{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:10:00Z","timestamp":1790665800525,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Classical treatments of shoulder instability are associated with recurrence. To determine whether the modification of the capsule properties may be an alternative procedure, the effect of crosslinking treatment on the structure and mechanical properties of diseased human shoulder capsules was investigated. Joint capsules harvested from patients during shoulder surgery (n = 5) were treated or not with UV and\/or riboflavin (0.1%, 1.0% and 2.5%). The structure and the mechanical properties of the capsules were determined by atomic force microscopy. The effect of treatments on cell death was investigated. Collagen fibrils were well-aligned and adjacent to each other with a D-periodicity of 66.9 \u00b1 3.2 nm and a diameter of 71.8 \u00b1 15.4 nm in control untreated capsules. No effect of treatments was observed on the organization of the collagen fibrils nor on their intrinsic characteristics, including D-periodicity or their mean diameter. The treatments also did not induce cell death. In contrast, UV + 2.5% riboflavin induced capsule stiffness, as revealed by the increased Young\u2019s modulus values (p &lt; 0.0001 for each patient). Our results showed that the crosslinking procedure changed the biomechanics of diseased capsules, while keeping their structural organisation unchanged at the single fibril level. The UV\/riboflavin crosslinking procedure may be a promising way to preserve the functions of collagen-based tissues and tune their elasticity for clinically relevant treatments.<\/jats:p>","DOI":"10.3390\/ijms23042297","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T09:18:42Z","timestamp":1645435122000},"page":"2297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of Collagen Crosslinking on Dislocated Human Shoulder Capsules\u2014Effect on Structural and Mechanical Properties"],"prefix":"10.3390","volume":"23","author":[{"given":"Pauline","family":"Cornette","sequence":"first","affiliation":[{"name":"Centre de Recherche Saint-Antoine (CRSA), INSERM, Sorbonne Universit\u00e9, F-75012 Paris, France"},{"name":"Laboratoire de R\u00e9activit\u00e9 de Surface, CNRS, Sorbonne Universit\u00e9, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem Lilia","family":"Jaabar","sequence":"additional","affiliation":[{"name":"Centre de Recherche Saint-Antoine (CRSA), INSERM, Sorbonne Universit\u00e9, F-75012 Paris, France"},{"name":"Laboratoire de R\u00e9activit\u00e9 de Surface, CNRS, Sorbonne Universit\u00e9, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-3633","authenticated-orcid":false,"given":"Vincent","family":"Dupres","sequence":"additional","affiliation":[{"name":"U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Institut Pasteur de Lille, CHU Lille, Inserm, CNRS, Universit\u00e9 Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-David","family":"Werthel","sequence":"additional","affiliation":[{"name":"Department of Orthopedy and Traumatology, AP-HP Ambroise Par\u00e9 Hospital, F-92100 Boulogne-Billancourt, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-7815","authenticated-orcid":false,"given":"Francis","family":"Berenbaum","sequence":"additional","affiliation":[{"name":"Centre de Recherche Saint-Antoine (CRSA), INSERM, Sorbonne Universit\u00e9, F-75012 Paris, France"},{"name":"Department of Rheumatology, AP-HP Saint-Antoine Hospital, DMU 3iD, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Houard","sequence":"additional","affiliation":[{"name":"Centre de Recherche Saint-Antoine (CRSA), INSERM, Sorbonne Universit\u00e9, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-4437","authenticated-orcid":false,"given":"Jessem","family":"Landoulsi","sequence":"additional","affiliation":[{"name":"Laboratoire de R\u00e9activit\u00e9 de Surface, CNRS, Sorbonne Universit\u00e9, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Nourissat","sequence":"additional","affiliation":[{"name":"Centre de Recherche Saint-Antoine (CRSA), INSERM, Sorbonne Universit\u00e9, F-75012 Paris, France"},{"name":"Clinique des Maussins, 67 Rue de Romainville, F-75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1177\/0363546519833920","article-title":"Long-Term, Prospective, Multicenter Study of Isolated Bankart Repair for a Patient Selection Method Based on the Instability Severity Index Score","volume":"47","author":"Thomazeau","year":"2019","journal-title":"Am. 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