{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:19:22Z","timestamp":1788016762413,"version":"build-2784847793"},"reference-count":134,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epilepsy and Alzheimer\u2019s disease (AD) incidence increases with age. There are reciprocal relationships between epilepsy and AD. Epilepsy is a risk factor for AD and, in turn, AD is an independent risk factor for developing epilepsy in old age, and abnormal AD biomarkers in PET and\/or CSF are frequently found in late-onset epilepsies of unknown etiology. Accordingly, epilepsy and AD share pathophysiological processes, including neuronal hyperexcitability and an early excitatory\u2013inhibitory dysregulation, leading to dysfunction in the inhibitory GABAergic and excitatory glutamatergic systems. Moreover, both \u03b2-amyloid and tau protein aggregates, the anatomopathological hallmarks of AD, have proepileptic effects. Finally, these aggregates have been found in the resection material of refractory temporal lobe epilepsies, suggesting that epilepsy leads to amyloid and tau aggregates. Some epileptic syndromes, such as medial temporal lobe epilepsy, share structural and functional neuroimaging findings with AD, leading to overlapping symptomatology, such as episodic memory deficits and toxic synergistic effects. In this respect, the existence of epileptiform activity and electroclinical seizures in AD appears to accelerate the progression of cognitive decline, and the presence of cognitive decline is much more prevalent in epileptic patients than in elderly patients without epilepsy. Notwithstanding their clinical significance, the diagnosis of clinical seizures in AD is a challenge. Most are focal and manifest with an altered level of consciousness without motor symptoms, and are often interpreted as cognitive fluctuations. Finally, despite the frequent association of epilepsy and AD dementia, there is a lack of clinical trials to guide the use of antiseizure medications (ASMs). There is also a potential role for ASMs to be used as disease-modifying drugs in AD.<\/jats:p>","DOI":"10.3390\/ijms23084307","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T21:33:42Z","timestamp":1649885622000},"page":"4307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Mechanisms Involved in Epileptogenesis in Alzheimer\u2019s Disease and Their Therapeutic Implications"],"prefix":"10.3390","volume":"23","author":[{"given":"Miren","family":"Altuna","sequence":"first","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain"},{"name":"CITA-Alzheimer, 20009 Donostia-San Sebasti\u00e1n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Olmedo-Saura","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Carmona-Iragui","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain"},{"name":"Barcelona Down Medical Center, Fundaci\u00f3 Catalana de S\u00edndrome de Down, 08029 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08041 Barcelona, Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain"},{"name":"Barcelona Down Medical Center, Fundaci\u00f3 Catalana de S\u00edndrome de Down, 08029 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s Disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1684\/j.1950-6945.2005.tb00108.x","article-title":"Epilepsy in Middle-Aged and Elderly People: A Three-Year Observation","volume":"7","author":"Paradowski","year":"2005","journal-title":"Epileptic Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e3241","DOI":"10.1212\/WNL.0000000000011077","article-title":"Bi-Directional Association between Epilepsy and Dementia: The Framingham Heart Study","volume":"95","author":"Stefanidou","year":"2020","journal-title":"Neurology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1007\/s00415-020-09937-7","article-title":"Seizures in Alzheimer\u2019s Disease Are Highly Recurrent and Associated with a Poor Disease Course","volume":"267","author":"Ricard","year":"2020","journal-title":"J. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3233\/JAD-191315","article-title":"Epilepsy in Neurodegenerative Dementias: A Clinical, Epidemiological, and EEG Study","volume":"74","author":"Arnaldi","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/1533317518813551","article-title":"Seizure in Alzheimer\u2019s Disease: An Underestimated Phenomenon","volume":"34","author":"Asadollahi","year":"2019","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Dement."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/JAD-170031","article-title":"Relative Incidence of Seizures and Myoclonus in Alzheimer\u2019s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia","volume":"60","author":"Beagle","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.yebeh.2018.05.043","article-title":"Nonlesional Late-Onset Epilepsy: Semiology, EEG, Cerebrospinal Fluid, and Seizure Outcome Characteristics","volume":"91","author":"Hamann","year":"2019","journal-title":"Epilepsy Behav."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neuroscience.2014.11.051","article-title":"Seizures in Alzheimer\u2019s Disease","volume":"286","author":"Born","year":"2015","journal-title":"Neuroscience"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/ageing\/afv061","article-title":"Incidence of Stroke and Seizure in Alzheimer\u2019s Disease Dementia","volume":"44","author":"Cook","year":"2015","journal-title":"Age Ageing"},{"key":"ref_11","first-page":"645","article-title":"Epilepsy Occurrence in Patients with Alzheimer\u2019s Disease: Clinical Experience in a Tertiary Dementia Center","volume":"37","author":"Giorgi","year":"2016","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/epi.13744","article-title":"The Association between Dementia and Epilepsy: A Systematic Review and Meta-Analysis","volume":"58","author":"Subota","year":"2017","journal-title":"Epilepsia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41582-021-00505-9","article-title":"Amyloid-\u03b2: A Potential Link between Epilepsy and Cognitive Decline","volume":"17","author":"Romoli","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3233\/JAD-170925","article-title":"Prevalence, Semiology, and Risk Factors of Epilepsy in Alzheimer\u2019s Disease: An Ambulatory EEG Study","volume":"63","author":"Hidasi","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1021\/acschemneuro.9b00460","article-title":"Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer\u2019s Disease","volume":"10","author":"Paudel","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1528-1167.2010.02909.x","article-title":"A Perfect Storm: Converging Paths of Epilepsy and Alzheimer\u2019s Dementia Intersect in the Hippocampal Formation","volume":"52","author":"Noebels","year":"2011","journal-title":"Epilepsia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e3248","DOI":"10.1212\/WNL.0000000000011080","article-title":"Dementia in Late-Onset Epilepsy: The Atherosclerosis Risk in Communities Study","volume":"95","author":"Johnson","year":"2020","journal-title":"Neurology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1001\/jamaneurol.2020.0187","article-title":"Association of Late-Onset Unprovoked Seizures of Unknown Etiology With the Risk of Developing Dementia in Older Veterans","volume":"77","author":"Keret","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jns.2006.11.004","article-title":"Epilepsy and Antiepileptic Drug Use in Elderly People as Risk Factors for Dementia","volume":"252","author":"Carter","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"ref_20","first-page":"247","article-title":"Ten Year Cumulative Incidence of Dementia after Late Onset Epilepsy of Unknown Etiology","volume":"86","author":"Ophir","year":"2021","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jamaneurol.2018.1935","article-title":"Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study","volume":"75","author":"Johnson","year":"2018","journal-title":"JAMA Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neurobiolaging.2018.09.006","article-title":"Alzheimer\u2019s Disease and Late-Onset Epilepsy of Unknown Origin: Two Faces of Beta Amyloid Pathology","volume":"73","author":"Costa","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Toniolo, S., Sen, A., and Husain, M. (2020). Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239318"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kazim, S.F., Seo, J.H., Bianchi, R., Larson, C.S., Sharma, A., Wong, R.K.S., Gorbachev, K.Y., and Pereira, A.C. (2021). Neuronal Network Excitability in Alzheimer\u2019s Disease: The Puzzle of Similar versus Divergent Roles of Amyloid \u03b2 and Tau. eNeuro, 8.","DOI":"10.1523\/ENEURO.0418-20.2020"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/brain\/awz381","article-title":"Alzheimer-like Amyloid and Tau Alterations Associated with Cognitive Deficit in Temporal Lobe Epilepsy","volume":"143","author":"Gourmaud","year":"2020","journal-title":"Brain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1755-5949.2011.00251.x","article-title":"Seizures and Epilepsy in Alzheimer\u2019s Disease","volume":"18","author":"Friedman","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/nan.12087","article-title":"A Comparative Study of the Dentate Gyrus in Hippocampal Sclerosis in Epilepsy and Dementia","volume":"40","author":"Bandopadhyay","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12017-009-8076-z","article-title":"Epileptic Seizures in AD Patients","volume":"12","author":"Larner","year":"2010","journal-title":"Neuromolecular Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/WAD.0000000000000134","article-title":"Epileptic Seizures in Alzheimer Disease: A Review","volume":"30","author":"Barcs","year":"2016","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Altuna, M., Gim\u00e9nez, S., and Fortea, J. (2021). Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132776"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1515\/revneuro-2017-0064","article-title":"Cracking Novel Shared Targets between Epilepsy and Alzheimer\u2019s Disease: Need of the Hour","volume":"29","author":"Garg","year":"2018","journal-title":"Rev. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1111\/jgs.17101","article-title":"Systematic Review of Coexistent Epileptic Seizures and Alzheimer\u2019s Disease: Incidence and Prevalence","volume":"69","author":"Xu","year":"2021","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_33","first-page":"69","article-title":"Myoclonic Epilepsy in Down Syndrome and Alzheimer Disease","volume":"32","author":"Salvado","year":"2017","journal-title":"Neurologia"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tait, L., Lopes, M.A., Stothart, G., Baker, J., Kazanina, N., Zhang, J., and Goodfellow, M. (2021). A Large-Scale Brain Network Mechanism for Increased Seizure Propensity in Alzheimer\u2019s Disease. PLoS Comput. Biol., 17.","DOI":"10.1101\/2021.01.19.427236"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/1533317514537547","article-title":"Potential Similarities in Temporal Lobe Epilepsy and Alzheimer\u2019s Disease: From Clinic to Pathology","volume":"30","author":"Li","year":"2015","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Dement."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainresbull.2020.04.009","article-title":"Epilepsy and Alzheimer\u2019s Disease: Potential Mechanisms for an Association","volume":"160","author":"Giorgi","year":"2020","journal-title":"Brain Res. Bull."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000119103","article-title":"Epilepsy and Dementia in the Elderly","volume":"25","author":"Hommet","year":"2008","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1212\/WNL.0000000000003048","article-title":"Seizures in Dominantly Inherited Alzheimer Disease","volume":"87","author":"Zarea","year":"2016","journal-title":"Neurology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuron.2020.06.005","article-title":"Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer\u2019s Disease","volume":"107","author":"Harris","year":"2020","journal-title":"Neuron"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2011.03.022","article-title":"Presenilin-1 Mutation Alzheimer\u2019s Disease: A Genetic Epilepsy Syndrome?","volume":"21","author":"Larner","year":"2011","journal-title":"Epilepsy Behav."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000093664","article-title":"Prevalence and Causes of Seizures at the Time of Diagnosis of Probable Alzheimer\u2019s Disease","volume":"22","author":"Lozsadi","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3233\/JAD-2011-110896","article-title":"Seizures Can Precede Cognitive Symptoms in Late-Onset Alzheimer\u2019s Disease","volume":"27","author":"Picco","year":"2011","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neurobiolaging.2018.11.022","article-title":"Seizures as an Early Symptom of Autosomal Dominant Alzheimer\u2019s Disease","volume":"76","author":"Noachtar","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.eplepsyres.2012.08.002","article-title":"Epileptic Amnesic Syndrome Revealing Alzheimer\u2019s Disease","volume":"102","author":"Cretin","year":"2012","journal-title":"Epilepsy Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kang, J.-Q. (2021). Epileptic Mechanisms Shared by Alzheimer\u2019s Disease: Viewed via the Unique Lens of Genetic Epilepsy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137133"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1528-1167.2006.00554.x","article-title":"Incidence and Predictors of Seizures in Patients with Alzheimer\u2019s Disease","volume":"47","author":"Amatniek","year":"2006","journal-title":"Epilepsia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1684\/epd.2010.0290","article-title":"Seizures in Alzheimer\u2019s Disease: A Retrospective Study of a Cohort of Outpatients","volume":"12","author":"Bernardi","year":"2010","journal-title":"Epileptic Disord."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eplepsyres.2015.05.009","article-title":"Incidence and Risk of Seizures in Alzheimer\u2019s Disease: A Nationwide Population-Based Cohort Study","volume":"115","author":"Cheng","year":"2015","journal-title":"Epilepsy Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/ene.14043","article-title":"Increased Risk of Epilepsy in Patients Registered in the Swedish Dementia Registry","volume":"27","author":"Zelano","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/archneurol.2011.830","article-title":"Incidence of New-Onset Seizures in Mild to Moderate Alzheimer Disease","volume":"69","author":"Irizarry","year":"2012","journal-title":"Arch. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic Activity in Alzheimer\u2019s Disease: Causes and Clinical Relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"137.e1","DOI":"10.1016\/j.neurobiolaging.2021.01.032","article-title":"A Novel Presenilin 1 Duplication Mutation (Ile168dup) Causing Alzheimer\u2019s Disease Associated with Myoclonus, Seizures and Pyramidal Features","volume":"103","author":"Abel","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.seizure.2018.07.015","article-title":"Epileptic Seizures in Autosomal Dominant Forms of Alzheimer\u2019s Disease","volume":"61","author":"Cortini","year":"2018","journal-title":"Seizure"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/13554794.2020.1747632","article-title":"Refractory Epilepsy in PSEN 1 Mutation (I83T)","volume":"26","author":"Fray","year":"2020","journal-title":"Neurocase"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3233\/JAD-150096","article-title":"Epileptic Prodromal Alzheimer\u2019s Disease, a Retrospective Study of 13 New Cases: Expanding the Spectrum of Alzheimer\u2019s Disease to an Epileptic Variant?","volume":"52","author":"Cretin","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000278620","article-title":"Prevalence and Clinical Significance of Epileptiform EEG Discharges in a Large Memory Clinic Cohort","volume":"29","author":"Liedorp","year":"2010","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3000605211062453","DOI":"10.1177\/03000605211062453","article-title":"Dementia with Non-Convulsive Seizures: A Case Report","volume":"49","author":"Chen","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neurol.2017.03.028","article-title":"Do We Know How to Diagnose Epilepsy Early in Alzheimer\u2019s Disease?","volume":"173","author":"Cretin","year":"2017","journal-title":"Rev. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S1474-4422(16)30229-0","article-title":"Neurological Manifestations of Autosomal Dominant Familial Alzheimer\u2019s Disease: A Comparison of the Published Literature with the Dominantly Inherited Alzheimer Network Observational Study (DIAN-OBS)","volume":"15","author":"Tang","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s12017-015-8355-9","article-title":"Neuronal Network Oscillations in Neurodegenerative Diseases","volume":"17","author":"Nimmrich","year":"2015","journal-title":"Neuromol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3233\/JAD-160994","article-title":"Sleep EEG Detects Epileptiform Activity in Alzheimer\u2019s Disease with High Sensitivity","volume":"56","author":"Barcs","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nm.4330","article-title":"Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer\u2019s Disease","volume":"23","author":"Lam","year":"2017","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/ana.24794","article-title":"Incidence and Impact of Subclinical Epileptiform Activity in Alzheimer\u2019s Disease","volume":"80","author":"Vossel","year":"2016","journal-title":"Ann. Neurol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111434","DOI":"10.1016\/j.mad.2021.111434","article-title":"Sleep Disorders and Late-Onset Epilepsy of Unknown Origin: Understanding New Trajectories to Brain Amyloidopathy","volume":"194","author":"Liguori","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e2259","DOI":"10.1212\/WNL.0000000000010612","article-title":"Association of Epileptiform Abnormalities and Seizures in Alzheimer Disease","volume":"95","author":"Lam","year":"2020","journal-title":"Neurology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"eaaw8954","DOI":"10.1126\/scitranslmed.aaw8954","article-title":"Paroxysmal Slow Cortical Activity in Alzheimer\u2019s Disease and Epilepsy Is Associated with Blood-Brain Barrier Dysfunction","volume":"11","author":"Milikovsky","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.clinph.2020.02.015","article-title":"Subclinical Epileptiform Activity during Sleep in Alzheimer\u2019s Disease and Mild Cognitive Impairment","volume":"131","author":"Brunetti","year":"2020","journal-title":"Clin. Neurophysiol. Off. J. Int. Fed. Clin. Neurophysiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(19)33064-8","article-title":"Epilepsy in Older People","volume":"395","author":"Sen","year":"2020","journal-title":"Lancet"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/14737175.2019.1629289","article-title":"The Overlap between Epilepsy and Alzheimer\u2019s Disease and the Consequences for Treatment","volume":"19","author":"Powell","year":"2019","journal-title":"Expert Rev. Neurother."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3389\/fneur.2019.01266","article-title":"A Longitudinal Study of Epileptic Seizures in Alzheimer\u2019s Disease","volume":"10","author":"Baker","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3233\/JAD-170392","article-title":"Adult-Onset Epilepsy in Presymptomatic Alzheimer\u2019s Disease: A Retrospective Study","volume":"60","author":"DiFrancesco","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3389\/fneur.2019.00878","article-title":"Precuneus-Dominant Degeneration of Parietal Lobe Is at Risk of Epilepsy in Mild Alzheimer\u2019s Disease","volume":"10","author":"Horvath","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00415-017-8694-6","article-title":"Seizures in Alzheimer\u2019s Disease: Is There More beneath the Surface?","volume":"265","author":"Edwards","year":"2018","journal-title":"J. Neurol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.clinph.2021.03.050","article-title":"Subclinical Epileptiform Activity Accelerates the Progression of Alzheimer\u2019s Disease: A Long-Term EEG Study","volume":"132","author":"Horvath","year":"2021","journal-title":"Clin. Neurophysiol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Nardi Cesarini, E., Babiloni, C., Salvadori, N., Farotti, L., Del Percio, C., Pascarelli, M.T., Noce, G., Lizio, R., Da Re, F., and Isella, V. (2020). Late-Onset Epilepsy With Unknown Etiology: A Pilot Study on Neuropsychological Profile, Cerebrospinal Fluid Biomarkers, and Quantitative EEG Characteristics. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00199"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/14656566.2020.1843636","article-title":"New Anti-Seizure Medication for Elderly Epilepsy Patients\u2014A Critical Narrative Review","volume":"22","author":"Rohracher","year":"2021","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.seizure.2020.12.007","article-title":"Best Care for Older People with Epilepsy: A Scoping Review","volume":"85","author":"Wojewodka","year":"2021","journal-title":"Seizure"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"108006","DOI":"10.1016\/j.yebeh.2021.108006","article-title":"Risk Factors for Dementia Development, Frailty, and Mortality in Older Adults with Epilepsy\u2014A Population-Based Analysis","volume":"120","author":"Subota","year":"2021","journal-title":"Epilepsy Behav."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"18-e3","DOI":"10.1111\/ene.13813","article-title":"Stroke-Related Epilepsy","volume":"26","author":"Feyissa","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/epi.16748","article-title":"Cognitive Decline in Older Adults with Epilepsy: The Cardiovascular Health Study","volume":"62","author":"Choi","year":"2021","journal-title":"Epilepsia"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1212\/WNL.0000000000011079","article-title":"Predictors of Mortality in Older Adults With Epilepsy: Implications for Learning Health Systems","volume":"96","author":"Blank","year":"2021","journal-title":"Neurology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yebeh.2013.05.001","article-title":"Clinical Features of Late-Onset Partial Cryptogenic Epilepsy: Toward an Idiopathic Temporal Epilepsy?","volume":"28","author":"Lambrecq","year":"2013","journal-title":"Epilepsy Behav."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"118065","DOI":"10.1016\/j.jns.2021.118065","article-title":"New-Onset Seizures in Older People: Clinical Features, Course and Outcomes","volume":"429","author":"Green","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/epi.16780","article-title":"Diagnosing Cognitive Disorders in Older Adults with Epilepsy","volume":"62","author":"Reyes","year":"2021","journal-title":"Epilepsia"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/brain\/awaa397","article-title":"Atrophy and Cognitive Profiles in Older Adults with Temporal Lobe Epilepsy Are Similar to Mild Cognitive Impairment","volume":"144","author":"Kaestner","year":"2021","journal-title":"Brain"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yebeh.2005.09.004","article-title":"Older Adults with Epilepsy Demonstrate Cognitive Impairments Compared with Patients with Amnestic Mild Cognitive Impairment","volume":"8","author":"Griffith","year":"2006","journal-title":"Epilepsy Behav."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/epi.16918","article-title":"Astrocyte and Glutamate Involvement in the Pathogenesis of Epilepsy in Alzheimer\u2019s Disease","volume":"62","author":"Dejakaisaya","year":"2021","journal-title":"Epilepsia"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.nbd.2019.04.010","article-title":"Excitatory-Inhibitory Imbalance in Alzheimer\u2019s Disease and Therapeutic Significance","volume":"127","author":"Etter","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/gb-2007-8-3-r32","article-title":"Alternative Ion Channel Splicing in Mesial Temporal Lobe Epilepsy and Alzheimer\u2019s Disease","volume":"8","author":"Heinzen","year":"2007","journal-title":"Genome Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s11064-021-03332-y","article-title":"Alzheimer\u2019s Disease and Epilepsy: A Perspective on the Opportunities for Overlapping Therapeutic Innovation","volume":"46","author":"Lehmann","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_91","first-page":"295","article-title":"From Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer\u2019s Disease","volume":"22","author":"Dulla","year":"2016","journal-title":"Neurosci. Rev. J. Bring. Neurobiol. Neurol. Psychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neurobiolaging.2016.08.025","article-title":"Epilepsy, Amyloid-\u03b2, and D1 Dopamine Receptors: A Possible Pathogenetic Link?","volume":"48","author":"Costa","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Sakimoto, Y., Oo, P.M.-T., Goshima, M., Kanehisa, I., Tsukada, Y., and Mitsushima, D. (2021). Significance of GABA(A) Receptor for Cognitive Function and Hippocampal Pathology. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212456"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.yebeh.2012.11.040","article-title":"Shared Cognitive and Behavioral Impairments in Epilepsy and Alzheimer\u2019s Disease and Potential Underlying Mechanisms","volume":"26","author":"Chin","year":"2013","journal-title":"Epilepsy Behav."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1684\/epd.2016.0808","article-title":"From Here to Epilepsy: The Risk of Seizure in Patients with Alzheimer\u2019s Disease","volume":"18","author":"Nicastro","year":"2016","journal-title":"Epileptic Disord."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer\u2019s Disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1021\/acs.jproteome.1c00180","article-title":"Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice","volume":"20","author":"Rao","year":"2021","journal-title":"J. Proteome Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fncel.2020.592374","article-title":"Fyn-Tau Ablation Modifies PTZ-Induced Seizures and Post-Seizure Hallmarks of Early Epileptogenesis","volume":"14","author":"Putra","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"108045","DOI":"10.1016\/j.celrep.2020.108045","article-title":"Fyn Kinase Controls Tau Aggregation In Vivo","volume":"32","author":"Briner","year":"2020","journal-title":"Cell Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.yebeh.2019.06.033","article-title":"Increased CSF Tau Is Associated with a Higher Risk of Seizures in Patients with Alzheimer\u2019s Disease","volume":"98","author":"Lopes","year":"2019","journal-title":"Epilepsy Behav."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/epi.16956","article-title":"Microglia Proliferation Plays Distinct Roles in Acquired Epilepsy Depending on Disease Stages","volume":"62","author":"Sorrentino","year":"2021","journal-title":"Epilepsia"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3233\/JAD-180098","article-title":"Role of Blood-Brain Barrier in Alzheimer\u2019s Disease","volume":"63","author":"Cai","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_103","first-page":"143908","article-title":"Blood-Brain Barrier Dysfunction in Epileptogenesis of the Temporal Lobe","volume":"2011","author":"Weissberg","year":"2011","journal-title":"Epilepsy Res. Treat."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Yamazaki, Y., and Kanekiyo, T. (2017). Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091965"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3389\/fnins.2018.01017","article-title":"Tau and MTOR: The Hotspots for Multifarious Diseases in Alzheimer\u2019s Development","volume":"12","author":"Mueed","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/archneurol.2009.15","article-title":"Epilepsy and Cognitive Impairments in Alzheimer Disease","volume":"66","author":"Palop","year":"2009","journal-title":"Arch. Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/d41586-020-01152-8","article-title":"Risk Factor for Alzheimer\u2019s Disease Breaks the Blood-Brain Barrier","volume":"581","author":"Ishii","year":"2020","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.yebeh.2008.08.012","article-title":"Recurrent Seizures in Patients with Dementia: Frequency, Seizure Types, and Treatment Outcome","volume":"14","author":"Rao","year":"2009","journal-title":"Epilepsy Behav."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1468-1331.2007.01907.x","article-title":"Levetiracetam Monotherapy in Alzheimer Patients with Late-Onset Seizures: A Prospective Observational Study","volume":"14","author":"Belcastro","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"E2895","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam Suppresses Neuronal Network Dysfunction and Reverses Synaptic and Cognitive Deficits in an Alzheimer\u2019s Disease Model","volume":"109","author":"Sanchez","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40266-020-00826-2","article-title":"Treatment of Seizures in Older Patients with Dementia","volume":"38","author":"Cretin","year":"2021","journal-title":"Drugs Aging"},{"key":"ref_113","first-page":"CD011922","article-title":"Treatment of Epilepsy for People with Alzheimer\u2019s Disease","volume":"5","author":"Liu","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1080\/14656566.2018.1496237","article-title":"Pharmacotherapeutic Strategies for Treating Epilepsy in Patients with Alzheimer\u2019s Disease","volume":"19","author":"Cretin","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1016\/j.celrep.2019.05.101","article-title":"Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer\u2019s Disease Model","volume":"27","author":"Fu","year":"2019","journal-title":"Cell Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jamaneurol.2021.3310","article-title":"Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial","volume":"78","author":"Vossel","year":"2021","journal-title":"JAMA Neurol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/s13063-021-05404-4","article-title":"An Investigation of Levetiracetam in Alzheimer\u2019s Disease (ILiAD): A Double-Blind, Placebo-Controlled, Randomised Crossover Proof of Concept Study","volume":"22","author":"Sen","year":"2021","journal-title":"Trials"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejphar.2006.06.022","article-title":"New Targets for Pharmacological Intervention in the Glutamatergic Synapse","volume":"545","author":"Gardoni","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/14737175.2017.1243469","article-title":"Treatment of Epilepsy in Patients with Alzheimer\u2019s Disease","volume":"17","author":"Giorgi","year":"2017","journal-title":"Expert Rev. Neurother."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s40263-016-0384-x","article-title":"Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond","volume":"30","author":"Gillard","year":"2016","journal-title":"CNS Drugs"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3233\/JAD-150687","article-title":"A Mitochondrial Role of SV2a Protein in Aging and Alzheimer\u2019s Disease: Studies with Levetiracetam","volume":"50","author":"Stockburger","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/14728214.2020.1808621","article-title":"Anti-Amyloid-\u03b2 Protein Agents for the Treatment of Alzheimer\u2019s Disease: An Update on Emerging Drugs","volume":"25","author":"Lozupone","year":"2020","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3233\/JAD-160742","article-title":"Levetiracetam Alters Oscillatory Connectivity in Alzheimer\u2019s Disease","volume":"58","author":"Musaeus","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3233\/JAD-143162","article-title":"Lamotrigine Reduces \u03b2-Site A\u03b2PP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy","volume":"46","author":"Wu","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s11064-015-1809-5","article-title":"Neuroprotection as a Potential Therapeutic Perspective in Neurodegenerative Diseases: Focus on Antiepileptic Drugs","volume":"41","author":"Caccamo","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7810196","DOI":"10.1155\/2016\/7810196","article-title":"Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer\u2019s-Like Mouse Model","volume":"2016","author":"Wang","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pbb.2015.04.011","article-title":"Lacosamide Reduces HDAC Levels in the Brain and Improves Memory: Potential for Treatment of Alzheimer\u2019s Disease","volume":"134","author":"Bang","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"bay050","DOI":"10.1093\/database\/bay050","article-title":"A Systematic Approach for Identifying Shared Mechanisms in Epilepsy and Its Comorbidities","volume":"2018","author":"Hoyt","year":"2018","journal-title":"Database"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1021\/acschemneuro.0c00414","article-title":"Gabapentin Inhibits Multiple Steps in the Amyloid Beta Toxicity Cascade","volume":"11","author":"Burgos","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/bcp.13844","article-title":"Gabapentin and Pregabalin to Treat Aggressivity in Dementia: A Systematic Review and Illustrative Case Report","volume":"85","author":"Supasitthumrong","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/cns.12445","article-title":"Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3\u03b2 Signaling Pathway in an Alzheimer\u2019s Disease Model","volume":"21","author":"Long","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1385\/JMN:19:3:301","article-title":"Neuroprotective Properties of Valproate: Potential Benefit for AD and Tauopathies","volume":"19","author":"Loy","year":"2002","journal-title":"J. Mol. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainresbull.2009.09.003","article-title":"Valproic Acid as a Promising Agent to Combat Alzheimer\u2019s Disease","volume":"81","author":"Zhang","year":"2010","journal-title":"Brain Res. Bull."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13195-021-00867-8","article-title":"Efficacy and Safety of Pharmacotherapy for Alzheimer\u2019s Disease and for Behavioural and Psychological Symptoms of Dementia in Older Patients with Moderate and Severe Functional Impairments: A Systematic Review of Controlled Trials","volume":"13","author":"Seibert","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/8\/4307\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:53:29Z","timestamp":1760136809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/8\/4307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,13]]},"references-count":134,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["ijms23084307"],"URL":"https:\/\/doi.org\/10.3390\/ijms23084307","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202203.0180.v1","asserted-by":"object"}]},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,13]]}}}