{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:40:34Z","timestamp":1790876434236,"version":"4.1.0"},"reference-count":161,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The copper(I)-catalyzed azide\u2212alkyne cycloaddition (CuAAC) reaction is considered to be the most representative ligation process within the context of the \u201cclick chemistry\u201d concept. This CuAAC reaction, which yields compounds containing a 1,2,3-triazole core, has become relevant in the construction of biologically complex systems, bioconjugation strategies, and supramolecular and material sciences. Although many CuAAC reactions are performed under homogenous conditions, heterogenous copper-based catalytic systems are gaining exponential interest, relying on the easy removal, recovery, and reusability of catalytically copper species. The present review covers the most recently developed copper-containing heterogenous solid catalytic systems that use solid inorganic\/organic hybrid supports, and which have been used in promoting CuAAC reactions. Due to the demand for 1,2,3-triazoles as non-classical bioisosteres and as framework-based drugs, the CuAAC reaction promoted by solid heterogenous catalysts has greatly improved the recovery and removal of copper species, usually by simple filtration. In so doing, the solving of the toxicity issue regarding copper particles in compounds of biological interest has been achieved. This protocol is also expected to produce a practical chemical process for accessing such compounds on an industrial scale.<\/jats:p>","DOI":"10.3390\/ijms23042383","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:47:45Z","timestamp":1645476465000},"page":"2383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Recent Advances in Copper-Based Solid Heterogeneous Catalysts for Azide\u2013Alkyne Cycloaddition Reactions"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6396-2114","authenticated-orcid":false,"given":"Noura","family":"Aflak","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie Analytique et Mol\u00e9culaire\/<i>LCAM<\/i>, Facult\u00e9 Polydisciplinaire de Safi, Universit\u00e9 Cadi Ayyad, Safi 46030, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-4837","authenticated-orcid":false,"given":"Hicham","family":"Ben El Ayouchia","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Mol\u00e9culaire\/<i>LCAM<\/i>, Facult\u00e9 Polydisciplinaire de Safi, Universit\u00e9 Cadi Ayyad, Safi 46030, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-6680","authenticated-orcid":false,"given":"Lahoucine","family":"Bahsis","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Mol\u00e9culaire\/<i>LCAM<\/i>, Facult\u00e9 Polydisciplinaire de Safi, Universit\u00e9 Cadi Ayyad, Safi 46030, Morocco"},{"name":"Laboratoire de Chimie de Coordination et d\u2019Analytique\/<i>LCCA<\/i>, D\u00e9partement de Chimie, Facult\u00e9 des Sciences d\u2019El Jadida, Universit\u00e9 Choua\u00efb Doukkali, El Jadida 24000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3254-6203","authenticated-orcid":false,"given":"Hafid","family":"Anane","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Mol\u00e9culaire\/<i>LCAM<\/i>, Facult\u00e9 Polydisciplinaire de Safi, Universit\u00e9 Cadi Ayyad, Safi 46030, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Julve","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia Molecular\/<i>ICMol<\/i>, Universidad de Valencia, C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2, 46980 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-914X","authenticated-orcid":false,"given":"Salah-Eddine","family":"Stiriba","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia Molecular\/<i>ICMol<\/i>, Universidad de Valencia, C\/Catedr\u00e1tico Jos\u00e9 Beltr\u00e1n 2, 46980 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5","article-title":"Click chemistry: Diverse chemical function from a few good reactions","volume":"40","author":"Kolb","year":"2001","journal-title":"Angew. 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