{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:03:29Z","timestamp":1760151809702,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The vertebrate G protein\u2013coupled receptor 37 and G protein\u2013coupled receptor 37-like 1 (GPR37 and GPR37L1) proteins have amino acid sequence homology to endothelin and bombesin-specific receptors. The prosaposin glycoprotein, its derived peptides, and analogues have been reported to interact with and activate both putative receptors. The GPR37 and GPR37L1 genes are highly expressed in human and rodent brains. GPR37 transcripts are most abundant in oligodendrocytes and in the neurons of the substantia nigra and hippocampus, while the GPR37L1 gene is markedly expressed in cerebellar Bergmann glia astrocytes. The human GPR37 protein is a substrate of parkin, and its insoluble form accumulates in brain samples from patients of inherited juvenile Parkinson\u2019s disease. Several Gpr37 and Gpr37l1 mouse mutant strains have been produced and applied to extensive in vivo and ex vivo analyses of respective receptor functions and involvement in brain and other organ pathologies. The genotypic and phenotypic characteristics of the different mouse strains so far published are reported and discussed, and their current and proposed applications to human disease modeling are highlighted.<\/jats:p>","DOI":"10.3390\/ijms23084288","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T21:33:42Z","timestamp":1649885622000},"page":"4288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications"],"prefix":"10.3390","volume":"23","author":[{"given":"Marzia","family":"Massimi","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, Italian National Research Council (CNR), I-00015 Monterotondo Scalo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2680-1821","authenticated-orcid":false,"given":"Chiara","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, Italian National Research Council (CNR), I-00015 Monterotondo Scalo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"La Sala","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, Italian National Research Council (CNR), I-00015 Monterotondo Scalo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-5948","authenticated-orcid":false,"given":"Rafaele","family":"Matteoni","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, Italian National Research Council (CNR), I-00015 Monterotondo Scalo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-5793(98)00170-7","article-title":"A New Family of Orphan G Protein-Coupled Receptors Predominantly Expressed in the Brain","volume":"424","author":"Valdenaire","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/geno.1997.4900","article-title":"Cloning of GPR37, a Gene Located on Chromosome 7 Encoding a Putative g- Protein-Coupled Peptide Receptor, from a Human Frontal Brain EST Library","volume":"45","author":"Marazziti","year":"1997","journal-title":"Genomics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/geno.1998.5433","article-title":"Molecular Cloning and Chromosomal Localization of the Mouse Gpr37 Gene Encoding an Orphan G-Protein-Coupled Peptide Receptor Expressed in Brain and Testis","volume":"53","author":"Marazziti","year":"1998","journal-title":"Genomics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9529","DOI":"10.1073\/pnas.1219004110","article-title":"GPR37 and GPR37L1 Are Receptors for the Neuroprotective and Glioprotective Factors Prosaptide and Prosaposin","volume":"110","author":"Meyer","year":"2013","journal-title":"Proc. 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