{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:57:00Z","timestamp":1791219420436,"version":"4.1.0"},"reference-count":93,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TU Research Scholar","award":["No. 1\/2560"],"award-info":[{"award-number":["No. 1\/2560"]}]},{"name":"TU Research Scholar","award":["No. T1\/2563"],"award-info":[{"award-number":["No. T1\/2563"]}]},{"name":"Chulabhorn International College of Medicine","award":["No. 1\/2560"],"award-info":[{"award-number":["No. 1\/2560"]}]},{"name":"Chulabhorn International College of Medicine","award":["No. T1\/2563"],"award-info":[{"award-number":["No. T1\/2563"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Elucidating transcriptome in the peripheral edge of the lesional (PE) skin could provide a better understanding of the molecules or signalings that intensify inflammation in the PE skin. Full-thickness biopsies of PE skin and uninvolved (UN) skin were obtained from psoriasis patients for RNA-seq. Several potential differentially expressed genes (DEGs) in the PE skin compared to those in the UN skin were identified. These DEGs enhanced functions such as angiogenesis, growth of epithelial tissue, chemotaxis and homing of cells, growth of connective tissues, and degranulation of myeloid cells beneath the PE skin. Moreover, the canonical pathways of IL-17A, IL-6, and IL-22 signaling were enriched by the DEGs. Finally, we proposed that inflammation in the PE skin might be driven by the IL-36\/TLR9 axis or IL-6\/Th17 axis and potentiated by IL-36\u03b1, IL-36\u03b3, IL-17C, IL-8, S100A7, S100A8, S100A9, S100A15, SERPINB4, and hBD-2. Along with IL-36\u03b1, IL-17C, and I\u03baB\u03b6, ROCK2 could be an equally important factor in the pathogenesis of psoriasis, which may involve self-sustaining circuits between innate and adaptive immune responses via regulation of IL-36\u03b1 and IL-36\u03b3 expression. Our finding provides new insight into signaling pathways in PE skin, which could lead to the discovery of new psoriasis targets.<\/jats:p>","DOI":"10.3390\/ijms23094983","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"4983","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Transcriptomic Profiling of Peripheral Edge of Lesions to Elucidate the Pathogenesis of Psoriasis Vulgaris"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-5062","authenticated-orcid":false,"given":"Suphagan","family":"Boonpethkaew","sequence":"first","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine, Rangsit Campus, Thammasat University, Klong Luang, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-5134","authenticated-orcid":false,"given":"Jitlada","family":"Meephansan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine, Rangsit Campus, Thammasat University, Klong Luang, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onjira","family":"Jumlongpim","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine, Rangsit Campus, Thammasat University, Klong Luang, Pathum Thani 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8978-6916","authenticated-orcid":false,"given":"Pattarin","family":"Tangtanatakul","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wipasiri","family":"Soonthornchai","sequence":"additional","affiliation":[{"name":"School of Science, University of Phayao, Phayao 56000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongkonnee","family":"Wongpiyabovorn","sequence":"additional","affiliation":[{"name":"Center of Excellence in Immunology and Immune-Mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratchanee","family":"Vipanurat","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Rajavithi Hospital, Ministry of Public Health, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-1803","authenticated-orcid":false,"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dastoli, S., Nistic\u00f2, S.P., Morrone, P., Patruno, C., Leo, A., Citraro, R., Gallelli, L., Russo, E., De Sarro, G., and Bennardo, L. 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