{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:59:48Z","timestamp":1781103588032,"version":"3.54.1"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11875061"],"award-info":[{"award-number":["11875061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["16J295"],"award-info":[{"award-number":["16J295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&amp;D Program of China","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"National Key R&amp;D Program of China","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"National Key R&amp;D Program of China","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"National Key R&amp;D Program of China","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"National Key R&amp;D Program of China","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"National Key R&amp;D Program of China","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"National Key R&amp;D Program of China","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"National Key R&amp;D Program of China","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"National Key R&amp;D Program of China","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"National Key R&amp;D Program of China","award":["16J295"],"award-info":[{"award-number":["16J295"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"Talent Project of Longyuan (Gansu province) Youth Innovation and Entrepreneurship","award":["16J295"],"award-info":[{"award-number":["16J295"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"National Natural Science Foundation of Gansu province","award":["16J295"],"award-info":[{"award-number":["16J295"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"National Laboratory of Heavy Ion Accelerator of Lanzhou","award":["16J295"],"award-info":[{"award-number":["16J295"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["16J295"],"award-info":[{"award-number":["16J295"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["16J295"],"award-info":[{"award-number":["16J295"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas","award":["16J295"],"award-info":[{"award-number":["16J295"]}]},{"name":"HIMAC Research Project Grant","award":["11875061"],"award-info":[{"award-number":["11875061"]}]},{"name":"HIMAC Research Project Grant","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}]},{"name":"HIMAC Research Project Grant","award":["E139222SR0"],"award-info":[{"award-number":["E139222SR0"]}]},{"name":"HIMAC Research Project Grant","award":["20JR5RA550"],"award-info":[{"award-number":["20JR5RA550"]}]},{"name":"HIMAC Research Project Grant","award":["E0HIRFL03P"],"award-info":[{"award-number":["E0HIRFL03P"]}]},{"name":"HIMAC Research Project Grant","award":["2021A1515010027"],"award-info":[{"award-number":["2021A1515010027"]}]},{"name":"HIMAC Research Project Grant","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}]},{"name":"HIMAC Research Project Grant","award":["JP15K21745"],"award-info":[{"award-number":["JP15K21745"]}]},{"name":"HIMAC Research Project Grant","award":["15H05935"],"award-info":[{"award-number":["15H05935"]}]},{"name":"HIMAC Research Project Grant","award":["16J295"],"award-info":[{"award-number":["16J295"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Concurrent exposure to ionizing radiation (IR) and psychological stress (PS) may affect the development of adverse health consequences in scenarios such as space missions, radiotherapy and nuclear accidents. IR can induce DNA damage and cell apoptosis in the kidneys, thus potentially leading to renal fibrosis, which is the ultimate outcome of various chronic progressive nephropathies and the morphological manifestation of a continuous coordinated response after renal injury. However, little is known regarding the effects of concurrent IR exposure and PS on renal damage, particularly renal fibrosis. In this study, using a chronic restraint-induced PS (CRIPS) model, we exposed Trp53-heterozygous mice to total body irradiation with 0.1 or 2 Gy 56Fe ions on the eighth day of 28 consecutive days of a restraint regimen. At the end of the restraint period, the kidneys were collected. The histopathological changes and the degree of kidney fibrosis were assessed with H&amp;E and Masson staining, respectively. Fibronectin (FN) and alpha smooth muscle actin (\u03b1-SMA), biomarkers of fibrosis, were detected by immunohistochemistry. Analysis of 8-hydroxy-2 deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, was performed with immunofluorescence, and terminal deoxynucleotidyl transferase-mediated nick end labeling assays were used to detect apoptotic cells. Histopathological observations did not indicate significant structural damage induced by IR or CRIPS + IR. Western blotting revealed that the expression of \u03b1-SMA was much higher in the CRIPS + IR groups than the CRIPS groups. However, no differences in the average optical density per area were observed for FN, \u03b1-SMA and 8-OHdG between the IR and CRIPS + IR groups. No difference in the induction of apoptosis was observed between the IR and CRIPS + IR groups. These results suggested that exposure to IR (0.1 and 2 Gy 56Fe ions), 28 consecutive days of CRIPS or both did not cause renal fibrosis. Thus, CRIPS did not alter the IR-induced effects on renal damage in Trp53-heterozygous mice in our experimental setup.<\/jats:p>","DOI":"10.3390\/ijms23094866","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"4866","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Concurrent Exposure to Chronic Restraint-Induced Stress and Total-Body Iron Ion Radiation on Induction of Kidney Injury in Mice"],"prefix":"10.3390","volume":"23","author":[{"given":"Duling","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 101408, China"},{"name":"Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 101408, China"},{"name":"Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6374-4272","authenticated-orcid":false,"given":"Takanori","family":"Katsube","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 101408, China"},{"name":"Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 101408, China"},{"name":"Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-639X","authenticated-orcid":false,"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China"},{"name":"Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Lanzhou 730000, China"},{"name":"School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 101408, China"},{"name":"Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.bbi.2007.07.010","article-title":"Understanding the interaction between psychosocial stress and immune-related diseases: A stepwise progression","volume":"21","author":"Kemeny","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.biopsych.2017.05.013","article-title":"Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume","volume":"82","author":"Schoenfeld","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3109\/09553001003746059","article-title":"Radiobiological basis in management of accidental radiation exposure","volume":"86","author":"Pandey","year":"2010","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1089\/ars.2013.5649","article-title":"Health Risks of Space Exploration: Targeted and Nontargeted Oxidative Injury by High-Charge and High-Energy Particles","volume":"20","author":"Li","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/09553000801902117","article-title":"Apoptosis of murine melanoma cells induced by heavy-ion radiation combined with Tp53 gene transfer","volume":"84","author":"Duan","year":"2008","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4703286","DOI":"10.1155\/2020\/4703286","article-title":"Space Radiation Biology for \u201cLiving in Space\u201d","volume":"2020","author":"Furukawa","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0022-5347(17)67152-0","article-title":"Radiation nephritis: A review","volume":"114","author":"Madrazo","year":"1975","journal-title":"J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1667\/RADE-20-00218.1","article-title":"Synergistic Effects of Chronic Restraint-Induced Stress and Low-Dose 56Fe-particle Irradiation on Induction of Chromosomal Aberrations in Trp53-Heterozygous Mice","volume":"196","author":"Katsube","year":"2021","journal-title":"Radiat. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/jrr\/rrv030","article-title":"Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice","volume":"56","author":"Wang","year":"2015","journal-title":"J. Radiat. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.7150\/ijbs.22805","article-title":"Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Trp53+\/\u2212 Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?","volume":"14","author":"Li","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s11255-012-0289-7","article-title":"The kidney in space","volume":"44","author":"Liakopoulos","year":"2012","journal-title":"Int. Urol. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/1440-1681.13394","article-title":"High-sucrose diet potentiates hyperaldosteronism and renal injury induced by stress in young adult rats","volume":"47","author":"Romero","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.addr.2017.12.019","article-title":"Targeting renal fibrosis: Mechanisms and drug delivery systems","volume":"129","author":"Nastase","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of Renal Fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13014-021-01764-y","article-title":"Radiation-induced kidney toxicity: Molecular and cellular pathogenesis","volume":"16","author":"Klaus","year":"2021","journal-title":"Radiat. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3010342","DOI":"10.1155\/2019\/3010342","article-title":"Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms","volume":"2019","author":"Wei","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wyld, M., Morton, R., Hayen, A., Howard, K., and Webster, A. (2012). A Systematic Review and Meta-Analysis of Utility-Based Quality of Life in Chronic Kidney Disease Treatments. PLoS Med., 9.","DOI":"10.1371\/journal.pmed.1001307"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.semnephrol.2018.05.008","article-title":"Precision Medicine for Nutritional Management in End-Stage Kidney Disease and Transition to Dialysis","volume":"38","author":"Wang","year":"2018","journal-title":"Semin. Nephrol."},{"key":"ref_19","first-page":"97","article-title":"Wingless\/int-1induced secreted protein-1: A new biomarker for renal fibrosis","volume":"34","author":"Zhou","year":"2021","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biocel.2005.09.005","article-title":"The renal cortical fibroblast in renal tubulointerstitial fibrosis","volume":"38","author":"Qi","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.taap.2012.05.013","article-title":"Urinary total arsenic and 8-hydroxydeoxyguanosine are associated with renal cell carcinoma in an area without obvious arsenic exposure","volume":"262","author":"Huang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"117187","DOI":"10.1016\/j.lfs.2019.117187","article-title":"The long noncoding RNA myocardial infarction-associated transcript modulates the epithelial-mesenchymal transition in renal interstitial fibrosis","volume":"241","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/ijms19020613","article-title":"Anti-Renal Fibrotic Effect of Exercise Training in Hypertension","volume":"19","author":"Huang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cbi.2018.04.018","article-title":"NGAL attenuates renal ischemia\/reperfusion injury through autophagy activation and apoptosis inhibition in rats","volume":"289","author":"Zhang","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jphs.2020.10.002","article-title":"Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro","volume":"145","author":"Xiang","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"ref_26","first-page":"757","article-title":"Effects of short-term high salt diet on tubule epithelial mesenchymal transformation and renal fibrosis in C57BL\/6J mice","volume":"28","author":"Huang","year":"2020","journal-title":"Chin. J. Hypertens."},{"key":"ref_27","first-page":"1000101","article-title":"Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy","volume":"2","author":"Cohen","year":"2013","journal-title":"J. Genet. Disord. Genet. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yan, Y., Zhang, K., Zhou, G., and Hu, W. (2020). MicroRNAs Responding to Space Radiation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186603"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00432-015-1974-6","article-title":"Radiation-induced fibrosis: Mechanisms and implications for therapy","volume":"141","author":"Straub","year":"2015","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Pavlakou, P., Dounousi, E., Roumeliotis, S., Eleftheriadis, T., and Liakopoulos, V. (2018). Oxidative Stress and the Kidney in the Space Environment. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103176"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.asr.2004.12.034","article-title":"Ground-based research with heavy ions for space radiation protection","volume":"35","author":"Durante","year":"2005","journal-title":"Adv. Space Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Turker, M.S., Grygoryev, D., Lasarev, M., Ohlrich, A., Rwatambuga, F.A., Johnson, S., Dan, C., Eckelmann, B., Hryciw, G., and Mao, J.-H. (2017). Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180412"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1667\/RR3276","article-title":"Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3\u20134 2003","volume":"162","author":"Stone","year":"2004","journal-title":"Radiat. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0968-4328(01)00006-3","article-title":"Radiation-induced kidney injury: A role for chronic oxidative stress?","volume":"33","author":"Robbins","year":"2002","journal-title":"Micron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1667\/RR1454.1","article-title":"Chronic Oxidative Stress as a Mechanism for Radiation Nephropathy","volume":"171","author":"Lenarczyk","year":"2009","journal-title":"Radiat. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4866\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:02:24Z","timestamp":1760137344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23094866"],"URL":"https:\/\/doi.org\/10.3390\/ijms23094866","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]}}}