{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:23:34Z","timestamp":1788535414499,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acne Vulgaris (AV) and Hidradenitis suppurativa (HS) are common chronic inflammatory skin conditions that affect the follicular units that often coexist or are involved in differential diagnoses. Inflammation in both these diseases may result from shared pathways, which may partially explain their frequent coexistence. MicroRNAs (miRNAs) are a class of endogenous, short, non-protein coding, gene-silencing or promoting RNAs that may promote various inflammatory diseases. This narrative review investigates the current knowledge regarding miRNAs and their link to AV and HS. The aim is to examine the role of these molecules in the pathogenesis of AV and HS and to identify possible common miRNAs that could explain the similar characteristics of these two diseases. Five miRNA (miR-155 miR-223-, miR-21, and miRNA-146a) levels were found to be altered in both HS and AV. These miRNAs are related to pathogenetic aspects common to both pathologies, such as the regulation of the innate immune response, regulation of the Th1\/Th17 axis, and fibrosis processes that induce scar formation. This review provides a starting point for further studies aimed at investigating the role of miRNAs in AV and HS for their possible use as diagnostic-therapeutic targets.<\/jats:p>","DOI":"10.3390\/ijms23063241","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:30:14Z","timestamp":1647811814000},"page":"3241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["MicroRNA Cross-Involvement in Acne Vulgaris and Hidradenitis Suppurativa: A Literature Review"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-8441","authenticated-orcid":false,"given":"Francesco","family":"Borgia","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Dermatology, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-3279","authenticated-orcid":false,"given":"Lucia","family":"Peterle","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Dermatology, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Custurone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Dermatology, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-5145","authenticated-orcid":false,"given":"Mario","family":"Vaccaro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Dermatology, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-7449","authenticated-orcid":false,"given":"Giovanni","family":"Pioggia","sequence":"additional","affiliation":[{"name":"Messina Unit, Institute for Biolomedical Research and Innovation, National Research Council of Italy (IRIB-CNR), Via Vincenzo Leanza, Mortelle, 98164 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15029","DOI":"10.1038\/nrdp.2015.29","article-title":"Acne vulgaris","volume":"1","author":"Makrantonaki","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jaad.2007.06.045","article-title":"The prevalence of acne in adults 20 years and older","volume":"58","author":"Collier","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bjd.13462","article-title":"A global perspective on the epidemiology of acne","volume":"172","author":"Tan","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/bjd.17981","article-title":"Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis","volume":"181","author":"Clayton","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kelh\u00e4l\u00e4, H.L., Palatsi, R., Fyhrquist, N., Lehtim\u00e4ki, S., V\u00e4yrynen, J.P., Kallioinen, M., Kubin, M.E., Greco, D., Tasanen, K., and Alenius, H. (2014). IL-17\/Th17 pathway is activated in acne lesions. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105238"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Scala, E., Cacciapuoti, S., Garzorz-Stark, N., Megna, M., Marasca, C., Seiringer, P., Volz, T., Eyerich, K., and Fabbrocini, G. (2021). Hidradenitis Suppurativa: Where We Are and Where We Are Going. Cells, 10.","DOI":"10.3390\/cells10082094"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jdv.16677","article-title":"Hidradenitis suppurativa: An update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life","volume":"35","author":"Nguyen","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/bjd.19556","article-title":"Aetiology and pathogenesis of hidradenitis suppurativa","volume":"183","author":"Wolk","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00011-017-1074-y","article-title":"The critical role of macrophages in the pathogenesis of hidradenitis suppurativa","volume":"11","author":"Shah","year":"2017","journal-title":"Inflamm. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/15476286.2019.1593094","article-title":"Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics","volume":"16","author":"Fan","year":"2019","journal-title":"RNA Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/ng1744","article-title":"Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs","volume":"38","author":"Yi","year":"2006","journal-title":"Nat. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jdermsci.2008.10.004","article-title":"MicroRNAs and the skin: Tiny players in the body\u2019s largest organ","volume":"53","author":"Sand","year":"2009","journal-title":"J. Dermatol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2500\/aap.2017.38.4013","article-title":"Involvement of microRNAs in skin disorders: A literature review","volume":"38","author":"Mannucci","year":"2017","journal-title":"Allergy Asthma Proc."},{"key":"ref_15","first-page":"s7","article-title":"Advances in the Understanding of the Pathogenesis of Inflammatory Acne","volume":"15","author":"Kircik","year":"2016","journal-title":"J. Drugs Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s10753-016-0492-2","article-title":"Expression of miRNA-155, miRNA-223, miRNA-31, miRNA-21, miRNA-125b, and miRNA-146a in the Inflammatory Pathway of Hidradenitis Suppurativa","volume":"40","author":"Hessam","year":"2016","journal-title":"Inflammation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.jid.2019.03.1161","article-title":"miR-146a Inhibits Biofilm-Derived Cutibacterium acnes\u2013Induced Inflammatory Reactions in Human Keratinocytes","volume":"139","author":"Zeng","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"21510","DOI":"10.1038\/s41598-021-00907-1","article-title":"miR-146a modulates TLR1\/2 and 4 induced inflammation and links it with proliferation and lipid production via the indirect regulation of GNG7 in human SZ95 sebocytes","volume":"11","author":"Dull","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/exd.12604","article-title":"Laser capture microdissection followed by next-generation sequencing identifies disease-related microRNAs in psoriatic skin that reflect systemic microRNA changes in psoriasis","volume":"24","author":"Mitsui","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jid.2015.12.024","article-title":"Staphylococcal LTA-Induced miR-143 Inhibits Propionibacterium acnes-Mediated Inflammatory Response in Skin","volume":"136","author":"Xia","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s10529-017-2369-3","article-title":"MiR-338-3p inhibits TNF-\u03b1-induced lipogenesis in human sebocytes","volume":"39","author":"Liu","year":"2017","journal-title":"Biotechnol. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1111\/jdv.14948","article-title":"Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics","volume":"32","author":"Liang","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/bjd.17256","article-title":"Downregulation of miR-14-5p contributes to hyperproliferation of keratinocytes and skin inflammation in psoriasis","volume":"180","author":"Yan","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1007\/s10753-020-01268-z","article-title":"Knockdown of H19 Inhibits the Pathogenesis of Acne Vulgaris by Targeting the miR-196a\/TLR2\/NF-kB Axis","volume":"43","author":"Yang","year":"2020","journal-title":"Inflammation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1073\/pnas.1019536108","article-title":"MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis","volume":"108","author":"Alivernini","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.jid.2017.05.033","article-title":"Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy","volume":"137","author":"Moran","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4103\/ijd.IJD_483_16","article-title":"Propionibacterium acnes and the Th1\/Th17 Axis, implications in acne pathogenesis and treatment","volume":"62","author":"Verma","year":"2017","journal-title":"Indian J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/ced.14792","article-title":"MicroRNAs as biomarkers of atrophic scarring in acne: A cross-sectional analysis of 41 patients","volume":"46","author":"Ghumra","year":"2021","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_31","first-page":"225re1","article-title":"Targeting miR-21 to Treat Psoriasis","volume":"6","author":"Schonthaler","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1172\/JCI74347","article-title":"MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis","volume":"125","author":"Murugaiyan","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41467-017-00972-z","article-title":"An NF-kB-microRNA regulatory network tunes macrophage inflammatory responses","volume":"8","author":"Mann","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"542","DOI":"10.23736\/S0392-0488.20.06629-8","article-title":"PAPA spectrum disorders","volume":"155","author":"Genovese","year":"2020","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/ced.13657","article-title":"Genetic association between the NLRP3 gene and acne vulgaris in a Chinese population","volume":"44","author":"Shen","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"22183","DOI":"10.1002\/jcp.28786","article-title":"MiR-21 upregulation increases IL-8 expression and tumorigenesis program in airway epithelial cells exposed to cigarette smoke","volume":"234","author":"Pace","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.2174\/1381612820666141226095701","article-title":"Microrna-21: A Central Regulator of Fibrotic Diseases Via Various Targets","volume":"21","author":"He","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"160125","DOI":"10.1183\/16000617.0125-2016","article-title":"A systematic review of overlapping microRNA patterns in systemic sclerosis and idiopathic pulmonary fibrosis","volume":"26","author":"Bagnato","year":"2017","journal-title":"Eur. Respir. Rev."},{"key":"ref_39","first-page":"367","article-title":"Understanding psoriasis: Role of miRNAs (Review)","volume":"9","author":"Timis","year":"2018","journal-title":"Biomed. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1165\/rcmb.2019-0172ED","article-title":"Idiopathic Pulmonary Fibrosis and Lung Cancer: Finding Similarities within Differences","volume":"61","author":"Reyfman","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cytogfr.2013.08.002","article-title":"ALK1-Smad1\/5 signaling pathway in fibrosis development: Friend or foe?","volume":"24","year":"2013","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000484604","article-title":"Ablation of FGFR2 in Fibroblasts Ameliorates Kidney Fibrosis after Ischemia\/Reperfusion Injury in Mice","volume":"3","author":"Xu","year":"2017","journal-title":"Kidney Dis."},{"key":"ref_43","first-page":"276","article-title":"FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis","volume":"10","author":"Dabral","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"22047","DOI":"10.18632\/oncotarget.25173","article-title":"MiR-33 promotes myocardial fibrosis by inhibiting MMP16 and stimulating p38 MAPK signaling","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/bjd.12381","article-title":"Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor-\u03b1 therapy","volume":"169","author":"Pivarcsi","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jdermsci.2016.02.009","article-title":"Inflammation induced changes in the expression levels of components of the microRNA maturation machinery Drosha, Dicer, Drosha co-factor DGRC8 and Exportin-5 in inflammatory lesions of hidradenitis suppurativa patients","volume":"82","author":"Hessam","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00403-017-1752-1","article-title":"The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: A significant dysregulation within active inflammatory lesions","volume":"309","author":"Hessam","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejca.2010.08.007","article-title":"Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer","volume":"47","author":"Dedes","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/bjd.18460","article-title":"AKT-dependent hyperproliferation of keratinocytes in familial hidradenitis suppurativa with a NCSTN mutation: A potential role of defective miR-100-5p","volume":"182","author":"He","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Teng, Y., Fan, Y., Ma, J., Lu, W., Liu, N., Chen, Y., Pan, W., and Tao, X. (2021). The PI3K\/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. Cells, 10.","DOI":"10.3390\/cells10051219"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/6\/3241\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:38:27Z","timestamp":1760135907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/6\/3241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["ijms23063241"],"URL":"https:\/\/doi.org\/10.3390\/ijms23063241","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,17]]}}}