{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:17:48Z","timestamp":1790511468602,"version":"4.1.0"},"reference-count":77,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epigenetic modifications rarely occur in isolation (as single \u201cepigenetic modifications\u201d). They usually appear together and form a network to control the epigenetic system. Cutaneous malignancies are usually affected by epigenetic changes. However, there is limited knowledge regarding the epigenetic changes associated with cutaneous lymphomas. In this review, we focused on cutaneous T-cell lymphomas such as mycosis fungoides, S\u00e9zary syndrome, and anaplastic large cell lymphoma. With regard to epigenetic changes, we summarize the detailed chemical modifications categorized into DNA methylation and histone acetylation and methylation. We also summarize the epigenetic modifications and characteristics of the drug for cutaneous T-cell lymphoma (CTCL). Furthermore, we discuss current research on epigenetic-targeted therapy against cutaneous T-cell lymphomas. Although the current method of treatment with histone deacetylase inhibitors does not exhibit sufficient therapeutic benefits in all cases of CTCL, epigenetic-targeted combination therapy might overcome this limitation for patients with CTCL.<\/jats:p>","DOI":"10.3390\/ijms23073538","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:31:21Z","timestamp":1648222281000},"page":"3538","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Epigenetics of Cutaneous T-Cell Lymphomas"],"prefix":"10.3390","volume":"23","author":[{"given":"Natsumi","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Occupational and Environmental Health,  Kitakyushu 807-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Occupational and Environmental Health,  Kitakyushu 807-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.jid.2020.10.012","article-title":"Role of Epigenetics in the Regulation of Immune Functions of the Skin","volume":"141","author":"Sawada","year":"2021","journal-title":"J. Investig. Derm."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"eabe1935","DOI":"10.1126\/sciimmunol.abe1935","article-title":"Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8\/9","volume":"6","author":"Sawada","year":"2021","journal-title":"Sci. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(18)31268-6","article-title":"Principles of DNA methylation and their implications for biology and medicine","volume":"392","author":"Dor","year":"2018","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/1439-7633(20020402)3:4<274::AID-CBIC274>3.0.CO;2-S","article-title":"Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases","volume":"3","author":"Jeltsch","year":"2002","journal-title":"ChemBioChem Eur. J. Chem. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/351239a0","article-title":"Demethylation of CpG islands in embryonic cells","volume":"351","author":"Frank","year":"1991","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3390\/ijms23031119","article-title":"Epigenetic Modification of PD-1\/PD-L1-Mediated Cancer Immunotherapy against Melanoma","volume":"23","author":"Nanamori","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0955-0674(00)00208-8","article-title":"Histone methylation versus histone acetylation: New insights into epigenetic regulation","volume":"13","author":"Rice","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s41588-020-00736-4","article-title":"Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation","volume":"52","author":"Morgan","year":"2020","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/genes9120633","article-title":"Enhancing the Anticancer Efficacy of Immunotherapy through Combination with Histone Modification Inhibitors","volume":"9","author":"Sun","year":"2018","journal-title":"Genes"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrg3173","article-title":"Histone methylation: A dynamic mark in health, disease and inheritance","volume":"13","author":"Greer","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0092-8674(93)90051-Q","article-title":"A positive role for histone acetylation in transcription factor access to nucleosomal DNA","volume":"72","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrn3427","article-title":"Histone acetylation: Molecular mnemonics on the chromatin","volume":"14","author":"Tsai","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cbpa.2019.01.024","article-title":"The roles of microRNAs in epigenetic regulation","volume":"51","author":"Yao","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/1523-1747.ep12521312","article-title":"Mycosis fungoides: Clinical course and cellular abnormalities","volume":"75","author":"Epstein","year":"1980","journal-title":"J. Investig. Derm."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0140-6736(08)60420-1","article-title":"Mycosis fungoides and S\u00e9zary syndrome","volume":"371","author":"Hwang","year":"2008","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2340\/00015555-0831","article-title":"CD8+ CD56+ mycosis fungoides with an indolent clinical behaviour: Case report and literature review","volume":"90","author":"Sawada","year":"2010","journal-title":"Acta Derm.-Venereol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1200\/JCO.2009.27.7665","article-title":"Survival outcomes and prognostic factors in mycosis fungoides\/S\u00e9zary syndrome: Validation of the revised International Society for Cutaneous Lymphomas\/European Organisation for Research and Treatment of Cancer staging proposal","volume":"28","author":"Agar","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"223.e1","DOI":"10.1016\/j.jaad.2013.08.033","article-title":"Primary cutaneous T-cell lymphoma (mycosis fungoides and S\u00e9zary syndrome): Part II. Prognosis, management, and future directions","volume":"70","author":"Jawed","year":"2014","journal-title":"J. Am. Acad. Derm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s40257-018-0380-7","article-title":"Current Status of HDAC Inhibitors in Cutaneous T-cell Lymphoma","volume":"19","author":"Lopez","year":"2018","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_23","first-page":"133","article-title":"Autologous bone marrow transplantation for advanced stage mycosis fungoides","volume":"7","author":"Bigler","year":"1991","journal-title":"Bone Marrow Transpl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1182\/blood-2011-05-351346","article-title":"EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: Lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma","volume":"118","author":"Kempf","year":"2011","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1001\/archdermatol.2009.280","article-title":"Applicability and prognostic value of the new TNM classification system in 135 patients with primary cutaneous anaplastic large cell lymphoma","volume":"145","author":"Benner","year":"2009","journal-title":"Arch. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1200\/JCO.1998.16.3.1197","article-title":"Role of the p16 tumor suppressor gene in cancer","volume":"16","author":"Liggett","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1200\/JCO.2005.11.353","article-title":"Epigenetic profiling of cutaneous T-cell lymphoma: Promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73","volume":"23","author":"Zoutman","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/labinvest.3780405","article-title":"p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides","volume":"82","author":"Navas","year":"2002","journal-title":"Lab. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0002-9440(10)65028-6","article-title":"p16(INK4a) gene alterations are frequent in lesions of mycosis fungoides","volume":"156","author":"Navas","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_30","first-page":"1211","article-title":"CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2\u2032deoxycytidine","volume":"11","author":"Otterson","year":"1995","journal-title":"Oncogene"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.biochi.2012.05.029","article-title":"Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2\u2032-deoxycytidine in anaplastic large cell lymphoma","volume":"94","author":"Hassler","year":"2012","journal-title":"Biochimie"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33835","DOI":"10.1074\/jbc.274.48.33835","article-title":"ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells","volume":"274","author":"Masumoto","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fcell.2020.00040","article-title":"Dual Role of Inflammasome Adaptor ASC in Cancer","volume":"8","author":"Protti","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/34184","article-title":"PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines","volume":"391","author":"Jiang","year":"1998","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/2030","article-title":"Differentiation and reversal of malignant changes in colon cancer through PPARgamma","volume":"4","author":"Sarraf","year":"1998","journal-title":"Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/bjd.12717","article-title":"A specific DNA methylation profile correlates with a high risk of disease progression in stage I classical (Alibert-Bazin type) mycosis fungoides","volume":"170","author":"Ferrara","year":"2014","journal-title":"Br. J. Derm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/jid.2014.364","article-title":"c-CBL E3 ubiquitin ligase is overexpressed in cutaneous T-cell lymphoma: Its inhibition promotes activation-induced cell death","volume":"135","author":"Wu","year":"2015","journal-title":"J. Investig. Derm."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/jid.2009.301","article-title":"Downregulation of Fas gene expression in S\u00e9zary syndrome is associated with promoter hypermethylation","volume":"130","author":"Jones","year":"2010","journal-title":"J. Investig. Derm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13277-015-4450-7","article-title":"The role of TWIST1 in epithelial-mesenchymal transition and cancers","volume":"37","author":"Zhu","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2004.07.011","article-title":"Epithelial-mesenchymal transitions: Twist in development and metastasis","volume":"118","author":"Kang","year":"2004","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1038\/jid.2015.116","article-title":"Promoter-Specific Hypomethylation Is Associated with Overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome","volume":"135","author":"Wong","year":"2015","journal-title":"J. Investig. Derm."},{"key":"ref_43","first-page":"e95","article-title":"Twist and Zeb1 expression identify mycosis fungoides patients with low risk of disease progression","volume":"34","author":"Uotila","year":"2020","journal-title":"J. Eur. Acad. Derm. Venereol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1593\/neo.121784","article-title":"Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2\/SIN3a deacetylating complex","volume":"15","author":"Piazza","year":"2013","journal-title":"Neoplasia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jid.2017.10.036","article-title":"Dual Role of EZH2 in Cutaneous Anaplastic Large Cell Lymphoma: Promoting Tumor Cell Survival and Regulating Tumor Microenvironment","volume":"138","author":"Yi","year":"2018","journal-title":"J. Investig. Derm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1158\/0008-5472.CAN-16-3144","article-title":"PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma","volume":"77","author":"Tsubota","year":"2017","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1158\/1535-7163.MCT-15-0750","article-title":"BRD4 Regulates EZH2 Transcription through Upregulation of C-MYC and Represents a Novel Therapeutic Target in Bladder Cancer","volume":"15","author":"Wu","year":"2016","journal-title":"Mol. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1182\/blood-2014-08-594507","article-title":"Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma","volume":"125","author":"Weilemann","year":"2015","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/PAS.0b013e3182a0218f","article-title":"GATA3: A multispecific but potentially useful marker in surgical pathology: A systematic analysis of 2500 epithelial and nonepithelial tumors","volume":"38","author":"Miettinen","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"65284","DOI":"10.18632\/oncotarget.11673","article-title":"GATA3 expression correlates with poor prognosis and tumor-associated macrophage infiltration in peripheral T cell lymphoma","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3324\/haematol.2011.054619","article-title":"Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype","volume":"98","author":"Joosten","year":"2013","journal-title":"Haematologica"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1158\/1078-0432.CCR-14-3322","article-title":"The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL)","volume":"21","author":"Litvinov","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_53","first-page":"1389","article-title":"Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment","volume":"7","author":"Santiago","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/jid.2014.487","article-title":"MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma","volume":"135","author":"Sandoval","year":"2015","journal-title":"J. Investig. Derm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1038\/jid.2015.328","article-title":"Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides","volume":"135","author":"Gallardo","year":"2015","journal-title":"J. Investig. Derm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jaad.2015.09.070","article-title":"Familial skin cancer syndromes: Increased melanoma risk","volume":"74","author":"Ransohoff","year":"2016","journal-title":"J. Am. Acad. Derm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"367450","DOI":"10.1155\/2012\/367450","article-title":"Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer","volume":"2012","author":"Stravodimou","year":"2012","journal-title":"PPAR Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11010-007-9487-5","article-title":"Involvement of PPAR-gamma and p53 in DHA-induced apoptosis in Reh cells","volume":"304","author":"Zand","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s12094-020-02496-3","article-title":"TWIST1 upregulation affects E-cadherin expression in brain metastases","volume":"23","author":"Brlek","year":"2021","journal-title":"Clin. Transl. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"14042","DOI":"10.1074\/jbc.M110.105262","article-title":"GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition","volume":"285","author":"Yan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_61","first-page":"377","article-title":"Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat","volume":"1","author":"Duvic","year":"2007","journal-title":"Biologics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1182\/blood-2006-06-025999","article-title":"Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)","volume":"109","author":"Duvic","year":"2007","journal-title":"Blood"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1200\/JCO.2008.21.6150","article-title":"Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma","volume":"27","author":"Piekarz","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/bjh.13222","article-title":"A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma","volume":"168","author":"Foss","year":"2015","journal-title":"Br. J. Haematol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"775253","DOI":"10.3389\/fonc.2021.775253","article-title":"Targeting Epigenetic Modifiers Can Reduce the Clonogenic Capacities of S\u00e9zary Cells","volume":"11","author":"Chebly","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Chebly, A., Ropio, J., Peloponese, J.M., Poglio, S., Prochazkova-Carlotti, M., Cherrier, F., Ferrer, J., Idrissi, Y., Segal-Bendirdjian, E., and Chouery, E. (2021). Exploring hTERT promoter methylation in cutaneous T-cell lymphomas. Mol. Oncol.","DOI":"10.1002\/1878-0261.12946"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1182\/blood-2013-05-500686","article-title":"Telomerase functions beyond telomere maintenance in primary cutaneous T-cell lymphoma","volume":"123","author":"Chevret","year":"2014","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00403-017-1761-0","article-title":"Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of S\u00e9zary T lymphoma: A transcriptomic approach","volume":"309","author":"Ragheb","year":"2017","journal-title":"Arch. Derm. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/2040620715576662","article-title":"Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: Emerging preclinical and clinical evidence","volume":"6","author":"Chaidos","year":"2015","journal-title":"Ther. Adv. Hematol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neo.2018.11.006","article-title":"Preclinical Studies Support Combined Inhibition of BET Family Proteins and Histone Deacetylases as Epigenetic Therapy for Cutaneous T-Cell Lymphoma","volume":"21","author":"Zhao","year":"2019","journal-title":"Neoplasia"},{"key":"ref_71","first-page":"657579","article-title":"Response to hydralazine-valproate in a patient with mycosis fungoides","volume":"2010","author":"Vega","year":"2010","journal-title":"Case Rep. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1038\/ncomms3035","article-title":"A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth","volume":"4","author":"Wang","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1158\/2159-8290.CD-14-1326","article-title":"Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis","volume":"5","author":"Black","year":"2015","journal-title":"Cancer Discov."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1200\/JCO.2006.10.2434","article-title":"Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma","volume":"25","author":"Olsen","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1200\/JCO.2015.65.9789","article-title":"Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study","volume":"34","author":"Lesokhin","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1038\/s41467-020-17414-y","article-title":"Exhausted T cell signature predicts immunotherapy response in ER-positive breast cancer","volume":"11","author":"Pawlowska","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.cell.2017.10.022","article-title":"Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer","volume":"171","author":"Topper","year":"2017","journal-title":"Cell"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/7\/3538\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:42:26Z","timestamp":1760136146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/7\/3538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":77,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["ijms23073538"],"URL":"https:\/\/doi.org\/10.3390\/ijms23073538","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,24]]}}}