{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:46:17Z","timestamp":1782276377362,"version":"3.54.5"},"reference-count":54,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Fondos Sectoriales Consejo Nacional de Ciencia y Tecnologia","doi-asserted-by":"publisher","award":["289499"],"award-info":[{"award-number":["289499"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Fondos Sectoriales Consejo Nacional de Ciencia y Tecnologia","doi-asserted-by":"publisher","award":["R-2015-785-015"],"award-info":[{"award-number":["R-2015-785-015"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Mexicano del Seguro Social (MM)","award":["289499"],"award-info":[{"award-number":["289499"]}]},{"name":"Instituto Mexicano del Seguro Social (MM)","award":["R-2015-785-015"],"award-info":[{"award-number":["R-2015-785-015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Corticotroph cells give rise to aggressive and rare pituitary neoplasms comprising ACTH-producing adenomas resulting in Cushing disease (CD), clinically silent ACTH adenomas (SCA), Crooke cell adenomas (CCA) and ACTH-producing carcinomas (CA). The molecular pathogenesis of these tumors is still poorly understood. To better understand the genomic landscape of all the lesions of the corticotroph lineage, we sequenced the whole exome of three SCA, one CCA, four ACTH-secreting PA causing CD, one corticotrophinoma occurring in a CD patient who developed Nelson syndrome after adrenalectomy and one patient with an ACTH-producing CA. The ACTH-producing CA was the lesion with the highest number of single nucleotide variants (SNV) in genes such as USP8, TP53, AURKA, EGFR, HSD3B1 and CDKN1A. The USP8 variant was found only in the ACTH-CA and in the corticotrophinoma occurring in a patient with Nelson syndrome. In CCA, SNV in TP53, EGFR, HSD3B1 and CDKN1A SNV were present. HSD3B1 and CDKN1A SNVs were present in all three SCA, whereas in two of these tumors SNV in TP53, AURKA and EGFR were found. None of the analyzed tumors showed SNV in USP48, BRAF, BRG1 or CABLES1. The amplification of 17q12 was found in all tumors, except for the ACTH-producing carcinoma. The four clinically functioning ACTH adenomas and the ACTH-CA shared the amplification of 10q11.22 and showed more copy-number variation (CNV) gains and single-nucleotide variations than the nonfunctioning tumors.<\/jats:p>","DOI":"10.3390\/ijms23094861","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"4861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas"],"prefix":"10.3390","volume":"23","author":[{"given":"Sergio","family":"Andonegui-Elguera","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Medica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Silva-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Medica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Pe\u00f1a-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Medica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Taniguchi-Ponciano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Medica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano 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Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-17-0796","article-title":"European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas","volume":"178","author":"Raverot","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/02688697.2019.1582750","article-title":"Pituitary carcinomas: Review of the current literature and report of atypical case","volume":"34","author":"Todeschini","year":"2020","journal-title":"Br. J. Neurosurg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1210\/jc.2011-1166","article-title":"Pituitary carcinoma with malignant growth from first presentation and fulminant clinical course-case report and review of the literature","volume":"96","author":"Dudziak","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1227\/NEU.0000000000000657","article-title":"Crooke\u2019s cell tumors of the pituitary","volume":"76","author":"Davidson","year":"2015","journal-title":"Neurosurgery"},{"key":"ref_6","first-page":"1039","article-title":"Recurrence in silent corticotroph adenomas after primary treatment: A systematic review and meta-analysis","volume":"104","author":"Fountas","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/jama.2016.19699","article-title":"Diagnosis and Treatment of Pituitary Adenomas: A Review","volume":"317","author":"Molitch","year":"2017","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1056\/NEJMra1810772","article-title":"Pituitary-Tumor Endocrinopathies","volume":"382","author":"Melmed","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00401-017-1769-8","article-title":"The 2017 World Health Organization classification of tumors of the pituitary gland: A sumary","volume":"134","author":"Lopes","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/cr.2016.114","article-title":"The genome-wide mutational landscape of pituitary adenomas","volume":"26","author":"Song","year":"2016","journal-title":"Cell Res."},{"key":"ref_11","unstructured":"NCBI (2022, February 23). Available online: https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs1047303#frequency_tab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e190115","DOI":"10.1001\/jamanetworkopen.2019.0115","article-title":"Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone","volume":"2","author":"Shiota","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mce.2017.02.017","article-title":"Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas","volume":"446","author":"Yagnik","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/iub.2225","article-title":"The effect of TP53 and P21 gene polymorphisms on papillary thyroid carcinoma susceptibility and clinical\/pathological features","volume":"72","author":"Heidari","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_15","first-page":"4258","article-title":"Crosstalk of Cyclin-dependent kinase inhibitor 1A (CDKN1A) gene polymorphism with p53 and CCND1 polymorphism in breast cancer","volume":"25","author":"Akhter","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"26526","DOI":"10.1038\/srep26526","article-title":"The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Taniguchi-Ponciano, K., Portocarrero-Ortiz, L.A., Guinto, G., Moreno-Jimenez, S., Gomez-Apo, E., Chavez-Macias, L., Pe\u00f1a-Mart\u00ednez, E., Silva-Rom\u00e1n, G., Vela-Pati\u00f1o, S., and Ordo\u00f1ez-Garc\u00eda, J. (2022). The kinome, cyclins and cyclin-dependent kinases of pituitary adenomas, a look into the gene expression rofile among tumors different lineages. BMC Med. Genom., 15.","DOI":"10.1186\/s12920-022-01206-y"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Sobral-Leite, M., Lips, E., Vieira-Monteiro, H., Giacomin, L., Freitas-Alves, D., Cornelissen, S., Mulder, L., Wesseling, J., Schmidt, M.K., and Vianna-Jorge, R. (2017). Evaluation of the EGFR polymorphism R497K in two cohorts of neoadjuvantly treated breast cancer patients. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0189750"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1172\/JCI32278","article-title":"ErbB receptors: From oncogenes to targeted cancer therapies","volume":"117","author":"Zhang","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3389\/fendo.2019.00785","article-title":"Expression of EGFR in Pituitary Corticotroph Adenomas and Its Relationship With Tumor Behavior","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_21","unstructured":"NCBI (2022, February 23). Available online: https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs2227983#frequency_tab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3389\/fonc.2020.01040","article-title":"AURKA rs2273535 T>A Polymorphism Associated With Cancer Risk: A Systematic Review With Meta-Analysis","volume":"10","author":"Wang","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_23","unstructured":"NCBI (2022, February 23). Available online: https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs2273535#frequency_tab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng.3166","article-title":"Mutations in the deubiquitinase gene USP8 cause Cushing\u2019s disease","volume":"47","author":"Reincke","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E997","DOI":"10.1210\/jc.2015-1453","article-title":"The Gene of the Ubiquitin-Specific Protease 8 Is Frequently Mutated in Adenomas Causing Cushing\u2019s Disease","volume":"100","author":"Theodoropoulou","year":"2015","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/cen.13802","article-title":"The USP8 mutational status may predict long-term remission in patients with Cushing\u2019s disease","volume":"89","author":"Albani","year":"2018","journal-title":"Clin. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11102-019-00973-9","article-title":"Cushing\u2019s disease due to somatic USP8 mutations: A systematic review and meta-analysis","volume":"22","author":"Wanichi","year":"2019","journal-title":"Pituitary"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1210\/clinem\/dgaa853","article-title":"USP8 and TP53 Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors","volume":"106","author":"Uzilov","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1530\/EJE-15-0689","article-title":"The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing\u2019s disease","volume":"174","author":"Hayashi","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Shao, X., Lv, N., Liao, J., Long, J., Xue, R., Ai, N., Xu, D., and Fan, X. (2019). Copy number variation is highly correlated with differential gene expression: A pan-cancer study. BMC Med Genet., 20.","DOI":"10.1186\/s12881-019-0909-5"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/gm62","article-title":"Copy number variations and cancer","volume":"1","author":"Shlien","year":"2009","journal-title":"Genome Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"P\u00f6s, O., Radvanszky, J., Styk, J., P\u00f6s, Z., Bugly\u00f3, G., Kajsik, M., Budis, J., Nagy, B., and Szemes, T. (2021). Copy Number Variation: Methods and Clinical Applications. Appl. Sci., 11.","DOI":"10.3390\/app11020819"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/neuonc\/noab102","article-title":"Single-cell transcriptome and genome analyses of pituitary neuroendocrine tumors","volume":"23","author":"Cui","year":"2021","journal-title":"Neuro-Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccell.2019.11.002","article-title":"Pangenomic Classification of Pituitary Neuroendocrine Tumors","volume":"37","author":"Neou","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_35","first-page":"2625","article-title":"Targets of gene amplification and overexpression at 17q in gastric cancer","volume":"62","author":"Varis","year":"2002","journal-title":"Cancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11264","DOI":"10.1073\/pnas.0802970105","article-title":"Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome","volume":"105","author":"Shlien","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/EJE-17-0933","article-title":"Treatment of aggressive pituitary tumours and carcinomas: Results of a European Society of Endocrinology (ESE) survey 2016","volume":"178","author":"McCormack","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Trouillas, J., Jaffrain-Rea, M., Vasiljevic, A., Raverot, G., Roncaroli, F., and Villa, C. (2020). How to Classify the Pituitary Neuroendocrine Tumors (PitNET)s in 2020. Cancers, 12.","DOI":"10.3390\/cancers12020514"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1158\/2326-6066.CIR-21-0543","article-title":"Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity","volume":"9","author":"Hu","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Park, J., Huang, S., Tougeron, D., and Sinicrope, F. (2013). MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065369"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41574-021-00550-w","article-title":"Aggressive pituitary tumours and pituitary carcinomas","volume":"17","author":"Raverot","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fendo.2018.00318","article-title":"Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions","volume":"9","author":"Syro","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mamidi, T.K.K., Wu, J., and Hicks, C. (2019). Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5440-8"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Caja, F., Vodickova, L., Kral, J., Vymetalkova, V., Naccarati, A., and Vodicka, P. (2020). Mismatch repair gene variant in sporadic solid cancers. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155561"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s12031-013-0047-z","article-title":"Genome-wide pathway analysis in major depresive disorder","volume":"51","author":"Song","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"ref_46","unstructured":"(2021, October 06). GATK. Available online: https:\/\/gatk.broadinstitute.org\/."},{"key":"ref_47","unstructured":"(2021, October 06). GDC, Available online: https:\/\/docs.gdc.cancer.gov\/."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"596554","DOI":"10.3389\/fendo.2020.596554","article-title":"Genetic and Epigenetic Causes of Pituitary Adenomas","volume":"11","author":"Chang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/js.2017-00364","article-title":"USP8 Mutations in Pituitary Cushing Adenomas-Targeted Analysis by Next-Generation Sequencing","volume":"2","author":"Ballmann","year":"2018","journal-title":"J. Endocr. Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/iji.12481","article-title":"Effect of maternal HIV infection, BMI and NOx air pollution exposure on birth outcomes in South African pregnant women genotyped for the p53 Pro72Arg (rs1042522)","volume":"47","author":"Naidoo","year":"2020","journal-title":"Int. J. Immunogenet."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Leite, M., Giacomin, L., Piranda, D., Festa-Vasconcellos, J., Indio-do-Brasil, V., Koifman, S., de Moura-Neto, R.S., de Carvalho, M.A., and Vianna-Jorge, R. (2014). Epidermal growth factor receptor gene polymorphisms are associated with prognostic features of breast cancer. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-190"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12769","DOI":"10.18632\/oncotarget.24355","article-title":"The Aurora-Kinase A Phe31-Ile polymorphism as possible predictor of response to treatment in head and neck squamous cell carcinoma","volume":"9","author":"Baumann","year":"2018","journal-title":"Oncotarget"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"10469","DOI":"10.1007\/s13277-016-4850-3","article-title":"Roles of CDKN1A gene polymorphisms (rs1801270 and rs1059234) in the development of cervical neoplasia","volume":"37","author":"Portari","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"19373","DOI":"10.1038\/s41598-020-76555-8","article-title":"Transcriptome and methylome analysis reveals three cellular origins of pituitary tumors","volume":"10","year":"2020","journal-title":"Sci. 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