{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:51:55Z","timestamp":1791640315434,"version":"4.3.4"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["SUB\/2\/DN\/21\/004\/2215"],"award-info":[{"award-number":["SUB\/2\/DN\/21\/004\/2215"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chitosan (CS)\/poly(ethylene oxide) (PEO)-based nanofiber mats have attracted particular attention as advanced materials for medical and pharmaceutical applications. In the scope of present studies, solution blow spinning was applied to produce nanofibers from PEO and CS and physicochemical and biopharmaceutical studies were carried out to investigate their potential as wound nanomaterial for skin healing and regeneration. Additional coating with hydrophobic poly(dimethylsiloxane) was applied to favor removal of nanofibers from the wound surface. Unmodified nanofibers displayed highly porous structure with the presence of uniform, randomly aligned nanofibers, in contrast to coated materials in which almost all the free spaces were filled in with poly(dimethylsiloxane). Infrared spectroscopy indicated that solution blow technique did not influence the molecular nature of native polymers. Obtained nanofibers exhibited sufficient wound exudate absorbency, which appears beneficial to moisturize the wound bed during the healing process. Formulations displayed greater tensile strength as compared to commercial hydrofiber-like dressing materials comprised of carboxymethylcellulose sodium or calcium alginate, which points toward their protective function against mechanical stress. Coating with hydrophobic poly(dimethylsiloxane) (applied to favor nanofiber removal from the wound surface) impacted porosity and decreased both mechanical properties and adherence to excised human skin, though the obtained values were comparable to those attained for commercial hydrofiber-like materials. In vitro cytotoxicity and irritancy studies showed biocompatibility and no skin irritant response of nanofibers in contact with a reconstituted three-dimensional human skin model, while scratch assay using human fibroblast cell line HDFa revealed the valuable potential of CS\/PEO nanofibers to promote cell migration at an early stage of injury.<\/jats:p>","DOI":"10.3390\/ijms23095135","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T02:19:48Z","timestamp":1651717188000},"page":"5135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Chitosan-Enriched Solution Blow Spun Poly(Ethylene Oxide) Nanofibers with Poly(Dimethylsiloxane) Hydrophobic Outer Layer for Skin Healing and Regeneration"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-8598","authenticated-orcid":false,"given":"Emilia","family":"Szyma\u0144ska","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6046-2061","authenticated-orcid":false,"given":"Micha\u0142","family":"Wojasi\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Chemical and Process Engineering, Warsaw University of Technology, Wary\u0144skiego 1, 00-645 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-6111","authenticated-orcid":false,"given":"Robert","family":"Czarnomysy","sequence":"additional","affiliation":[{"name":"Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kili\u0144skiego 1, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"D\u0119bowska","sequence":"additional","affiliation":[{"name":"Dr Irena Eris Centre for Science and Research, Armii Krajowej 12, 05-500 Piaseczno, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3411-9793","authenticated-orcid":false,"given":"Iwona","family":"\u0141opianiak","sequence":"additional","affiliation":[{"name":"Faculty of Chemical and Process Engineering, Warsaw University of Technology, Wary\u0144skiego 1, 00-645 Warsaw, Poland"},{"name":"Doctoral School No. 1, Warsaw University of Technology, Plac Politechniki 1, 00-661 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Adasiewicz","sequence":"additional","affiliation":[{"name":"Student Scientific Group, Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Ciach","sequence":"additional","affiliation":[{"name":"Faculty of Chemical and Process Engineering, Warsaw University of Technology, Wary\u0144skiego 1, 00-645 Warsaw, Poland"},{"name":"Centre for Advanced Materials and Technologies (CEZAMAT), Warsaw University of Technology, Poleczki 19, 02-822 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1013-610X","authenticated-orcid":false,"given":"Katarzyna","family":"Winnicka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref_1","unstructured":"Hashmi, S. 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