication. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010317"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12126","DOI":"10.1128\/JVI.01146-08","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus forms a multimolecular complex of integrins (alphaVbeta5, alphaVbeta3, and alpha3beta1) and CD98-xCT during infection of human dermal microvascular endothelial cells, and CD98-xCT is essential for the postentry stage of infection","volume":"82","author":"Veettil","year":"2008","journal-title":"J. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0092-8674(02)00628-1","article-title":"Integrin alpha3beta1 (CD 49c\/29) is a cellular receptor for Kaposi\u2019s sarcoma-associated herpesvirus (KSHV\/HHV-8) entry into the target cells","volume":"108","author":"Akula","year":"2002","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1742-4690-10-123","article-title":"HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-alpha and IL-10","volume":"10","author":"Leghmari","year":"2013","journal-title":"Retrovirology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1128\/JVI.00262-16","article-title":"HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways to Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes","volume":"90","author":"Leghmari","year":"2016","journal-title":"J. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ben Haij, N., Planes, R., Leghmari, K., Serrero, M., Delobel, P., Izopet, J., BenMohamed, L., and Bahraoui, E. (2015). HIV-1 Tat protein induces production of proinflammatory cytokines by human dendritic cells and monocytes\/macrophages through engagement of TLR4-MD2-CD14 complex and activation of NF-kappaB pathway. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129425"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Planes, R., and Bahraoui, E. (2013). HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: Effect on T cells proliferation. PLoS ONE, 8.","DOI":"10.1371\/annotation\/d333f74d-496e-48e7-ac30-6dcfdbd7a25b"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1128\/JVI.00825-14","article-title":"HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and Toll-like receptor 4-mediated mechanisms","volume":"88","author":"Planes","year":"2014","journal-title":"J. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1089\/vim.2013.0134","article-title":"Disseminated Kaposi\u2019s Sarcoma in Patients with HIV Infection Correlates to High Serum Levels of IL-10","volume":"27","author":"Genre","year":"2014","journal-title":"Viral Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Jary, A., Veyri, M., Gothland, A., Leducq, V., Calvez, V., and Marcelin, A.G. (2021). Kaposi\u2019s Sarcoma-Associated Herpesvirus, the Etiological Agent of All Epidemiological Forms of Kaposi\u2019s Sarcoma. Cancers, 13.","DOI":"10.3390\/cancers13246208"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1023\/A:1006737029616","article-title":"Antiangiogenic, antitumoural and antimetastatic effects of two distamycin A derivatives with anti-HIV-1 Tat activity in a Kaposi\u2019s sarcoma-like murine model","volume":"17","author":"Possati","year":"1999","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm0302-225","article-title":"HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi\u2019s sarcoma","volume":"8","author":"Sgadari","year":"2002","journal-title":"Nat. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ijc.25550","article-title":"Human immunodeficiency virus protease inhibitors reduce the growth of human tumors via a proteasome-independent block of angiogenesis and matrix metalloproteinases","volume":"128","author":"Toschi","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrc1479","article-title":"Antitumor effects of antiretroviral therapy","volume":"4","author":"Monini","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/QAD.0b013e3283262a8d","article-title":"Clinical course of classic Kaposi\u2019s sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir","volume":"23","author":"Monini","year":"2009","journal-title":"AIDS"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Hampson, L., Maranga, I.O., Masinde, M.S., Oliver, A.W., Batman, G., He, X., Desai, M., Okemwa, P.M., Stringfellow, H., and Martin-Hirsch, P. (2016). A Single-Arm, Proof-Of-Concept Trial of Lopimune (Lopinavir\/Ritonavir) as a Treatment for HPV-Related Pre-Invasive Cervical Disease. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147917"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1517\/14656566.2011.577066","article-title":"Pharmacological management of Kaposi\u2019s sarcoma","volume":"12","author":"Sgadari","year":"2011","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1007\/s00705-021-05158-z","article-title":"New insights into pathogenesis point to HIV-1 Tat as a key vaccine target","volume":"166","author":"Ensoli","year":"2021","journal-title":"Arch. 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