{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:44:15Z","timestamp":1791927855410,"version":"4.3.4"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2013\/19560-6; 2017\/23195-2; 2017\/18072-9; 2016\/26263-6"],"award-info":[{"award-number":["2013\/19560-6; 2017\/23195-2; 2017\/18072-9; 2016\/26263-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["2016-5\/423320"],"award-info":[{"award-number":["2016-5\/423320"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Foundation for the Study of Diabetes\/Sanofi","award":["2015"],"award-info":[{"award-number":["2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetes mellitus (DM) burden encompasses diabetic kidney disease (DKD), the leading cause of end-stage renal disease worldwide. Despite compelling evidence indicating that pharmacological intervention curtails DKD progression, the search for non-pharmacological strategies can identify novel targets for drug development against metabolic diseases. One of those emergent strategies comprises the modulation of the intestinal microbiota through fecal transplant from healthy donors. This study sought to investigate the benefits of fecal microbiota transplant (FMT) on functional and morphological parameters in a preclinical model of type 2 DM, obesity, and DKD using BTBRob\/ob mice. These animals develop hyperglycemia and albuminuria in a time-dependent manner, mimicking DKD in humans. Our main findings unveiled that FMT prevented body weight gain, reduced albuminuria and tumor necrosis factor-\u03b1 (TNF-\u03b1) levels within the ileum and ascending colon, and potentially ameliorated insulin resistance in BTBRob\/ob mice. Intestinal structural integrity was maintained. Notably, FMT was associated with the abundance of the succinate-consuming Odoribacteraceae bacteria family throughout the intestine. Collectively, our data pointed out the safety and efficacy of FMT in a preclinical model of type 2 DM, obesity, and DKD. These findings provide a basis for translational research on intestinal microbiota modulation and testing its therapeutic potential combined with current treatment for DM.<\/jats:p>","DOI":"10.3390\/ijms23073842","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:34:29Z","timestamp":1648762469000},"page":"3842","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Fecal Microbiota Transplant in a Pre-Clinical Model of Type 2 Diabetes Mellitus, Obesity and Diabetic Kidney Disease"],"prefix":"10.3390","volume":"23","author":[{"given":"Rosana M. C.","family":"Bastos","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo 05652-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio","family":"Simpl\u00edcio-Filho","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo 05652-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"S\u00e1vio-Silva","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo 05652-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4535-0621","authenticated-orcid":false,"given":"Luiz Felipe V.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"BiomeHub, Santa Catarina 88040-900, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano N. 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Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41581-018-0001-y","article-title":"CKD in diabetes: Diabetic kidney disease versus nondiabetic kidney disease","volume":"14","author":"Anders","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic Kidney Disease: Challenges, Progress, and Possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"Backhed","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature12198","article-title":"Gut metagenome in European women with normal, impaired and diabetic glucose control","volume":"498","author":"Karlsson","year":"2013","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4161\/gmic.19625","article-title":"Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity","volume":"3","author":"Cani","year":"2012","journal-title":"Gut Microbes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Larsen, N., Vogensen, F.K., van den Berg, F.W., Nielsen, D.S., Andreasen, A.S., Pedersen, B.K., Al-Soud, W.A., Sorensen, S.J., Hansen, L.H., and Jakobsen, M. (2010). Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009085"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1016\/j.clnu.2018.12.024","article-title":"Dietary fat, the gut microbiota, and metabolic health\u2014A systematic review conducted within the MyNewGut project","volume":"38","author":"Wolters","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2337\/db11-0227","article-title":"Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice","volume":"60","author":"Everard","year":"2011","journal-title":"Diabetes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.1038\/s41598-017-07335-0","article-title":"Anti-diabetic Effects of Clostridium butyricum CGMCC0313.1 through Promoting the Growth of Gut Butyrate-producing Bacteria in Type 2 Diabetic Mice","volume":"7","author":"Jia","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.clnu.2014.10.004","article-title":"A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity","volume":"34","author":"Beserra","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fcimb.2019.00455","article-title":"Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets","volume":"9","author":"Wang","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"590370","DOI":"10.3389\/fmicb.2020.590370","article-title":"Microbiota Transplant in the Treatment of Obesity and Diabetes: Current and Future Perspectives","volume":"11","author":"Napolitano","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1681\/ASN.2009121290","article-title":"BTBR Ob\/Ob mutant mice model progressive diabetic nephropathy","volume":"21","author":"Hudkins","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"G645","DOI":"10.1152\/ajpgi.00015.2016","article-title":"Glucosensing in the gastrointestinal tract: Impact on glucose metabolism","volume":"310","author":"Fournel","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/MED.0000000000000448","article-title":"Gastrointestinal hormones and regulation of gastric emptying","volume":"26","author":"Camilleri","year":"2019","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.rvsc.2014.01.007","article-title":"Characterization of the gut microbiota in leptin deficient obese mice\u2014Correlation to inflammatory and diabetic parameters","volume":"96","author":"Ellekilde","year":"2014","journal-title":"Res. Vet. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.1038\/srep05922","article-title":"Transfer of gut microbiota from lean and obese mice to antibiotic-treated mice","volume":"4","author":"Ellekilde","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.nbd.2014.10.015","article-title":"BTBR ob\/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses","volume":"73","author":"Hur","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"S\u00e1vio-Silva, C., Soinski-Sousa, P.E., Simpl\u00edcio-Filho, A., Bastos, R.M.C., Beyerstedt, S., and Rangel, \u00c9.B. (2021). Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041546"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mam.2011.10.012","article-title":"Leptin as an immunomodulator","volume":"33","author":"Procaccini","year":"2012","journal-title":"Mol. Aspects Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1394097","DOI":"10.1155\/2019\/1394097","article-title":"Gut Microbiota Composition and Structure of the Ob\/Ob and Db\/Db Mice","volume":"2019","author":"Yang","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2006.03.003","article-title":"Leptin and atherosclerosis","volume":"189","author":"Beltowski","year":"2006","journal-title":"Atherosclerosis"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-P\u00e9rez, A., S\u00e1nchez-Jim\u00e9nez, F., Vilari\u00f1o-Garc\u00eda, T., and S\u00e1nchez-Margalet, V. (2020). Role of Leptin in Inflammation and Vice Versa. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165887"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2337\/diabetes.52.2.252","article-title":"Role of leptin in the regulation of glucagon-like peptide-1 secretion","volume":"52","author":"Anini","year":"2003","journal-title":"Diabetes"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.18632\/aging.102469","article-title":"Abnormal gut microbiota composition contributes to the development of type 2 diabetes mellitus in db\/db mice","volume":"11","author":"Yu","year":"2019","journal-title":"Aging"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Koliada, A., Syzenko, G., Moseiko, V., Budovska, L., Puchkov, K., Perederiy, V., Gavalko, Y., Dorofeyev, A., Romanenko, M., and Tkach, S. (2017). Association between body mass index and Firmicutes\/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol., 17.","DOI":"10.1186\/s12866-017-1027-1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/s41396-018-0068-2","article-title":"Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota","volume":"12","author":"Serena","year":"2018","journal-title":"ISME J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Magne, F., Gotteland, M., Gauthier, L., Zazueta, A., Pesoa, S., Navarrete, P., and Balamurugan, R. (2020). The Firmicutes\/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?. Nutrients, 12.","DOI":"10.3390\/nu12051474"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/oby.2009.167","article-title":"Microbiota and SCFA in lean and overweight healthy subjects","volume":"18","author":"Schwiertz","year":"2010","journal-title":"Obesity"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s42523-019-0007-1","article-title":"Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob\/ob mice","volume":"1","author":"Kashani","year":"2019","journal-title":"Anim. Microbiome"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3389\/fimmu.2018.00832","article-title":"Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases","volume":"9","author":"Grazioli","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_40","first-page":"1209","article-title":"Circulating succinate is elevated in rodent models of hypertension and metabolic disease","volume":"20","author":"Sadagopan","year":"2007","journal-title":"Am. J. Hypertens."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11892-018-1104-3","article-title":"Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes","volume":"18","author":"Chen","year":"2018","journal-title":"Curr. Diabetes Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s42000-019-00093-w","article-title":"Metformin and gut microbiota: Their interactions and their impact on diabetes","volume":"18","author":"Vallianou","year":"2019","journal-title":"Hormones"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.2147\/DMSO.S286430","article-title":"Effects of Metformin on the Gut Microbiota in Obesity and Type 2 Diabetes Mellitus","volume":"13","author":"Zhang","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12933-018-0708-x","article-title":"SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice","volume":"17","author":"Lee","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.3748\/wjg.v26.i23.3225","article-title":"Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice","volume":"26","author":"Herat","year":"2020","journal-title":"World. J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"15582","DOI":"10.1038\/s41598-019-52103-x","article-title":"Metabolic and gut microbiome changes following GLP-1 or dual GLP-1\/GLP-2 receptor agonist treatment in diet-induced obese mice","volume":"9","author":"Madsen","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fendo.2018.00233","article-title":"A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota","volume":"9","author":"Zhao","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhao, C., Hu, Y., Chen, H., Li, B., Cao, L., Xia, J., and Yin, Y. (2020). An in vitro evaluation of the effects of different statins on the structure and function of human gut bacterial community. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230200"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3389\/fmicb.2019.01947","article-title":"Alterations in Gut Microbiota by Statin Therapy and Possible Intermediate Effects on Hyperglycemia and Hyperlipidemia","volume":"10","author":"Kim","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1100\/tsw.2007.117","article-title":"The physiology of obese-hyperglycemic mice [ob\/ob mice]","volume":"7","year":"2007","journal-title":"Sci. World J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1210\/en.2012-1496","article-title":"Hepatocyte Growth Factor Plays a Key Role in Insulin Resistance-Associated Compensatory Mechanisms","volume":"153","author":"Oliveira","year":"2012","journal-title":"Endocrinology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e2710","DOI":"10.1210\/clinem\/dgaa327","article-title":"GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists","volume":"105","author":"Holst","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.molmet.2017.01.006","article-title":"Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob\/ob mice","volume":"6","author":"Harada","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_54","first-page":"F580","article-title":"Direct hemodynamic effect of insulin in the isolated perfused kidney","volume":"257","author":"Cohen","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/ki.1992.400","article-title":"Glomerular hemodynamic alterations during acute hyperinsulinemia in normal and diabetic rats","volume":"42","author":"Tucker","year":"1992","journal-title":"Kidney Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19417","DOI":"10.1038\/s41598-020-76474-8","article-title":"Gut microbiota and metabolic health among overweight and obese individuals","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s00125-017-4261-z","article-title":"SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes","volume":"60","author":"Robben","year":"2017","journal-title":"Diabetologia"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1574-6941.2002.tb00942.x","article-title":"Sulfate-reducing bacteria in human feces and their association with inflammatory bowel diseases","volume":"40","author":"Loubinoux","year":"2002","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jare.2020.03.007","article-title":"Possible synergy effect of hydrogen sulfide and acetate produced by sulfate-reducing bacteria on inflammatory bowel disease development","volume":"27","author":"Kushkevych","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_60","first-page":"180","article-title":"The causes of intestinal dysbiosis: A review","volume":"9","author":"Hawrelak","year":"2004","journal-title":"Altern. Med. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.freeradbiomed.2017.08.017","article-title":"Hydrogen sulfide-producing cystathionine \u03b3-lyase is critical in the progression of kidney fibrosis","volume":"112","author":"Han","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4239\/wjd.v8.i6.249","article-title":"Diabetes-induced mechanophysiological changes in the small intestine and colon","volume":"8","author":"Zhao","year":"2017","journal-title":"World J. Diabetes"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Kyoko, O.O., Kono, H., Ishimaru, K., Miyake, K., Kubota, T., Ogawa, H., Okumura, K., Shibata, S., and Nakao, A. (2014). Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: Implications in intestinal permeability and susceptibility to colitis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098016"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.aar3318","article-title":"Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection","volume":"359","author":"Thaiss","year":"2018","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Chakaroun, R.M., Massier, L., and Kovacs, P. (2020). Gut Microbiome, Intestinal Permeability, and Tissue Bacteria in Metabolic Disease: Perpetrators or Bystanders?. Nutrients, 12.","DOI":"10.3390\/nu12041082"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3164\/jcbn.09-83","article-title":"A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL\/6 Mice Fed a High Fat Diet","volume":"46","author":"Fraulob","year":"2010","journal-title":"J. Clin. Biochem. 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