{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:05:49Z","timestamp":1784293549101,"version":"3.55.0"},"reference-count":77,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["K 125436, Z. Magl\u00f3czky"],"award-info":[{"award-number":["K 125436, Z. Magl\u00f3czky"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Brain Research Program","award":["2017-1.2.1-NKP-2017-00002"],"award-info":[{"award-number":["2017-1.2.1-NKP-2017-00002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Focal cortical dysplasia (FCD) is one of the most common causes of drug-resistant epilepsy. As several studies have revealed, the abnormal functioning of the perisomatic inhibitory system may play a role in the onset of seizures. Therefore, we wanted to investigate whether changes of perisomatic inhibitory inputs are present in FCD. Thus, the input properties of abnormal giant- and control-like principal cells were examined in FCD type IIB patients. Surgical samples were compared to controls from the same cortical regions with short postmortem intervals. For the study, six subjects were selected\/each group. The perisomatic inhibitory terminals were quantified in parvalbumin and neuronal nuclei double immunostained sections using a confocal fluorescent microscope. The perisomatic input of giant neurons was extremely abundant, whereas control-like cells of the same samples had sparse inputs. A comparison of pooled data shows that the number of parvalbumin-immunopositive perisomatic terminals contacting principal cells was significantly larger in epileptic cases. The analysis showed some heterogeneity among epileptic samples. However, five out of six cases had significantly increased perisomatic input. Parameters of the control cells were homogenous. The reorganization of the perisomatic inhibitory system may increase the probability of seizure activity and might be a general mechanism of abnormal network activity.<\/jats:p>","DOI":"10.3390\/ijms23094746","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:16:28Z","timestamp":1650921388000},"page":"4746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reorganization of Parvalbumin Immunopositive Perisomatic Innervation of Principal Cells in Focal Cortical Dysplasia Type IIB in Human Epileptic Patients"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-7520","authenticated-orcid":false,"given":"Cec\u00edlia","family":"Szekeres-Paraczky","sequence":"first","affiliation":[{"name":"Human Brain Research Laboratory, Institute of Experimental Medicine, ELKH, 1083 Budapest, Hungary"},{"name":"Szent\u00e1gothai J\u00e1nos Doctoral School of Neuroscience, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Szocsics","sequence":"additional","affiliation":[{"name":"Human Brain Research Laboratory, Institute of Experimental Medicine, ELKH, 1083 Budapest, Hungary"},{"name":"Szent\u00e1gothai J\u00e1nos Doctoral School of Neuroscience, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lor\u00e1nd","family":"Er\u0151ss","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery and Center of Neuromodulation, National Institute of Mental Health Neurology and Neurosurgery, 1145 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-5351","authenticated-orcid":false,"given":"D\u00e1niel","family":"Fab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery and Center of Neuromodulation, National Institute of Mental Health Neurology and Neurosurgery, 1145 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"M\u00f3d","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Borb\u00e1la Hospital, 2800 Tatab\u00e1nya, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Magl\u00f3czky","sequence":"additional","affiliation":[{"name":"Human Brain Research Laboratory, Institute of Experimental Medicine, ELKH, 1083 Budapest, Hungary"},{"name":"Szent\u00e1gothai J\u00e1nos Doctoral School of Neuroscience, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/cns.12345","article-title":"Basic mechanisms of epileptogenesis in pediatric cortical dysplasia","volume":"21","author":"Abdijadid","year":"2015","journal-title":"CNS Neurosci. 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