{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:43:00Z","timestamp":1790775780803,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["PI20\/00465"],"award-info":[{"award-number":["PI20\/00465"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["RD21\/0006\/0007"],"award-info":[{"award-number":["RD21\/0006\/0007"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Regional Development Fund (FEDER)","award":["PI20\/00465"],"award-info":[{"award-number":["PI20\/00465"]}]},{"name":"European Regional Development Fund (FEDER)","award":["RD21\/0006\/0007"],"award-info":[{"award-number":["RD21\/0006\/0007"]}]},{"DOI":"10.13039\/501100004587","name":"The Neurovascular Research Laboratory","doi-asserted-by":"publisher","award":["PI20\/00465"],"award-info":[{"award-number":["PI20\/00465"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"The Neurovascular Research Laboratory","doi-asserted-by":"publisher","award":["RD21\/0006\/0007"],"award-info":[{"award-number":["RD21\/0006\/0007"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The pathological accumulation of parenchymal and vascular amyloid-beta (A\u03b2) are the main hallmarks of Alzheimer\u2019s disease (AD) and Cerebral Amyloid Angiopathy (CAA), respectively. Emerging evidence raises an important contribution of vascular dysfunction in AD pathology that could partially explain the failure of anti-A\u03b2 therapies in this field. Transgenic mice models of cerebral \u03b2-amyloidosis are essential to a better understanding of the mechanisms underlying amyloid accumulation in the cerebrovasculature and its interactions with neuritic plaque deposition. Here, our main objective was to evaluate the progression of both parenchymal and vascular deposition in APP23 and 5xFAD transgenic mice in relation to age and sex. We first showed a significant age-dependent accumulation of extracellular A\u03b2 deposits in both transgenic models, with a greater increase in APP23 females. We confirmed that CAA pathology was more prominent in the APP23 mice, demonstrating a higher progression of A\u03b2-positive vessels with age, but not linked to sex, and detecting a pronounced burden of cerebral microbleeds (cMBs) by magnetic resonance imaging (MRI). In contrast, 5xFAD mice did not present CAA, as shown by the negligible A\u03b2 presence in cerebral vessels and the occurrence of occasional cMBs comparable to WT mice. In conclusion, the APP23 mouse model is an interesting tool to study the overlap between vascular and parenchymal A\u03b2 deposition and to evaluate future disease-modifying therapy before its translation to the clinic.<\/jats:p>","DOI":"10.3390\/ijms23094972","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"4972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral \u03b2-Amyloidosis: A Neuropathological Study"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1038-5242","authenticated-orcid":false,"given":"Paula","family":"Marazuela","sequence":"first","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Paez-Montserrat","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1480-622X","authenticated-orcid":false,"given":"Anna","family":"Bonaterra-Pastra","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-6562","authenticated-orcid":false,"given":"Montse","family":"Sol\u00e9","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8844-0091","authenticated-orcid":false,"given":"Mar","family":"Hern\u00e1ndez-Guillamon","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","article-title":"Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease","volume":"18","author":"Weller","year":"2008","journal-title":"Brain Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/bpa.12159","article-title":"Failure of Perivascular Drainage of \u03b2-amyloid in Cerebral Amyloid Angiopathy","volume":"24","author":"Hawkes","year":"2014","journal-title":"Brain Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.nicl.2017.05.002","article-title":"Amyloid positron emission tomography in sporadic cerebral amyloid angiopathy: A systematic critical update","volume":"15","author":"Farid","year":"2017","journal-title":"NeuroImage: Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1523\/JNEUROSCI.21-05-01619.2001","article-title":"Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy","volume":"21","author":"Winkler","year":"2001","journal-title":"J. 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