{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:43:48Z","timestamp":1792133028409,"version":"4.4.0"},"reference-count":95,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometrial cancer (EC) is the fourth most common cancer in women in developed countries. Although it is usually diagnosed in postmenopausal women, its incidence has increased in young women, as well in recent decades, with an estimated rate of 4% in those under 40 years of age. Factors involved in this increase, particularly in resource-rich countries, include delayed childbearing and the rise in obesity. The new molecular classification of EC should help to personalize treatment, through appropriate candidate selection. With the currently available evidence, the use of oral progestin either alone or in combination with other drugs such as metformin, levonorgestrel-releasing intrauterine devices and hysteroscopic resection, seems to be feasible and safe in women with early-stage EC limited to the endometrium. However, there is a lack of high-quality evidence of the efficacy and safety of conservative management in EC. Randomized clinical trials in younger women and obese patients are currently underway.<\/jats:p>","DOI":"10.3390\/ijms23052531","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T10:00:40Z","timestamp":1645783240000},"page":"2531","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Fertility-Sparing Approaches in Atypical Endometrial Hyperplasia and Endometrial Cancer Patients: Current Evidence and Future Directions"],"prefix":"10.3390","volume":"23","author":[{"given":"Nayanar-Adela","family":"Contreras","sequence":"first","affiliation":[{"name":"Gynecology Department, Hospital El Pilar, Balmes 268-270, 08006 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9380-0338","authenticated-orcid":false,"given":"Jordi","family":"Sabadell","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Hospital Universitari Vall d\u2019Hebron, Vall d\u2019Hebron Barcelona Hospital Campus, Universitat Aut\u00f2noma de Barcelona, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Verdaguer","sequence":"additional","affiliation":[{"name":"Department of Gynaecology-ASSIR, Ronda General Prim 35, Matar\u00f3, 08302 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Juli\u00e0","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Hospital de Viladecans, Avda de Gav\u00e0 38, Viladecans, 08840 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eulalia","family":"Fern\u00e1ndez-Montol\u00ed","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Hospital Universitari de Bellvitge, Universitat de Barcelona-IDIBELL, Feixa Llarga s\/n, L\u00b4Hospitalet de LLobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/ijc.27711","article-title":"Global estimates of cancer prevalence for 27 sites in the adult population in 2008","volume":"132","author":"Bray","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_2","unstructured":"Cancer Research UK (2020, November 15). Uterine Cancer Incidence Statistics. Available online: https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/uterine-cancer#heading-Zero."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","article-title":"Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018","volume":"103","author":"Ferlay","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"ref_4","unstructured":"National Cancer Institute: Surveillance, Epidemiology, and End Results Program (2020, November 15). Stat Fact Sheets: Endometrial Cancer, Available online: http:\/\/seer.cancer.gov\/statfacts\/html\/corp.html."},{"key":"ref_5","unstructured":"WHO International Agency for Research on Cancer (2021, November 28). Population Fact Sheet: United States of America. Available online: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/840-united-states-of-america-fact-sheets.pdf."},{"key":"ref_6","unstructured":"WHO International Agency for Research on Cancer (2021, November 28). Population Fact Sheet: Europe. Available online: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/908-europe-fact-sheets.pdf."},{"key":"ref_7","unstructured":"WHO International Agency for Research on Cancer (2021, November 28). Population Fact Sheet: Spain. Available online: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/724-spain-fact-sheets.pdf."},{"key":"ref_8","unstructured":"Zaino, R., Carinelli, S.G., and Ellenson, L.H. (2014). Tumours of the uterine corpus: Epithelial tumours and precursors. WHO Classification of Tumours of Female Reproductive Organs, WHO Press."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1097\/PAS.0b013e31825dd4ff","article-title":"Clinical outcome of atypical endometrial hyperplasia diagnosed on an endometrial biopsy: Institutional experience and review of literature","volume":"36","author":"Rakha","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/1097-0142(19850715)56:2<403::AID-CNCR2820560233>3.0.CO;2-X","article-title":"The behavior of endometrial hyperplasia. A long-term study of \u201cuntreated\u201d hyperplasia in 170 patients","volume":"56","author":"Kurman","year":"1985","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.maturitas.2009.02.005","article-title":"Endometrial hyperplasia and the risk of progression to carcinoma","volume":"63","author":"Lacey","year":"2009","journal-title":"Maturitas"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/01.AOG.0000255980.88205.15","article-title":"Prognostic factors for uterine cancer in reproductive-aged women","volume":"109","author":"Lee","year":"2007","journal-title":"Obstet. Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ygyno.2009.05.038","article-title":"Young patients with endometrial cancer: How many could be eligible for fertility-sparing treatment?","volume":"114","author":"Navarria","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_14","unstructured":"American Cancer Society (2020, November 15). Survival by Stage of Endometrial Cancer. Available online: https:\/\/www.cancer.org\/cancer\/endometrial-cancer\/detection-diagnosis-staging\/survival-rates.html."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1514010","article-title":"Endometrial Cancer","volume":"383","author":"Lu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1200\/JCO.2012.48.2596","article-title":"Type I and II endometrial cancers: Have they different risk factors?","volume":"31","author":"Setiawan","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jmig.2017.07.022","article-title":"Updates on conservative management of endometrial cancer","volume":"25","author":"Corzo","year":"2018","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"(2014). Committee Opinion, No. 601: Tamoxifen and uterine cancer. Obstet. Gynecol., 123, 1394\u20131397.","DOI":"10.1097\/01.AOG.0000450757.18294.cf"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.6004\/jnccn.2018.0006","article-title":"Uterine neoplasms, Version 1.2018, NCCN clinical practice guidelines in oncology","volume":"16","author":"Koh","year":"2018","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_20","unstructured":"American Cancer Society (2017). Surgery for Endometrial Cancer, American Cancer Society. Available online: http:\/\/www.ecoeco.org\/publica\/encyc.htm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdv484","article-title":"ESMO-ESGOESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up","volume":"27","author":"Colombo","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with 25endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_23","first-page":"1","article-title":"Births: Final Data for 2014","volume":"64","author":"Hamilton","year":"2015","journal-title":"Natl. Vital. Stat. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.5468\/ogs.19169","article-title":"Fertility-sparing treatment in early endometrial cancer: Current state and future strategies","volume":"63","author":"Obermair","year":"2020","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/ijgc-2020-001783","article-title":"Fertility considerations prior to conservative management of gynecologic cancers","volume":"31","author":"Stewart","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1097\/IGC.0000000000000493","article-title":"European Society of Gynecological Oncology Task Force for Fertility Preservation: Clinical Recommendations for Fertility-Sparing Management in Young Endometrial Cancer Patients","volume":"25","author":"Rodolakis","year":"2015","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"iv153","DOI":"10.1093\/annonc\/mdx243","article-title":"Appendix 5: Endometrial cancer: eUpdate published online 8 June 2017 (www.esmo.org\/Guidelines\/Gynaecological-Cancers)","volume":"28","author":"Colombo","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1634\/theoncologist.2013-0445","article-title":"Progestins in the Fertility-Sparing Treatment and Retreatment of Patients With Primary and Recurrent Endometrial Cancer","volume":"20","author":"Park","year":"2015","journal-title":"Oncologist"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ygyno.2007.11.044","article-title":"Comparison of the validity of magnetic resonance imaging and positron emission tomography\/computed tomography in the preoperative evaluation of patients with uterine corpus cancer","volume":"108","author":"Park","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cavaliere, A.F., Perelli, F., Zaami, S., D\u2019Indinosante, M., Turrini, I., Giusti, M., Gullo, G., Vizzielli, G., Mattei, A., and Scambia, G. (2021). Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212248"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Gullo, G., Etrusco, A., Cucinella, G., Perino, A., Chiantera, V., Lagan\u00e0, A.S., Tomaiuolo, R., Vitagliano, A., Giampaolino, P., and Noventa, M. (2021). Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111825"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Alexa, M., Hasenburg, A., and Battista, M. (2021). The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions. Cancers, 13.","DOI":"10.3390\/cancers13061478"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/path.5034","article-title":"The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses","volume":"244","author":"McAlpine","year":"2018","journal-title":"J. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ygyno.2019.03.098","article-title":"Molecular classification defines outcomes and opportunities in young women with endometrial carcinoma","volume":"153","author":"Britton","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02490129","article-title":"Conservative therapy for endometrial carcinoma in young women treated with repeated curettage and progestogen","volume":"2","author":"Niwa","year":"1997","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ygyno.2014.06.003","article-title":"Endometrial cancer: A review and current management strategies: Part II","volume":"134","author":"Burke","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejogrb.2017.04.015","article-title":"BGCS uterine cancer guidelines: Recommendations for practice","volume":"213","author":"Sundar","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10067","DOI":"10.7314\/APJCP.2014.15.23.10067","article-title":"Antiproliferative Effect of Metformin on the Endometrium\u2014A Clinical Trial","volume":"15","author":"Tabrizi","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/aogs.13733","article-title":"Predictive accuracy of hormone receptors in conservatively treated endometrial hyperplasia and early endometrioid carcinoma","volume":"99","author":"Raffone","year":"2020","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/aogs.13586","article-title":"Should progesterone and estrogen receptors be assessed for predicting the response to conservative treatment of endometrial hyperplasia and cancer? A systematic review and meta-analysis","volume":"98","author":"Raffone","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jmig.2020.10.009","article-title":"Predictive Accuracy of Progesterone Receptor B in Young Women with Atypical Endometrial Hyperplasia and Early Endometrial Cancer Treated with Hysteroscopic Resection plus LNG-IUD Insertion","volume":"28","author":"Raffone","year":"2021","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5653\/cerm.2020.03629","article-title":"Fertility-sparing treatment in women with endometrial cancer","volume":"47","author":"Won","year":"2020","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2012.08.011","article-title":"Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: A systematic review and meta-analysis","volume":"207","author":"Gallos","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1200\/JCO.2006.08.8344","article-title":"Multicenter Phase II Study of Fertility-Sparing Treatment with Medroxyprogesterone Acetate for Endometrial Carcinoma and Atypical Hyperplasia in Young Women","volume":"25","author":"Ushijima","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e8034","DOI":"10.1097\/MD.0000000000008034","article-title":"Comparison of fertility-sparing treatments in patients with early endometrial cancer and atypical complex hyperplasia: A meta-analysis and systematic review","volume":"96","author":"Wei","year":"2017","journal-title":"Medicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/jjco\/hys171","article-title":"Treatment with medroxyprogesterone acetate plus levonorgestrel-releasing intrauterine system for early-stage endometrial cancer in young women: Single-arm, prospective multicenter study: Korean gynecologic oncology group study (KGOG2009)","volume":"42","author":"Kim","year":"2012","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5468\/OGS.2013.56.2.67","article-title":"Clinical applications of levonorgestrel-releasing intrauterine system to gynecologic diseases","volume":"56","author":"Kim","year":"2013","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ygyno.2011.11.043","article-title":"Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: A meta-analysis and systematic review of the literature","volume":"125","author":"Baker","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ygyno.2017.07.120","article-title":"Effects of metformin on endometrial cancer: Systematic review and meta-analysis","volume":"147","author":"Meireles","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1158\/1940-6207.CAPR-17-0398","article-title":"Prospective Randomized Biomarker Study of Metformin and Lifestyle Intervention for Prevention in Obese Women at Increased Risk for Endometrial Cancer","volume":"11","author":"Yates","year":"2018","journal-title":"Cancer Prev. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ygyno.2020.02.008","article-title":"The addition of metformin to progestin therapy in the fertility-sparing treatment of women with atypical hyperplasia\/endometrial intraepithelial neoplasia or endometrial cancer: Little impact on response and low live-birth rates","volume":"157","author":"Murdock","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ygyno.2015.10.020","article-title":"Body mass index and mortality in endometrial cancer: A systematic review and meta-analysis","volume":"140","author":"Secord","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/jnci\/djy040","article-title":"The Effects of Metformin and Weight Loss on Biomarkers Associated With Breast Cancer Outcomes","volume":"110","author":"Patterson","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1200\/JCO.2016.70.5822","article-title":"Intentional Weight Loss and Endometrial Cancer Risk","volume":"35","author":"Luo","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s11695-018-3151-x","article-title":"Does Bariatric Surgery Affect the Incidence of Endometrial Cancer Development? A Systematic Review","volume":"28","author":"Winder","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ygyno.2017.07.144","article-title":"Changes in inflammatory endometrial cancer risk biomarkers in individuals undergoing surgical weight loss","volume":"147","author":"Linkov","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cacc.2009.10.005","article-title":"Bariatric surgery: Techniques, outcomes and complications","volume":"21","author":"Khwaja","year":"2010","journal-title":"Curr. Anaesth. Crit. Care"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.soard.2014.09.024","article-title":"Bariatric surgery and risk of postoperative endometrial cancer: A systematic review and meta-analysis","volume":"11","author":"Upala","year":"2015","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.puhe.2015.04.017","article-title":"The effect of body mass index on endometrial cancer: A meta-analysis","volume":"129","author":"Jenabi","year":"2015","journal-title":"Public Health"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/1471-0528.12106","article-title":"Obesity-driven endometrial cancer: Is weight loss the answer?","volume":"120","author":"Mackintosh","year":"2013","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3332\/ecancer.2015.505","article-title":"Hysteroscopic surgery for conservative management in endometrial cancer: A review of the literature","volume":"9","author":"Alonso","year":"2015","journal-title":"Ecancermedicalscience"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.3802\/jgo.2017.28.e2","article-title":"Fertility preserving treatment with hysteroscopic resection followed by progestin therapy in young women with early endometrial cancer","volume":"28","author":"Falcone","year":"2017","journal-title":"J. Gynecol. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ygyno.2019.01.014","article-title":"Treatment efficiency of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young women with endometrial atypical hyperplasia and endometrial cancer","volume":"153","author":"Yang","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jmig.2018.07.001","article-title":"Hysteroscopic Endometrial Focal Resection followed by Levonorgestrel Intrauterine Device Insertion as a Fertility-Sparing Treatment of Atypical Endometrial Hyperplasia and Early Endometrial Cancer: A Retrospective Study","volume":"26","author":"Giampaolino","year":"2019","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.3802\/jgo.2017.28.e16","article-title":"Hysteroscopy in fertility-sparing management for early endometrial cancer: A double-edged sword","volume":"28","author":"Park","year":"2017","journal-title":"J. Gynecol. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/cncr.30529","article-title":"Does hormonal therapy for fertility preservation affect the survival of young women with early-stage endometrial cancer?","volume":"123","author":"Greenwald","year":"2017","journal-title":"Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Leone Roberti Maggiore, U., Khamisy-Farah, R., Bragazzi, N.L., Bogani, G., Martinelli, F., Lopez, S., Chiappa, V., Signorelli, M., Ditto, A., and Raspagliesi, F. (2021). Fertility-Sparing Treatment of Patients with Endometrial Cancer: A Review of the Literature. J. Clin. Med., 10.","DOI":"10.3390\/jcm10204784"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1007\/s12325-021-01693-y","article-title":"Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol","volume":"38","author":"Sabadell","year":"2021","journal-title":"Adv. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.fertnstert.2013.11.028","article-title":"Prognostic factors of oncologic and reproductive outcomes in fertility-sparing management of endometrial atypical hyperplasia and adenocarcinoma: Systematic review and meta-analysis","volume":"101","author":"Koskas","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_70","first-page":"CD009458","article-title":"Oral and intrauterine progestogens for atypical endometrial hyperplasia","volume":"4","author":"Luo","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/IGC.0000000000001164","article-title":"Fertility-Preserving Treatment in Young Women With Grade 1 Presumed Stage IA Endometrial Adenocarcinoma: A Meta-Analysis","volume":"28","author":"Fan","year":"2018","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ijgo.12882","article-title":"A systematic review and meta-analysis of prognostic factors for remission in fertility-sparing management of endometrial atypical hyperplasia and adenocarcinoma","volume":"146","author":"Guillon","year":"2019","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1136\/ijgc-2021-002699","article-title":"Outcomes of women treated with progestin and metformin for atypical endometrial hyperplasia and early endometrial cancer: A systematic review and meta-analysis","volume":"31","author":"Garg","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ygyno.2021.01.029","article-title":"Corrigendum to \u201cComplete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: Results of a randomized clinical trial\u201d","volume":"161","author":"Janda","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e035416","DOI":"10.1136\/bmjopen-2019-035416","article-title":"Medroxyprogesterone acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and endometrial carcinoma: Trial protocol for a prospective, randomised, open, blinded-endpoint design, dose-response trial (FELICIA trial)","volume":"10","author":"Mitsuhashi","year":"2020","journal-title":"BMJ Open"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.3802\/jgo.2020.31.e82","article-title":"Pushing the envelope: Expanding fertility sparing treatment of endometrial cancer","volume":"31","author":"Stewart","year":"2020","journal-title":"J. Gynecol. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/IGC.0000000000000927","article-title":"Combined Oral Medroxyprogesterone\/Levonorgestrel-Intrauterine System Treatment for Women With Grade 2 Stage IA Endometrial Cancer","volume":"27","author":"Hwang","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.3802\/jgo.2020.31.e74","article-title":"Fertility-sparing treatment for intramucous, moderately differentiated, endometrioid endometrial cancer: A Gynecologic Cancer Inter-Group (GCIG) study","volume":"31","author":"Falcone","year":"2020","journal-title":"J. Gynecol. Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/gutjnl-2015-309675","article-title":"Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: First report from the prospective Lynch syndrome database","volume":"66","author":"Bernstein","year":"2017","journal-title":"Gut"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41436-019-0596-9","article-title":"Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: Findings from the Prospective Lynch Syndrome Database","volume":"22","author":"Sampson","year":"2020","journal-title":"Genet. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/jnci\/djp473","article-title":"Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers","volume":"102","author":"Baglietto","year":"2010","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1200\/JCO.2007.10.8597","article-title":"Prospective Determination of Prevalence of Lynch Syndrome in Young Women With Endometrial Cancer","volume":"25","author":"Lu","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2147\/TACG.S48625","article-title":"Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome)","volume":"7","author":"Win","year":"2014","journal-title":"Appl. Clin. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7810","DOI":"10.1158\/0008-5472.CAN-06-1114","article-title":"Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients","volume":"66","author":"Hampel","year":"2006","journal-title":"Cancer Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13643-018-0792-8","article-title":"The prevalence of Lynch syndrome in women with endometrial cancer: A systematic review protocol","volume":"7","author":"Ryan","year":"2018","journal-title":"Syst. Rev."},{"key":"ref_86","unstructured":"IARC (International Agency for Research on Cancer) (2022, January 10). Global Cancer Observatory. Available online: https:\/\/gco.iarc.fr\/projects."},{"key":"ref_87","unstructured":"P\u00e9rez Segura, P., and Fern\u00e1ndez-Martos, C. (2022, January 10). SEOM (Sociedad Espa\u00f1ola de Oncolog\u00eda M\u00e9dica). Gu\u00eda de Manejo de C\u00e1ncer de Colon Hereditario no Polip\u00f3sico (HNPCC). Available online: https:\/\/www.seom.org\/seomcms\/images\/stories\/recursos\/sociosyprofs\/documentacion\/socios\/2006\/hnpcc\/guiaHNPCC.pdf."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0016-5085(99)70510-X","article-title":"New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC","volume":"116","author":"Vasen","year":"1999","journal-title":"Gastroenterology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djh034","article-title":"Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability","volume":"96","author":"Umar","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/89.23.1758","article-title":"A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines","volume":"89","author":"Boland","year":"1997","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/jmg.2010.077677","article-title":"Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers","volume":"47","author":"Sjursen","year":"2010","journal-title":"J. Med. Genet."},{"key":"ref_92","first-page":"1032","article-title":"NCCN Guidelines Version 3.2019 Genetic\/Familial High-Risk Assessment Colorectal","volume":"17","author":"Provenzale","year":"2019","journal-title":"JNCCN"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jama.296.12.1507","article-title":"Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: A systematic review","volume":"296","author":"Lindor","year":"2006","journal-title":"JAMA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00404-018-4820-7","article-title":"Conservative management of endometrial cancer: A survey amongst European clinicians","volume":"298","author":"Zapardiel","year":"2018","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bulcan.2017.06.018","article-title":"Syndrome de Lynch et cancer de l\u2019endom\u00e8tre","volume":"104","author":"Bats","year":"2017","journal-title":"Bull. Cancer"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/5\/2531\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:27:17Z","timestamp":1760135237000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/5\/2531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":95,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["ijms23052531"],"URL":"https:\/\/doi.org\/10.3390\/ijms23052531","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]}}}