{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:15:01Z","timestamp":1788002101073,"version":"build-2784847793"},"reference-count":99,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The SARS-CoV-2 infection is a highly contagious viral infection, which has claimed millions of lives in the last two years. The infection can cause acute respiratory distress, myocarditis, and systemic inflammatory response in severe cases. The interaction of the viral spike protein with the angiotensin-converting enzyme in various tissues causes damage to vital organs and tissues, leading to complications in the post-infection period. Vaccines and antiviral drugs have improved patient response to the infection, but the long-term effect on vital organs is still unknown. Investigations are now focused on supportive nutrient therapies, which can mitigate the susceptibility as well as the long-term complications of COVID-19. Selenium is one such micronutrient that plays a vital role in preventing oxidative stress induced by the virus. Further, selenium is important for effective immune response, controlling systemic inflammation, and maintain overall health of humans. We examine the role of selenium in various aspects of SARS-CoV-2 infection and address the importance of selenium supplementation in reducing the susceptibility and severity of infection in this review.<\/jats:p>","DOI":"10.3390\/ijms23094809","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:40:57Z","timestamp":1651066857000},"page":"4809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Can Selenium Reduce the Susceptibility and Severity of SARS-CoV-2?\u2014A Comprehensive Review"],"prefix":"10.3390","volume":"23","author":[{"given":"Muhammed","family":"Majeed","sequence":"first","affiliation":[{"name":"Sami-Sabinsa Group Limited, 19\/1&19\/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560-058, Karnataka, India"},{"name":"Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-4110","authenticated-orcid":false,"given":"Kalyanam","family":"Nagabhushanam","sequence":"additional","affiliation":[{"name":"Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priji","family":"Prakasan","sequence":"additional","affiliation":[{"name":"Sami-Sabinsa Group Limited, 19\/1&19\/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560-058, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-1726","authenticated-orcid":false,"given":"Lakshmi","family":"Mundkur","sequence":"additional","affiliation":[{"name":"Sami-Sabinsa Group Limited, 19\/1&19\/2, I Main, II Phase, Peenya Industrial Area, Bangalore 560-058, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species Severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","author":"Gorbalenya","year":"2020","journal-title":"Nat. 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