{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:43:34Z","timestamp":1791326614383,"version":"4.3.1"},"reference-count":102,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center","doi-asserted-by":"publisher","award":["2017\/25\/B\/NZ5\/01961"],"award-info":[{"award-number":["2017\/25\/B\/NZ5\/01961"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Preeclampsia (PE) is characterised by high levels and activity of the transcription factor Nuclear Factor kappa B (NF\u0138B) in the maternal blood and placental cells. This factor is responsible for the regulation of over 400 genes known to influence processes related to inflammation, apoptosis and angiogenesis, and cellular responses to oxidative stress and hypoxia. Although high NF\u0138B activity induces hypoxia and inflammation, which are beneficial for the process of implantation, NF\u0138B level should be reduced in the later stages of physiological pregnancy to favour maternal immunosuppression and maintain gestation. It is believed that the downregulation of NF\u0138B activity by pharmacotherapy might be a promising way to treat preeclampsia. Interestingly, many of the drugs adopted for the prevention and treatment of preeclampsia have been found to regulate NF\u0138B activity. Despite this, further innovation is urgently needed to ensure treatment safety and efficacy. The present article summarizes the current state of knowledge about the drugs recommended by cardiology, obstetrics, and gynaecology societies for the prevention and treatment of preeclampsia with regard to their impact on the cellular regulation of NF\u0138B pathways.<\/jats:p>","DOI":"10.3390\/ijms23052881","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T10:21:16Z","timestamp":1646648476000},"page":"2881","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Targeting of Nuclear Factor Kappa B by Drugs Adopted for the Prevention and Treatment of Preeclampsia"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-2046","authenticated-orcid":false,"given":"Agata","family":"Sakowicz","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology, Medical University of Lodz, 90-752 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.NPR.0000443230.18099.e9","article-title":"Late-onset postpartum preeclampsia: A case study","volume":"39","author":"Clark","year":"2014","journal-title":"Nurse Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/ckj\/sfs101","article-title":"Pre-eclampsia before 20-week gestation: Diagnosis, investigation and management","volume":"5","author":"Thomas","year":"2012","journal-title":"Clin. 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