{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:46:52Z","timestamp":1790758012153,"version":"4.1.0"},"reference-count":136,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia e Innovaci\u00f3n and Fondo Europeo de Desarrollo Regional","award":["PID2020-116498RB-I00"],"award-info":[{"award-number":["PID2020-116498RB-I00"]}]},{"name":"Comunidad de Madrid (CM)","award":["AORTASANA B2017\/BMD-3676"],"award-info":[{"award-number":["AORTASANA B2017\/BMD-3676"]}]},{"name":"CM-Universidad Aut\u00f3noma de Madrid","award":["SI1-PJI-2019-00321"],"award-info":[{"award-number":["SI1-PJI-2019-00321"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vascular remodeling is a typical feature of vascular diseases, such as atherosclerosis, aneurysms or restenosis. Excessive inflammation is a key mechanism underlying vascular remodeling via the modulation of vascular fibrosis, phenotype and function. Recent evidence suggests that not only augmented inflammation but unresolved inflammation might also contribute to different aspects of vascular diseases. Resolution of inflammation is mediated by a family of specialized pro-resolving mediators (SPMs) that limit immune cell infiltration and initiate tissue repair mechanisms. SPMs (lipoxins, resolvins, protectins, maresins) are generated from essential polyunsaturated fatty acids. Synthases and receptors for SPMs were initially described in immune cells, but they are also present in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), where they regulate processes important for vascular physiology, such as EC activation and VSMC phenotype. Evidence from genetic models targeting SPM pathways and pharmacological supplementation with SPMs have demonstrated that these mediators may play a protective role against the development of vascular remodeling in atherosclerosis, aneurysms and restenosis. This review focuses on the latest advances in understanding the role of SPMs in vascular cells and their therapeutic effects in the vascular remodeling associated with different cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/ijms23073592","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:31:21Z","timestamp":1648222281000},"page":"3592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Specialized Pro-Resolving Lipid Mediators: New Therapeutic Approaches for Vascular Remodeling"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-3049","authenticated-orcid":false,"given":"Luc\u00eda Serrano","family":"D\u00edaz del Campo","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Instituto de Investigaci\u00f3n Hospital La Paz, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-1505","authenticated-orcid":false,"given":"Raquel","family":"Rodrigues-D\u00edez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Instituto de Investigaci\u00f3n Hospital La Paz, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-1692","authenticated-orcid":false,"given":"Mercedes","family":"Salaices","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Instituto de Investigaci\u00f3n Hospital La Paz, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Briones","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Instituto de Investigaci\u00f3n Hospital La Paz, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-3320","authenticated-orcid":false,"given":"Ana B.","family":"Garc\u00eda-Redondo","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Instituto de Investigaci\u00f3n Hospital La Paz, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"},{"name":"Departamento de Fisiolog\u00eda, Instituto de Investigaci\u00f3n Hospital La Paz, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.ATV.0000253884.13901.e4","article-title":"Implications of early structural-functional changes in the endothelium for vascular disease","volume":"27","author":"Simionescu","year":"2007","journal-title":"Arterioscler. 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