{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:57:47Z","timestamp":1789570667986,"version":"build-2803163510"},"reference-count":55,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T00:00:00Z","timestamp":1648944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-III-P2-2.1-PED-2019-2695"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-2695"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Designing and obtaining new synthetic smart biointerfaces with specific and controlled characteristics relevant for applications in biomedical and bioengineering domains represents one of the main challenges in these fields. In this work, Matrix-Assisted Pulsed Laser Evaporation (MAPLE) is used to obtain synthetic biointerfaces of poly(N-isopropyl acrylamide-butyl acrylate) p(NIPAM-BA) copolymer with different characteristics (i.e., roughness, porosity, wettability), and their effect on normal HEK 293 T and murine melanoma B16-F1 cells is studied. For this, the influence of various solvents (chloroform, dimethylsulfoxide, water) and fluence variation (250\u2013450 mJ\/cm2) on the morphological, roughness, wettability, and physico\u2013chemical characteristics of the coatings are evaluated by atomic force microscopy, scanning electron microscopy, contact angle measurements, Fourier-transform-IR spectroscopy, and X-ray photoelectron spectroscopy. Coatings obtained by the spin coating method are used for reference. No significant alteration in the chemistry of the surfaces is observed for the coatings obtained by both methods. All p(NIPAM-BA) coatings show hydrophilic character, with the exception of those obtained with chloroform at 250 mJ\/cm2. The surface morphology is shown to depend on both solvent type and laser fluence and it ranges from smooth surfaces to rough and porous ones. Physico\u2013chemical and biological analysis reveal that the MAPLE deposition method with fluences of 350\u2013450 mJ\/cm2 when using DMSO solvent is more appropriate for bioengineering applications due to the surface characteristics (i.e., pore presence) and to the good compatibility with normal cells and cytotoxicity against melanoma cells.<\/jats:p>","DOI":"10.3390\/ijms23073988","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T06:04:01Z","timestamp":1648965841000},"page":"3988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Poly(N-isopropylacrylamide-butylacrylate) Copolymer Biointerfaces and Their Characteristic Influence on Cell Behavior In Vitro"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-7073","authenticated-orcid":false,"given":"Nicoleta-Luminita","family":"Dumitrescu","sequence":"first","affiliation":[{"name":"Lasers Department, National Institute for Lasers, Plasma, and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-1825","authenticated-orcid":false,"given":"Madalina","family":"Icriverzi","sequence":"additional","affiliation":[{"name":"Ligand-Receptor Interactions Department, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-0916","authenticated-orcid":false,"given":"Anca","family":"Bonciu","sequence":"additional","affiliation":[{"name":"FOTOPLASMAT Department, National Institute for Lasers, Plasma, and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania"},{"name":"Faculty of Physics, Biophysics and Medical Physics Department, University of Bucharest, 405 Atomistilor, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-5682","authenticated-orcid":false,"given":"Paula","family":"Florian","sequence":"additional","affiliation":[{"name":"Ligand-Receptor Interactions Department, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-9268","authenticated-orcid":false,"given":"Antoniu","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Lasers Department, National Institute for Lasers, Plasma, and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Roseanu","sequence":"additional","affiliation":[{"name":"Ligand-Receptor Interactions Department, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-8038","authenticated-orcid":false,"given":"Laurentiu","family":"Rusen","sequence":"additional","affiliation":[{"name":"Lasers Department, National Institute for Lasers, Plasma, and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-5342","authenticated-orcid":false,"given":"Valentina","family":"Dinca","sequence":"additional","affiliation":[{"name":"FOTOPLASMAT Department, National Institute for Lasers, Plasma, and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5728-2860","authenticated-orcid":false,"given":"Florin","family":"Grama","sequence":"additional","affiliation":[{"name":"Surgical Department, Carol Davila University of Medicine & Pharmacy, 37 Dionisie Lupu Street, 030171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8921","DOI":"10.1039\/C5TB01863C","article-title":"Biomaterials for in situ tissue regeneration: Development and perspectives","volume":"3","author":"Li","year":"2015","journal-title":"J. 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