{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:01:19Z","timestamp":1789513279711,"version":"build-2803163510"},"reference-count":10,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","award":["22H03281"],"award-info":[{"award-number":["22H03281"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Special Issue \u201cOrofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021\u201d contains 6 articles published by 41 authors from different countries focusing on nucleus accumbens core GABAergic neurons, receptor-interacting serine\/threonine-protein kinase 1, pannexin 1-mediated ATP signaling, ultra-low-frequency transcutaneous electrical nerve stimulation, and triamcinolone acetonide. The content covers several pain models, including neuropathic pain caused by peripheral nerve constriction or malpositioned dental implants, tongue cancer, myogenous temporomandibular dysfunction, and oral ulcerative mucositis. In addition, a review paper on trigeminal neuralgia is included.<\/jats:p>","DOI":"10.3390\/ijms23094826","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:40:57Z","timestamp":1651066857000},"page":"4826","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-2605","authenticated-orcid":false,"given":"Yoshizo","family":"Matsuka","sequence":"first","affiliation":[{"name":"Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00702-020-02157-3","article-title":"Chronic orofacial pain","volume":"127","author":"Ananthan","year":"2020","journal-title":"J. Neural Transm."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/0333102419893823","article-title":"International Classification of Orofacial Pain, (ICOP)","volume":"40","author":"Benoliel","year":"2020","journal-title":"Cephalalgia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: Progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jpain.2013.06.008","article-title":"An overview of animal models of pain: Disease models and outcome measures","volume":"14","author":"Gregory","year":"2003","journal-title":"J. Pain"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Islam, J., KC, E., Kim, S., Kim, H.K., and Park, Y.S. (2021). Stimulating GABAergic Neurons in the Nucleus Accumbens Core Alters the Trigeminal Neuropathic Pain Responses in a Rat Model of Infraorbital Nerve Injury. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168421"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Son, J.Y., Ju, J.S., Kim, Y.M., and Ahn, D.K. (2022). TNF-\u03b1-Mediated RIPK1 Pathway Participates in the Development of Trigeminal Neuropathic Pain in Rats. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010506"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Koyama, R., Iwata, K., Hayashi, Y., Hitomi, S., Shibuta, I., Furukawa, A., Asano, S., Kaneko, T., Yonehara, Y., and Shinoda, M. (2021). Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal Subnucleus Caudalis Is Involved in Tongue Cancer Pain. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111404"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hsieh, Y.-L., Yang, C.-C., and Yang, N.-P. (2021). Ultra-Low Frequency Transcutaneous Electrical Nerve Stimulation on Pain Modulation in a Rat Model with Myogenous Temporomandibular Dysfunction. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189906"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Naniwa, M., Nakatomi, C., Hitomi, S., Matsuda, K., Tabuchi, T., Sugiyama, D., Kubo, S., Miyamura, Y., Yoshino, K., and Akifusa, S. (2021). Analgesic Mechanisms of Steroid Ointment against Oral Ulcerative Mucositis in a Rat Model. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212600"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chen, Q.L., Yi, D.I., Perez, J.N.J., Liu, M., Chang, S.D., Barad, M.J., Lim, M., and Qian, X. (2022). The Molecular Basis and Pathophysiology of Trigeminal Neuralgia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073604"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4826\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:02:03Z","timestamp":1760137323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23094826"],"URL":"https:\/\/doi.org\/10.3390\/ijms23094826","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]}}}