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Psychiatric disorders are caused by a complex combination of genetic (G) and environmental (E) factors. Polysialylation represents a unique posttranslational modification of a protein, and such changes in neural cell adhesion molecules (NCAMs) have been reported in postmortem brains from patients with psychiatric disorders. To understand the G \u00d7 E effect on polysialylated NCAM expression, in this study, we performed precise measurements of polySia and NCAM using a disrupted-in-schizophrenia 1 (DISC1)-mutant mouse (G), a mouse model of schizophrenia, under acute stress conditions (E). This is the first study to reveal a lower number and smaller length of polySia in the suprachiasmatic nucleus of DISC1 mutants relative to those in wild-type (WT) mice. In addition, an analysis of polySia and NCAM responses to acute stress in five brain regions (olfactory bulb, prefrontal cortex, suprachiasmatic nucleus, amygdala, and hippocampus) revealed that the pattern of changes in these responses in WT mice and DISC1 mutants differed by region. These differences could indicate the vulnerability of DISC1 mutants to stress.<\/jats:p>","DOI":"10.3390\/ijms23095207","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T14:49:38Z","timestamp":1651848578000},"page":"5207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Polysialylation in a DISC1 Mutant Mouse"],"prefix":"10.3390","volume":"23","author":[{"given":"Yuka","family":"Takahashi","sequence":"first","affiliation":[{"name":"Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Abe","sequence":"additional","affiliation":[{"name":"Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-2900","authenticated-orcid":false,"given":"Masaya","family":"Hane","sequence":"additional","affiliation":[{"name":"Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Integrated Glyco-Biomedical Research Center (iGMED), Institute for Glyco-core Research (iGCORE), Nagoya University, Chikusa, Nagoya 464-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Integrated Glyco-Biomedical Research Center (iGMED), Institute for Glyco-core Research (iGCORE), Nagoya University, Chikusa, Nagoya 464-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Integrated Glyco-Biomedical Research Center (iGMED), Institute for Glyco-core Research (iGCORE), Nagoya University, Chikusa, Nagoya 464-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-6185","authenticated-orcid":false,"given":"Chihiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan"},{"name":"Integrated Glyco-Biomedical Research Center (iGMED), Institute for Glyco-core Research (iGCORE), Nagoya University, Chikusa, Nagoya 464-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(09)60995-8","article-title":"Schizophrenia","volume":"374","author":"Kapur","year":"2009","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kosz\u0142a, O., Targowska-Duda, K.M., K\u0119dzierska, E., and Kaczor, A.A. (2020). In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia. Biomolecules, 10.","DOI":"10.3390\/biom10010160"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421\u2013427.","DOI":"10.1038\/nature13595"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100892","DOI":"10.1016\/j.mam.2020.100892","article-title":"Polysialylation and disease","volume":"79","author":"Sato","year":"2021","journal-title":"Mol. Aspects Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/jb\/mvt057","article-title":"Disialic. oligosialic and polysialic acids: Distribution, functions and related disease","volume":"154","author":"Sato","year":"2013","journal-title":"J. Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pneurobio.2006.08.003","article-title":"PSA-NCAM in mammalian structural plasticity and neurogenesis","volume":"80","author":"Bonfanti","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0306-4522(92)90107-D","article-title":"Mapping of the distribution of polysialylated neural cell adhesion molecule throughout the central nervous system of the adult rat: An immunohistochemical study","volume":"49","author":"Bonfanti","year":"1992","journal-title":"Neuroscience"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.accb.2018.09.003","article-title":"Sialic Acids in Neurology","volume":"76","author":"Sato","year":"2019","journal-title":"Adv. Carbohydr. Chem. Biochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10719-018-9832-9","article-title":"Mental disorders and an acidic glycan-from the perspective of polysialic acid (PSA\/polySia) and the synthesizing enzyme, ST8SIA2","volume":"35","author":"Sato","year":"2018","journal-title":"Glycoconj. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00429-013-0638-z","article-title":"Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice","volume":"220","author":"Malinovskaja","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1073\/pnas.92.7.2785","article-title":"Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains","volume":"92","author":"Barbeau","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neulet.2012.09.032","article-title":"Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients","volume":"530","author":"Varea","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0300-9084(03)00051-8","article-title":"Polysialyltransferases: Major players in polysialic acid synthesis on the neural cell adhesion molecule","volume":"85","author":"Angata","year":"2003","journal-title":"Biochimie"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.biopsych.2005.08.016","article-title":"Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia","volume":"59","author":"Arai","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21535","DOI":"10.1074\/jbc.M111.221143","article-title":"Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia","volume":"286","author":"Isomura","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1351\/PAC-CON-11-12-10","article-title":"Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient","volume":"84","author":"Hane","year":"2012","journal-title":"Pure Appl. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/glycob\/cwv049","article-title":"Protective effects of polysialic acid on proteolytic cleavage of FGF2 and proBDNF\/BDNF","volume":"25","author":"Hane","year":"2015","journal-title":"Glycobiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/glycob\/cwx057","article-title":"Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4","volume":"27","author":"Mori","year":"2017","journal-title":"Glycobiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.bbrc.2016.08.079","article-title":"Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products","volume":"478","author":"Hane","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpsychires.2011.10.011","article-title":"Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients","volume":"46","author":"Varea","year":"2012","journal-title":"J. Psychiatry Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Abe, C., Nishimura, S., Mori, A., Niimi, Y., Yang, Y., Hane, M., Kitajima, K., and Sato, C. (2017). Chlorpromazine Increases the Expression of Polysialic Acid (PolySia) in Human Neuroblastoma Cells and Mouse Prefrontal Cortex. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061123"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1038\/s41598-019-46240-6","article-title":"Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain","volume":"9","author":"Abe","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00041444-200106000-00003","article-title":"Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder","volume":"11","author":"Devon","year":"2001","journal-title":"Psychiatry Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuron.2007.04.015","article-title":"Behavioral phenotypes of Disc1 missense mutations in mice","volume":"54","author":"Clapcote","year":"2007","journal-title":"Neuron"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuroscience.2015.12.061","article-title":"Utility and validity of DISC1 mouse models in biological psychiatry","volume":"321","author":"Tomoda","year":"2016","journal-title":"Neuroscience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"18923","DOI":"10.1074\/jbc.270.32.18923","article-title":"Characterization of the antigenic specificity of four different anti-(alpha 2-->8-linked polysialic acid) antibodies using lipid-conjugated oligo\/polysialic acids","volume":"270","author":"Sato","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mori, A., Yang, Y., Takahashi, Y., Hane, M., Kitajima, K., and Chihiro, S. (2020). Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165892"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"15422","DOI":"10.1074\/jbc.275.20.15422","article-title":"Frequent occurrence of pre-existing alpha 2-->8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins. Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo-, and poly-Sia antibodies specific for defined chain lengths","volume":"275","author":"Sato","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2174\/187152706778559336","article-title":"The hypothalamic-pituitary-adrenal axis: What can it tell us about stressors?","volume":"5","author":"Armario","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0301-0082(93)90035-Q","article-title":"Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system","volume":"40","author":"Whitnall","year":"1993","journal-title":"Prog. Neurobiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/hmg\/ddx076","article-title":"Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function","volume":"26","author":"Eachus","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0163-7258(97)00004-1","article-title":"The olfactory bulbectomized rat as a model of depression: An update","volume":"74","author":"Kelly","year":"1997","journal-title":"Pharmacol. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/367455a0","article-title":"Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning","volume":"367","author":"Cremer","year":"1994","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1176\/appi.ajp.157.5.828","article-title":"Reduced olfactory bulb volume in patients with schizophrenia","volume":"157","author":"Turetsky","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/10673229.2010.511060","article-title":"Olfactory dysfunction in schizophrenia: A review of neuroanatomy and psychophysiological measurements","volume":"18","author":"Nguyen","year":"2010","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"732360","DOI":"10.3389\/fncel.2021.732360","article-title":"Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: Implications for Neuropsychiatric Disorders","volume":"15","author":"Ruggiero","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1101\/sqb.2007.72.033","article-title":"Suprachiasmatic nucleus clock time in the mammalian circadian system","volume":"72","author":"Okamura","year":"2007","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrn2868","article-title":"Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease","volume":"11","author":"Wulff","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pnpbp.2012.12.021","article-title":"Sleep and circadian rhythm dysregulation in schizophrenia","volume":"43","author":"Monti","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10577","DOI":"10.1523\/JNEUROSCI.1767-06.2006","article-title":"Dopaminergic control of sleep-wake states","volume":"26","author":"Dzirasa","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neures.2016.06.006","article-title":"Abnormal wake\/sleep pattern in a novel gain-of-function model of DISC1","volume":"112","author":"Altimus","year":"2016","journal-title":"Neurosci. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0031-9384(01)00468-1","article-title":"Genetic deletions of NCAM and PSA impair circadian function in the mouse","volume":"73","author":"Shen","year":"2001","journal-title":"Physiol. Behav."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/jnnp.20.1.11","article-title":"Loss of recent memory after bilateral hippocampal lesions","volume":"20","author":"Scoville","year":"1957","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-1-4939-2895-8_10","article-title":"Glucocorticoids and the Brain: Neural Mechanisms Regulating the Stress Response","volume":"872","author":"Shirazi","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0306-4522(00)00484-X","article-title":"Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1","volume":"102","author":"Sandi","year":"2001","journal-title":"Neuroscience"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1046\/j.1460-9568.2003.02513.x","article-title":"Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus","volume":"17","author":"Pham","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/hmg\/9.9.1415","article-title":"Disruption of two novel genes by a translocation co-segregating with schizophrenia","volume":"9","author":"Millar","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/sj.mp.4001880","article-title":"Disrupted in Schizophrenia 1 Interactome: Evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia","volume":"12","author":"Camargo","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"12768","DOI":"10.1523\/JNEUROSCI.3355-09.2009","article-title":"Understanding the role of DISC1 in psychiatric disease and during normal development","volume":"29","author":"Brandon","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.bbrc.2004.03.163","article-title":"DISC1 localizes to the centrosome by binding to kendrin","volume":"317","author":"Miyoshi","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2007.07.010","article-title":"Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain","volume":"130","author":"Duan","year":"2007","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1128\/MCB.00205-07","article-title":"Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development","volume":"27","author":"Angata","year":"2007","journal-title":"Mol. Cell Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/5207\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:07:14Z","timestamp":1760137634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/5207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23095207"],"URL":"https:\/\/doi.org\/10.3390\/ijms23095207","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,6]]}}}