{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:11:08Z","timestamp":1790053868664,"version":"4.0.1"},"reference-count":112,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the grants from key scientific and technological projects in Henan Province, China","award":["202102310153"],"award-info":[{"award-number":["202102310153"]}]},{"name":"the grants from Construction of first-class medical disciplines in Medical College of Henan University from 2020 to 2021 for Hongggang Wang","award":["1"],"award-info":[{"award-number":["1"]}]},{"name":"the innovation and Entrepreneurship Training Program for Henan University Students in 2021","award":["20211021002 and 20217003002"],"award-info":[{"award-number":["20211021002 and 20217003002"]}]},{"name":"the Henan Provincial Social Science Planning Decision Consulting Project","award":["2018JC38"],"award-info":[{"award-number":["2018JC38"]}]},{"name":"the Graduate Education Reform and Quality Improvement Project of Henan Province","award":["YJS2021AL074"],"award-info":[{"award-number":["YJS2021AL074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The endoplasmic reticulum (ER) is a key organelle responsible for the synthesis, modification, folding and assembly of proteins; calcium storage; and lipid synthesis. When ER homeostatic balance is disrupted by a variety of physiological and pathological factors\u2014such as glucose deficiency, environmental toxins, Ca2+ level changes, etc.\u2014ER stress can be induced. Abnormal ER stress can be involved in many diseases. NOD-like receptor family pyrin domain-containing 3 (NLRP3), an intracellular receptor, can perceive internal and external stimuli. It binds to apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 to assemble into a protein complex called the NLRP3 inflammasome. Evidence indicates that ER stress and the NLRP3 inflammasome participate in many pathological processes; however, the exact mechanism remains to be understood. In this review, we summarized the role of ER stress and the NLRP3 inflammasome in liver disorders and analyzed the mechanisms, to provide references for future related research.<\/jats:p>","DOI":"10.3390\/ijms23073528","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:31:21Z","timestamp":1648222281000},"page":"3528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders"],"prefix":"10.3390","volume":"23","author":[{"given":"Xueqin","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Nursing and Health, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-4959","authenticated-orcid":false,"given":"Haitao","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Nursing and Health, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Nursing and Health, School of Nursing and Health, Henan University, Jinming Avenue, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-3563","authenticated-orcid":false,"given":"Honggang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-8437","authenticated-orcid":false,"given":"Dongdong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Henan University, Kaifeng 475004, China"},{"name":"Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. 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