{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:47:49Z","timestamp":1787028469736,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005375","name":"Latvian Council of Science","doi-asserted-by":"publisher","award":["lzp-2018\/1-0156"],"award-info":[{"award-number":["lzp-2018\/1-0156"]}],"id":[{"id":"10.13039\/501100005375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chemokines and their receptors regulate the migration of immune cells and the dissemination of cancer cells. CCR1, CCR2, CCR3, and CCR5 all belong to a single protein homology cluster and respond to the same inflammatory chemokines. We previously reported that CCR1 and CCR2B are induced upon Epstein-Barr virus (EBV) infection of B cells in vitro. EBV is present in almost all cases of endemic Burkitt lymphoma (BL); however, the contribution of EBV in the pathogenesis of the disease is not fully understood. Here, we analyzed the relation of the expression of CCR1, CCR2, CCR3, and CCR5, the EBV DNA load and expression of EBV latent genes in nine EBV-carrying and four EBV-negative BL cell lines. We revealed that CCR1 is expressed at high mRNA and protein levels in two CD10-negative BL cell lines with co-expression of the EBV latent genes EBNA2, LMP1, and LMP2. Low levels of CCR2 transcripts were found in three BL cell lines. CCR3 and CCR5 transcripts were hardly detectable. Our data suggest that in vivo, CCR1 may be involved in the dissemination of BL cells and in the selection of BL cells with restricted EBV gene expression programs.<\/jats:p>","DOI":"10.3390\/ijms23073434","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T14:55:35Z","timestamp":1647960935000},"page":"3434","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2"],"prefix":"10.3390","volume":"23","author":[{"given":"Laura","family":"Zvejniece","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Virology, Riga Stradins University, 5 Ratsupites Street, 1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Kozireva","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Virology, Riga Stradins University, 5 Ratsupites Street, 1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanna","family":"Rudevica","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, 1 Ratsupites Street k-1, 1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainars","family":"Leonciks","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, 1 Ratsupites Street k-1, 1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbro","family":"Ehlin-Henriksson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institute, SE-171 65 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-4035","authenticated-orcid":false,"given":"Elena","family":"Kashuba","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institute, SE-171 65 Stockholm, Sweden"},{"name":"Laboratory of Molecular Mechanisms of Cell Transformation, RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, 45 Vasylkivska Street, UA-03022 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-4499","authenticated-orcid":false,"given":"Irina","family":"Kholodnyuk","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Virology, Riga Stradins University, 5 Ratsupites Street, 1067 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-pathol-012513-104640","article-title":"Leukocyte chemoattractant receptors in human disease pathogenesis","volume":"10","author":"Zabel","year":"2015","journal-title":"Annu. 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