{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:17:42Z","timestamp":1792804662008,"version":"4.5.0"},"reference-count":97,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INSERM","id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"crossref"}]},{"name":"CHU de Poitiers"},{"name":"University of Poitiers","id":[{"id":"https:\/\/ror.org\/04xhy8q59","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Organ transplantation remains the treatment of last resort in case of failure of a vital organ (lung, liver, heart, intestine) or non-vital organ (essentially the kidney and pancreas) for which supplementary treatments exist. It remains the best alternative both in terms of quality-of-life and life expectancy for patients and of public health expenditure. Unfortunately, organ shortage remains a widespread issue, as on average only about 25% of patients waiting for an organ are transplanted each year. This situation has led to the consideration of recent donor populations (deceased by brain death with extended criteria or deceased after circulatory arrest). These organs are sensitive to the conditions of conservation during the ischemia phase, which have an impact on the graft\u2019s short- and long-term fate. This evolution necessitates a more adapted management of organ donation and the optimization of preservation conditions. In this general review, the different aspects of preservation will be considered. Initially done by hypothermia with the help of specific solutions, preservation is evolving with oxygenated perfusion, in hypothermia or normothermia, aiming at maintaining tissue metabolism. Preservation time is also becoming a unique evaluation window to predict organ quality, allowing repair and\/or optimization of recipient choice.<\/jats:p>","DOI":"10.3390\/ijms23094989","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"4989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Preservation of Organs to Be Transplanted: An Essential Step in the Transplant Process"],"prefix":"10.3390","volume":"23","author":[{"given":"Maryne","family":"Lepoittevin","sequence":"first","affiliation":[{"name":"Biochemistry Department, CHU Poitiers, 86021 Poitiers, France"},{"name":"Faculty of Medicine and Pharmacy, University of Poitiers, 86073 Poitiers, France"},{"name":"INSERM U1313, IRMETIST, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Giraud","sequence":"additional","affiliation":[{"name":"Biochemistry Department, CHU Poitiers, 86021 Poitiers, France"},{"name":"Faculty of Medicine and Pharmacy, University of Poitiers, 86073 Poitiers, France"},{"name":"INSERM U1313, IRMETIST, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kerforne","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Poitiers, 86073 Poitiers, France"},{"name":"INSERM U1313, IRMETIST, 86021 Poitiers, France"},{"name":"Cardio-Thoracic and Vascular Surgery Intensive Care Unit, Coordination of P.M.O., CHU Poitiers, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Barrou","sequence":"additional","affiliation":[{"name":"INSERM U1313, IRMETIST, 86021 Poitiers, France"},{"name":"Sorbonne Universit\u00e9 Campus Pierre et Marie Curie, Facult\u00e9 de M\u00e9decine, 75005 Paris, France"},{"name":"Service M\u00e9dico-Chirurgical de Transplantation R\u00e9nale, APHP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"},{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Badet","sequence":"additional","affiliation":[{"name":"INSERM U1313, IRMETIST, 86021 Poitiers, France"},{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine, Campus Lyon Sant\u00e9 Est, Universit\u00e9 Claude Bernard, 69622 Lyon, France"},{"name":"Service d\u2019Urologie et Transplantation, Hospices Civils de Lyon, H\u00f4pital Edouard-Herriot, 69003 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petru","family":"Bucur","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service de Chirurgie Digestive et Endocrinienne, Transplantation H\u00e9patique, CHU de Tours, 37170 Chambray les Tours, France"},{"name":"Groupement d\u2019Imagerie M\u00e9dicale, CHU de Tours, 37000 Tours, France"},{"name":"University Hospital Federation SUPORT Tours Poitiers Limoges, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephrem","family":"Salam\u00e9","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service de Chirurgie Digestive et Endocrinienne, Transplantation H\u00e9patique, CHU de Tours, 37170 Chambray les Tours, France"},{"name":"Groupement d\u2019Imagerie M\u00e9dicale, CHU de Tours, 37000 Tours, France"},{"name":"University Hospital Federation SUPORT Tours Poitiers Limoges, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Goumard","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service de Chirurgie Digestive, H\u00e9pato-Bilio-Pancr\u00e9atique et Transplantation H\u00e9patique, APHP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-2222","authenticated-orcid":false,"given":"Eric","family":"Savier","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service de Chirurgie Digestive, H\u00e9pato-Bilio-Pancr\u00e9atique et Transplantation H\u00e9patique, APHP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-9352","authenticated-orcid":false,"given":"Julien","family":"Branchereau","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service d\u2019Urologie et de Transplantation, CHU de Nantes, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Battistella","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service de Cardiologie et Maladies Vasculaires, CHU de Montpellier, CEDEX 5, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Mercier","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service de Chirurgie Thoracique et Cardio-Vasculaire, Centre Chirurgical Marie LANNELONGUE, 92350 Le Plessis Robinson, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha","family":"Mussot","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"Service de Chirurgie Thoracique et Cardio-Vasculaire, Centre Chirurgical Marie LANNELONGUE, 92350 Le Plessis Robinson, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-071X","authenticated-orcid":false,"given":"Thierry","family":"Hauet","sequence":"additional","affiliation":[{"name":"Biochemistry Department, CHU Poitiers, 86021 Poitiers, France"},{"name":"Faculty of Medicine and Pharmacy, University of Poitiers, 86073 Poitiers, France"},{"name":"INSERM U1313, IRMETIST, 86021 Poitiers, France"},{"name":"Soci\u00e9t\u00e9 Francophone de Transplantation et de l\u2019Ecole Francophone pour le Pr\u00e9l\u00e8vement Multi-Organes, 75013 Paris, France"},{"name":"University Hospital Federation SUPORT Tours Poitiers Limoges, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7482-0031","authenticated-orcid":false,"given":"Raphael","family":"Thuillier","sequence":"additional","affiliation":[{"name":"Biochemistry Department, CHU Poitiers, 86021 Poitiers, France"},{"name":"Faculty of Medicine and Pharmacy, University of Poitiers, 86073 Poitiers, France"},{"name":"INSERM U1313, IRMETIST, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","unstructured":"ABM (2022, February 25). Rapport M\u00e9dicale et Scientifique de l\u2019agence de La Biom\u00e9decine. Available online: https:\/\/rams.agence-biomedecine.fr\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00134-019-05533-0","article-title":"Organ donation after circulatory death: Current status and future potential","volume":"45","author":"Smith","year":"2019","journal-title":"Intensive Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/00007890-200211150-00014","article-title":"Donor characteristics associated with reduced graft survival: An approach to expanding the pool of kidney donors","volume":"74","author":"Port","year":"2002","journal-title":"Transplantation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/lt.25419","article-title":"Liver Transplantation in France","volume":"25","author":"Durand","year":"2019","journal-title":"Liver Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/lt.25320","article-title":"Liver Transplantation Today: Where We Are Now and Where We Are Going","volume":"24","author":"Bodzin","year":"2018","journal-title":"Liver Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41581-021-00425-3","article-title":"Organ donation and transplantation: A multi-stakeholder call to action","volume":"17","author":"Vanholder","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3389\/fimmu.2020.00631","article-title":"Transplanting Marginal Organs in the Era of Modern Machine Perfusion and Advanced Organ Monitoring","volume":"11","author":"Resch","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.transproceed.2018.05.034","article-title":"\u201cSuper-rapid\u201d Technique in Donation After Circulatory Death Liver Donors: Advantages and Disadvantages","volume":"51","author":"Hidalgo","year":"2019","journal-title":"Transplant. Proc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/tri.13951","article-title":"ESOT Workstream 04 of the TLJ (Transplant Learning Journey) project Consensus Statement on Normothermic Regional Perfusion in Donation after Circulatory Death: Report from the European Society for Organ Transplantation\u2019s Transplant Learning Journey","volume":"34","author":"Jochmans","year":"2021","journal-title":"Transpl. Int."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"De Beule, J., and Jochmans, I. (2020). Kidney Perfusion as an Organ Quality Assessment Tool\u2014Are We Counting Our Chickens before They Have Hatched?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030879"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/ajt.15063","article-title":"Defining the optimal duration for normothermic regional perfusion in the kidney donor: A porcine preclinical study","volume":"19","author":"Kerforne","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"673562","DOI":"10.3389\/fimmu.2021.673562","article-title":"Renal Delivery of Pharmacologic Agents during Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials","volume":"12","author":"Franzin","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.purol.2013.06.007","article-title":"Non-heart-beating renal donors: Organization in a non-university hospital","volume":"24","author":"Arnoux","year":"2014","journal-title":"Prog. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.freeradbiomed.2021.04.023","article-title":"Targeting oxidative stress, a crucial challenge in renal transplantation outcome","volume":"169","author":"Carcy","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.nephro.2016.02.020","article-title":"Toward a customized preservation for each kidney graft?","volume":"12","author":"Kerforne","year":"2016","journal-title":"Nephrol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez, A.R., S\u00e1nchez-Tarjuelo, R., Cravedi, P., Ochando, J., and L\u00f3pez-Hoyos, M. (2020). Review: Ischemia Reperfusion Injury\u2014A Translational Perspective in Organ Transplantation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228549"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/MOT.0000000000000061","article-title":"Impact of brain death on ischemia\/reperfusion injury in liver transplantation","volume":"19","author":"Dziodzio","year":"2014","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrneph.2012.83","article-title":"New strategies to optimize kidney recovery and preservation in transplantation","volume":"8","author":"Bon","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nrd4422","article-title":"Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases","volume":"13","author":"Eltzschig","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12967-018-1764-4","article-title":"Hypercholesterolemia-induced increase in plasma oxidized LDL abrogated pro angiogenic response in kidney grafts","volume":"17","author":"Kerforne","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ma\u00efga, S., Allain, G., Hauet, T., Roumy, J., Baulier, E., Scepi, M., Dierick, M., Van Hoorebeke, L., Hannaert, P., and Guy, F. (2017). Renal auto-transplantation promotes cortical microvascular network remodeling in a preclinical porcine model. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181067"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1479-5876-12-76","article-title":"Diet-induced increase in plasma oxidized LDL promotes early fibrosis in a renal porcine auto-transplantation model","volume":"12","author":"Chatauret","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fimmu.2019.02014","article-title":"Interleukin-1 Family Cytokines: Keystones in Liver Inflammatory Diseases","volume":"10","author":"Barbier","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/01.tp.0000256284.78721.ba","article-title":"Donor Factors Influencing Graft Outcomes in Live Donor Kidney Transplantation","volume":"83","author":"Issa","year":"2007","journal-title":"Transplantation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/tri.12344","article-title":"Hypothermic or normothermic abdominal regional perfusion in high-risk donors with extended warm ischemia times: Impact on outcomes?","volume":"28","author":"Hessheimer","year":"2014","journal-title":"Transpl. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1097\/TP.0000000000003679","article-title":"Advances in kidney preservation techniques and their application in clinical practice","volume":"105","author":"Hosgood","year":"2021","journal-title":"Transplantation"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Chazelas, P., Steichen, C., Favreau, F., Trouillas, P., Hannaert, P., Thuillier, R., Giraud, S., Hauet, T., and Guillard, J. (2021). Oxidative Stress Evaluation in Ischemia Reperfusion Models: Characteristics, Limits and Perspectives. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052366"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9206257","DOI":"10.1155\/2018\/9206257","article-title":"Barriers and Advances in Kidney Preservation","volume":"2018","author":"Steichen","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.med.46.1.235","article-title":"ORGAN PRESERVATION","volume":"46","author":"Southard","year":"1995","journal-title":"Annu. Rev. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/TP.0b013e3182090fa3","article-title":"Improving Long-Term Outcome in Allograft Transplantation: Role of Ionic Composition and Polyethylene Glycol","volume":"91","author":"Thuillier","year":"2011","journal-title":"Transplantation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/S1166-7087(14)70062-4","article-title":"Polyethylene glycols and organ protection against I\/R injury","volume":"24","author":"Giraud","year":"2014","journal-title":"Prog. Urol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1177\/0963689719872699","article-title":"Preservation Solutions for Kidney Transplantation: History, Advances and Mechanisms","volume":"28","author":"Chen","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000499610","article-title":"Organ Preservation into the 2020s: The Era of Dynamic Intervention","volume":"46","author":"Petrenko","year":"2019","journal-title":"Transfus. Med. Hemother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1111\/ajt.12904","article-title":"Mechanistic Analysis of Nonoxygenated Hypothermic Machine Perfusion\u2019s Protection on Warm Ischemic Kidney Uncovers Greater eNOS Phosphorylation and Vasodilation","volume":"14","author":"Chatauret","year":"2014","journal-title":"Am. J. Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Brat, A., de Vries, K.M., van Heurn, E.W., Huurman, V.A., de Jongh, W., Leuvenink, H.G., van Zuilen, A.D., Haase-Kromwijk, B.J., de Jonge, J., and Berger, S.P. (Transplantation, 2021). Hypothermic Machine Perfusion as a National Standard Preservation Method for Deceased Donor Kidneys, Transplantation, ahead of print.","DOI":"10.1097\/TP.0000000000003845"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.amjsurg.2021.06.019","article-title":"Machine perfusion of kidney allografts affects early but not late graft function","volume":"223","author":"Singh","year":"2021","journal-title":"Am. J. Surg."},{"key":"ref_37","unstructured":"Val, A.R., Guarrera, J., Porte, R.J., Selzner, M., Spiro, M., Raptis, D.A., and Friend, P.J. (2022). Does machine perfusion improve immediate and short-term outcomes by enhancing graft function and recipient recovery after liver transplantation?\u2014A systematic review of the literature, meta-analysis and expert panel recommendations. Clin. Transplant., e14638."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10258","DOI":"10.3389\/ti.2022.10258","article-title":"Machine Perfusion for Human Heart Preservation: A Systematic Review","volume":"35","author":"Qin","year":"2022","journal-title":"Transpl. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1111\/ajt.14963","article-title":"The future of marginal kidney repair in the context of normothermic machine perfusion","volume":"18","author":"Dirito","year":"2018","journal-title":"Am. J. Transplant."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/ajt.16307","article-title":"Normothermic kidney perfusion: An overview of protocols and strategies","volume":"21","author":"Elliott","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1097\/TP.0000000000002245","article-title":"Normothermic Ex Vivo Kidney Perfusion Reduces Warm Ischemic Injury of Porcine Kidney Grafts Retrieved after Circulatory Death","volume":"102","author":"Hamar","year":"2018","journal-title":"Transplantation"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pool, M.B.F., Hamelink, T.L., van Goor, H., Heuvel, M.C.V.D., Leuvenink, H.G.D., and Moers, C. (2021). Prolonged ex-vivo normothermic kidney perfusion: The impact of perfusate composition. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0251595"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1097\/TP.0000000000003415","article-title":"A Short Period of Normothermic Machine Perfusion May Not Be Able to Predict Primary Nonfunction in Uncontrolled Circulatory Death Kidneys","volume":"105","author":"Hosgood","year":"2021","journal-title":"Transplantation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e012237","DOI":"10.1136\/bmjopen-2016-012237","article-title":"Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation","volume":"7","author":"Hosgood","year":"2017","journal-title":"BMJ Open"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.29337\/ijsp.165","article-title":"Additional Normothermic Machine Perfusion versus Hypothermic Machine Perfusion in Suboptimal Donor Kidney Transplantation: Protocol of a Randomized, Controlled, Open-Label Trial","volume":"25","author":"Rijkse","year":"2021","journal-title":"Int. J. Surg. Protoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/SLA.0000000000004268","article-title":"Hypothermic Oxygenated Perfusion Versus Normothermic Regional Perfusion in Liver Transplantation From Controlled Donation after Circulatory Death: First International Comparative Study","volume":"272","author":"Muller","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.trre.2019.06.001","article-title":"Normothermic perfusion and outcomes after liver transplantation","volume":"33","author":"Hessheimer","year":"2019","journal-title":"Transplant. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41586-018-0047-9","article-title":"A randomized trial of normothermic preservation in liver transplantation","volume":"557","author":"Nasralla","year":"2018","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1056\/NEJMoa1014597","article-title":"Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation","volume":"364","author":"Cypel","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S2213-2600(19)30200-0","article-title":"Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): A single-arm, pivotal trial","volume":"7","author":"Loor","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e005517","DOI":"10.1161\/CIRCHEARTFAILURE.118.005517","article-title":"Heart Transplantation with Donation after Circulatory Death","volume":"12","author":"Niederberger","year":"2019","journal-title":"Circ. Heart Fail."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/cts.12906","article-title":"Reduction of Renal Preservation\/Reperfusion Injury by Controlled Hyperthermia During Ex Vivo Machine Perfusion","volume":"14","author":"Minor","year":"2020","journal-title":"Clin. Transl. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"13897","DOI":"10.1038\/s41598-019-50101-7","article-title":"Cold Preflush of Porcine Kidney Grafts Prior to Normothermic Machine Perfusion Aggravates Ischemia Reperfusion Injury","volume":"9","author":"Fabry","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/TP.0000000000001343","article-title":"Continuous Normothermic Ex Vivo Kidney Perfusion Improves Graft Function in Donation after Circulatory Death Pig Kidney Transplantation","volume":"101","author":"Kaths","year":"2017","journal-title":"Transplantation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/ajt.14932","article-title":"Twenty-four\u2013hour normothermic perfusion of discarded human kidneys with urine recirculation","volume":"19","author":"Weissenbacher","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/ajt.15647","article-title":"First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation","volume":"20","author":"Minor","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/MOT.0000000000000405","article-title":"Kidney perfusion: Some like it Hot Others Prefer to Keep it Cool","volume":"22","author":"Jochmans","year":"2017","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/TP.0000000000003817","article-title":"Renal Normothermic Machine Perfusion: The Road Toward Clinical Implementation of a Promising Pretransplant Organ Assessment Tool","volume":"106","author":"Hamelink","year":"2021","journal-title":"Transplantation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1097\/TP.0000000000003295","article-title":"Review of Current Machine Perfusion Therapeutics for Organ Preservation","volume":"104","author":"Xu","year":"2020","journal-title":"Transplantation"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/MOT.0000000000000402","article-title":"Role of temperature in reconditioning and evaluation of cold preserved kidney and liver grafts","volume":"22","author":"Minor","year":"2017","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kasil, A., Giraud, S., Couturier, P., Amiri, A., Danion, J., Donatini, G., Matillon, X., Hauet, T., and Badet, L. (2019). Individual and Combined Impact of Oxygen and Oxygen Transporter Supplementation during Kidney Machine Preservation in a Porcine Preclinical Kidney Transplantation Model. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081992"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(20)32411-9","article-title":"Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): A randomised, double-blind, paired, phase 3 trial","volume":"396","author":"Jochmans","year":"2020","journal-title":"Lancet"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/00007890-199803150-00005","article-title":"Cold preservation of isolated rabbit proximal tubules induces radical-mediated cell Injury","volume":"65","author":"Peters","year":"1998","journal-title":"Transplantation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/TP.0000000000002542","article-title":"The Effects of Oxygenation on Ex Vivo Kidneys Undergoing Hypothermic Machine Perfusion","volume":"103","author":"Patel","year":"2019","journal-title":"Transplantation"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/TP.0000000000000379","article-title":"Influence of Oxygen Concentration during Hypothermic Machine Perfusion on Porcine Kidneys from Donation after Circulatory Death","volume":"98","author":"Hoyer","year":"2014","journal-title":"Transplantation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/ajt.15100","article-title":"The effect on early renal function of various dynamic preservation strategies in a preclinical pig ischemia-reperfusion autotransplant model","volume":"19","author":"Darius","year":"2018","journal-title":"Am. J. Transplant."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jss.2013.04.071","article-title":"Benefits of active oxygenation during hypothermic machine perfusion of kidneys in a preclinical model of deceased after cardiac death donors","volume":"184","author":"Thuillier","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"17726","DOI":"10.1038\/s41598-020-74839-7","article-title":"Decrease of renal resistance during hypothermic oxygenated machine perfusion is associated with early allograft function in extended criteria donation kidney transplantation","volume":"10","author":"Meister","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/jamasurg.2021.0949","article-title":"Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant; A Randomized Clinical Trial","volume":"156","author":"Husen","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e751","DOI":"10.1097\/TXD.0000000000001218","article-title":"Prolonged Normothermic Ex Vivo Kidney Perfusion Is Superior to Cold Nonoxygenated and Oxygenated Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts","volume":"7","author":"Mazilescu","year":"2021","journal-title":"Transplant. Direct"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/13543784.2019.1628217","article-title":"Preventing acute kidney injury during transplantation: The application of novel oxygen carriers","volume":"28","author":"Thuillier","year":"2019","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/TP.0000000000002967","article-title":"Renal Protection Against Ischemia Reperfusion Injury: Hemoglobin-based Oxygen Carrier-201 Versus Blood as an Oxygen Carrier in Ex Vivo Subnormothermic Machine Perfusion","volume":"104","author":"Bhattacharjee","year":"2020","journal-title":"Transplantation"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"100119","DOI":"10.1016\/j.jhepr.2020.100119","article-title":"Adding the oxygen carrier M101 to a cold-storage solution could be an alternative to HOPE for liver graft preservation","volume":"2","author":"Alix","year":"2020","journal-title":"JHEP Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1021\/bc990173h","article-title":"Poly(ethylene glycol)-Conjugation and Deoxygenation Enable Long-Term Preservation of Hemoglobin-Vesicles as Oxygen Carriers in a Liquid State","volume":"11","author":"Sakai","year":"2000","journal-title":"Bioconj. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10930-010-9264-2","article-title":"Towards the Development of Hemerythrin-Based Blood Substitutes","volume":"29","author":"Mot","year":"2010","journal-title":"J. Protein Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/aor.12307","article-title":"Dose-Ranging Study of the Performance of the Natural Oxygen Transporter HEMO2Life in Organ Preservation","volume":"38","author":"Mallet","year":"2014","journal-title":"Artif. Organs"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/ajt.15798","article-title":"First-in-human use of a marine oxygen carrier (M101) for organ preservation: A safety and proof-of-principle study","volume":"20","author":"Badet","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/SLA.0000000000003540","article-title":"Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial","volume":"270","author":"Fujiyoshi","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/ajt.15228","article-title":"Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution","volume":"19","author":"Matton","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/ajt.14583","article-title":"The first case of ischemia-free organ transplantation in humans: A proof of concept","volume":"18","author":"He","year":"2018","journal-title":"Am. J. Transplant."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fmed.2019.00276","article-title":"The First Case of Ischemia-Free Kidney Transplantation in Humans","volume":"6","author":"He","year":"2019","journal-title":"Front. Med."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Mesnard, B., Ogbemudia, A.E., Karam, G., Dengu, F., Hackim, G., Rigaud, J., Blancho, G., Drouin, S., Timsit, M.O., and Branchereau, J. (2021). What is the evidence for oxygenation during kidney preservation for transplantation in 2021? A scoping review. World J. Urol.","DOI":"10.1007\/s00345-021-03757-8"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41587-019-0223-y","article-title":"Supercooling extends preservation time of human livers","volume":"37","author":"Tessier","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1038\/s41596-020-0319-3","article-title":"Subzero non-frozen preservation of human livers in the supercooled state","volume":"15","author":"Tessier","year":"2020","journal-title":"Nat. Protoc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"E308","DOI":"10.1111\/aor.13499","article-title":"Dissemination of a novel organ perfusion technique: Ex vivo normothermic perfusion of deceased donor kidneys","volume":"43","author":"Chandak","year":"2019","journal-title":"Artif. Organs"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/MOT.0000000000000403","article-title":"Subzero organ preservation: The Dawn of a New Ice Age?","volume":"22","author":"Bruinsma","year":"2017","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5500\/wjt.v10.i1.1","article-title":"Therapeutics administered during ex vivo liver machine perfusion: An overview","volume":"10","author":"Buchwald","year":"2020","journal-title":"World J. Transplant."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1681\/ASN.2016010012","article-title":"Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome","volume":"28","author":"Melis","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1111\/ajt.15994","article-title":"The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death-induced renal injuries in a preclinical porcine kidney transplantation model","volume":"20","author":"Giraud","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/dom.13969","article-title":"Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets","volume":"22","author":"Jaisser","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1681\/ASN.2016040477","article-title":"Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1","volume":"28","author":"Cat","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/TP.0b013e3181ac620b","article-title":"A Comprehensive Risk Quantification Score for Deceased Donor Kidneys: The Kidney Donor Risk Index","volume":"88","author":"Rao","year":"2009","journal-title":"Transplantation"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/tri.12736","article-title":"Comparison of survival outcomes between Expanded Criteria Donor and Standard Criteria Donor kidney transplant recipients: A systematic review and meta-analysis","volume":"29","author":"Querard","year":"2016","journal-title":"Transpl. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"l4923","DOI":"10.1136\/bmj.l4923","article-title":"Prediction system for risk of allograft loss in patients receiving kidney transplants: International derivation and validation study","volume":"366","author":"Loupy","year":"2019","journal-title":"BMJ"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1016\/j.jmb.2018.07.003","article-title":"How Mitochondrial Metabolism Contributes to Macrophage Phenotype and Functions","volume":"430","author":"Benmoussa","year":"2018","journal-title":"J. Mol. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev-immunol-102119-073855","article-title":"Trained Immunity: Reprogramming Innate Immunity in Health and Disease","volume":"39","author":"Bekkering","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ceb.2019.12.006","article-title":"Advances in understanding molecular regulation of innate immune memory","volume":"63","author":"Fanucchi","year":"2020","journal-title":"Curr. Opin. Cell Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4989\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:04:48Z","timestamp":1760137488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/4989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,30]]},"references-count":97,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23094989"],"URL":"https:\/\/doi.org\/10.3390\/ijms23094989","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,30]]}}}