{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:22:56Z","timestamp":1790673776258,"version":"4.1.0"},"reference-count":205,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["SAF2017-83674-C2-1-R"],"award-info":[{"award-number":["SAF2017-83674-C2-1-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["SAF2017-83674-C2-2-R"],"award-info":[{"award-number":["SAF2017-83674-C2-2-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["PROMETEO\/2018\/114"],"award-info":[{"award-number":["PROMETEO\/2018\/114"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["ACIF\/2017\/169"],"award-info":[{"award-number":["ACIF\/2017\/169"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Spanish Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["MICIN\/AEI\/1013039\/5011100011033 (PID2020-115934RB-I00)"],"award-info":[{"award-number":["MICIN\/AEI\/1013039\/5011100011033 (PID2020-115934RB-I00)"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Spanish Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PRE2018-083980"],"award-info":[{"award-number":["PRE2018-083980"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The cornea is an avascular connective tissue that is crucial, not only as the primary barrier of the eye but also as a proper transparent refractive structure. Corneal transparency is necessary for vision and is the result of several factors, including its highly organized structure, the physiology of its few cellular components, the lack of myelinated nerves (although it is extremely innervated), the tightly controlled hydration state, and the absence of blood and lymphatic vessels in healthy conditions, among others. The avascular, immune-privileged tissue of the cornea is an ideal model to study the interactions between its well-characterized and dense sensory nerves (easily accessible for both focal electrophysiological recording and morphological studies) and the low number of resident immune cell types, distinguished from those cells migrating from blood vessels. This paper presents an overview of the corneal structure and innervation, the resident dendritic cell (DC) subpopulations present in the cornea, their distribution in relation to corneal nerves, and their role in ocular inflammatory diseases. A mouse model in which sensory axons are constitutively labeled with tdTomato and DCs with green fluorescent protein (GFP) allows further analysis of the neuro-immune crosstalk under inflammatory and steady-state conditions of the eye.<\/jats:p>","DOI":"10.3390\/ijms23062997","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T11:46:47Z","timestamp":1646912807000},"page":"2997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["An Experimental Model of Neuro\u2013Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-3735","authenticated-orcid":false,"given":"Laura","family":"Frutos-Rinc\u00f3n","sequence":"first","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez\u2014Consejo Superior de Investigaciones Cient\u00edficas, 03550 San Juan de Alicante, Spain"},{"name":"The European University of Brain and Technology-NeurotechEU, 03550 San Juan de Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6746-1800","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"G\u00f3mez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez\u2014Consejo Superior de Investigaciones Cient\u00edficas, 03550 San Juan de Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-5495","authenticated-orcid":false,"given":"Almudena","family":"\u00cd\u00f1igo-Portugu\u00e9s","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez\u2014Consejo Superior de Investigaciones Cient\u00edficas, 03550 San Juan de Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-068X","authenticated-orcid":false,"given":"M. Carmen","family":"Acosta","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez\u2014Consejo Superior de Investigaciones Cient\u00edficas, 03550 San Juan de Alicante, Spain"},{"name":"The European University of Brain and Technology-NeurotechEU, 03550 San Juan de Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-3649","authenticated-orcid":false,"given":"Juana","family":"Gallar","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Universidad Miguel Hern\u00e1ndez\u2014Consejo Superior de Investigaciones Cient\u00edficas, 03550 San Juan de Alicante, Spain"},{"name":"The European University of Brain and Technology-NeurotechEU, 03550 San Juan de Alicante, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica y Sanitaria de Alicante, 03010 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"36414","DOI":"10.1038\/srep36414","article-title":"Intraepithelial dendritic cells and sensory nerves are structurally associated and functional interdependent in the cornea","volume":"6","author":"Gao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-323-05714-1.00004-2","article-title":"Cornea and sclera","volume":"Volume 4","author":"Dawson","year":"2011","journal-title":"Adler\u2019s Physiology of the Eye"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jcrs.2010.12.037","article-title":"Anatomy and physiology of the cornea","volume":"37","author":"DelMonte","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Saude, T. (1993). Ocular Anatomy and Physiology, Blackwell Science Ltd.","DOI":"10.1097\/00006324-199407000-00009"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/01.ico.0000148312.01805.53","article-title":"White-to-white corneal diameter: Normal values in healthy humans obtained with the Orbscan II topography system","volume":"24","author":"Erb","year":"2005","journal-title":"Cornea"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: Structure, contents and function","volume":"76","author":"Marfurt","year":"2003","journal-title":"Exp. Eye Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1167\/iovs.09-5119","article-title":"Cold thermoreceptors, unexpected players in tear production and ocular dryness sensations","volume":"52","author":"Belmonte","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S1542-0124(12)70112-X","article-title":"Nerves and sensations from the eye surface","volume":"2","author":"Belmonte","year":"2004","journal-title":"Ocul. Surf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1167\/iovs.16-20033","article-title":"Functional properties of sensory nerve terminals of the mouse cornea","volume":"58","author":"Bech","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.1957.sp005758","article-title":"The structure and transparency of the cornea","volume":"136","author":"Maurice","year":"1957","journal-title":"J. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.exer.2010.06.021","article-title":"The molecular basis of corneal transparency","volume":"91","author":"Hassell","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature05249","article-title":"Corneal avascularity is due to soluble VEGF receptor-1","volume":"443","author":"Ambati","year":"2006","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1073\/pnas.0506112103","article-title":"Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision","volume":"103","author":"Cursiefen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","first-page":"2283","article-title":"Structure of corneal layers, collagen fibrils, and proteoglycans of tree shrew cornea","volume":"17","author":"Almubrad","year":"2011","journal-title":"Mol. Vis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/exer.2001.1045","article-title":"Epithelial mucins of the ocular surface: Structure, biosynthesis and function","volume":"73","author":"Gipson","year":"2001","journal-title":"Exp. Eye Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1167\/iovs.08-2941","article-title":"Dimensions and morphology of the cornea in three strains of mice","volume":"50","author":"Henriksson","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1001\/archopht.1961.01840020697016","article-title":"Cell Turnover in the Adult Human Eye","volume":"65","author":"Hanna","year":"1961","journal-title":"Arch. Ophthalmol."},{"key":"ref_18","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft","year":"1983","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"108033","DOI":"10.1016\/j.exer.2020.108033","article-title":"Bowman\u2019s layer in the cornea\u2013 structure and function and regeneration","volume":"195","author":"Wilson","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00003226-200007000-00001","article-title":"Bowman\u2019s layer structure and function: Critical or dispensable to corneal function? A Hypothesis","volume":"19","author":"Wilson","year":"2000","journal-title":"Cornea"},{"key":"ref_21","first-page":"44","article-title":"The ins and outs of corneal wound healing","volume":"153","author":"Lee","year":"2016","journal-title":"Rev. Optom."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6336(11)80031-8","article-title":"Corneal and Ocular Surface Histochemistry","volume":"25","author":"Hazlett","year":"1993","journal-title":"Prog. Histochem. Cytochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0042-6989(70)90068-4","article-title":"The transparency of the corneal stroma","volume":"10","author":"Maurice","year":"1970","journal-title":"Vision Res."},{"key":"ref_24","first-page":"2568","article-title":"Keratocyte gap junctional communication in normal and wounded rabbit corneas and human corneas","volume":"36","author":"Watsky","year":"1995","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1167\/iovs.02-1188","article-title":"Molecular mechanisms controlling the fibrotic repair phenotype in cornea: Implications for surgical outcomes","volume":"44","author":"Stramer","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00315823","article-title":"On the ultrastructure of the developing and adult mouse corneal stroma","volume":"168","author":"Haustein","year":"1983","journal-title":"Anat. Embryol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.ophtha.2013.01.018","article-title":"Human corneal anatomy redefined: A novel pre-Descemet\u2019s layer (Dua\u2019s layer)","volume":"120","author":"Dua","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_28","first-page":"3","article-title":"The anterior segment and ocular adnexae","volume":"Volume 1","author":"Smith","year":"2002","journal-title":"Systematic Evaluation of the Mouse Eye: Anatomy, Pathology and Biomethods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100762","DOI":"10.1016\/j.preteyeres.2019.05.003","article-title":"Corneal nerves in health and disease","volume":"73","author":"Dhillon","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/B978-0-323-05714-1.00016-9","article-title":"Sensory innervation of the eye","volume":"Volume 16","author":"Belmonte","year":"2011","journal-title":"Adler\u2019s Physiology of the Eye"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1001\/archneurpsyc.1928.02210160177016","article-title":"Corneal and scleral anesthesia of the lower hale of the eye in a case of trauma of the superior maxillary nerve","volume":"20","author":"Vonderahe","year":"1928","journal-title":"Arch. Neurol. Psychiatry"},{"key":"ref_32","first-page":"195","article-title":"Ocular fibers of the maxillary nerve in monkeys","volume":"118","author":"Ruskell","year":"1974","journal-title":"J. Anat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cne.903360405","article-title":"Immunohistochemical localization of tyrosine hydroxylase in corneal nerves","volume":"336","author":"Marfurt","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1748-1716.1966.tb03287.x","article-title":"Connections between Adrenergic Nerves and other Tissue Components in the Eye","volume":"67","author":"Ehinger","year":"1966","journal-title":"Acta Physiol. Scand."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0165-1838(87)90115-9","article-title":"Sympathetic innervation of the cornea from the superior cervical ganglion. An HRP study in the cat","volume":"20","author":"Morgan","year":"1987","journal-title":"J. Auton. Nerv. Syst."},{"key":"ref_36","first-page":"461","article-title":"Sensory and sympathetic innervation of the mammalian cornea. A retrograde tracing study","volume":"30","author":"Marfurt","year":"1989","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_37","first-page":"398","article-title":"Histochemical demonstration of adrenergic nerves in the stroma of human cornea","volume":"28","author":"Toivanen","year":"1987","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.exer.2009.12.010","article-title":"Anatomy of the human corneal innervation","volume":"90","author":"Marfurt","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.exer.2010.07.007","article-title":"Mapping the entire human corneal nerve architecture","volume":"91","author":"He","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_40","unstructured":"Marfurt, C.F. (2000). Nervous control of the cornea. Nervous Control of the Eye, Harwood Academic Publishers."},{"key":"ref_41","first-page":"1075","article-title":"Sensitivity and neural organization of the cat cornea","volume":"30","year":"1989","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_42","first-page":"68","article-title":"Observations on the innervation of the cornea","volume":"85","author":"Zander","year":"1951","journal-title":"J. Anat."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/cne.23207","article-title":"Sensory and sympathetic innervation of the mouse and guinea pig corneal epithelium","volume":"521","author":"Ivanusic","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1167\/iovs.10-5902","article-title":"Innervation of the mouse cornea during development","volume":"52","author":"Mckenna","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1167\/iovs.12-9704","article-title":"Changes in mouse corneal epithelial innervation with age","volume":"53","author":"Wang","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/glia.23102","article-title":"Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves","volume":"65","author":"Stepp","year":"2017","journal-title":"Glia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3959(82)90092-6","article-title":"Density and organization of free nerve endings in the corneal epithelium of the rabbit","volume":"14","author":"Beuerman","year":"1982","journal-title":"Pain"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF02134093","article-title":"Nerve structures in human central corneal epithelium","volume":"218","author":"Schimmelpfennig","year":"1982","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1350-9462(96)00027-4","article-title":"Neurobiology of ocular pain","volume":"16","author":"Belmonte","year":"1997","journal-title":"Progr. Ret. Eye Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/eye.1993.12","article-title":"Corneal epithelial cell migration in humans: \u2018hurricane and blizzard keratopathy\u2019","volume":"7","author":"Dua","year":"1993","journal-title":"Eye"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/bjo.2009.173799","article-title":"Architecture and distribution of human corneal nerves","volume":"94","author":"Fares","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1167\/iovs.07-1324","article-title":"Age-related changes in rat corneal epithelial nerve density","volume":"49","author":"Dvorscak","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1167\/iovs.02-0705","article-title":"Centripetal Movement of Corneal Epithelial Cells in the Normal Adult Mouse","volume":"44","author":"Nagasaki","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1167\/iovs.05-0794","article-title":"Mapping of the normal human corneal sub-basal nerve plexus by in vivo laser scanning confocal microscopy","volume":"46","author":"Patel","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Alamri, A.S., Wood, R.J., Ivanusic, J.J., and Brock, J.A. (2018). The neurochemistry and morphology of functionally identified corneal polymodal nociceptors and cold thermoreceptors. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195108"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.exer.2003.09.023","article-title":"Neural basis of sensation in intact and injured corneas","volume":"78","author":"Belmonte","year":"2004","journal-title":"Exp. Eye Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1469-7793.2001.t01-1-00511.x","article-title":"Sensory experiences in humans and single-unit activity in cats evoked by polymodal stimulation of the cornea","volume":"534","author":"Acosta","year":"2001","journal-title":"J. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1002\/cne.23560","article-title":"Piezo2 expression in corneal afferent neurons","volume":"522","author":"Bron","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"8976","DOI":"10.1523\/JNEUROSCI.0247-20.2020","article-title":"Piezo2 mediates low-threshold mechanically evoked pain in the cornea","volume":"40","author":"Viana","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1113\/jphysiol.1981.sp013989","article-title":"Responses of cat corneal sensory receptors to mechanical and thermal stimulation","volume":"321","author":"Belmonte","year":"1981","journal-title":"J. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1113\/jphysiol.1991.sp018621","article-title":"Excitation by irritant chemical substances of sensory afferent units in the cat\u2019s cornea","volume":"437","author":"Belmonte","year":"1991","journal-title":"J. Physiol."},{"key":"ref_62","first-page":"1944","article-title":"Reduction by antiinflammatory drugs of the response of corneal sensory nerve fibers to chemical irritation","volume":"38","author":"Chen","year":"1997","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1113\/jphysiol.1993.sp019791","article-title":"Response of sensory units with unmyelinated fibres to mechanical, thermal and chemical stimulation of the cat\u2019s cornea","volume":"468","author":"Gallar","year":"1993","journal-title":"J. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1167\/iovs.07-0012","article-title":"Impulse activity in corneal sensory nerve fibers after photorefractive keratectomy","volume":"48","author":"Gallar","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/jn.1969.32.6.1025","article-title":"Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli","volume":"32","author":"Bessou","year":"1969","journal-title":"J. Neurophysiol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Meyer, R.A., Ringkamp, M., Campbell, J.N., and Raja, S.N. (2006). Peripheral mechanisms of cutaneous nociception. Wall & Melzack\u2019s Textbook of Pain, Elsevier.","DOI":"10.1016\/B0-443-07287-6\/50006-0"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1085\/jgp.200308814","article-title":"Effects of heating and cooling on nerve terminal impulses recorded from cold-sensitive receptors in the guinea-pig cornea","volume":"121","author":"Carr","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.pain.2014.04.025","article-title":"Tear fluid hyperosmolality increases nerve impulse activity of cold thermoreceptor endings of the cornea","volume":"155","author":"Parra","year":"2014","journal-title":"Pain"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.pain.2013.07.012","article-title":"Changes in sensory activity of ocular surface sensory nerves during allergic keratoconjunctivitis","volume":"154","author":"Acosta","year":"2013","journal-title":"Pain"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1167\/iovs.03-1366","article-title":"Tear secretion induced by selective stimulation of corneal and conjunctival sensory nerve fibers","volume":"45","author":"Acosta","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/nm.2264","article-title":"Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea","volume":"16","author":"Parra","year":"2010","journal-title":"Nat. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1038\/ncomms8150","article-title":"TRPM8 is a neuronal osmosensor that regulates eye blinking in mice","volume":"6","author":"Quallo","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/cne.24454","article-title":"Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice","volume":"526","author":"Alcalde","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3928\/1081-597X-20040501-06","article-title":"Recovery of corneal sensitivity to mechanical and chemical stimulation after laser in situ keratomileusis","volume":"20","author":"Gallar","year":"2004","journal-title":"J. Refract. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.3389\/fmed.2021.767967","article-title":"Unilateral Corneal Insult Also Alters Sensory Nerve Activity in the Contralateral Eye","volume":"8","author":"Luna","year":"2021","journal-title":"Front. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1167\/iovs.13-13774","article-title":"Corneal sensory nerve activity in an experimental model of UV keratitis","volume":"55","author":"Acosta","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/j.pain.0000000000000455","article-title":"Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease","volume":"157","author":"Luna","year":"2016","journal-title":"Pain"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/ICO.0000000000002116","article-title":"Pain, Dryness, and Itch Sensations in Eye Surface Disorders Are Defined by a Balance between Inflammation and Sensory Nerve Injury","volume":"38","author":"Belmonte","year":"2019","journal-title":"Cornea"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.62.1.2","article-title":"Sodium Channel Blockers Modulate Abnormal Activity of Regenerating Nociceptive Corneal Nerves After Surgical Lesion","volume":"62","author":"Luna","year":"2021","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_80","first-page":"3329","article-title":"Reduction of capsaicin-induced ocular pain and neurogenic inflammation by calcium antagonists","volume":"34","author":"Gonzalez","year":"1993","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.62.3.26","article-title":"Modulating ocular surface pain through neurokinin-1 receptor blockade","volume":"62","author":"Vitar","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2006.02.035","article-title":"Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons","volume":"1085","author":"Murata","year":"2006","journal-title":"Brain Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.4103\/1673-5374.308666","article-title":"Corneal neuromediator profiles following laser refractive surgery","volume":"16","author":"Yang","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/ncb2529","article-title":"Direct inhibition of the cold-Activated TRPM8 ion channel by G\u03b1 q","volume":"14","author":"Zhang","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.it.2017.11.007","article-title":"When Clarity Is Crucial: Regulating Ocular Surface Immunity","volume":"39","author":"Foulsham","year":"2018","journal-title":"Trends Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fimmu.2016.00037","article-title":"Ocular Immune Privilege and Transplantation","volume":"7","author":"Taylor","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1167\/iovs.19-28632","article-title":"The eye sees eye to eye with the immune system: The 2019 Proctor lecture","volume":"60","author":"Niederkorn","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_88","first-page":"58","article-title":"Immunity to homologous grafted skin; the fate of skin homografts","volume":"29","author":"Medawar","year":"1948","journal-title":"Br. J. Exp. Pathol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/eye.2008.259","article-title":"Privilege revisited: An evaluation of the eye\u2019s defence mechanisms","volume":"23","author":"Forrester","year":"2009","journal-title":"Eye"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/09273948.2010.512696","article-title":"Review of ocular immune privilege in the year 2010: Modifying the immune privilege of the eye","volume":"18","author":"Hori","year":"2010","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_91","first-page":"2264","article-title":"Identification of a novel macrophage population in the normal mouse corneal stroma","volume":"43","author":"Reynolds","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_92","first-page":"639","article-title":"Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells","volume":"43","author":"Hamrah","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1189\/jlb.1102544","article-title":"Corneal immunity is mediated by heterogeneous population of antigen-presenting cells","volume":"74","author":"Hamrah","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1167\/iovs.02-0838","article-title":"The corneal stroma is endowed with a significant number of resident dendritic cells","volume":"44","author":"Hamrah","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"108099","DOI":"10.1016\/j.celrep.2020.108099","article-title":"Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis","volume":"32","author":"Jamali","year":"2020","journal-title":"Cell Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fimmu.2012.00338","article-title":"Good news-bad news: The Yin and Yang of immune privilege in the eye","volume":"3","author":"Forrester","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.4049\/jimmunol.1002321","article-title":"Foxp3-Mediated Suppression of CD95L Expression Confers Resistance to Activation-Induced Cell Death in Regulatory T Cells","volume":"187","author":"Weiss","year":"2011","journal-title":"J. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","article-title":"The PD-1 pathway in tolerance and autoimmunity","volume":"236","author":"Francisco","year":"2010","journal-title":"Immunol. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.4049\/jimmunol.1300182","article-title":"Both MC5r and A2Ar Are Required for Protective Regulatory Immunity in the Spleen of Post\u2013Experimental Autoimmune Uveitis in Mice","volume":"191","author":"Lee","year":"2013","journal-title":"J. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00726-011-1184-8","article-title":"Vasoactive intestinal peptide: A neuropeptide with pleiotropic immune functions","volume":"45","author":"Delgado","year":"2013","journal-title":"Amino Acids"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1094-5539(03)00049-X","article-title":"Calcitonin gene-related peptide as inflammatory mediator","volume":"16","author":"Springer","year":"2003","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1084\/jem.137.5.1142","article-title":"Identification of a novel cell type in peripheral lymphoid organs of mice: I. Morphology, quantitation, tissue distribution","volume":"137","author":"Steinman","year":"1973","journal-title":"J. Exp. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.3389\/fimmu.2018.03176","article-title":"Human dendritic cells: Their heterogeneity and clinical application potential in cancer immunotherapy","volume":"10","author":"Patente","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1084\/jem.182.2.283","article-title":"The endoeytie activity of dendritic cells","volume":"182","author":"Steinman","year":"1995","journal-title":"J. Exp. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","article-title":"Cell biology of antigen processing in vitro and in vivo","volume":"23","author":"Trombetta","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nri1845","article-title":"Dendritic cells in a mature age","volume":"6","author":"Reis","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-100311-102839","article-title":"Decisions about dendritic cells: Past, present, and future","volume":"30","author":"Steinman","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1084\/jem.194.6.769","article-title":"Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo","volume":"194","author":"Hawiger","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri.2016.116","article-title":"Dendritic cell migration in health and disease","volume":"17","author":"Worbs","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1007\/s00018-015-2005-0","article-title":"Human dendritic cell subsets and function in health and disease","volume":"72","author":"Mok","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1084\/jem.182.5.1591","article-title":"Extent of T cell receptor ligation can determine the functional differentiation of naive cd4+ T cells","volume":"182","author":"Constant","year":"1995","journal-title":"J. Exp. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0092-8674(04)00451-9","article-title":"Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells","volume":"117","author":"Amsen","year":"2004","journal-title":"Cell"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2332\/allergolint.R-07-146","article-title":"Dendritic cells\u2014A conductor of T cell differentiation","volume":"56","author":"Kadowaki","year":"2007","journal-title":"Allergol. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.4049\/jimmunol.179.6.3515","article-title":"Dendritic Cell Expression of OX40 Ligand Acts as a Costimulatory, Not Polarizing, Signal for Optimal Th2 Priming and Memory Induction In Vivo","volume":"179","author":"Jenkins","year":"2007","journal-title":"J. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ni1430","article-title":"CNS myeloid DCs presenting endogenous myelin peptides \u201cpreferentially\u201d polarize CD4+ TH-17 cells in relapsing EAE","volume":"8","author":"Bailey","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/cmi.2012.10","article-title":"Regulation of TH17 cell differentiation by innate immune signals","volume":"9","author":"Huang","year":"2012","journal-title":"Cell. Mol. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/imr.12181","article-title":"Dendritic cell-epithelial cell crosstalk in the gut","volume":"260","author":"Rescigno","year":"2014","journal-title":"Immunol. Rev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.2003.tb06029.x","article-title":"Dendritic cell function in Vivo during the steady state: A role in peripheral tolerance","volume":"987","author":"Steinman","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2015.07.011","article-title":"Regulatory dendritic cells in autoimmunity: A comprehensive review","volume":"63","author":"Liu","year":"2015","journal-title":"J. Autoimmun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3389\/fimmu.2015.00569","article-title":"Tolerogenic dendritic cells for regulatory T cell induction in man","volume":"6","author":"Raker","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nri2132","article-title":"Tolerogenic dendritic cells and the quest for transplant tolerance","volume":"7","author":"Morelli","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01015.x","article-title":"Dendritic cell control of tolerogenic responses","volume":"241","author":"Manicassamy","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"967","DOI":"10.4049\/jimmunol.179.2.967","article-title":"Induction of Regulatory T Cells and Dominant Tolerance by Dendritic Cells Incapable of Full Activation","volume":"179","author":"Yates","year":"2007","journal-title":"J. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"Geissmann","year":"2010","journal-title":"Science"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"6787","DOI":"10.3892\/mmr.2017.7448","article-title":"Discrimination of the heterogeneity of bone marrow-derived dendritic cells","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ni.3294","article-title":"Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses","volume":"17","author":"Halim","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.20061011","article-title":"Monocytes give rise to mucosal, but not splenic, conventional dendritic cells","volume":"204","author":"Varol","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.immuni.2013.10.004","article-title":"Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin","volume":"39","author":"Tamoutounour","year":"2013","journal-title":"Immunity"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen","volume":"38","author":"Plantinga","year":"2013","journal-title":"Immunity"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor","volume":"176","author":"Inaba","year":"1992","journal-title":"J. Exp. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.179.4.1109","article-title":"Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte\/macrophage colony-stimulating factor plus iuterleukin 4 and downregulated by tumor necrosis factor \u03b1","volume":"179","author":"Sallusto","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.20100348","article-title":"Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells","volume":"207","author":"Bachem","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fimmu.2015.00330","article-title":"Human and mouse mononuclear phagocyte networks: A tale of two species?","volume":"6","author":"Reynolds","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-immunol-061020-053707","article-title":"Dendritic cells revisited","volume":"39","author":"Cardoso","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8\u03b1+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1084\/jem.20021263","article-title":"ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8\u03b1+ Dendritic Cells","volume":"196","author":"Schiavoni","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ni903","article-title":"Transcriptional profiling identifies Id2 function in dendritic cell development","volume":"4","author":"Hacker","year":"2003","journal-title":"Nat. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1182\/blood-2010-07-295873","article-title":"NFIL3\/E4BP4 is a key transcription factor for CD8\u03b1+ dendritic cell development","volume":"117","author":"Kashiwada","year":"2011","journal-title":"Blood"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1084\/jem.20111457","article-title":"Characterization of resident and migratory dendritic cells in human lymph nodes","volume":"209","author":"Segura","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3389\/fimmu.2017.00971","article-title":"Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cells","volume":"8","author":"Mok","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.4049\/jimmunol.0803404","article-title":"Human Liver Dendritic Cells Promote T Cell Hyporesponsiveness","volume":"182","author":"Bamboat","year":"2009","journal-title":"J. Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ni.2768","article-title":"Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice","volume":"15","author":"Watchmaker","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-417028-5.00001-6","article-title":"Ontogeny and functional specialization of dendritic cells in human and mouse","volume":"Volume 120","author":"Haniffa","year":"2013","journal-title":"Advances in Immunology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.immuni.2013.04.011","article-title":"IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses","volume":"38","author":"Schlitzer","year":"2013","journal-title":"Immunity"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-immunol-032713-120204","article-title":"Transcriptional Control of Dendritic Cell Development","volume":"34","author":"Murphy","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1074-7613(00)80649-4","article-title":"RelB is essential for the development of myeloid-related CD8\u03b1- dendritic cells but not of lymphoid-related CD8\u03b1+ dendritic cells","volume":"9","author":"Wu","year":"1998","journal-title":"Immunity"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zhu, X.J., Yang, Z.F., Chen, Y., Wang, J., and Rosmarin, A.G. (2012). PU.1 Is Essential for CD11c Expression in CD8+\/CD8- Lymphoid and Monocyte-Derived Dendritic Cells during GM-CSF or FLT3L-Induced Differentiation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052141"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1100066","article-title":"IRF8 Mutations and Human Dendritic-Cell Immunodeficiency","volume":"365","author":"Hambleton","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-immunol-031210-101345","article-title":"Plasmacytoid dendritic cells: Recent progress and open questions","volume":"29","author":"Reizis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"100877","DOI":"10.1016\/j.preteyeres.2020.100877","article-title":"Plasmacytoid dendritic cells in the eye","volume":"80","author":"Jamali","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1084\/jem.20130443","article-title":"Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells","volume":"210","author":"Sawai","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_154","first-page":"279","article-title":"Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation","volume":"5","author":"Chistiakov","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1172\/JCI11734","article-title":"Human thymus contains IFN-\u03b1-producing CD11c-, myeloid CD11c+, and mature interdigitating dendritic cells","volume":"107","author":"Durand","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1084\/jem.194.8.1171","article-title":"CD11c+B220+Gr-1+ cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells","volume":"194","author":"Nakano","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.4049\/jimmunol.179.5.2690","article-title":"Cutting Edge: Peyer\u2019s Patch Plasmacytoid Dendritic Cells (pDCs) Produce Low Levels of Type I Interferons: Possible Role for IL-10, TGF\u03b2, and Prostaglandin E 2 in Conditioning a Unique Mucosal pDC Phenotype","volume":"179","author":"Contractor","year":"2007","journal-title":"J. Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3389\/fimmu.2019.00441","article-title":"Characterization of antigen-presenting cell subsets in human liver-draining lymph nodes","volume":"10","author":"Boor","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.20050500","article-title":"Plasmacytoid predendritic cells initiate psoriasis through interferon-\u03b1 production","volume":"202","author":"Nestle","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.it.2010.05.004","article-title":"Trafficking properties of plasmacytoid dendritic cells in health and disease","volume":"31","author":"Sozzani","year":"2010","journal-title":"Trends Immunol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"s1175","DOI":"10.2741\/1185","article-title":"Identification, rare-event detection and analysis of dendritic cell subsets in broncho-alveolar lavage fluid and peripheral blood by flow cytometry","volume":"8","author":"Donnenberg","year":"2003","journal-title":"Front. Biosci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.4049\/jimmunol.177.11.7510","article-title":"Cutting Edge: Plasmacytoid Dendritic Cells Provide Innate Immune Protection against Mucosal Viral Infection In Situ","volume":"177","author":"Lund","year":"2006","journal-title":"J. Immunol."},{"key":"ref_163","first-page":"15","article-title":"Plasmacytoid T cells. Immunohistochemical evidence for their monocyte\/macrophage origin","volume":"133","author":"Facchetti","year":"1988","journal-title":"Am. J. Pathol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.4049\/jimmunol.0802008","article-title":"CD2 Distinguishes Two Subsets of Human Plasmacytoid Dendritic Cells with Distinct Phenotype and Functions","volume":"182","author":"Matsui","year":"2009","journal-title":"J. Immunol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.immuni.2008.07.013","article-title":"Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells","volume":"29","author":"Klechevsky","year":"2008","journal-title":"Immunity"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/jid.1961.80","article-title":"An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary\u2019s Hospital Medical School (University of London) London, W. 2, England","volume":"37","author":"Birbeck","year":"1961","journal-title":"J. Investig. Dermatol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.immuni.2012.04.012","article-title":"Human Tissues Contain CD141 hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103 + Nonlymphoid Dendritic Cells","volume":"37","author":"Haniffa","year":"2012","journal-title":"Immunity"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/sj.emboj.7600085","article-title":"Runx3 regulates mouse TGF-\u03b2-mediated dendritic cell function and its absence results in airway inflammation","volume":"23","author":"Fainaru","year":"2004","journal-title":"EMBO J."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1084\/jem.20130930","article-title":"Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks","volume":"210","author":"Chopin","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.immuni.2012.10.018","article-title":"Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation","volume":"38","author":"Segura","year":"2013","journal-title":"Immunity"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1182\/blood-2004-04-1448","article-title":"Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate","volume":"105","author":"Bakri","year":"2005","journal-title":"Blood"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.4049\/jimmunol.175.10.6570","article-title":"Differential Expression of IFN Regulatory Factor 4 Gene in Human Monocyte-Derived Dendritic Cells and Macrophages","volume":"175","author":"Lehtonen","year":"2005","journal-title":"J. Immunol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/archopht.121.8.1132","article-title":"Alterations in corneal stromal dendritic cell phenotype and distribution in inflammation","volume":"121","author":"Hamrah","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1167\/iovs.05-0054","article-title":"Distinct populations of dendritic cells in the normal human donor corneal epithelium","volume":"46","author":"Yamagami","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/ICO.0000000000001005","article-title":"Novel insights into the immunoregulatory function and localization of dendritic cells","volume":"35","author":"Hattori","year":"2016","journal-title":"Cornea"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2353\/ajpath.2007.070008","article-title":"\u03b3\u03b4 T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion","volume":"171","author":"Li","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ajpath.2012.04.010","article-title":"NK cells modulate the inflammatory response to corneal epithelial abrasion and thereby support wound healing","volume":"181","author":"Liu","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1167\/iovs.06-1184","article-title":"Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers","volume":"48","author":"Mayer","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Del Palomar, A.P., Montol\u00edo, A., Cego\u00f1ino, J., Dhanda, S.K., Lio, C.T., and Bose, T. (2019). The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122110"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/02713683.2013.842592","article-title":"In vivo confocal microscopy of the ocular surface: From bench to bedside","volume":"39","author":"Villani","year":"2014","journal-title":"Curr. Eye Res."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Bitirgen, G., Korkmaz, C., Zamani, A., Ozkagnici, A., Zengin, N., Ponirakis, G., and Malik, R.A. (2021). Corneal confocal microscopy identifies corneal nerve fibre loss and increased dendritic cells in patients with long COVID. Br. J. Ophthalmol.","DOI":"10.1136\/bjophthalmol-2021-319450"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1167\/iovs.10-7048","article-title":"Inflammation and the nervous system: The connection in the cornea in patients with infectious keratitis","volume":"52","author":"Cruzat","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1167\/iovs.15-16560","article-title":"Contralateral clinically unaffected eyes of patients with unilateral infectious keratitis demonstrate a sympathetic immune response","volume":"56","author":"Cruzat","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1136\/bjophthalmol-2015-307429","article-title":"In vivo confocal microscopy of inflammatory cells in the corneal subbasal nerve plexus in patients with different subtypes of anterior uveitis","volume":"100","author":"Postole","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1167\/iovs.09-3629","article-title":"Changes in corneal epithelial layer inflammatory cells in aqueous tear-deficient dry eye","volume":"51","author":"Lin","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.exer.2008.03.002","article-title":"Alterations in corneal sensitivity and nerve morphology in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"86","author":"Tuisku","year":"2008","journal-title":"Exp. Eye Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/ICO.0b013e31802e3b55","article-title":"In vivo confocal microscopic evaluation of langerhans cell density and distribution in the corneal epithelium of healthy volunteers and contact lens wearers","volume":"26","author":"Zhivov","year":"2007","journal-title":"Cornea"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1167\/iovs.14-15411","article-title":"Correlation Between Human Tear Cytokine Levels and Cellular Corneal Changes in Patients with Bacterial Keratitis by In Vivo Confocal Microscopy","volume":"55","author":"Yamaguchi","year":"2014","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/1753425912471692","article-title":"Inflammation in dry eye associated with rheumatoid arthritis: Cytokine and in vivo confocal microscopy study","volume":"19","author":"Villani","year":"2013","journal-title":"Innate Immun."},{"key":"ref_190","first-page":"2158","article-title":"The role of corneal plasmacytoid dendritic cells in acute herpes simplex virus infection","volume":"54","author":"Hu","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Khandelwal, P., Blanco-Mezquita, T., Emami, P., Lee, H.S., Reyes, N.J., Mathew, R., Huang, R., and Saban, D.R. (2013). Ocular Mucosal CD11b+ and CD103+ Mouse Dendritic Cells under Normal Conditions and in Allergic Immune Responses. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064193"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1172\/JCI85097","article-title":"Dendritic cell dysfunction and diabetic sensory neuropathy in the cornea","volume":"126","author":"Gao","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1167\/iovs.17-22550","article-title":"Activation of Dendritic Cells in Dry Eye Mouse Model","volume":"59","author":"Maruoka","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_194","first-page":"331","article-title":"Plasmacytoid Dendritic Cells Mediate T cell Responses by Direct Interaction in Lymph Nodes during Herpes Simplex Virus-1 Keratitis","volume":"57","author":"Sendra","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1128\/JVI.74.4.1827-1839.2000","article-title":"Anterograde Transport of Herpes Simplex Virus Type 1 in Cultured, Dissociated Human and Rat Dorsal Root Ganglion Neurons","volume":"74","author":"Armati","year":"2000","journal-title":"J. Virol."},{"key":"ref_196","first-page":"3618","article-title":"Plasmacytoid dendritic cells modulate corneal inflammation through transforming growth factor (TGF)-beta1","volume":"58","author":"Sendra","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Hu, K., Harris, D.L., Yamaguchi, T., Von Andrian, U.H., and Hamrah, P. (2015). A dual role for corneal dendritic cells in herpes simplex keratitis: Local suppression of corneal damage and promotion of systemic viral dissemination. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137123"},{"key":"ref_198","first-page":"1694","article-title":"Role of plasmacytoid dendritic cell in the immune regulation in sutured inflamed cornea","volume":"55","author":"Sendra","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1167\/iovs.14-14307","article-title":"Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea","volume":"55","author":"Leppin","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1167\/iovs.13-12995","article-title":"A novel association between resident tissue macrophages and nerves in the peripheral stroma of the murine cornea","volume":"55","author":"Chinnery","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/ICO.0000000000001014","article-title":"Translational Immunoimaging and Neuroimaging Demonstrate Corneal Neuroimmune Crosstalk","volume":"35","author":"Hamrah","year":"2016","journal-title":"Cornea"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1186\/1744-8069-7-66","article-title":"Generation and characterization of an Advillin-Cre driver mouse line","volume":"7","author":"Zurborg","year":"2011","journal-title":"Mol. Pain"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Rincon Frutos, L., Luna, C., Antonio G\u00f3mez S\u00e1nchez, J., Carmen Acosta, M., Belmonte, C., Seyed-Razavi, Y., Hamrah, P., and Gallar, J. (2022). Dendritic cell depletion modifies corneal nerve activity and mice nociceptive behaviour. 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