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TRPA1 expression in resident tissue cells, inflammatory, and immune cells, through the indirect modulation of a large series of intracellular pathways, orchestrates a range of cellular processes, such as cytokine production, cell differentiation, and cytotoxicity. Therefore, the TRPA1 pathway has been proposed as a protective mechanism to detect and respond to harmful agents in various pathological conditions, including several inflammatory diseases. Specific attention has been paid to TRPA1 contribution to the transition of inflammation and immune responses from an early defensive response to a chronic pathological condition. In this view, TRPA1 antagonists may be regarded as beneficial tools for the treatment of inflammatory conditions.<\/jats:p>","DOI":"10.3390\/ijms23094529","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T01:55:51Z","timestamp":1650506151000},"page":"4529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["TRPA1 Role in Inflammatory Disorders: What Is Known So Far?"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-2497","authenticated-orcid":false,"given":"Lorenzo","family":"Landini","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-725X","authenticated-orcid":false,"given":"Daniel","family":"Souza Monteiro de Araujo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-6744","authenticated-orcid":false,"given":"Mustafa","family":"Titiz","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierangelo","family":"Geppetti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-8395","authenticated-orcid":false,"given":"Romina","family":"Nassini","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-6929","authenticated-orcid":false,"given":"Francesco","family":"De Logu","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/gb-2011-12-3-218","article-title":"The transient receptor potential family of ion channels","volume":"12","author":"Nilius","year":"2011","journal-title":"Genome Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","article-title":"TRP channels as cellular sensors","volume":"426","author":"Clapham","year":"2003","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41594-018-0148-z","article-title":"Organellar TRP channels","volume":"25","author":"Zhang","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/23328940.2015.1040604","article-title":"TRP ion channels in thermosensation, thermoregulation and metabolism","volume":"2","author":"Wang","year":"2015","journal-title":"Temperature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/164_2019_336","article-title":"Ion channel pharmacology for pain modulation","volume":"260","author":"Geppetti","year":"2019","journal-title":"Concepts Princ. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.phrs.2019.02.019","article-title":"The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel","volume":"142","author":"Landini","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2014.04.021","article-title":"TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout","volume":"72","author":"Trevisan","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41419-020-02863-6","article-title":"TRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice","volume":"11","author":"Adembri","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fimmu.2020.00097","article-title":"The TRPM2 ion channel regulates inflammatory functions of neutrophils during listeria monocytogenes infection","volume":"11","author":"Brockman","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3389\/fimmu.2020.02124","article-title":"Role of the intracellular sodium homeostasis in chemotaxis of activated murine neutrophils","volume":"11","author":"Najder","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"606893","DOI":"10.3389\/fimmu.2020.606893","article-title":"TRPM7 kinase is essential for neutrophil recruitment and function via regulation of Akt\/mTOR signaling","volume":"11","author":"Nadolni","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1053\/j.gastro.2010.09.045","article-title":"Transient receptor potential vanilloid 4 activated inflammatory signals by intestinal epithelial cells and colitis in mice","volume":"140","author":"Cenac","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4049\/jimmunol.1501688","article-title":"TRPV4 mechanosensitive ion channel regulates lipopolysaccharide-stimulated macrophage phagocytosis","volume":"196","author":"Scheraga","year":"2016","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1165\/rcmb.2014-0225OC","article-title":"Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury","volume":"54","author":"Yin","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature03896","article-title":"A possible unifying principle for mechanosensation","volume":"436","author":"Kung","year":"2005","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrn2149","article-title":"TRP channels in mechanosensation: Direct or indirect activation?","volume":"8","author":"Christensen","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"L353","DOI":"10.1152\/ajplung.00315.2009","article-title":"TRPV4 channels augment macrophage activation and ventilator-induced lung injury","volume":"299","author":"Hamanaka","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.4049\/jimmunol.1102147","article-title":"TRPV1 deletion enhances local inflammation and accelerates the onset of systemic inflammatory response syndrome","volume":"188","author":"Fernandes","year":"2012","journal-title":"J. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"925171","DOI":"10.1155\/2013\/925171","article-title":"Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-alpha-induced inflammation in macrophages: Role of liver X receptor \u03b1","volume":"2013","author":"Zhao","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1074\/jbc.274.11.7325","article-title":"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts","volume":"274","author":"Jaquemar","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tins.2012.04.002","article-title":"Sensing pressure with ion channels","volume":"35","author":"Nilius","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/physrev.00005.2019","article-title":"Mammalian transient receptor potential TRPA1 channels: From structure to disease","volume":"100","author":"Talavera","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","volume":"445","author":"Macpherson","year":"2007","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress","volume":"28","author":"Andersson","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"32691","DOI":"10.1074\/jbc.M803568200","article-title":"The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/aww038","article-title":"TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes\/macrophages and oxidative stress","volume":"139","author":"Trevisan","year":"2016","journal-title":"Brain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.0705923104","article-title":"4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1","volume":"104","author":"Trevisani","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/brain\/awy177","article-title":"TRPA1\/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice","volume":"141","author":"Marone","year":"2018","journal-title":"Brain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1074\/jbc.M607849200","article-title":"Transient receptor potential channel A1 is directly gated by calcium ions","volume":"282","author":"Doerner","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nn1843","article-title":"Direct activation of the ion channel TRPA1 by Ca2+","volume":"10","author":"Zurborg","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/BJ20101256","article-title":"The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1","volume":"433","author":"Samad","year":"2011","journal-title":"Biochem. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1074\/jbc.M110.106153","article-title":"Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel","volume":"285","author":"Staruschenko","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Liedtke, W.B., and Heller, S. (2007). TRPA1 in Auditory and Nociceptive Organs. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades, CRC Press\/Taylor & Francis. Frontiers in Neuroscience.","DOI":"10.1201\/9781420005844"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/FJC.0b013e3181f580d9","article-title":"Endothelium-dependent cerebral artery dilation mediated by transient receptor potential and Ca2+-activated K+ channels","volume":"57","author":"Earley","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e122402","DOI":"10.1172\/jci.insight.122402","article-title":"TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility","volume":"4","author":"Yang","year":"2019","journal-title":"JCI Insight"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/10799893.2011.602413","article-title":"Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells","volume":"31","author":"Mukhopadhyay","year":"2011","journal-title":"J. Recept. Signal Transduct."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Nassini, R., Pedretti, P., Moretto, N., Fusi, C., Carnini, C., Facchinetti, F., Viscomi, A.R., Pisano, A.R., Stokesberry, S., and Brunmark, C. (2012). Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042454"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"102059","DOI":"10.1016\/j.pupt.2021.102059","article-title":"The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells","volume":"70","author":"Luostarinen","year":"2021","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/jn.00524.2018","article-title":"TRPA1: A molecular view","volume":"121","author":"Meents","year":"2019","journal-title":"J. Neurophysiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pharmthera.2011.10.008","article-title":"TRPA1 antagonists as potential analgesic drugs","volume":"133","author":"Andrade","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1021\/jm100062h","article-title":"Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents","volume":"53","author":"Baraldi","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1073\/pnas.1215555110","article-title":"UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes","volume":"110","author":"Bellono","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cbi.2013.08.012","article-title":"Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells","volume":"206","author":"Buch","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1476-5381.2012.02018.x","article-title":"TRPA1 channels in the vasculature","volume":"167","author":"Earley","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.4049\/jimmunol.1300300","article-title":"TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis","volume":"191","author":"Oh","year":"2013","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.4049\/jimmunol.181.7.5024","article-title":"Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A","volume":"181","author":"Prasad","year":"2008","journal-title":"J. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbrc.2018.05.097","article-title":"Transient receptor potential ankyrin 1 channels are involved in spontaneous peptide hormone release from astrocytes","volume":"501","author":"Takizawa","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature16519","article-title":"Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia","volume":"529","author":"Hamilton","year":"2016","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s12192-020-01131-y","article-title":"Transient receptor potential ankyrin 1 contributes to the lysophosphatidylcholine-induced oxidative stress and cytotoxicity in OLN-93 oligodendrocyte","volume":"25","author":"Tian","year":"2020","journal-title":"Cell Stress Chaperones"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s41467-017-01739-2","article-title":"Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice","volume":"8","author":"Nassini","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1172\/JCI128022","article-title":"Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice","volume":"129","author":"Landini","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1080\/14728222.2020.1815191","article-title":"TRPA1 as a therapeutic target for nociceptive pain","volume":"24","author":"Nassini","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bbi.2020.04.037","article-title":"Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I","volume":"88","author":"Kudsi","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1158\/0008-5472.CAN-20-3326","article-title":"Peripheral nerve resident macrophages and schwann cells mediate cancer-induced pain","volume":"81","author":"Marini","year":"2021","journal-title":"Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1124\/mol.108.054445","article-title":"Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1","volume":"75","author":"Ghatta","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"ref_57","first-page":"30","article-title":"Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1","volume":"4","author":"Dhaka","year":"2008","journal-title":"Mol. Pain"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1124\/mol.107.040832","article-title":"Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1)","volume":"73","author":"Undem","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12045","DOI":"10.1073\/pnas.0802354105","article-title":"Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1","volume":"105","author":"Materazzi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","unstructured":"Geppetti, P., and Holzer, P. (1996). Neurogenic Inflammation, CRC Press."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41582-018-0003-1","article-title":"CGRP as the target of new migraine therapies\u2014Successful translation from bench to clinic","volume":"14","author":"Edvinsson","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41467-022-28204-z","article-title":"Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice","volume":"13","author":"Nassini","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"136380","DOI":"10.1016\/j.neulet.2021.136380","article-title":"The role of TRP ion channels in migraine and headache","volume":"768","author":"Iannone","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/112_2014_18","article-title":"The TRPA1 channel in inflammatory and neuropathic pain and migraine","volume":"167","author":"Nassini","year":"2014","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"72S","DOI":"10.1378\/chest.129.1_suppl.72S","article-title":"Cough and the common cold: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Pratter","year":"2006","journal-title":"Chest"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1164\/ajrccm\/141.3.640","article-title":"Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy","volume":"141","author":"Irwin","year":"1990","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1164\/ajrccm.154.4.8887607","article-title":"Systemic oxidative stress in asthma, COPD, and smokers","volume":"154","author":"Rahman","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"S258","DOI":"10.1067\/mai.2000.110159","article-title":"Allergen sensitization through the skin induces systemic allergic responses","volume":"106","author":"Beck","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2222.2008.03149.x","article-title":"Inflammatory and oxidative stress biomarkers in allergic rhinitis: The effect of smoking","volume":"39","author":"Tanou","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/ACI.0b013e3282f3d913","article-title":"Importance of oxidative stress in the pathogenesis and treatment of asthma","volume":"8","author":"Riedl","year":"2008","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1113\/jphysiol.2007.148379","article-title":"Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs","volume":"586","author":"Nassenstein","year":"2008","journal-title":"J. Physiol."},{"key":"ref_73","first-page":"535","article-title":"Transient receptor potential channels as novel drug targets in respiratory diseases","volume":"11","author":"Nassini","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2015.03.022","article-title":"Vagal sensory neuron subtypes that differentially control breathing","volume":"161","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1877381801002030071","article-title":"The rising role of TRPA1 in asthma","volume":"2","author":"Facchinetti","year":"2010","journal-title":"Open Drug Discov. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI34192","article-title":"TRPA1 is a major oxidant sensor in murine airway sensory neurons","volume":"118","author":"Bessac","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_78","first-page":"2574","article-title":"Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents","volume":"118","author":"Andre","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0091-3057(91)90374-B","article-title":"Marijuana and tobacco smoke gas-phase cytotoxins","volume":"40","author":"Huber","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/toxsci\/kfi043","article-title":"Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine","volume":"84","author":"Witschi","year":"2005","journal-title":"Toxicol. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1038\/ncomms4125","article-title":"TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins","volume":"5","author":"Meseguer","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2174\/1871528113666140323202419","article-title":"Substance P at the neuro-immune crosstalk in the modulation of inflammation, asthma and antimicrobial host defense","volume":"13","author":"Sun","year":"2014","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0900591106","article-title":"A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma","volume":"106","author":"Caceres","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41598-020-57936-5","article-title":"Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma","volume":"10","author":"Reese","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/pai.12673","article-title":"TRPA1 gene polymorphisms and childhood asthma","volume":"28","author":"Gallo","year":"2017","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1164\/rccm.201508-1602OC","article-title":"Neurophenotypes in airway diseases. Insights from translational cough studies","volume":"193","author":"Belvisi","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-physiol-030212-183811","article-title":"TRPA1: A gatekeeper for inflammation","volume":"75","author":"Bautista","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/ar3464","article-title":"Integrins and their ligands in rheumatoid arthritis","volume":"13","author":"Lowin","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/s13075-015-0845-5","article-title":"Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner","volume":"17","author":"Lowin","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12950-016-0114-7","article-title":"The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets","volume":"13","author":"Lowin","year":"2016","journal-title":"J. Inflamm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphar.2017.00053","article-title":"Transient receptor potential ankyrin 1 channel expression on peripheral blood leukocytes from rheumatoid arthritic patients and correlation with pain and disability","volume":"8","author":"Pereira","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bcp.2018.05.015","article-title":"Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1)","volume":"154","author":"Lowin","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3389\/fphar.2019.00964","article-title":"TRPA1 ion channel determines beneficial and detrimental effects of GYY4137 in murine serum-transfer arthritis","volume":"10","author":"Batai","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"C354","DOI":"10.1152\/ajpcell.00096.2012","article-title":"Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin","volume":"304","author":"Hatano","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41419-020-02892-1","article-title":"Cannabidiol (CBD): A killer for inflammatory rheumatoid arthritis synovial fibroblasts","volume":"11","author":"Lowin","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Nummenmaa, E., Hamalainen, M., Pemmari, A., Moilanen, L.J., Tuure, L., Nieminen, R.M., Moilanen, T., Vuolteenaho, K., and Moilanen, E. (2020). Transient receptor potential ankyrin 1 (TRPA1) is involved in upregulating interleukin-6 expression in osteoarthritic chondrocyte models. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010087"},{"key":"ref_98","unstructured":"World Health Organization (2022, January 24). International Classification of Diseases 11th Revision. Available online: https:\/\/icd.who.int\/browse11\/l-m\/en."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"354.e1","DOI":"10.1016\/j.ajog.2018.12.039","article-title":"Clinical diagnosis of endometriosis: A call to action","volume":"220","author":"Agarwal","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.1111445","article-title":"The pains of endometriosis","volume":"308","author":"Berkley","year":"2005","journal-title":"Science"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.pain.2010.06.023","article-title":"Viscero-visceral hyperalgesia: Characterization in different clinical models","volume":"151","author":"Giamberardino","year":"2010","journal-title":"Pain"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/gutjnl-2011-300306","article-title":"Visceral hypersensitivity in endometriosis: A new target for treatment?","volume":"61","author":"Issa","year":"2012","journal-title":"Gut"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/0884217503261085","article-title":"More than just menstrual cramps: Symptoms and uncertainty among women with endometriosis","volume":"33","author":"Lemaire","year":"2004","journal-title":"J. Obstet. Gynecol. Neonatal. Nurs."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"E1738","DOI":"10.1210\/jc.2014-2282","article-title":"Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis","volume":"99","author":"Greaves","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1744806917705564","DOI":"10.1177\/1744806917705564","article-title":"Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis","volume":"13","author":"Bohonyi","year":"2017","journal-title":"Mol. Pain"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1097\/j.pain.0000000000001832","article-title":"Nonsurgical mouse model of endometriosis-associated pain that responds to clinically active drugs","volume":"161","author":"Fattori","year":"2020","journal-title":"Pain"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: Pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3389\/fcimb.2020.00468","article-title":"Increasing evidence that irritable bowel syndrome and functional gastrointestinal disorders have a microbial pathogenesis","volume":"10","author":"Carco","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0140-6736(12)60026-9","article-title":"Crohn\u2019s disease","volume":"380","author":"Baumgart","year":"2012","journal-title":"Lancet"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Eckmann","year":"2012","journal-title":"Lancet"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.3748\/wjg.v16.i25.3168","article-title":"Impact of pain on health-related quality of life in patients with inflammatory bowel disease","volume":"16","author":"Schirbel","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/ajg.2012.260","article-title":"Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: Systematic review and meta-analysis","volume":"107","author":"Halpin","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ibd.20848","article-title":"Pain and inflammatory bowel disease","volume":"15","author":"Bielefeldt","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"G885","DOI":"10.1152\/ajpgi.00463.2014","article-title":"Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: Pathophysiology, translational relevance, and challenges","volume":"308","author":"Prusator","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neulet.2008.05.093","article-title":"Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis","volume":"440","author":"Yang","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/jgh.13226","article-title":"Elevated H2O2 levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel","volume":"31","author":"Kogure","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"8632","DOI":"10.1038\/s41598-020-65618-5","article-title":"Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis","volume":"10","author":"Jain","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Kun, J., Szitter, I., Kem\u00e9ny, A., Perkecz, A., Kereskai, L., Poh\u00f3czky, K., Vincze, A., G\u00f3di, S., Szab\u00f3, I., and Szolcs\u00e1nyi, J. (2014). Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108164"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1136\/gutjnl-2015-310710","article-title":"The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1","volume":"66","author":"Bertin","year":"2017","journal-title":"Gut"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1053\/j.gastro.2011.07.002","article-title":"TRPA1 and substance P mediate colitis in mice","volume":"141","author":"Engel","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"104464","DOI":"10.1016\/j.phrs.2019.104464","article-title":"The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients","volume":"149","author":"Pagano","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis--an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"ref_126","first-page":"612","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"Sacks","year":"2018","journal-title":"Int. J. Stroke"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/CRD.0000000000000021","article-title":"Inflammation and atherosclerosis: A review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy","volume":"22","author":"Hartman","year":"2014","journal-title":"Cardiol. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1748-1716.2010.02203.x","article-title":"Transient receptor potential ankyrin 1: Emerging pharmacology and indications for cardiovascular biology","volume":"203","author":"Bodkin","year":"2011","journal-title":"Acta Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"eaaw5618","DOI":"10.1126\/sciimmunol.aaw5618","article-title":"Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway","volume":"4","author":"Wei","year":"2019","journal-title":"Sci. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3892\/ijmm.2015.2129","article-title":"P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation","volume":"35","author":"Peng","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.1801101","article-title":"ATP-gated P2X7 receptors require chloride channels to promote inflammation in human macrophages","volume":"202","author":"Janks","year":"2019","journal-title":"J. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1161\/ATVBAHA.115.307397","article-title":"Extracellular ATP induces vascular inflammation and atherosclerosis via purinergic receptor Y2 in mice","volume":"36","author":"Stachon","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11010-020-03818-3","article-title":"Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage","volume":"473","author":"Tian","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","article-title":"Molecular physiology of P2X receptors","volume":"82","author":"North","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-2999(99)00350-7","article-title":"Pharmacological characterization of recombinant human and rat P2X receptor subtypes","volume":"376","author":"Bianchi","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"812","DOI":"10.7150\/ijbs.15229","article-title":"Transient receptor potential ankyrin 1 channel involved in atherosclerosis and macrophage-foam cell formation","volume":"12","author":"Zhao","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.atherosclerosis.2020.04.004","article-title":"TRPA1 regulates macrophages phenotype plasticity and atherosclerosis progression","volume":"301","author":"Wang","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/cmi.2012.15","article-title":"New insights of T cells in the pathogenesis of psoriasis","volume":"9","author":"Cai","year":"2012","journal-title":"Cell. Mol. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.jaci.2017.01.011","article-title":"The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies","volume":"139","author":"Brunner","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.clindermatol.2014.12.004","article-title":"Epidemiology of childhood atopic dermatitis","volume":"33","author":"Garg","year":"2015","journal-title":"Clin. Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: A systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s43440-020-00206-y","article-title":"Pruritus in psoriasis and atopic dermatitis: Current treatments and new perspectives","volume":"73","author":"Kahremany","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nn.2789","article-title":"TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch","volume":"14","author":"Wilson","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/all.12488","article-title":"Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist","volume":"69","author":"Saarnilehto","year":"2014","journal-title":"Allergy"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"118906","DOI":"10.1016\/j.lfs.2020.118906","article-title":"TRPA1 deficiency alleviates inflammation of atopic dermatitis by reducing macrophage infiltration","volume":"266","author":"Zeng","year":"2021","journal-title":"Life Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1096\/fj.13-229948","article-title":"TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis","volume":"27","author":"Liu","year":"2013","journal-title":"FASEB J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"107472","DOI":"10.1016\/j.celrep.2020.03.036","article-title":"Periostin activation of integrin receptors on sensory neurons induces allergic itch","volume":"31","author":"Mishra","year":"2020","journal-title":"Cell Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1111\/jcmm.14392","article-title":"Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jid.2017.12.029","article-title":"The genetics of chronic itch: Gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch","volume":"138","author":"Nattkemper","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.jid.2018.02.040","article-title":"TRPA1 acts in a protective manner in imiquimod-induced psoriasiform dermatitis in mice","volume":"138","author":"Kodji","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/1346-8138.12119","article-title":"Mustard seed (Sinapis Alba Linn) attenuates imiquimod-induced psoriasiform inflammation of BALB\/c mice","volume":"40","author":"Yang","year":"2013","journal-title":"J. Dermatol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1002\/glia.23051","article-title":"TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis","volume":"64","author":"Saghy","year":"2016","journal-title":"Glia"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12974-016-0557-z","article-title":"Role of transient receptor potential ankyrin 1 channels in Alzheimer\u2019s disease","volume":"13","author":"Lee","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2018.03.020","article-title":"Behavioural alterations and morphological changes are attenuated by the lack of TRPA1 receptors in the cuprizone-induced demyelination model in mice","volume":"320","author":"Kriszta","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"113241","DOI":"10.1016\/j.expneurol.2020.113241","article-title":"TRPA1 activation mediates nociception behaviors in a mouse model of relapsing-remitting experimental autoimmune encephalomyelitis","volume":"328","author":"Dalenogare","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1007\/s12035-020-01891-9","article-title":"Nociception in a progressive multiple sclerosis model in mice is dependent on spinal TRPA1 channel activation","volume":"57","author":"Ritter","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"ra2","DOI":"10.1126\/scisignal.2005659","article-title":"Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation","volume":"8","author":"Sullivan","year":"2015","journal-title":"Sci. Signal."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e35316","DOI":"10.7554\/eLife.35316","article-title":"Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke","volume":"7","author":"Pires","year":"2018","journal-title":"eLife"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2174\/18715273113129990056","article-title":"TRP channels: New potential therapeutic approaches in CNS neuropathies","volume":"12","author":"Morelli","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1750-3639.1991.tb00666.x","article-title":"Alzheimer\u2019s disease: A description of the structural lesions","volume":"1","author":"Probst","year":"1991","journal-title":"Brain Pathol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","article-title":"The precursor of Alzheimer\u2019s disease amyloid A4 protein resembles a cell-surface receptor","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nbd.2008.02.003","article-title":"The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway","volume":"30","author":"Ferreiro","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/glia.20338","article-title":"Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice","volume":"53","author":"Seabrook","year":"2006","journal-title":"Glia"},{"key":"ref_169","first-page":"136","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease","volume":"3","author":"Wang","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e058550","DOI":"10.1002\/alz.058550","article-title":"Role of endothelial TRPA1 expression in blood-brain barrier dysfunction","volume":"17","author":"Yang","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/brain\/awab281","article-title":"Astrocyte-neuron interplay is critical for Alzheimer\u2019s disease pathogenesis and is rescued by TRPA1 channel blockade","volume":"145","author":"Paumier","year":"2021","journal-title":"Brain"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0972-2327.167713","article-title":"Research in Parkinson\u2019s disease in India: A review","volume":"19","author":"Surathi","year":"2016","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Cacabelos, R. (2017). Parkinson\u2019s disease: From pathogenesis to pharmacogenomics. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030551"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2165\/00023210-200317100-00004","article-title":"Neuroprotective strategies in Parkinson\u2019s disease: An update on progress","volume":"17","author":"Mandel","year":"2003","journal-title":"CNS Drugs"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1038\/s41467-018-04569-y","article-title":"TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons","volume":"9","author":"Maatouk","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-94-024-1088-4_5","article-title":"TRPC channels and programmed cell death","volume":"976","author":"Zhou","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fnins.2020.00782","article-title":"TRP channels role in pain associated with neurodegenerative diseases","volume":"14","author":"Duitama","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mcn.2018.01.006","article-title":"Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson\u2019s disease","volume":"88","author":"Ambaw","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jnc.14025","article-title":"Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury","volume":"141","author":"Tian","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40035-021-00239-0","article-title":"Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson\u2019s disease: Implication of acrolein and TRPA1","volume":"10","author":"Shi","year":"2021","journal-title":"Transl. Neurodegener."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"45741","DOI":"10.1038\/srep45741","article-title":"Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: Involvement of alpha-synuclein aggregation and programmed cell death","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12031-016-0828-2","article-title":"Neuroprotective role of MicroRNA-22 in a 6-hydroxydopamine-induced cell model of parkinson\u2019s disease via regulation of its target gene TRPM7","volume":"60","author":"Yang","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1152\/jn.00994.2010","article-title":"Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat","volume":"106","author":"Chung","year":"2011","journal-title":"J. Neurophysiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"105026","DOI":"10.1016\/j.phrs.2020.105026","article-title":"Therapeutic potential of pharmacological agents targeting TRP channels in CNS disorders","volume":"159","author":"Thapak","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler. J."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"Sawcer","year":"2011","journal-title":"Nature"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10072-015-2146-9","article-title":"Headache in multiple sclerosis and autoimmune disorders","volume":"36","author":"Prone","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11916-010-0143-5","article-title":"Tension-type headache and migraine in multiple sclerosis","volume":"14","author":"Kister","year":"2010","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1007\/s10072-009-0053-7","article-title":"Headache and multiple sclerosis: Clinical and therapeutic correlations","volume":"30","year":"2009","journal-title":"Neurol. Sci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s10194-019-0968-1","article-title":"Migraine-provoking substances evoke periorbital allodynia in mice","volume":"20","author":"Landini","year":"2019","journal-title":"J. Headache Pain"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S1474-4422(15)00334-8","article-title":"The search for the target antigens of multiple sclerosis, part 1: Autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets","volume":"15","author":"Hohlfeld","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3389\/fimmu.2020.00760","article-title":"B and T cells driving multiple sclerosis: Identity, mechanisms and potential triggers","volume":"11","author":"Rijvers","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1750-3639.2007.00110.x","article-title":"Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis","volume":"18","author":"Gray","year":"2008","journal-title":"Brain Pathol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbadis.2010.06.011","article-title":"Radical changes in multiple sclerosis pathogenesis","volume":"1812","author":"Witte","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.freeradbiomed.2008.09.023","article-title":"Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression","volume":"45","author":"Schreibelt","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nn.3000","article-title":"TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3","volume":"15","author":"Shigetomi","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Gudi, V., \u0160kuljec, J., Yildiz, \u00d6., Frichert, K., Skripuletz, T., Moharregh-Khiabani, D., Voss, E., Wissel, K., Wolter, S., and Stangel, M. (2011). Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022623"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"8284","DOI":"10.1523\/JNEUROSCI.0841-12.2012","article-title":"IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination","volume":"32","author":"Kang","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/glia.20469","article-title":"Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination","volume":"55","author":"Zeger","year":"2007","journal-title":"Glia"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Mihai, D.P., Nitulescu, G.M., Ion, G.N.D., Ciotu, C.I., Chirita, C., and Negres, S. (2019). Computational drug repurposing algorithm targeting TRPA1 calcium channel as a potential therapeutic solution for multiple sclerosis. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11090446"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Dalenogare, D.P., Ritter, C., Bellinaso, F.R.A., Kudsi, S.Q., Pereira, G.C., Fialho, M.F.P., Luckemeyer, D.D., Antoniazzi, C.T.D., Landini, L., and Ferreira, J. (2021). Periorbital nociception in a progressive multiple sclerosis mouse model is dependent on TRPA1 channel activation. Pharmaceuticals, 14.","DOI":"10.3390\/ph14080831"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2021.07.011","article-title":"TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice","volume":"175","author":"Peres","year":"2021","journal-title":"Brain Res. Bull."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4529\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:57:11Z","timestamp":1760137031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":202,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23094529"],"URL":"https:\/\/doi.org\/10.3390\/ijms23094529","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]}}}