{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:50:31Z","timestamp":1789156231948,"version":"build-2803163510"},"reference-count":212,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, University and Research (MIUR), Italy","award":["PhD program in \u201cFood Health and Longevity\u201d"],"award-info":[{"award-number":["PhD program in \u201cFood Health and Longevity\u201d"]}]},{"name":"University of Piemonte Orientale","award":["FAR-2017"],"award-info":[{"award-number":["FAR-2017"]}]},{"name":"Cassa di Risparmio di Torino","award":["Research Grant for post-Doc"],"award-info":[{"award-number":["Research Grant for post-Doc"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory disorder with multifactorial aetiology and malignant transformation potential. Despite the treatments so far identified, new tailored and safe specific measures are needed. Recently, human microbiota imbalance has been linked to several immune-mediated diseases, opening new therapeutic perspectives for probiotics; besides their ability to directly interact with the host microbiota, they also display a strain-specific immune-modulatory effect. Thus, this non-systematic review aims to elucidate the molecular pathways underlying probiotic activity, mainly those of Lactobacilli and Bifidobacteria and their metabolites in OLP pathogenesis and malignant transformation, focusing on the most recent in vitro and in vivo research evidence. Findings related to their activity in other immune-mediated diseases are here included, suggesting a probiotic translational use in OLP. Probiotics show immune-modulatory and microbiota-balancing activities; they protect the host from pathogens, hamper an excessive effector T cell response, reduce nuclear factor-kappa B (NF-kB) signalling and basal keratinocytes abnormal apoptosis, shifting the mucosal response towards the production of anti-inflammatory cytokines, thus preventing uncontrolled damage. Therefore, probiotics could be a highly encouraging prevention and immunotherapeutic approach for a safer and more sustainable OLP management.<\/jats:p>","DOI":"10.3390\/ijms23073489","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T12:20:25Z","timestamp":1648038025000},"page":"3489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Probiotics as Potential Biological Immunomodulators in the Management of Oral Lichen Planus: What\u2019s New?"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8547-3090","authenticated-orcid":false,"given":"Paola","family":"Zanetta","sequence":"first","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Universit\u00e0 del Piemonte Orientale (UPO), Corso Trieste 15\/A, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4396","authenticated-orcid":false,"given":"Margherita","family":"Ormelli","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Universit\u00e0 del Piemonte Orientale (UPO), Corso Trieste 15\/A, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Amoruso","sequence":"additional","affiliation":[{"name":"Probiotical Research Srl, Via Mattei 3, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-6919","authenticated-orcid":false,"given":"Marco","family":"Pane","sequence":"additional","affiliation":[{"name":"Probiotical Research Srl, Via Mattei 3, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-6595","authenticated-orcid":false,"given":"Barbara","family":"Azzimonti","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Universit\u00e0 del Piemonte Orientale (UPO), Corso Trieste 15\/A, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8090-7718","authenticated-orcid":false,"given":"Diletta Francesca","family":"Squarzanti","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Universit\u00e0 del Piemonte Orientale (UPO), Corso Trieste 15\/A, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/clinchem\/43.7.1209","article-title":"Plasma malondialdehyde as biomarker for oxidative stress: Reference interval and effects of life-style factors","volume":"43","author":"Nielsen","year":"1997","journal-title":"Clin. Chem."},{"key":"ref_2","first-page":"e685","article-title":"Clinical features of oral lichen planus. A retrospective study of 65 cases","volume":"15","author":"Figueiredo","year":"2010","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.tripleo.2011.04.009","article-title":"Oral lichen planus and malignant transformation: A longitudinal cohort study","volume":"112","author":"Bombeccari","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/odi.13323","article-title":"Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Daume, L., Kreis, C., Bohner, L., Kleinheinz, J., and Jung, S. (2020). Does the Clinical Form of Oral Lichen Planus (OLP) Influence the Oral Health\u2013Related Quality of Life (OHRQoL)?. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17186633"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.oooo.2016.05.004","article-title":"Diagnosis of oral lichen planus: A position paper of the American Academy of Oral and Maxillofacial Pathology","volume":"122","author":"Cheng","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41579-020-0367-2","article-title":"Host\u2013microbiota interactions in immune-mediated diseases","volume":"18","author":"Ruff","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","article-title":"Association between periodontal pathogens and systemic disease","volume":"42","author":"Bui","year":"2019","journal-title":"Biomed. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000510979","article-title":"Oral Microbiota and Cancer Development","volume":"88","author":"Tuominen","year":"2021","journal-title":"Pathobiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10123-021-00168-y","article-title":"Oral lichen planus: A microbiologist point of view","volume":"24","author":"Villa","year":"2021","journal-title":"Int. Microbiol."},{"key":"ref_11","first-page":"32","article-title":"Sur un cas de lichen de Wilson gingival avec neoplastic voisine dans la region maxillaire","volume":"17","author":"Hallopeau","year":"1910","journal-title":"Bull. Soc. Fr. Dermatol. Syphiligr."},{"key":"ref_12","unstructured":"Barnes, L., Eveson, J., Reichart, P., and Sidransky, D. (2005). Pathology and Genetics of Head and Neck Tumours, International Agency for Research on Cancer (IARC), IARC Press. [3rd ed.]."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.mehy.2010.07.002","article-title":"Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer","volume":"75","author":"Liu","year":"2010","journal-title":"Med. Hypotheses"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/jop.12996","article-title":"Oral lichen planus has a very low malignant transformation rate: A systematic review and meta-analysis using strict diagnostic and inclusion criteria","volume":"50","author":"Idrees","year":"2021","journal-title":"J. Oral Pathol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1111\/odi.13812","article-title":"Oral cancer development in lichen planus and related conditions-3.0 evidence level: A systematic review of systematic reviews","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/154411130201300405","article-title":"The pathogenesis of oral lichen planus","volume":"13","author":"Sugerman","year":"2002","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.archoralbio.2017.04.026","article-title":"Probiotics: A non-conventional therapy for oral lichen planus","volume":"81","author":"Han","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1600-0714.2010.00946.x","article-title":"Pathogenesis of oral lichen planus-a review","volume":"39","author":"Roopashree","year":"2010","journal-title":"J. Oral Pathol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3855\/jidc.8062","article-title":"Candida albicans induces TLR2\/MyD88\/NF-\u03baB signaling and inflammation in oral lichen planus-derived keratinocytes","volume":"12","author":"Liu","year":"2018","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tripleo.2004.06.077","article-title":"Current controversies in oral lichen planus: Report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis","volume":"100","author":"Lodi","year":"2005","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jop.12142","article-title":"Inflammation-related cytokines in oral lichen planus: An overview","volume":"44","author":"Lu","year":"2015","journal-title":"J. Oral Pathol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1007\/s12602-020-09664-5","article-title":"Alteration of Streptococcus salivarius in Buccal Mucosa of Oral Lichen Planus and Controlled Clinical Trial in OLP Treatment","volume":"12","author":"Li","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000346750","article-title":"Topical Retinoids in Oral Lichen Planus Treatment: An Overview","volume":"226","author":"Petruzzi","year":"2013","journal-title":"Dermatology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.sdentj.2012.05.002","article-title":"Treatment of symptomatic oral lichen planus (OLP) with 0.1% tacrolimus powder in Oraguard-B\u2013A pilot prospective study","volume":"24","author":"Malik","year":"2012","journal-title":"Saudi Dent. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1080\/10408398.2011.619671","article-title":"Immune System Stimulation by Probiotic Microorganisms","volume":"54","author":"Ashraf","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1600240","DOI":"10.1002\/mnfr.201600240","article-title":"Probiotics, gut microbiota, and their influence on host health and disease","volume":"61","author":"Delgado","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8008","DOI":"10.1002\/jcp.27559","article-title":"Probiotics importance and their immunomodulatory properties","volume":"234","author":"Yousefi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Jung, J.-I., Baek, S.-M., Nguyen, T.H., Kim, J.W., Kang, C.-H., Kim, S., and Imm, J.-Y. (2021). Effects of Probiotic Culture Supernatant on Cariogenic Biofilm Formation and RANKL-Induced Osteoclastogenesis in RAW 264.7 Macrophages. Molecules, 26.","DOI":"10.3390\/molecules26030733"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Chowdhury, A.H., C\u00e1mara, M., Verma, C., Eremin, O., Kulkarni, A.D., and Lobo, D.N. (2019). Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC\u00ae and Azithromycin in Healthy Individuals. Nutrients, 11.","DOI":"10.3390\/nu11102470"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yu, R., Zuo, F., Ma, H., and Chen, S. (2019). Exopolysaccharide-Producing Bifidobacterium adolescentis Strains with Similar Adhesion Property Induce Differential Regulation of Inflammatory Immune Response in Treg\/Th17 Axis of DSS-Colitis Mice. Nutrients, 11.","DOI":"10.3390\/nu11040782"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"680073","DOI":"10.3389\/fimmu.2021.680073","article-title":"Lactobacillus casei CCFM1074 Alleviates Collagen-Induced Arthritis in Rats via Balancing Treg\/Th17 and Modulating the Metabolites and Gut Microbiota","volume":"12","author":"Fan","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/jop.13087","article-title":"Altered expression of CCN1 in oral lichen planus associated with keratinocyte activation and IL-1\u03b2, ICAM1, and CCL5 up-regulation","volume":"49","author":"Wang","year":"2020","journal-title":"J. Oral Pathol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.7754\/Clin.Lab.2012.121029","article-title":"IL-1 Alpha Regulates CXCL1, CXCL10 and ICAM1 in Network Form in Oral Keratinocytes","volume":"59","author":"Wu","year":"2013","journal-title":"Clin. Lab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00403-018-1829-5","article-title":"Expression of IL33 and IL35 in oral lichen planus","volume":"310","author":"Javvadi","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clim.2004.12.003","article-title":"A comparison of the pro-inflammatory, NF-\u03baB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients","volume":"114","author":"Rhodus","year":"2005","journal-title":"Clin. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Abboud, C.S., da Brand\u00e3o, E.H.S., Cunha, K.R.L., Sousa Brito, K., de Gallo, C.B., Molon, A.C., Horliana, A.C.R.T., Franco, A.S.L., Thongprasom, K., and Rodrigues, M.F.S.D. (2021). Serum and salivary cytokines in patients with oral lichen planus treated with Photobiomodulation. Oral Dis.","DOI":"10.1111\/odi.14084"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chiamulera, M.M.A., Zancan, C.B., Remor, A.P., Cordeiro, M.F., Gleber-Netto, F.O., and Baptistella, A.R. (2021). Salivary cytokines as biomarkers of oral cancer: A systematic review and meta-analysis. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-07932-3"},{"key":"ref_38","first-page":"e659","article-title":"Salivary inflammatory proteins in patients with oral potentially malignant disorders","volume":"11","author":"Dikova","year":"2019","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mehrbani, S., Motahari, P., Azar, F., and Ahari, M. (2020). Role of interleukin-4 in pathogenesis of oral lichen planus: A systematic review. Med. Oral Patol. Oral Cir. Bucal, e410\u2013e415.","DOI":"10.4317\/medoral.23460"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.oooo.2019.04.003","article-title":"Serum and salivary interleukin-4 levels in patients with oral lichen planus: A systematic review and meta-analysis","volume":"128","author":"Mozaffari","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1590\/1807-3107bor-2018.vol32.0082","article-title":"Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: A systematic review","volume":"32","author":"Humberto","year":"2018","journal-title":"Braz. Oral Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.archoralbio.2018.11.015","article-title":"IL-25 promotes Th2-type reactions and correlates with disease severity in the pathogenesis of oral lichen planus","volume":"98","author":"Wang","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/odi.12090","article-title":"Interactions between Golli-MBP and Th1\/Th2 cytokines in patients with oral lichen planus","volume":"20","author":"Ding","year":"2014","journal-title":"Oral Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ijos.2013.74","article-title":"Interferon-\u03b3 and interleukin-4 detected in serum and saliva from patients with oral lichen planus","volume":"6","author":"Liu","year":"2014","journal-title":"Int. J. Oral Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.oooo.2018.11.006","article-title":"Evaluation of serum and salivary interferon-\u03b3 levels in patients with oral lichen planus: A systematic review and meta-analysis of case-control studies","volume":"127","author":"Mozaffari","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e704","DOI":"10.1097\/MD.0000000000000704","article-title":"Cytokine Profiles Contribute to Understanding the Pathogenic Difference Between Good Syndrome and Oral Lichen Planus","volume":"94","author":"Maehara","year":"2015","journal-title":"Medicine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.oooo.2018.02.013","article-title":"Mixed and inhomogeneous expression profile of Th1\/Th2 related cytokines detected by cytometric bead array in the saliva of patients with oral lichen planus","volume":"126","author":"Wei","year":"2018","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/jop.12595","article-title":"The cellular character of liquefaction degeneration in oral lichen planus and the role of interferon gamma","volume":"46","author":"Liu","year":"2017","journal-title":"J. Oral Pathol. Med."},{"key":"ref_49","first-page":"554","article-title":"Salivary Interferon Gamma and Interleukin-4 Levels in Patients Suffering from Oral Lichen Planus","volume":"17","author":"Malekzadeh","year":"2015","journal-title":"Cell J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s10753-009-9118-2","article-title":"IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population","volume":"32","author":"Liu","year":"2009","journal-title":"Inflammation"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mozaffari, H.R., Molavi, M., Lopez-Jornet, P., Sadeghi, M., Safaei, M., Imani, M.M., Sharifi, R., Moradpoor, H., Golshah, A., and Jamshidy, L. (2019). Salivary and Serum Interferon-Gamma\/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis. Medicina, 55.","DOI":"10.3390\/medicina55060257"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Babiuch, K., Ku\u015bnierz-Cabala, B., K\u0119sek, B., Oko\u0144, K., Darczuk, D., and Chomyszyn-Gajewska, M. (2020). Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1\u03b1, IL-6, IL-8, and TNF-\u03b1 in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030867"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cyto.2007.11.004","article-title":"NF-\u03baB-dependent cytokines in saliva and serum from patients with oral lichen planus: A study in an ethnic Chinese population","volume":"41","author":"Zhang","year":"2008","journal-title":"Cytokine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/mc.20113","article-title":"The feasibility of monitoring NF-\u03baB associated cytokines: TNF-\u03b1, IL-1\u03b1, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus","volume":"44","author":"Rhodus","year":"2005","journal-title":"Mol. Carcinog."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5125\/jkaoms.2015.41.4.171","article-title":"Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis","volume":"41","author":"Kaur","year":"2015","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/jop.12199","article-title":"Interleukin-6 and neopterin levels in the serum and saliva of patients with Lichen Planus and oral Lichen Planus","volume":"43","author":"Darczuk","year":"2014","journal-title":"J. Oral Pathol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.adaj.2017.05.007","article-title":"The relationship between levels of salivary and serum interleukin-6 and oral lichen planus: A systematic review and meta-analysis","volume":"148","author":"Liu","year":"2017","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5114\/ceji.2018.74880","article-title":"Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: A meta-analysis study","volume":"43","author":"Mozaffari","year":"2018","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3892\/etm.2021.9722","article-title":"Interleukin-6 released by oral lichen planus myofibroblasts promotes angiogenesis","volume":"21","author":"Xu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3892\/br.2017.887","article-title":"Identifying the association between interleukin-6 and lichen planus: A meta-analysis","volume":"6","author":"Yin","year":"2017","journal-title":"Biomed. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10787-017-0352-1","article-title":"Predictive value of salivary microRNA-320a, vascular endothelial growth factor receptor 2, CRP and IL-6 in Oral lichen planus progression","volume":"25","author":"Shahidi","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1016\/j.oooo.2017.06.117","article-title":"Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: A systematic review and meta-analysis study","volume":"124","author":"Mozaffari","year":"2017","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/283465","article-title":"Quantitative Analysis of Salivary TNF- \u03b1 in Oral Lichen Planus Patients","volume":"2015","author":"Malarkodi","year":"2015","journal-title":"Int. J. Dent."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1365-2133.2005.06497.x","article-title":"Serum interleukin-8 level is a more sensitive marker than serum interleukin-6 level in monitoring the disease activity of oral lichen planus","volume":"152","author":"Sun","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3892\/etm.2021.10419","article-title":"High serum level of interleukin-6 is linked with dyslipidemia in oral lichen planus","volume":"22","author":"Toader","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/jop.12938","article-title":"Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus","volume":"49","author":"Wei","year":"2020","journal-title":"J. Oral Pathol. Med."},{"key":"ref_67","first-page":"4648","article-title":"TRIM21 causes abnormal expression of IL-6 in oral lichen planus via the TRIB2-MAPK signal axis","volume":"12","author":"Jiang","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4103\/1735-3327.192277","article-title":"Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study","volume":"13","author":"Tavangar","year":"2016","journal-title":"Dent. Res. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/1735-3327.208771","article-title":"Salivary levels of interleukin-8 in oral lichen planus and diabetic patients: A biochemical study","volume":"14","author":"Tavangar","year":"2017","journal-title":"Dent. Res. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.cyto.2012.08.007","article-title":"Cytokine profiles in serum of patients with oral lichen planus","volume":"60","author":"Pekiner","year":"2012","journal-title":"Cytokine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.biopha.2018.05.076","article-title":"Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124\/STAT3 pathway in oral lichen planus","volume":"105","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"151901","DOI":"10.1016\/j.imbio.2019.151901","article-title":"Neutrophil extracellular traps (NETs) formation induced by TGF-\u03b2 in oral lichen planus\u2013Possible implications for the development of oral cancer","volume":"225","author":"Jablonska","year":"2020","journal-title":"Immunobiology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"701094","DOI":"10.1155\/2014\/701094","article-title":"Overexpression and Selectively Regulatory Roles of IL-23\/IL-17 Axis in the Lesions of Oral Lichen Planus","volume":"2014","author":"Lu","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00403-013-1429-3","article-title":"Expression of Foxp3 and interleukin-17 in lichen planus lesions with emphasis on difference in oral and cutaneous variants","volume":"306","author":"Shen","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.oooo.2016.07.005","article-title":"Altered expression of interleukin-17A and its targeting microRNAs in oral lichen planus: A pilot study","volume":"122","author":"Shen","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"100983","DOI":"10.1016\/j.isci.2020.100983","article-title":"Renin Promotes STAT4 Phosphorylation to Induce IL-17 Production in Keratinocytes of Oral Lichen Planus","volume":"23","author":"Ge","year":"2020","journal-title":"iScience"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.pathol.2016.06.002","article-title":"Regulatory T-cells and IL17A(+) cells infiltrate oral lichen planus lesions","volume":"48","author":"Javvadi","year":"2016","journal-title":"Pathology"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Yang, J., Tan, Y., and Zhou, G. (2021). T cell-derived exosomes containing cytokines induced keratinocytes apoptosis in oral lichen planus. Oral Dis.","DOI":"10.1111\/odi.13795"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"16935","DOI":"10.1038\/srep16935","article-title":"MicroRNA-155-IFN-\u03b3 Feedback Loop in CD4+T Cells of Erosive type Oral Lichen Planus","volume":"5","author":"Hu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-0714.2007.00593.x","article-title":"Simultaneous detection of IFN-gamma and IL-4 in lesional tissues and whole unstimulated saliva from patients with oral lichen planus","volume":"37","author":"Tao","year":"2008","journal-title":"J. Oral Pathol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jds.2021.01.005","article-title":"FoxP3+CD4+, IFN-\u03b3+CD4+, and IFN-\u03b3+CD8+ cell levels in erosive and non-erosive types of oral lichen planus patients","volume":"16","author":"Sun","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tripleo.2004.05.006","article-title":"Oral and serum IL-6 levels in oral lichen planus patients","volume":"98","author":"Gu","year":"2004","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/PAI.0000000000000096","article-title":"Immunoexpression of Th17-related Cytokines in Oral Lichen Planus","volume":"23","author":"Nonaka","year":"2015","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_84","first-page":"91","article-title":"Serum Level of Interleukin 17 in Patients with Erosive and Non erosive Oral Lichen Planus","volume":"7","author":"Pouralibaba","year":"2013","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospects"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1601-0825.2005.01165.x","article-title":"Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone","volume":"12","author":"Rhodus","year":"2006","journal-title":"Oral Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"847632","DOI":"10.1155\/2010\/847632","article-title":"Levels of Salivary IFN-gamma, TNF-Alfa, and TNF Receptor-2 As Prognostic Markers in (Erosive) Oral Lichen Planus","volume":"2010","author":"Ghallab","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12964-019-0331-9","article-title":"Vitamin D\/VDR signaling inhibits LPS-induced IFN\u03b3 and IL-1\u03b2 in Oral epithelia by regulating hypoxia-inducible factor-1\u03b1 signaling pathway","volume":"17","author":"Ge","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s10753-020-01185-1","article-title":"Study on the Role of Salivary Flora and NF-\u03baB Inflammatory Signal Pathway in Oral Lichen Planus","volume":"43","author":"Deng","year":"2020","journal-title":"Inflammation"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"18137","DOI":"10.1038\/s41598-019-54615-y","article-title":"Cytokines Levels and Salivary Microbiome Play A Potential Role in Oral Lichen Planus Diagnosis","volume":"9","author":"Cavalieri","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/1348-0421.12232","article-title":"Analysis of oral microbial community and Th17-associated cytokines in saliva of patients with oral lichen planus","volume":"59","author":"Wang","year":"2015","journal-title":"Microbiol. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wang, L., Yang, Y., Xiong, X., Yu, T., Wang, X., Meng, W., Wang, H., Luo, G., and Ge, L. (2018). Oral lichen-planus-associated fibroblasts acquire myofibroblast characteristics and secrete pro-inflammatory cytokines in response to Porphyromonas gingivalis lipopolysaccharide stimulation. BMC Oral Health, 18.","DOI":"10.1186\/s12903-018-0656-6"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/1040841X.2021.1872487","article-title":"Oral microbiota and vitamin D impact on oropharyngeal squamous cell carcinogenesis: A narrative literature review","volume":"47","author":"Zanetta","year":"2021","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s10753-013-9594-2","article-title":"Interaction Between Oral Lichen Planus and Chronic Periodontitis with Th17-Associated Cytokines in Serum","volume":"36","author":"Wang","year":"2013","journal-title":"Inflammation"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s00784-013-1131-z","article-title":"Oral lichen planus may enhance the expression of Th17-associated cytokines in local lesions of chronic periodontitis","volume":"18","author":"Wang","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/hed.20869","article-title":"MMPs, TIMP-2, and TGF-\u03b21 in the cancerization of oral lichen planus","volume":"30","author":"Chen","year":"2008","journal-title":"Head Neck"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1007\/s00784-018-2704-7","article-title":"Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus","volume":"23","author":"Romano","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.archoralbio.2013.01.015","article-title":"MMP-1, MMP-9, and TIMP-1 levels in oral lichen planus patients with gingivitis or periodontitis","volume":"58","author":"Ertugrul","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"ref_98","first-page":"23","article-title":"Expression of Matrix Metalloproteinase 9 in Patients with Oral Lichen Planus","volume":"55","author":"Laco","year":"2012","journal-title":"Acta Medica"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4103\/0973-029X.190951","article-title":"Expression of matrix metalloproteinase-9 in oral potentially malignant disorders: A systematic review","volume":"20","author":"Venugopal","year":"2016","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/jop.12690","article-title":"The association and potentially destructive role of Th9\/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus","volume":"47","author":"Wang","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jobcr.2020.10.009","article-title":"Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study","volume":"10","author":"Hazzaa","year":"2020","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4103\/jomfp.JOMFP_27_19","article-title":"Immunohistochemical and clinical significance of matrix metalloproteinase-2 and its inhibitor in oral lichen planus","volume":"23","author":"Agarwal","year":"2019","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.biopha.2016.02.043","article-title":"miR-125b inhibits keratinocyte proliferation and promotes keratinocyte apoptosis in oral lichen planus by targeting MMP-2 expression through PI3 K\/Akt\/mTOR pathway","volume":"80","author":"Wang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5005\/jp-journals-10024-1645","article-title":"Serum and Saliva MMP-3 in Patients with OLP and Oral SCC","volume":"16","author":"Mahboobi","year":"2015","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_105","first-page":"10","article-title":"Serum level of matrix metalloproteinase-3 in patients with oral lichen planus","volume":"14","author":"Farzin","year":"2012","journal-title":"Iran. Red Crescent Med. J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1468-3083.2006.01693.x","article-title":"Matrix metalloproteinase gene expression in oral lichen planus: Erosive vs. reticular forms","volume":"20","author":"Mazzarella","year":"2006","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S1995-7645(13)60110-8","article-title":"COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma","volume":"6","author":"Li","year":"2013","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3109\/10520295.2015.1016115","article-title":"Possible salivary and serum biomarkers for oral lichen planus","volume":"90","author":"Totan","year":"2015","journal-title":"Biotech. Histochem."},{"key":"ref_109","first-page":"218","article-title":"Serum and saliva collagenase-3 (MMP-13) in patients with oral lichen planus and oral squamous cell carcinoma","volume":"29","year":"2015","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12765","article-title":"Intestinal dysbiosis and probiotic applications in autoimmune diseases","volume":"152","author":"Leite","year":"2017","journal-title":"Immunology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"430","DOI":"10.5009\/gnl18316","article-title":"Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease","volume":"13","author":"Zhou","year":"2019","journal-title":"Gut Liver"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1073\/pnas.0904055107","article-title":"Generation of regulatory dendritic cells and CD4 + Foxp3 + T cells by probiotics administration suppresses immune disorders","volume":"107","author":"Kwon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3920\/BM2015.0119","article-title":"Immunological mechanisms involved in probiotic-mediated protection against Citrobacter rodentium-induced colitis","volume":"7","author":"Jiang","year":"2016","journal-title":"Benef. Microbes"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"9570","DOI":"10.3168\/jds.2019-16840","article-title":"Protective effect of Lactobacillus fermentum CQPC04 on dextran sulfate sodium\u2013induced colitis in mice is associated with modulation of the nuclear factor-\u03baB signaling pathway","volume":"102","author":"Zhou","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Tong, L., Zhang, X., Hao, H., Liu, Q., Zhou, Z., Liang, X., Liu, T., Gong, P., Zhang, L., and Zhai, Z. (2021). Lactobacillus rhamnosus GG Derived Extracellular Vesicles Modulate Gut Microbiota and Attenuate Inflammatory in DSS-Induced Colitis Mice. Nutrients, 13.","DOI":"10.3390\/nu13103319"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Wang, G., Huang, S., Cai, S., Yu, H., Wang, Y., Zeng, X., and Qiao, S. (2020). Lactobacillus reuteri Ameliorates Intestinal Inflammation and Modulates Gut Microbiota and Metabolic Disorders in Dextran Sulfate Sodium-Induced Colitis in Mice. Nutrients, 12.","DOI":"10.3390\/nu12082298"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.3748\/wjg.v16.i33.4145","article-title":"Effect of probiotics on pro-inflammatory cytokines and NF-\u03baB activation in ulcerative colitis","volume":"16","author":"Hegazy","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.3748\/wjg.v26.i43.6782","article-title":"Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane\/dextran sodium sulfate model","volume":"26","author":"Silveira","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3748\/wjg.v24.i18.1995","article-title":"Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice","volume":"24","author":"Mendes","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12934-020-01466-2","article-title":"Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2\/9 signaling pathway","volume":"19","author":"Yue","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1080\/01635581.2012.700758","article-title":"Cell-Free Supernatants from Probiotic Lactobacillus casei and Lactobacillus rhamnosus GG Decrease Colon Cancer Cell Invasion In Vitro","volume":"64","author":"Escamilla","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_122","first-page":"6028606","article-title":"Lactobacillus delbrueckii Ameliorates Intestinal Integrity and Antioxidant Ability in Weaned Piglets after a Lipopolysaccharide Challenge","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Jang, A.-Y., Rod-in, W., Monmai, C., Sohn, M., Kim, T.-R., Jeon, M.-G., and Park, W.J. (2021). Anti-inflammatory potential of Lactobacillus reuteri LM1071 via eicosanoid regulation in LPS-stimulated RAW 264.7 cells. J. Appl. Microbiol.","DOI":"10.1111\/jam.15331"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Li, S.-C., Hsu, W.-F., Chang, J.-S., and Shih, C.-K. (2019). Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Shows a Stronger Anti-Inflammatory Effect than Individual Strains in HT-29 Cells. Nutrients, 11.","DOI":"10.3390\/nu11050969"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10068-021-01009-4","article-title":"Effects of Lactobacillus curvatus MG5246 on inflammatory markers in Porphyromonas gingivalis lipopolysaccharide-sensitized human gingival fibroblasts and periodontitis rat model","volume":"31","author":"Jung","year":"2022","journal-title":"Food Sci. Biotechnol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s13577-017-0172-z","article-title":"Lactobacillus paracasei strain 06TCa19 suppresses inflammatory chemokine induced by Helicobacter pylori in human gastric epithelial cells","volume":"30","author":"Takeda","year":"2017","journal-title":"Hum. Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.3168\/jds.2017-13654","article-title":"Screening probiotics from Lactobacillus strains according to their abilities to inhibit pathogen adhesion and induction of pro-inflammatory cytokine IL-8","volume":"101","author":"Tuo","year":"2018","journal-title":"J. Dairy Sci."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Chen, S., Li, Y., Chu, B., Yuan, L., Liu, N., Zhu, Y., and Wang, J. (2021). Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella typhimurium via Inhibiting TLR4, NF-\u03baB, and NLRP3 Inflammasome Signaling Pathways. Microorganisms, 9.","DOI":"10.3390\/microorganisms9091983"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1128\/AEM.03668-13","article-title":"Dose-Dependent Effects of Lactobacillus rhamnosus on Serum Interleukin-17 Production and Intestinal T-Cell Responses in Pigs Challenged with Escherichia coli","volume":"80","author":"Zhu","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1007\/s10620-012-2503-y","article-title":"Probiotic Lactobacillus rhamnosus GG Modulates the Mucosal Immune Response in Giardia intestinalis-Infected BALB\/c Mice","volume":"58","author":"Goyal","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"ref_131","first-page":"559","article-title":"Dual Effects of Cell Free Supernatants from Lactobacillus acidophilus and Lactobacillus rhamnosus GG in Regulation of MMP-9 by Up-Regulating TIMP-1 and Down-Regulating CD147 in PMADifferentiated THP-1 Cells","volume":"19","author":"Maghsood","year":"2018","journal-title":"Cell J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3920\/BM2016.0156","article-title":"Lactobacillus fermentum IM12 attenuates inflammation in mice by inhibiting NF-\u03baB-STAT3 signalling pathway","volume":"8","author":"Lim","year":"2017","journal-title":"Benef. Microbes"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/19490976.2019.1589281","article-title":"Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota","volume":"10","author":"Jang","year":"2019","journal-title":"Gut Microbes"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Pahumunto, N., Basic, A., \u00d6stberg, A.-K., Teanpaisan, R., and Dahlen, G. (2020). Oral Lactobacillus strains reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to Aggregatibacter actinomycetemcomitans subtypes in vitro. BMC Microbiol., 20.","DOI":"10.1186\/s12866-020-01959-5"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Griet, M., Zelaya, H., Mateos, M.V., Salva, S., Juarez, G.E., de Valdez, G.F., Villena, J., Salvador, G.A., and Rodriguez, A.V. (2014). Soluble Factors from Lactobacillus reuteri CRL1098 Have Anti-Inflammatory Effects in Acute Lung Injury Induced by Lipopolysaccharide in Mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110027"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.imlet.2020.10.008","article-title":"Combinatmarion treatment with Lactobacillus acidophilus LA-1, vitamin B, and curcumin ameliorates the progression of osteoarthritis by inhibiting the pro-inflammatory mediators","volume":"228","author":"Jhun","year":"2020","journal-title":"Immunol. Lett."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.lfs.2010.12.013","article-title":"Lactobacillus casei enhances type II collagen\/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis","volume":"88","author":"So","year":"2011","journal-title":"Life Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"104931","DOI":"10.1016\/j.micpath.2021.104931","article-title":"Analysis of inflammasomes and CYP27B1 genes in cuprizone demyelinated C57BL\/6 mice and evaluation of Th1 and Th2 patterns after oral administration of Lactobacillus casei strain T2 (IBRC-M10783)","volume":"155","author":"Digehsara","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1902\/jop.2015.140612","article-title":"Clinical and Biochemical Evaluation of Lozenges Containing Lactobacillus reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Chronic Periodontitis","volume":"86","author":"Cakar","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Marlina, E., Goodman, R.N., Mercadante, V., Shephard, M., McMillan, R., Hodgson, T., Leeson, R., Porter, S., Barber, J.A., and Fedele, S. (2021). A proof of concept pilot trial of probiotics in symptomatic oral lichen planus (CABRIO). Oral Dis.","DOI":"10.1111\/odi.14014"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cytogfr.2020.10.004","article-title":"An evaluation of the effects of probiotics on tumoral necrosis factor (TNF-\u03b1) signaling and gene expression","volume":"57","author":"Vincenzi","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jaut.2008.04.012","article-title":"Immune deficiency or hyperactivity-Nf-\u03bab illuminates autoimmunity","volume":"31","author":"Pai","year":"2008","journal-title":"J. Autoimmun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Lin, Z., Ku, S., Lim, T., Park, S.Y., Park, M.S., Ji, G.E., O\u2019Brien, K., and Hwang, K.T. (2021). Antioxidant and Anti-Inflammatory Properties of Recombinant Bifidobacterium bifidum BGN4 Expressing Antioxidant Enzymes. Microorganisms, 9.","DOI":"10.3390\/microorganisms9030595"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.3748\/wjg.v12.i23.3729","article-title":"Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-\u03baB activation","volume":"12","author":"Riedel","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2613.2008.00632.x","article-title":"Anti-inflammatory effects of the genus Bifidobacterium on macrophages by modification of phospho-I\u03baB and SOCS gene expression","volume":"90","author":"Okada","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.3168\/jds.2018-16197","article-title":"Lactobacillus plantarum CAU1055 ameliorates inflammation in lipopolysaccharide-induced RAW 264.7 cells and a dextran sulfate sodium\u2013induced colitis animal model","volume":"102","author":"Choi","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"18597","DOI":"10.1038\/s41598-020-75702-5","article-title":"Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice","volume":"10","author":"Singh","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1128\/AEM.03127-09","article-title":"Selection of Bifidobacteria Based on Adhesion and Anti-Inflammatory Capacity In Vitro for Amelioration of Murine Colitis","volume":"76","author":"Preising","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1007\/s10620-019-05628-0","article-title":"Lactobacillus rhamnosus GG Ameliorates Liver Injury and Hypoxic Hepatitis in Rat Model of CLP-Induced Sepsis","volume":"64","author":"Ding","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.3389\/fimmu.2020.551449","article-title":"Inhibitory Effects of the Lactobacillus rhamnosus GG Effector Protein HM0539 on Inflammatory Response Through the TLR4\/MyD88\/NF-\u03baB Axis","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_152","first-page":"4607491","article-title":"Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages","volume":"2017","author":"Eslava","year":"2017","journal-title":"J. Immunol. Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Noda, M., Sultana, N., Hayashi, I., Fukamachi, M., and Sugiyama, M. (2019). Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis. Molecules, 24.","DOI":"10.3390\/molecules24162970"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Noda, M., Danshiitsoodol, N., Kanno, K., Uchida, T., and Sugiyama, M. (2021). The Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS\u2013Induced Ulcerative Colitis. Microorganisms, 9.","DOI":"10.3390\/microorganisms9112243"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Fontana, L., Plaza-D\u00edaz, J., Robles-Bol\u00edvar, P., Valente-God\u00ednez, H., S\u00e1ez-Lara, M.J., Abad\u00eda-Molina, F., G\u00f3mez-Llorented, C., Gil, \u00c1., and \u00c1lvarez-Mercado, A.I. (2021). Bifidobacterium breve CNCM I-4035, Lactobacillus paracasei CNCM I-4034 and Lactobacillus rhamnosus CNCM I-4036 Modulate Macrophage Gene Expression and Ameliorate Damage Markers in the Liver of Zucker-Lepr fa\/fa Rats. Nutrients, 13.","DOI":"10.3390\/nu13010202"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbrc.2006.02.080","article-title":"Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-\u03baB-mediated IL-8 gene expression","volume":"343","author":"Sougioultzis","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_157","first-page":"1657","article-title":"Expressions of NF--kappaBp65, TRAF2, cyclinD1 and their association with cell apoptosis in oral lichen planus","volume":"27","author":"Yao","year":"2007","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_158","first-page":"11","article-title":"Expression of caspase-8, receptor interacting protein and nuclear factor-kappaBp65 in oral lichen planus","volume":"45","author":"Shi","year":"2010","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1600-0714.2009.00779.x","article-title":"Activation of nuclear factor-kappa B correlates with tumor necrosis factor-alpha in oral lichen planus: A clinicopathologic study in atrophic-erosive and reticular form","volume":"38","author":"Zhou","year":"2009","journal-title":"J. Oral Pathol. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/path.1423","article-title":"NF-kappaB expression in oral and cutaneous lichen planus","volume":"201","author":"Santoro","year":"2003","journal-title":"J. Pathol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s10753-015-0145-x","article-title":"The Activation of NF-\u03baB in Infiltrated Mononuclear Cells Negatively Correlates with Treg Cell Frequency in Oral Lichen Planus","volume":"38","author":"Zhang","year":"2015","journal-title":"Inflammation"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/jop.12168","article-title":"Low expression of glucocorticoid receptor \u03b1 in oral lichen planus correlates with activation of nuclear factor \u03baB: A preliminary study","volume":"43","author":"Lin","year":"2014","journal-title":"J. Oral Pathol. Med."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Rusanen, P., Marttila, E., Uittamo, J., Hagstr\u00f6m, J., Salo, T., and Rautemaa-Richardson, R. (2017). TLR1-10, NF-\u03baB and p53 expression is increased in oral lichenoid disease. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181361"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/cei.13091","article-title":"New evidence of connections between increased O-GlcNAcylation and inflammasome in the oral mucosa of patients with oral lichen planus","volume":"192","author":"Phoomak","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/eji.201545523","article-title":"Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells","volume":"45","author":"Gaidt","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: A review of the major forms of apoptosis, necrosis and autophagy","volume":"43","year":"2019","journal-title":"Cell Biol. Int."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1745-7270.2005.00108.x","article-title":"Caspase Family Proteases and Apoptosis","volume":"37","author":"Fan","year":"2005","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.tripleo.2010.05.070","article-title":"Caspase cascade pathways in apoptosis of oral lichen planus","volume":"110","author":"Mattila","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_169","first-page":"357","article-title":"Importance of apoptotic mechanisms in inflammatory infiltrate of oral lichen planus lesions","volume":"26","year":"2006","journal-title":"Anticancer Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10753-012-9561-3","article-title":"Proliferation and Apoptosis of Peripheral Blood Mononuclear Cells in Patients with Oral Lichen Planus","volume":"36","author":"Shan","year":"2013","journal-title":"Inflammation"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2230.2008.03029.x","article-title":"Increased caspase-3 and altered expression of apoptosis-associated proteins, Bcl-2 and Bax in lichen planus","volume":"34","year":"2009","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_172","first-page":"465","article-title":"The expression and changes of apoptosis protein Bcl-2 and Bax in oral lichen planus","volume":"24","author":"Li","year":"2015","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"ref_173","first-page":"204","article-title":"No differences in caspase-3 and Bax expression in atrophic-erosive vs. reticular oral lichen planus","volume":"22","year":"2007","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_174","first-page":"136","article-title":"Assessment of bax and bcl-2 immunoexpression in patients with oral lichen planus and oral squamous cell carcinoma","volume":"2","author":"Nafarzadeh","year":"2013","journal-title":"Int. J. Mol. Cell. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/PAI.0000000000000945","article-title":"Immunohistochemical Characterization of Bcl-2 in Oral Potentially Malignant Disorders","volume":"29","author":"Ortega","year":"2021","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/ijd.12279","article-title":"Immunohistochemical expression of Bcl-2 and Ki-67 in oral lichen planus and leukoplakia with different degrees of dysplasia","volume":"54","author":"Pigatti","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"105244","DOI":"10.1016\/j.archoralbio.2021.105244","article-title":"Inflammatory and immune-related factor Caspase 1 contributes to the development of oral lichen planus","volume":"131","author":"Zeng","year":"2021","journal-title":"Arch. Oral Biol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0714.2004.00221.x","article-title":"Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas\/Apo-1 and Bcl-2 in oral lichen planus","volume":"33","author":"Chrysomali","year":"2004","journal-title":"J. Oral Pathol. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1034\/j.1600-0722.2001.00081.x","article-title":"Apoptosis in oral lichen planus","volume":"109","author":"Neppelberg","year":"2001","journal-title":"Eur. J. Oral Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0103-64402008000300001","article-title":"Role of apoptosis in erosive and reticular oral lichen planus exhibiting variable epithelial thickness","volume":"19","author":"Brant","year":"2008","journal-title":"Braz. Dent. J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2174\/1574892814666191022163540","article-title":"MDM2-p53 Interaction Inhibitors: The Current State-of-Art and Updated Patent Review (2010-Present)","volume":"14","author":"Rusiecki","year":"2019","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"ref_182","first-page":"1015","article-title":"Implications on pathogenesis and risk of oral lichen planus neoplastic transformation: An ex-vivo retrospective immunohistochemical study","volume":"34","author":"Squarzanti","year":"2019","journal-title":"Histol. Histopathol."},{"key":"ref_183","first-page":"1278","article-title":"Expression and role of p53 in oral lichen planus patients","volume":"22","author":"Petrovic","year":"2017","journal-title":"J. BUON"},{"key":"ref_184","first-page":"118","article-title":"Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus","volume":"19","author":"Shiva","year":"2018","journal-title":"J. Dent."},{"key":"ref_185","first-page":"235","article-title":"Estimation of malignant transformation rate in cases of oral epithelial dysplasia and lichen planus using immunohistochemical expression of Ki-67, p53, BCL-2, and BAX markers","volume":"12","author":"Shailaja","year":"2015","journal-title":"Dent. Res. J."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Sugimura, N., Li, Q., Chu, E.S.H., Lau, H.C.H., Fong, W., Liu, W., Liang, C., Nakatsu, G., Su, A.C.Y., and Coker, O.O. (2021). Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis. Gut.","DOI":"10.1136\/gutjnl-2020-323951"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"126921","DOI":"10.1016\/j.micres.2021.126921","article-title":"Extracellular vesicles of Lacticaseibacillus paracasei PC-H1 induce colorectal cancer cells apoptosis via PDK1\/AKT\/Bcl-2 signaling pathway","volume":"255","author":"Shi","year":"2021","journal-title":"Microbiol. Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/1751-2980.12930","article-title":"Saccharomyces cerevisiae may serve as a probiotic in colorectal cancer by promoting cancer cell apoptosis","volume":"21","author":"Li","year":"2020","journal-title":"J. Dig. Dis."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1111\/jam.15060","article-title":"In vitro evaluation of anticancer effects of different probiotic strains on HCT-116 cell line","volume":"131","author":"Yenuganti","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/fsn3.2032","article-title":"Probiotic Saccharomyces cerevisiae var. boulardii supernatant inhibits survivin gene expression and induces apoptosis in human gastric cancer cells","volume":"9","author":"Pakbin","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Pakbin, B., Dibazar, S.P., Allahyari, S., Javadi, M., Amani, Z., Farasat, A., and Darzi, S. (2022). Anticancer Properties of Probiotic Saccharomyces boulardii Supernatant on Human Breast Cancer Cells. Probiotics Antimicrob. Proteins, 1\u20139.","DOI":"10.1007\/s12602-022-10030-w"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1177\/0960327119851255","article-title":"Heat-killed probiotic bacteria induce apoptosis of HT-29 human colon adenocarcinoma cell line via the regulation of Bax\/Bcl2 and caspases pathway","volume":"38","author":"Tafvizi","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Yuan, L., Chu, B., Chen, S., Li, Y., Liu, N., Zhu, Y., and Zhou, D. (2021). Exopolysaccharides from Bifidobacterium animalis Ameliorate Escherichia coli-Induced IPEC-J2 Cell Damage via Inhibiting Apoptosis and Restoring Autophagy. Microorganisms, 9.","DOI":"10.3390\/microorganisms9112363"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10123-018-00051-3","article-title":"Probiotic mixture of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 attenuates hippocampal apoptosis induced by lipopolysaccharide in rats","volume":"22","author":"Mohammadi","year":"2019","journal-title":"Int. Microbiol."},{"key":"ref_195","first-page":"370","article-title":"Oral lichen planus: A narrative review","volume":"6","author":"Guida","year":"2014","journal-title":"Front. Biosci. (Elite Ed.)"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Zhong, E.F., Chang, A., Stucky, A., Chen, X., Mundluru, T., Khalifeh, M., and Sedghizadeh, P.P. (2020). Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens. Pathogens, 9.","DOI":"10.1101\/2020.02.12.946863"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/imm.13397","article-title":"Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment","volume":"164","author":"Yang","year":"2021","journal-title":"Immunology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"9778","DOI":"10.1002\/jcp.27663","article-title":"Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model","volume":"234","author":"Khorasani","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"155581","DOI":"10.1016\/j.cyto.2021.155581","article-title":"Lactobacillus johnsonii activates porcine monocyte derived dendritic cells maturation to modulate Th cellular immune response","volume":"144","author":"Zheng","year":"2021","journal-title":"Cytokine"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Bernardo, D., S\u00e1nchez, B., Al-Hassi, H.O., Mann, E.R., Urdaci, M.C., Knight, S.C., and Margolles, A. (2012). Microbiota\/host crosstalk biomarkers: Regulatory response of human intestinal dendritic cells exposed to Lactobacillus extracellular encrypted peptide. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036262"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/mnfr.201300596","article-title":"Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp","volume":"58","author":"Mann","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/s41598-020-58177-2","article-title":"GABA potentiate the immunoregulatory effects of Lactobacillus brevis BGZLS10-17 via ATG5-dependent autophagy in vitro","volume":"10","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/08916934.2020.1777282","article-title":"Feeding lactobacilli impacts lupus progression in (NZBxNZW)F1 lupus-prone mice by enhancing immunoregulation","volume":"53","author":"Manirarora","year":"2020","journal-title":"Autoimmunity"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.3389\/fmicb.2017.02430","article-title":"Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment","volume":"8","author":"Ekmekciu","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1038\/s41598-020-62161-1","article-title":"Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses","volume":"10","author":"Alard","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s41385-021-00413-7","article-title":"Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis","volume":"14","author":"Lin","year":"2021","journal-title":"Mucosal Immunol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"e1213","DOI":"10.1002\/cti2.1213","article-title":"Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17\/Treg balance in colitis via TLR4 and TLR2","volume":"9","author":"Jia","year":"2020","journal-title":"Clin. Transl. Immunol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"618150","DOI":"10.3389\/fimmu.2021.618150","article-title":"A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma","volume":"12","author":"Xia","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"623451","DOI":"10.3389\/fimmu.2021.623451","article-title":"Lactobacillus acidipiscis Induced Regulatory Gamma Delta T Cells and Attenuated Experimental Autoimmune Encephalomyelitis","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"7569431","DOI":"10.1155\/2016\/7569431","article-title":"Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment","volume":"2016","author":"Dolpady","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.imlet.2019.10.009","article-title":"Heat-killed probiotic regulates the body\u2019s regulatory immunity to attenuate subsequent experimental autoimmune arthritis","volume":"216","author":"Jia","year":"2019","journal-title":"Immunol. Lett."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Chae, C.-S., Kwon, H.-K., Hwang, J.-S., Kim, J.-E., and Im, S.-H. (2012). Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis. 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