{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:17:22Z","timestamp":1792804642036,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Development and Innovation Fund d","award":["K-135752"],"award-info":[{"award-number":["K-135752"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00005"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00005"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["MTA11010 and TK2016-78"],"award-info":[{"award-number":["MTA11010 and TK2016-78"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New National Excellence Program of the Ministry for Innovation and Technology from the Source of National research, Development and Innovation Fund","award":[": UNKP-21-4-II-DE-361 and UNKP-21-4-II-DE-363"],"award-info":[{"award-number":[": UNKP-21-4-II-DE-361 and UNKP-21-4-II-DE-363"]}],"id":[{"id":"https:\/\/ror.org\/02ey3ab96","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cytokine and chemokine receptors can promote tumor progression, invasion, and metastasis development by inducing different intracellular signaling pathways. The aim of this study was to determine the cytokine and chemokine receptor gene expression patterns in human melanoma cell lines. We found a large set of cytokine and chemokine receptor genes that were significantly differentially expressed between melanoma cell lines that originated from different subtypes of primary melanomas as well as cell lines that originated from melanoma metastases. The relative expressions of two receptor genes (CCR2 and TNFRSF11B) were positively correlated with the invasive potential of the cell lines, whereas a negative correlation was observed for the TNFRSF14 gene expression. We also found a small set of receptor genes that exhibited a significantly decreased expression in association with a BRAFV600E mutation. Based on our results, we assume that the analyzed cytokine and chemokine receptor collection may provide potential to distinguish the different subtypes of melanomas, helping us to understand the biological behavior of BRAFV600E-mutated melanoma cells.<\/jats:p>","DOI":"10.3390\/ijms23052644","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:11:14Z","timestamp":1646079074000},"page":"2644","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cytokine and Chemokine Receptor Patterns of Human Malignant Melanoma Cell Lines"],"prefix":"10.3390","volume":"23","author":[{"given":"Viktoria","family":"Koroknai","sequence":"first","affiliation":[{"name":"MTA-DE Public Health Research Group, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Sz\u00e1sz","sequence":"additional","affiliation":[{"name":"MTA-DE Public Health Research Group, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"J\u00e1mbor","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Doctoral School of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-2321","authenticated-orcid":false,"given":"Margit","family":"Bal\u00e1zs","sequence":"additional","affiliation":[{"name":"MTA-DE Public Health Research Group, University of Debrecen, 4032 Debrecen, Hungary"},{"name":"Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.immunol.24.021605.090616","article-title":"Structural biology of shared cytokine receptors","volume":"27","author":"Wang","year":"2009","journal-title":"Annu. 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