{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:59:03Z","timestamp":1779080343299,"version":"3.51.4"},"reference-count":64,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2013\/07104-6"],"award-info":[{"award-number":["2013\/07104-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Duchenne muscular dystrophy (DMD) is a muscle disease characterized by the absence of the protein dystrophin, which causes a loss of sarcolemma integrity, determining recurrent muscle injuries, decrease in muscle function, and progressive degeneration. Currently, there is a need for therapeutic treatments to improve the quality of life of DMD patients. Here, we investigated the effects of a low-intensity aerobic training (37 sessions) on satellite cells, peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1\u03b1 protein (PGC-1\u03b1), and different types of fibers of the psoas muscle from mdx mice (DMD experimental model). Wildtype and mdx mice were randomly divided into sedentary and trained groups (n = 24). Trained animals were subjected to 37 sessions of low-intensity running on a motorized treadmill. Subsequently, the psoas muscle was excised and analyzed by immunofluorescence for dystrophin, satellite cells, myosin heavy chain (MHC), and PGC-1\u03b1 content. The minimal Feret\u2019s diameters of the fibers were measured, and light microscopy was applied to observe general morphological features of the muscles. The training (37 sessions) improved morphological features in muscles from mdx mice and caused an increase in the number of quiescent\/activated satellite cells. It also increased the content of PGC-1\u03b1 in the mdx group. We concluded that low-intensity aerobic exercise (37 sessions) was able to reverse deleterious changes determined by DMD.<\/jats:p>","DOI":"10.3390\/ijms23094483","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T22:07:26Z","timestamp":1650406046000},"page":"4483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Low-Intensity and Long-Term Aerobic Exercise on the Psoas Muscle of mdx Mice: An Experimental Model of Duchenne Muscular Dystrophy"],"prefix":"10.3390","volume":"23","author":[{"given":"Emilly","family":"Sigoli","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Federal University of S\u00e3o Carlos (UFSCar), Rod. Washington Lu\u00eds, km 235-SP-310-S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-2395","authenticated-orcid":false,"given":"Rosangela Aline","family":"Ant\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of S\u00e3o Carlos (UFSCar), Rod. Washington Lu\u00eds, km 235-SP-310-S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paula","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of S\u00e3o Carlos (UFSCar), Rod. Washington Lu\u00eds, km 235-SP-310-S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Oliveira Passos","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of S\u00e3o Carlos (UFSCar), Rod. Washington Lu\u00eds, km 235-SP-310-S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-2799","authenticated-orcid":false,"given":"Patty Karina dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of S\u00e3o Carlos (UFSCar), Rod. Washington Lu\u00eds, km 235-SP-310-S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-2236","authenticated-orcid":false,"given":"Daiane Leite","family":"da Roza","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Behaviour, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo-Ribeir\u00e3o Preto, S\u00e3o Paulo 14051-160, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7080-9364","authenticated-orcid":false,"given":"Dilson E.","family":"Rassier","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Physical Education, McGill University, Montreal, QC H2W 1S4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anabelle Silva","family":"Cornachione","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of S\u00e3o Carlos (UFSCar), Rod. Washington Lu\u00eds, km 235-SP-310-S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinph.2019.09.023","article-title":"Intramuscular blood flow in Duchenne and Becker Muscular Dystrophy: Quantitative power Doppler sonography relates to disease severity","volume":"131","author":"Dietz","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"015","DOI":"10.34024\/rnc.2006.v14.8782","article-title":"Perfil cl\u00ednico e funcional dos pacientes com Distrofia Muscular de Duchenne assistidos na Associa\u00e7\u00e3o Brasileira de Distrofia Muscular (ABDIM) attending the Brazilian Association of muscular dystrophy (ABDIM)","volume":"14","author":"Santos","year":"2006","journal-title":"Rev. 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