{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:01:47Z","timestamp":1769598107234,"version":"3.49.0"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>There is evidence that asbestos could play a role in the carcinogenesis of digestive cancers. The presence of asbestos fibres in histological samples from gastric, biliary, colon cancers has been reported, but the mechanism is still controversial. It has been hypothesised that asbestos reaches these sites, especially through contaminated water; however, some experimental studies have shown that the inhaled fibres are mobile, so they can migrate to many organs, directly or via blood and lymph flow. We report four unusual cases of colorectal cancers in patients with a long history of asbestos exposure who also developed synchronous or metachronous mesothelioma. We evaluated the roles of BRCA associated protein-1 (BAP1) and cyclin-dependent kinase inhibitor 2A (CDKN2A) in colon cancer and mesothelioma to support the hypothesis that BAP-1 and CDKN2A are tumour suppressor genes involved in disease progression, recurrence, or death in both digestive cancers and mesothelioma. Potentially, these markers may be used as predictors of worse prognosis, but we also stress the importance of clinical surveillance of exposed patients because asbestos could induce cancer in any organ.<\/jats:p>","DOI":"10.3390\/ijms23052630","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:47:17Z","timestamp":1645994837000},"page":"2630","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mesothelioma and Colorectal Cancer: Report of Four Cases with Synchronous and Metachronous Presentation"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-4560","authenticated-orcid":false,"given":"Gabriella","family":"Serio","sequence":"first","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-3108","authenticated-orcid":false,"given":"Federica","family":"Pezzuto","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV, Pathology Unit, University of Padova, 61 N. A. Gabelli St., 35121 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8954-5888","authenticated-orcid":false,"given":"Francesco","family":"Fortarezza","sequence":"additional","affiliation":[{"name":"Pathology Unit, University Hospital of Padova, University of Padova, 61 N. A. Gabelli St., 35121 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Marzullo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Celeste","family":"Delfino","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Occupational Health Division, Internal Medicine Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-1201","authenticated-orcid":false,"given":"Antonio","family":"d\u2019Amati","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Egidio","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0914-5359","authenticated-orcid":false,"given":"Sonia","family":"Maniglio","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Caporusso","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0860-3044","authenticated-orcid":false,"given":"Teresa","family":"Lettini","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation\u2014DETO, Pathology Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-1806","authenticated-orcid":false,"given":"Domenica","family":"Cavone","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Occupational Health Division, Internal Medicine Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-2871","authenticated-orcid":false,"given":"Luigi","family":"Vimercati","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine, Occupational Health Division, Internal Medicine Unit, University of Bari, G. Cesare 1 Sq., 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vimercati, L., Cavone, D., Delfino, M., Bruni, B., De Maria, L., Caputi, A., Sponselli, S., Rossi, R., Resta, L., and Fortarezza, F. (2021). Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature. Cancers, 13.","DOI":"10.3390\/cancers13092278"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-019-0512-4","article-title":"Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: A systematic review and the experience of the Apulia (southern Italy) mesothelioma register","volume":"18","author":"Vimercati","year":"2019","journal-title":"Environ. 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