{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:13:39Z","timestamp":1792034019018,"version":"4.4.0"},"reference-count":193,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003339","name":"Spanish National Research Council","doi-asserted-by":"publisher","award":["PID2020-115876GB-I00"],"award-info":[{"award-number":["PID2020-115876GB-I00"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In this review, we provide recent data on the role of mTOR kinase in the brain under physiological conditions and after damage, with a particular focus on cerebral ischemia. We cover the upstream and downstream pathways that regulate the activation state of mTOR complexes. Furthermore, we summarize recent advances in our understanding of mTORC1 and mTORC2 status in ischemia\u2013hypoxia at tissue and cellular levels and analyze the existing evidence related to two types of neural cells, namely glia and neurons. Finally, we discuss the potential use of mTORC1 and mTORC2 as therapeutic targets after stroke.<\/jats:p>","DOI":"10.3390\/ijms23052814","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T20:38:16Z","timestamp":1646599096000},"page":"2814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Dysregulation of mTOR Signaling after Brain Ischemia"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-5498","authenticated-orcid":false,"given":"Mario","family":"Villa-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda (Fisiolog\u00eda Animal), Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"},{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CBMSO), Universidad Aut\u00f3noma de Madrid\/CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7769-0829","authenticated-orcid":false,"given":"Gerardo","family":"Mart\u00edn-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda (Fisiolog\u00eda Animal), Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-8085","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"P\u00e9rez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda (Fisiolog\u00eda Animal), Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"},{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CBMSO), Universidad Aut\u00f3noma de Madrid\/CSIC, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00239-011-9469-9","article-title":"Evolution of the TOR pathway","volume":"73","author":"Zwartkruis","year":"2011","journal-title":"J. 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