{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:15:57Z","timestamp":1786720557652,"version":"build-2736575974"},"reference-count":100,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Henan Province, China","award":["202102310153"],"award-info":[{"award-number":["202102310153"]}]},{"name":"Henan Province, China","award":["20211021002"],"award-info":[{"award-number":["20211021002"]}]},{"name":"Henan Province, China","award":["20217003002"],"award-info":[{"award-number":["20217003002"]}]},{"name":"Medical College of Henan University","award":["202102310153"],"award-info":[{"award-number":["202102310153"]}]},{"name":"Medical College of Henan University","award":["20211021002"],"award-info":[{"award-number":["20211021002"]}]},{"name":"Medical College of Henan University","award":["20217003002"],"award-info":[{"award-number":["20217003002"]}]},{"name":"Innovation and Entrepreneurship Training Program for Henan University Students","award":["202102310153"],"award-info":[{"award-number":["202102310153"]}]},{"name":"Innovation and Entrepreneurship Training Program for Henan University Students","award":["20211021002"],"award-info":[{"award-number":["20211021002"]}]},{"name":"Innovation and Entrepreneurship Training Program for Henan University Students","award":["20217003002"],"award-info":[{"award-number":["20217003002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) is a recently discovered cytoplasmic multiprotein complex involved in inflammation. The NLRP3 inflammasome contains NLRP3, apoptosis-related specific protein (ASC) and precursor caspase-1. The NLRP3 inflammasome is involved in many diseases, including diabetes. H2S is a harmful gas with a rotten egg smell. Recently, it has been identified as the third gas signal molecule after nitric oxide and carbon monoxide. It has many biological functions and plays an important role in many diseases, including diabetes. In recent years, it has been reported that H2S regulation of the NLRP3 inflammasome contributes to a variety of diseases. However, the mechanism has not been fully understood. In this review, we summarized the recent role and mechanism of H2S in regulating the NLRP3 inflammasome in diabetes, in order to provide a theoretical basis for future research.<\/jats:p>","DOI":"10.3390\/ijms23094818","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:40:57Z","timestamp":1651066857000},"page":"4818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Role of H2S Regulating NLRP3 Inflammasome in Diabetes"],"prefix":"10.3390","volume":"23","author":[{"given":"Huijie","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"},{"name":"School of Nursing and Health, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-3563","authenticated-orcid":false,"given":"Honggang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/imr.12286","article-title":"Initiation and perpetuation of NLRP3 inflammasome activation and assembly","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell Mol. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cytogfr.2014.07.001","article-title":"Advances in Nod-like receptors (NLR) biology","volume":"25","author":"Barbe","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/glia.22499","article-title":"Human astrocytes express a novel NLRP2 inflammasome","volume":"61","author":"Minkiewicz","year":"2013","journal-title":"Glia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.4049\/jimmunol.171.12.6329","article-title":"Cutting edge: CIAS1\/cryopyrin\/PYPAF1\/NALP3\/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties","volume":"171","author":"Harton","year":"2003","journal-title":"J. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/jpi.12303","article-title":"Same molecule but different expression: Aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin","volume":"60","author":"Volt","year":"2016","journal-title":"J. Pineal Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3389\/fimmu.2019.02538","article-title":"Pharmacological Inhibitors of the NLRP3 Inflammasome","volume":"10","author":"Zahid","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7269150","DOI":"10.1155\/2020\/7269150","article-title":"The role of autophagy and NLRP3 inflammasome in liver fibrosis","volume":"2020","author":"Tao","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-beta","volume":"9","author":"Halle","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fimmu.2013.00333","article-title":"Functions of NOD-Like Receptors in Human Diseases","volume":"4","author":"Zhong","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cell.2014.01.063","article-title":"Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation","volume":"156","author":"Cai","year":"2014","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.12688\/f1000research.8614.1","article-title":"Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation","volume":"5","author":"Prochnicki","year":"2016","journal-title":"F1000Research"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1084\/jem.20171749","article-title":"A noncanonical function of cGAMP in inflammasome priming and activation","volume":"214","author":"Swanson","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/FJC.0000000000000704","article-title":"NLRP3 Inflammasome: A Novel Player in Metabolically Induced Inflammation-Potential Influence on the Myocardium","volume":"74","author":"Sokolova","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Meyers, A.K., and Zhu, X. (2020). The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging. Cells, 9.","DOI":"10.3390\/cells9081808"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.7150\/ijbs.47595","article-title":"Hydrogen sulfide plays an important role by influencing NLRP3 inflammasome","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00018-016-2406-8","article-title":"H2S biosynthesis and catabolism: New insights from molecular studies","volume":"74","author":"Rose","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7150\/ijbs.38143","article-title":"Hydrogen sulfide plays an important protective role through influencing endoplasmic reticulum stress in diseases","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bone.2019.03.034","article-title":"Role of hydrogen sulfide in the musculoskeletal system","volume":"124","author":"Behera","year":"2019","journal-title":"Bone"},{"key":"ref_29","first-page":"3948","article-title":"Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3\/HIF-1alpha pathway in H9c2 cardiomyocytes","volume":"18","author":"Li","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.freeradbiomed.2019.07.022","article-title":"S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2","volume":"143","author":"Tocmo","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/2045-9912.266990","article-title":"Hydrogen sulphide-releasing aspirin enhances cell capabilities of anti-oxidative lesions and anti-inflammation","volume":"9","author":"Zhao","year":"2019","journal-title":"Med. Gas Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/HYPERTENSIONAHA.116.08964","article-title":"Impaired hydrogen sulfide-mediated vasodilation contributes to microvascular endothelial dysfunction in hypertensive adults","volume":"69","author":"Greaney","year":"2017","journal-title":"Hypertension"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1177\/1535370217732325","article-title":"Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt\/eNOS\/NO pathway","volume":"242","author":"Jin","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3389\/fphar.2017.00608","article-title":"H2S-Induced sulfhydration: Biological function and detection methodology","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","article-title":"Diabetic cardiomyopathy: A hyperglycaemia- and insulin-resistance-induced heart disease","volume":"61","author":"Jia","year":"2018","journal-title":"Diabetologia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41401-018-0042-6","article-title":"Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy","volume":"40","author":"Knapp","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12933-020-01188-0","article-title":"Impact of peroxisome proliferator-activated receptor-alpha on diabetic cardiomyopathy","volume":"20","author":"Wang","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.2337\/db16-1237","article-title":"MICU1 alleviates diabetic cardiomyopathy through mitochondrial Ca2+-dependent antioxidant response","volume":"66","author":"Ji","year":"2017","journal-title":"Diabetes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.molmed.2021.03.004","article-title":"Sirtuins: To be or not to be in diabetic cardiomyopathy","volume":"27","author":"Palomer","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1177\/1535370219861283","article-title":"LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis","volume":"244","author":"Ge","year":"2019","journal-title":"Exp. Biol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Jubaidi, F.F., Zainalabidin, S., Taib, I.S., Hamid, Z.A., and Budin, S.B. (2021). The potential role of flavonoids in ameliorating diabetic cardiomyopathy via alleviation of cardiac oxidative stress, inflammation and apoptosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105094"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"111410","DOI":"10.1016\/j.biopha.2021.111410","article-title":"Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats","volume":"138","author":"Abukhalil","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1159\/000453208","article-title":"Exogenous hydrogen sulfide attenuates high glucose-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation by suppressing TLR4\/NF-kappaB pathway in H9c2 cells","volume":"40","author":"Huang","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/kjm2.12305","article-title":"Skimmin protects diabetic cardiomyopathy in streptozotocin-induced diabetic rats","volume":"37","author":"Liang","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41401-020-0490-7","article-title":"Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation","volume":"42","author":"Song","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.7150\/ijbs.29680","article-title":"Metformin inhibits the NLRP3 inflammasome via AMPK\/mTOR-dependent effects in diabetic cardiomyopathy","volume":"15","author":"Yang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1535370219899899","article-title":"Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats","volume":"245","author":"Jia","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.3382\/ps\/pez066","article-title":"Dietary selenomethionine increases antioxidant capacity of geese by improving glutathione and thioredoxin systems","volume":"98","author":"Wan","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/cvr\/cvy183","article-title":"A thioredoxin-mimetic peptide exerts potent anti-inflammatory, antioxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet","volume":"115","author":"Canesi","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/eji.202048851","article-title":"The thioredoxin-1 inhibitor Txnip restrains effector T-cell and germinal center B-cell expansion","volume":"51","author":"Muri","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fsi.2018.09.064","article-title":"Characterization and immune function of the thioredoxin-interacting protein (TXNIP) from Litopenaeus vannamei","volume":"84","author":"Zuo","year":"2019","journal-title":"Fish. Shellfish Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1089\/ars.2017.7440","article-title":"Dl-3-n-Butylphthalide inhibits NLRP3 inflammasome and mitigates Alzheimer\u2019s-like pathology via Nrf2-TXNIP-TrX axis","volume":"30","author":"Wang","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"102033","DOI":"10.1016\/j.redox.2021.102033","article-title":"Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy","volume":"45","author":"Dai","year":"2021","journal-title":"Redox Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6617816","DOI":"10.1155\/2021\/6617816","article-title":"RIPK3-mediated necroptosis in diabetic cardiomyopathy requires CaMKII activation","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.2147\/DMSO.S300388","article-title":"Changes of necroptosis in irbesartan medicated cardioprotection in diabetic rats","volume":"14","author":"Xu","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2022.01.028","article-title":"Protective role of hydrogen sulfide against diabetic cardiomyopathy via alleviating necroptosis","volume":"181","author":"Gong","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.freeradbiomed.2020.12.449","article-title":"Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress","volume":"164","author":"Mohammed","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10495-018-1455-x","article-title":"Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis","volume":"23","author":"Chen","year":"2018","journal-title":"Apoptosis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1039\/c9mt00295b","article-title":"The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine","volume":"12","author":"Zhang","year":"2020","journal-title":"Metallomics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"mfab048","DOI":"10.1093\/mtomcs\/mfab048","article-title":"Selenomethionine alleviates LPS-induced JNK\/NLRP3 inflammasome-dependent necroptosis by modulating miR-15a and oxidative stress in chicken lungs","volume":"13","author":"Wang","year":"2021","journal-title":"Metallomics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1038\/s41467-021-24736-y","article-title":"S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo\/YAP-dependent diabetes-accelerated atherosclerosis","volume":"12","author":"Chao","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1161\/01.CIR.0000013954.65303.C5","article-title":"Prevention conference VI: Diabetes and cardiovascular disease: Writing group II: Pathogenesis of atherosclerosis in diabetes","volume":"105","author":"Eckel","year":"2002","journal-title":"Circulation"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"94","DOI":"10.7555\/JBR.33.20190071","article-title":"H 2S protects against diabetes-accelerated atherosclerosis by preventing the activation of NLRP3 inflammasome","volume":"34","author":"Zheng","year":"2019","journal-title":"J. Biomed. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"399","DOI":"10.15537\/smj.2015.4.10307","article-title":"Gestational diabetes mellitus","volume":"36","author":"Alfadhli","year":"2015","journal-title":"Saudi Med. J."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"ACOG (2018). ACOG Practice bulletin No. 190: Gestational diabetes mellitus. Obstet. Gynecol., 131, e49\u2013e64.","DOI":"10.1097\/AOG.0000000000002501"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/dme.12381","article-title":"Trying to understand gestational diabetes","volume":"31","author":"Catalano","year":"2014","journal-title":"Diabet. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12958-019-0522-7","article-title":"Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice","volume":"17","author":"Zhang","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s40268-022-00382-7","article-title":"NLRP3 inhibitor tranilast attenuates gestational diabetes mellitus in a genetic mouse model","volume":"22","author":"Cao","year":"2022","journal-title":"Drugs R D"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"118850","DOI":"10.1016\/j.lfs.2020.118850","article-title":"Silenced microRNA-222 suppresses inflammatory response in gestational diabetes mellitus mice by promoting CXCR4","volume":"266","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3892\/etm.2021.11017","article-title":"NLRP3 inflammasome activation in gestational diabetes mellitus placentas is associated with hydrogen sulfide synthetase deficiency","volume":"23","author":"Wu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Unamuno, X., Gomez-Ambrosi, J., Rodriguez, A., Becerril, S., Fruhbeck, G., and Catalan, V. (2018). Adipokine dysregulation and adipose tissue inflammation in human obesity. Eur. J. Clin. Investig., 48.","DOI":"10.1111\/eci.12997"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.coph.2017.08.006","article-title":"Adipose tissue inflammation in obesity: A metabolic or immune response?","volume":"37","author":"Stolarczyk","year":"2017","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1042\/CS20190578","article-title":"Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis","volume":"133","author":"Anthony","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/s41423-019-0296-z","article-title":"NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling","volume":"18","author":"Unamuno","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"ref_77","first-page":"300060521992981","article-title":"GLP-1 alleviates NLRP3 inflammasome-dependent inflammation in perivascular adipose tissue by inhibiting the NF-kappaB signalling pathway","volume":"49","author":"Chen","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"bio043653","DOI":"10.1242\/bio.043653","article-title":"Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway","volume":"8","author":"Wang","year":"2019","journal-title":"Biol. Open"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2014.01.009","article-title":"Hydrogen sulfide protected gastric epithelial cell from ischemia\/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-kappaB dependent anti-inflammation pathway","volume":"725","author":"Guo","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cyto.2010.12.006","article-title":"Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung","volume":"53","author":"Chen","year":"2011","journal-title":"Cytokine"},{"key":"ref_81","first-page":"771","article-title":"Hydrogen sulfide modulates high glucose-induced NLRP3 inflammasome activation in 3T3-L1 adipocytes","volume":"19","author":"Hu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wang, W., and Lo, A.C.Y. (2018). Diabetic Retinopathy: Pathophysiology and Treatments. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061816"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000499541","article-title":"Diabetic retinopathy in the context of patients with diabetes","volume":"62","author":"Hernandez","year":"2019","journal-title":"Ophthalmic Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S2213-8587(18)30128-1","article-title":"Incidence and progression of diabetic retinopathy: A systematic review","volume":"7","author":"Sabanayagam","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.2147\/DMSO.S301157","article-title":"Salusin-beta mediates high glucose-induced inflammation and apoptosis in retinal capillary endothelial cells via a ROS-dependent pathway in diabetic retinopathy","volume":"14","author":"Wang","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9247947","DOI":"10.1155\/2021\/9247947","article-title":"Geniposide attenuates hyperglycemia-induced oxidative stress and inflammation by activating the Nrf2 signaling pathway in experimental diabetic retinopathy","volume":"2021","author":"Tu","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.freeradbiomed.2021.03.016","article-title":"Suppressing long noncoding RNA OGRU ameliorates diabetic retinopathy by inhibition of oxidative stress and inflammation via miR-320\/USP14 axis","volume":"169","author":"Fu","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zeng, Q., Luo, Y., Fang, J., Xu, S., Hu, Y.H., and Yin, M. (2021). Circ_0000615 promotes high glucose-induced human retinal pigment epithelium cell apoptosis, inflammation and oxidative stress via miR-646\/YAP1 axis in diabetic retinopathy. Eur. J. Ophthalmol., 11206721211020200.","DOI":"10.1177\/11206721211020200"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8908960","DOI":"10.1155\/2019\/8908960","article-title":"Hydrogen sulfide attenuates high glucose-induced human retinal pigment epithelial cell inflammation by inhibiting ROS formation and NLRP3 inflammasome activation","volume":"2019","author":"Wang","year":"2019","journal-title":"Mediators Inflamm."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"107399","DOI":"10.1016\/j.intimp.2021.107399","article-title":"Hydrogen sulfide exacerbated periodontal inflammation and induced autophagy in experimental periodontitis","volume":"93","author":"Ni","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.bbapap.2014.01.002","article-title":"H2S and its role in redox signaling","volume":"1844","author":"Kabil","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"8061823","DOI":"10.1155\/2019\/8061823","article-title":"Hydrogen sulfide gas exposure induces necroptosis and promotes inflammation through the MAPK\/NF-kappaB pathway in broiler spleen","volume":"2019","author":"Chi","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Trevisan, C.S.C., Garcia-Araujo, A.S., Duarte, A., Furino, V.O., Russo, T.L., Fujimoto, A., Souza, H.C.D., Jaenisch, R.B., Arena, R., and Borghi-Silva, A. (2021). Effects of respiratory muscle training on parasympathetic activity in diabetes mellitus. Braz. J. Med. Biol. Res., 54.","DOI":"10.1590\/1414-431x2020e10865"},{"key":"ref_94","first-page":"2145","article-title":"Protective effect of genistein on diaphragm injury in diabetic rats","volume":"37","author":"Jia","year":"2018","journal-title":"Lat. Am. J. Pharm."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"R290","DOI":"10.1152\/ajpregu.00108.2017","article-title":"Changes in microvascular density differentiate metabolic health outcomes in monkeys with prior radiation exposure and subsequent skeletal muscle ECM remodeling","volume":"313","author":"Fanning","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/hep.29523","article-title":"NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice","volume":"67","author":"Wree","year":"2018","journal-title":"Hepatology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molimm.2018.05.003","article-title":"Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation","volume":"99","author":"Li","year":"2018","journal-title":"Mol. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mce.2018.08.002","article-title":"NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice","volume":"478","author":"Wu","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1177\/1535370220931038","article-title":"Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats","volume":"245","author":"Yang","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbrc.2017.02.021","article-title":"Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression","volume":"485","author":"Li","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4818\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:01:57Z","timestamp":1760137317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":100,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23094818"],"URL":"https:\/\/doi.org\/10.3390\/ijms23094818","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]}}}