{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:26:27Z","timestamp":1785345987341,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST108-2320-B-030-006"],"award-info":[{"award-number":["MOST108-2320-B-030-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chi Mei Medical Center and Fu Jen Catholic University Education and Development Cooperation Project","award":["105-CM-FJU-03, 105-CM-FJU-01"],"award-info":[{"award-number":["105-CM-FJU-03, 105-CM-FJU-01"]}]},{"name":"Cathay General Hospital and Fu Jen Catholic University Education and Development Cooperation Project","award":["109-CGH-FJU-07"],"award-info":[{"award-number":["109-CGH-FJU-07"]}]},{"name":"Far Eastern Memorial Hospital and Fu Jen Catholic University Education and Development Cooperation Project","award":["110-FEMH-FJU-03"],"award-info":[{"award-number":["110-FEMH-FJU-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Erectile dysfunction (ED) is an agonizing complication of diabetes mellitus (DM) and it is challenging to treat ED in DM patients. Platelet-rich plasma (PRP) is a unique therapeutic strategy comprising intrinsic growth factors. An attempt was made to explore the potentiality of the PRP treatment in DM-induced ED rats in various groups (control, DM-non-ED, DM-ED, and DM-ED treated with PRP). Streptozotocin (STZ) was used to induce DM in rats. The blood glucose levels of the DM rats were maintained at &gt;300 mg\/dl. In the 18-week experiment, survival rate, body weight, intracavernous pressure (ICP) variations, and arterial blood pressure were analyzed. The tissue restoration results were validated by histological, immunofluorescence, and transmission electron microscopic analysis. PRP treatment of DM-ED rats significantly increased all parameters of erectile function compared to pre-treatment of PRP and DM-ED treated with vehicle. The histological results revealed that PRP treatment substantially enhanced the regeneration of myelinated nerves and decreased the atrophy of corporal smooth muscle. Notably, the PRP treatment immensely enhanced the survival rate in post-surgery DM-ED rats. These results indicated certain benefits of PRP treatment in delaying damage and preventing post-surgery complications in DM patients. Hence, PRP treatment is a novel multifactorial strategy for DM-ED patients.<\/jats:p>","DOI":"10.3390\/ijms23063017","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T20:19:10Z","timestamp":1646943550000},"page":"3017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intracavernous Injection of Platelet-Rich Plasma Therapy Enhances Erectile Function and Decreases the Mortality Rate in Streptozotocin-Induced Diabetic Rats"],"prefix":"10.3390","volume":"23","author":[{"given":"Chun-Hou","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Surgery, Cardinal Tien Hospital, New Taipei City 231, Taiwan"},{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kau-Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan City 71004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu-Dong","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Nursing, College of Healthcare & Management, Asia Eastern University of Science and Technology, New Taipei City 220, Taiwan"},{"name":"Graduate Institute of Medicine, Yuan Ze University, Taoyuan City 320, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chiang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"},{"name":"Department of Urology, Cathay General Hospital, Taipei City 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-0357","authenticated-orcid":false,"given":"Chellappan","family":"Praveen Rajneesh","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-He","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-2741","authenticated-orcid":false,"given":"Jai-Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"},{"name":"Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"},{"name":"Department of Leisure and Sports Management, Cheng Shiu University, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Sun","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242, Taiwan"},{"name":"Department of Urology, Fu Jen Catholic University Hospital, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-2219","authenticated-orcid":false,"given":"Yi-No","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/1008-682X.182817","article-title":"Therapeutic effects of adipose-derived stem cells-based microtissues on erectile dysfunction in streptozotocin-induced diabetic rats","volume":"19","author":"Zhou","year":"2017","journal-title":"Asian J. 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