{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:56:48Z","timestamp":1781931408328,"version":"3.54.5"},"reference-count":58,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007660","name":"University of Antwerp","doi-asserted-by":"publisher","award":["GOA-BOF: 33931"],"award-info":[{"award-number":["GOA-BOF: 33931"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012541","name":"Hercules Foundation","doi-asserted-by":"publisher","award":["AUHA\/13\/03"],"award-info":[{"award-number":["AUHA\/13\/03"]}],"id":[{"id":"10.13039\/501100012541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Given the unprecedented rise in the world\u2019s population, the prevalence of prominent age-related disorders, like cardiovascular disease and dementia, will further increase. Recent experimental and epidemiological evidence suggests a mechanistic overlap between cardiovascular disease and dementia with a specific focus on the linkage between arterial stiffness, a strong independent predictor of cardiovascular disease, and\/or hypertension with Alzheimer\u2019s disease. In the present study, we investigated whether pharmacological induction of arterial stiffness and hypertension with angiotensin II (1 \u00b5g\u00b7kg\u22121\u00b7min\u22121 for 28 days via an osmotic minipump) impairs the progression of Alzheimer\u2019s disease in two mouse models (hAPP23+\/\u2212 and hAPPswe\/PSEN1dE9 mice). Our results show increased arterial stiffness in vivo and hypertension in addition to cardiac hypertrophy after angiotensin II treatment. However, visuospatial learning and memory and pathological cerebral amyloid load in both Alzheimer\u2019s disease mouse models were not further impaired. It is likely that the 28-day treatment period with angiotensin II was too short to observe additional effects on cognition and cerebral pathology.<\/jats:p>","DOI":"10.3390\/ijms23052738","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T08:17:03Z","timestamp":1646122623000},"page":"2738","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Short-Term Pharmacological Induction of Arterial Stiffness and Hypertension with Angiotensin II Does Not Affect Learning and Memory and Cerebral Amyloid Load in Two Murine Models of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-2926","authenticated-orcid":false,"given":"Jhana O.","family":"Hendrickx","sequence":"first","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, 2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Calus","sequence":"additional","affiliation":[{"name":"Laboratory of Neurochemistry and Behaviour, University of Antwerp, 2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-2964","authenticated-orcid":false,"given":"Peter Paul","family":"De Deyn","sequence":"additional","affiliation":[{"name":"Laboratory of Neurochemistry and Behaviour, University of Antwerp, 2610 Antwerp, Belgium"},{"name":"Department of Neurology and Alzheimer Center, University of Groningen, 9713 GZ Groningen, The Netherlands"},{"name":"University Medical Center Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Van Dam","sequence":"additional","affiliation":[{"name":"Laboratory of Neurochemistry and Behaviour, University of Antwerp, 2610 Antwerp, Belgium"},{"name":"Department of Neurology and Alzheimer Center, University of Groningen, 9713 GZ Groningen, The Netherlands"},{"name":"University Medical Center Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3848-8702","authenticated-orcid":false,"given":"Guido R. Y.","family":"De Meyer","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, 2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, January 30). Report on Ageing and Health. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ageing-and-health."},{"key":"ref_2","unstructured":"(2022, January 30). WHO Cardiovascular Diseases (CVDs). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)#:~:text=Cardiovascular%20diseases%20(CVDs)%20are%20the,%2D%20and%20middle%2Dincome%20countries."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"GBD 2019 Collaborators (2021). Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019. Alzheimer\u2019s Dement. Transl. Res. 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