{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:52:36Z","timestamp":1774047156105,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Advanced Scientific Research of the Federal State Budgetary Educational Institution of Higher Education","award":["#20-415-740011"],"award-info":[{"award-number":["#20-415-740011"]}]},{"name":"Chelyabinsk State University","award":["#20-415-740011"],"award-info":[{"award-number":["#20-415-740011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We investigated the presence of a molecular pathway from hepatic 11-\u03b2HSD-1 to brain MAO-A in the dynamics of plasma corticosterone involvement in anxiety development. During 14 days following repeated exposure of rats to predator scent stress for 10 days, the following variables were measured: hepatic 11-\u03b2HSD-1 and brain MAO-A activities, brain norepinephrine, plasma corticosterone concentrations, and anxiety, as reflected by performance on an elevated plus maze. Anxiety briefly decreased and then increased after stress exposure. This behavioral response correlated inversely with plasma corticosterone and with brain MAO-A activity. A mathematical model described the dynamics of the biochemical variables and predicted the factor(s) responsible for the development and dynamics of anxiety. In the model, hepatic 11-\u03b2HSD-1 was considered a key factor in defining the dynamics of plasma corticosterone. In turn, plasma corticosterone and oxidation of brain ketodienes and conjugated trienes determined the dynamics of brain MAO-A activity, and MAO-A activity determined the dynamics of brain norepinephrine. Finally, plasma corticosterone was modeled as the determinant of anxiety. Solution of the model equations demonstrated that plasma corticosterone is mainly determined by the activity of hepatic 11-\u03b2HSD-1 and, most importantly, that corticosterone plays a critical role in the dynamics of anxiety following repeated stress.<\/jats:p>","DOI":"10.3390\/ijms23094881","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T12:06:01Z","timestamp":1651147561000},"page":"4881","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety"],"prefix":"10.3390","volume":"23","author":[{"given":"Vadim","family":"Tseilikman","sequence":"first","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim","family":"Lapshin","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Klebanov","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"School of Electronic Engineering and Computer Science, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-5264","authenticated-orcid":false,"given":"George","family":"Chrousos","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vasilieva","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Pashkov","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-9299","authenticated-orcid":false,"given":"Julia","family":"Fedotova","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Laboratory of Neuroendocrinology, Pavlov Institute of Physiology, RAS, 199034 St. Petersburg, Russia"},{"name":"International Research Centre \u201cBiotechnologies of the Third Millennium\u201d, ITMO University, 191002 St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"Zelman Institute of Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav","family":"Shatilov","sequence":"additional","affiliation":[{"name":"Basic Medicine Department, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8102-173X","authenticated-orcid":false,"given":"Eugenia","family":"Manukhina","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"},{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Basic Medicine Department, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-9655","authenticated-orcid":false,"given":"Alexey","family":"Sarapultsev","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science, 620049 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-1021","authenticated-orcid":false,"given":"H. Fred","family":"Downey","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/13651501.2019.1699575","article-title":"Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug na\u00efve patients with post-traumatic stress disorder: An exploratory study in the everyday \u2018real world\u2019 clinical practice","volume":"24","author":"Vellante","year":"2020","journal-title":"Int. J. Psychiatry Clin. 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