{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:32:36Z","timestamp":1790112756117,"version":"4.0.1"},"reference-count":185,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Peritoneal dialysis (PD) is an efficient renal replacement therapy for patients with end-stage renal disease. Even if it ensures an outcome equivalent to hemodialysis and a better quality of life, in the long-term, PD is associated with the development of peritoneal fibrosis and the consequents patient morbidity and PD technique failure. This unfavorable effect is mostly due to the bio-incompatibility of PD solution (mainly based on high glucose concentration). In the present review, we described the mechanisms and the signaling pathway that governs peritoneal fibrosis, epithelial to mesenchymal transition of mesothelial cells, and angiogenesis. Lastly, we summarize the present and future strategies for developing more biocompatible PD solutions.<\/jats:p>","DOI":"10.3390\/ijms23094831","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"4831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Fibrosis of Peritoneal Membrane as Target of New Therapies in Peritoneal Dialysis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-2481","authenticated-orcid":false,"given":"Valentina","family":"Masola","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-6314","authenticated-orcid":false,"given":"Mario","family":"Bonomini","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology and Dialysis, G. d\u2019Annunzio University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-4597","authenticated-orcid":false,"given":"Silvio","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Piazza Miraglia, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-5322","authenticated-orcid":false,"given":"Lorenzo","family":"Di Liberato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology and Dialysis, G. d\u2019Annunzio University, 66013 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Vecchi","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Santa Maria Hospital, 05100 Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1191-7418","authenticated-orcid":false,"given":"Maurizio","family":"Onisto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-2370","authenticated-orcid":false,"given":"Giovanni","family":"Gambaro","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Department of Medicine, Piazzale A. Stefani 1, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Sant\u2019Eugenio Hospital, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arduino","family":"Arduini","sequence":"additional","affiliation":[{"name":"R&D Department, Iperboreal Pharma, 65122 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s40258-018-00455-2","article-title":"Cost Effectiveness of Dialysis Modalities: A Systematic Review of Economic Evaluations","volume":"17","author":"Howell","year":"2019","journal-title":"Appl. Health Econ. 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