{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:15:08Z","timestamp":1789668908490,"version":"4.0.1"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Wound healing is a complex process that is mediated and influenced by several cytokines, chemokines, and growth factors. Interleukin-22 (IL-22) is a cytokine that plays a critical role in tissue regeneration. Our study is a systematic review that addressed the implications of IL-22 in the healing of wounds caused by external factors. Thirteen studies were included in our review, most of them being experimental studies. Three clinical studies underlined the potential role of IL-22 in day-to-day clinical practice. IL-22 plays a central role in wound healing, stimulating the proliferation, migration, and differentiation of the cells involved in tissue repair. However, overexpression of IL-22 can cause negative effects, such as keloid scars or peritoneal adhesions. The results of the presented studies are promising, but further research that validates the roles of IL-22 in clinical practice and analyzes its potential implication in surgical healing is welcomed.<\/jats:p>","DOI":"10.3390\/ijms23073693","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:44:52Z","timestamp":1648590292000},"page":"3693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Role of IL-22 in Wound Healing. Potential Implications in Clinical Practice"],"prefix":"10.3390","volume":"23","author":[{"given":"Roxana Delia","family":"Zaharie","sequence":"first","affiliation":[{"name":"Gastroenterology Department, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Street Emil Isac No. 13, 400023 Cluj-Napoca, Romania"},{"name":"Gastroenterology Department, Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. O. Fodor\u201d, Street Croitorilor No. 19\u201321, 400162 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103lin","family":"Popa","sequence":"additional","affiliation":[{"name":"Surgery Department, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Street Emil Isac No. 13, 400023 Cluj-Napoca, Romania"},{"name":"Surgery Department, Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. O. Fodor\u201d, Street Croitorilor No. 19\u201321, 400162 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-3822","authenticated-orcid":false,"given":"Diana","family":"Schlanger","sequence":"additional","affiliation":[{"name":"Surgery Department, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Street Emil Isac No. 13, 400023 Cluj-Napoca, Romania"},{"name":"Surgery Department, Regional Institute of Gastroenterology and Hepatology \u201cProf. Dr. O. 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