{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:04:21Z","timestamp":1792605861373,"version":"4.5.0"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003069","name":"IPN-Multidisciplinary Project","doi-asserted-by":"publisher","award":["SIP-20210140"],"award-info":[{"award-number":["SIP-20210140"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory disease distinguished by an excessive proliferation and abnormal differentiation of keratinocytes. Immune cells, such as T lymphocytes and neutrophils, and inflammatory cytokines, such as Tumor Necrosis Factor-\u03b1 (TNF-\u03b1) and interleukin 17 (IL-17), are essential for maintaining psoriatic lesions. Additionally, a hypoxic milieu present in the skin promotes the expression of transcriptional factor hypoxia-inducible factor-1 alpha (HIF-1\u03b1). This protein regulates the expression of angiogenic and glycolytic factors, such as vascular endothelial grown factor and lactate dehydrogenase (LDH), both relevant in chronic inflammation. The von Hippel\u2013Lindau protein (pVHL) is a negative regulator of HIF-1\u03b1. Previously, we found that pVHL was almost absent in the lesions of psoriasis patients; therefore, we investigated the impact of rescue pVHL expression in lesional skin. We used the imiquimod-induced psoriasis-like mouse model as an adenoviral vector that allowed us to express pVHL in the skin. Our data show that, in lesional skin, pVHL expression was reduced, whereas HIF-1\u03b1 was increased. Remarkably, the retrieval of pVHL prevented psoriatic lesions, diminishing erythema, scale, and epidermal and vascular thickness. Furthermore, pVHL expression was capable of reducing HIF-1\u03b1, LDH, TNF-\u03b1 and immune cell infiltration (mainly IL-17+ neutrophils). In conclusion, our results demonstrate that pVHL has a protective role to play in the pathophysiology of psoriasis.<\/jats:p>","DOI":"10.3390\/ijms23095226","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T08:04:21Z","timestamp":1651997061000},"page":"5226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Protective Role of pVHL in Imiquimod-Induced Psoriasis-like Skin Inflammation"],"prefix":"10.3390","volume":"23","author":[{"given":"Isa\u00ed","family":"Mart\u00ednez-Torres","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n de Carpio, Col. Santo Tomas, Alcald\u00eda Miguel Hidalgo, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-9416","authenticated-orcid":false,"given":"Araceli","family":"Tepale-Segura","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n de Carpio, Col. Santo Tomas, Alcald\u00eda Miguel Hidalgo, Ciudad de M\u00e9xico C.P. 11340, Mexico"},{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauht\u00e9moc 330 Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, Ciudad de M\u00e9xico C.P. 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-4854","authenticated-orcid":false,"given":"Octavio","family":"Castro-Escamilla","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauht\u00e9moc 330 Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, Ciudad de M\u00e9xico C.P. 06720, Mexico"},{"name":"Unidad de Investigaci\u00f3n en Virolog\u00eda y C\u00e1ncer, Hospital Infantil De M\u00e9xico Federico G\u00f3mez, Dr. M\u00e1rquez 162. Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, Ciudad de M\u00e9xico C.P. 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Cancino-Diaz","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n de Carpio, Col. Santo Tomas, Alcaldia Miguel Hidalgo, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Rodr\u00edguez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n de Carpio, Col. Santo Tomas, Alcald\u00eda Miguel Hidalgo, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Mayra","family":"Perez-Tapia","sequence":"additional","affiliation":[{"name":"Unidad de Desarrollo e Invstigaci\u00f3n en Bioterap\u00e9uticos (UDIBI), Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Bonifaz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauht\u00e9moc 330 Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, Ciudad de M\u00e9xico C.P. 06720, Mexico"},{"name":"Coordinaci\u00f3n de Investigaci\u00f3n en Salud, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauht\u00e9moc 330 Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, Ciudad de M\u00e9xico C.P. 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-7892","authenticated-orcid":false,"given":"Mario Eugenio","family":"Cancino-Diaz","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n de Carpio, Col. Santo Tomas, Alcald\u00eda Miguel Hidalgo, Ciudad de M\u00e9xico C.P. 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of Psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. Rev. 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