{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:05:06Z","timestamp":1772935506513,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In patients with chronic kidney disease (CKD) and in animal models of CKD, the transcription factor Aryl Hydrocabon Receptor (AhR) is overactivated. In addition to the canonical AhR targets constituting the AhR signature, numerous other genes are regulated by this factor. We identified neuronal pentraxin 1 (NPTX1) as a new AhR target. Belonging to the inflammatory protein family, NPTX1 seems of prime interest regarding the inflammatory state observed in CKD. Endothelial cells were exposed to tryptophan-derived toxins, indoxyl sulfate (IS) and indole-3-acetic acid (IAA). The adenine mouse model of CKD was used to analyze NPTX1 expression in the burden of uremia. NPTX1 expression was quantified by RT-PCR and western blot. AhR involvement was analyzed using silencing RNA. We found that IS and IAA upregulated NPTX1 expression in an AhR-dependent way. Furthermore, this effect was not restricted to uremic indolic toxins since the dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) do the same. In CKD mice, NPTX1 expression was increased in the aorta. Therefore, NPTX1 is a new target of AhR and further work is necessary to elucidate its exact role during CKD.<\/jats:p>","DOI":"10.3390\/ijms23042369","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:47:45Z","timestamp":1645476465000},"page":"2369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells"],"prefix":"10.3390","volume":"23","author":[{"given":"Romain","family":"Vial","sequence":"first","affiliation":[{"name":"Centre de N\u00e9phrologie et Transplantation R\u00e9nale, Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de La Conception, 147 Boulevard Baille, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-2157","authenticated-orcid":false,"given":"St\u00e9phane","family":"Poitevin","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Cardiovasculaire et Nutrition (C2VN), Institut de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Institut National de la Recherche pour l\u2019Agriculture, l\u2019Alimentation et l\u2019Environnement (INRAE), Aix Marseille University, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"McKay","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Cardiovasculaire et Nutrition (C2VN), Institut de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Institut National de la Recherche pour l\u2019Agriculture, l\u2019Alimentation et l\u2019Environnement (INRAE), Aix Marseille University, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-7884","authenticated-orcid":false,"given":"St\u00e9phane","family":"Burtey","sequence":"additional","affiliation":[{"name":"Centre de N\u00e9phrologie et Transplantation R\u00e9nale, Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de La Conception, 147 Boulevard Baille, 13005 Marseille, France"},{"name":"Centre de Recherche en Cardiovasculaire et Nutrition (C2VN), Institut de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Institut National de la Recherche pour l\u2019Agriculture, l\u2019Alimentation et l\u2019Environnement (INRAE), Aix Marseille University, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Cerini","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Cardiovasculaire et Nutrition (C2VN), Institut de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Institut National de la Recherche pour l\u2019Agriculture, l\u2019Alimentation et l\u2019Environnement (INRAE), Aix Marseille University, 13005 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"ref_2","unstructured":"(2022, February 02). 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