{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:32:33Z","timestamp":1769279553207,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Ministery of Research and Innovation, CNCS-UEFISCDI","doi-asserted-by":"publisher","award":["PN-III-P4-ID-PCCF-2016-0172"],"award-info":[{"award-number":["PN-III-P4-ID-PCCF-2016-0172"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Prognosis after myocardial infarction (MI) varies greatly depending on the extent of damaged area and the management of biological processes during recovery. Reportedly, the inhibition of the pro-inflammatory S100A9 reduces myocardial damage after MI. We hypothesize that a S100A9 blockade induces changes of major signaling pathways implicated in post-MI healing. Mass spectrometry-based proteomics and gene analyses of infarcted mice left ventricle were performed. The S100A9 blocker (ABR-23890) was given for 3 days after coronary ligation. At 3 and 7 days post-MI, ventricle samples were analyzed versus control and Sham-operated mice. Blockade of S100A9 modulated the expressed proteins involved in five biological processes: leukocyte cell\u2013cell adhesion, regulation of the muscle cell apoptotic process, regulation of the intrinsic apoptotic signaling pathway, sarcomere organization and cardiac muscle hypertrophy. The blocker induced regulation of 36 proteins interacting with or targeted by the cellular tumor antigen p53, prevented myocardial compensatory hypertrophy, and reduced cardiac markers of post-ischemic stress. The blockade effect was prominent at day 7 post-MI when the quantitative features of the ventricle proteome were closer to controls. Blockade of S100A9 restores key biological processes altered post-MI. These processes could be valuable new pharmacological targets for the treatment of ischemic heart. Mass spectrometry data are available via ProteomeXchange with identifier PXD033683.<\/jats:p>","DOI":"10.3390\/ijms23095289","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T21:23:27Z","timestamp":1652131407000},"page":"5289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Short-Term Blockade of Pro-Inflammatory Alarmin S100A9 Favorably Modulates Left Ventricle Proteome and Related Signaling Pathways Involved in Post-Myocardial Infarction Recovery"],"prefix":"10.3390","volume":"23","author":[{"given":"Raluca Maria","family":"Boteanu","sequence":"first","affiliation":[{"name":"Department of Proteomics, Institute of Cellular Biology and Pathology \u201cN. Simionescu\u201d of the Romanian Academy, 050568 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2168-7182","authenticated-orcid":false,"given":"Viorel-Iulian","family":"Suica","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Institute of Cellular Biology and Pathology \u201cN. Simionescu\u201d of the Romanian Academy, 050568 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-1937","authenticated-orcid":false,"given":"Elena","family":"Uyy","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Institute of Cellular Biology and Pathology \u201cN. Simionescu\u201d of the Romanian Academy, 050568 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luminita","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Institute of Cellular Biology and Pathology \u201cN. Simionescu\u201d of the Romanian Academy, 050568 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurel","family":"Cerveanu-Hogas","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Institute of Cellular Biology and Pathology \u201cN. Simionescu\u201d of the Romanian Academy, 050568 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-3502","authenticated-orcid":false,"given":"Razvan Gheorghita","family":"Mares","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Simionescu","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Institute of Cellular Biology and Pathology \u201cN. Simionescu\u201d of the Romanian Academy, 050568 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-5050","authenticated-orcid":false,"given":"Alexandru","family":"Schiopu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Department of Clinical Sciences Malm\u00f6, Lund University, 21428 Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Antohe","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Institute of Cellular Biology and Pathology \u201cN. Simionescu\u201d of the Romanian Academy, 050568 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: Pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"H71","DOI":"10.1152\/ajpheart.00131.2018","article-title":"Myocardial infarction remodeling that progresses to heart failure: A signaling misunderstanding","volume":"315","author":"Mouton","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/FJC.0000000000000777","article-title":"Spatiotemporal dynamics of immune cells in early left ventricular remodeling after acutemyocardial infarction in mice","volume":"75","author":"Bejjani","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11897-015-0255-7","article-title":"Cellular Immunity and Cardiac Remodeling After Myocardial Infarction: Role of Neutrophils, Monocytes, and Macrophages","volume":"12","author":"Shinagawa","year":"2015","journal-title":"Curr. Heart Fail Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.ijcard.2016.06.223","article-title":"PARP inhibition and postinfarction myocardial remodeling","volume":"217","author":"Halmosi","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.118.039262","article-title":"S100a8\/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic\/ReperfusionInjury","volume":"140","author":"Li","year":"2019","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/CIRCRESAHA.120.315865","article-title":"S100A9 links inflammation and repair in myocardial infarction","volume":"127","author":"Koenis","year":"2020","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1093\/eurheartj\/ehz461","article-title":"Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction","volume":"40","author":"Yndigegn","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Ortiz, A., and Serrador, J.M. (2020). Erm proteins at the crossroad of leukocyte polarization, migration and intercellular adhesion. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041502"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12967-017-1191-y","article-title":"Apoptosis in ischemic heart disease","volume":"15","author":"Teringova","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0167-5273(00)00264-3","article-title":"Prognostic value of left ventricular hypertrophy and geometry in patients with a first, uncomplicated myocardial infarction","volume":"74","author":"Carluccio","year":"2000","journal-title":"Int. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1073\/pnas.1621436114","article-title":"P53 Regulates the Cardiac Transcriptome","volume":"114","author":"Mak","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","first-page":"117","article-title":"Comparative proteomic analysis in left ventricular remodeling following myocardial infarction in rats","volume":"25","author":"Gu","year":"2012","journal-title":"Biomed. Environ. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"R\u00fcdebusch, J., Benkner, A., Poesch, A., D\u00f6rr, M., V\u00f6lker, U., Grube, K., Hammer, E., and Felix, S.B. (2017). Dynamic adaptation of myocardial proteome during heart failure development. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185915"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1038\/s41598-018-25817-7","article-title":"Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue","volume":"8","author":"Yajima","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3389\/fphys.2019.00750","article-title":"Cardiac proteome profiling in ischemic and dilated cardiomyopathy mouse models","volume":"10","author":"Lu","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41420-019-0152-z","article-title":"The whole transcriptome and proteome changes in the early stage of myocardial infarction","volume":"5","author":"Li","year":"2019","journal-title":"Cell Death Discov."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.2337\/diabetes.53.8.1979","article-title":"Increased serum levels of MRP-8\/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin","volume":"53","author":"Bouma","year":"2004","journal-title":"Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1074\/jbc.M102950200","article-title":"The S100 family heterodimer, MRP-8\/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells","volume":"277","author":"Robinson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.CIR.0000051363.86009.3C","article-title":"Temporal response and localization of integrins \u03b21 and \u03b23 in the heart after myocardial infarction: Regulation by cytokines","volume":"107","author":"Sun","year":"2003","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1182\/bloodadvances.2020002423","article-title":"Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength","volume":"4","author":"Panicker","year":"2020","journal-title":"Blood Adv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"jcs215541","DOI":"10.1242\/jcs.215541","article-title":"Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration","volume":"131","author":"Tomlins","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"H476","DOI":"10.1152\/ajpheart.00180.2016","article-title":"Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation","volume":"311","author":"Miyawaki","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/BJ20090465","article-title":"A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway","volume":"422","author":"Li","year":"2009","journal-title":"Biochem. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"H1422","DOI":"10.1152\/ajpheart.2001.281.3.H1422","article-title":"Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis","volume":"281","author":"Williams","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1159\/000354505","article-title":"SIRT5: A safeguard against oxidative stress-induced apoptosis in cardiomyocytes","volume":"32","author":"Liu","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"798","DOI":"10.2337\/diabetes.55.03.06.db05-1039","article-title":"Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy","volume":"55","author":"Shen","year":"2006","journal-title":"Diabetes"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19767","DOI":"10.1074\/jbc.M117.809897","article-title":"Sirtuin 5 is required for mouse survival in response to cardiac pressure overload","volume":"292","author":"Hershberger","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jacbts.2017.09.009","article-title":"The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease","volume":"3","author":"Myers","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/CIRCULATIONAHA.105.576785","article-title":"Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress","volume":"113","author":"Donath","year":"2006","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/MCB.00738-07","article-title":"p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC","volume":"28","author":"Li","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00109-016-1413-4","article-title":"Transgenic overexpression of adenine nucleotide translocase 1 protects ischemic hearts against oxidative stress","volume":"94","author":"Klumpe","year":"2016","journal-title":"J. Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1074\/jbc.M704990200","article-title":"Beta-2-glycoprotein 1-dependent macrophage uptake of apoptotic cells","volume":"283","author":"Maiti","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"49251","DOI":"10.1074\/jbc.M407165200","article-title":"A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1101\/gad.860301","article-title":"Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer","volume":"15","author":"Pilotte","year":"2001","journal-title":"Genes Dev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/j.ijcard.2013.04.045","article-title":"Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1","volume":"168","author":"Yan","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"16409","DOI":"10.1074\/jbc.M109.005736","article-title":"Nucleophosmin blocks mitochondrial localization of p53 and apoptosis","volume":"284","author":"Dhar","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1073\/pnas.1017935108","article-title":"Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin","volume":"108","author":"Avitabile","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bbadis.2013.09.016","article-title":"Stressing on the nucleolus in cardiovascular disease","volume":"1842","author":"Hariharan","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00395-010-0122-3","article-title":"Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: The effect of NHE-1 inhibition","volume":"106","author":"Javadov","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/CS20130828","article-title":"Role of MIF in myocardial ischaemia and infarction: Insight from recent clinical and experimental findings","volume":"127","author":"Dayawansa","year":"2014","journal-title":"Clin. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1111\/j.1582-4934.2010.01235.x","article-title":"Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure","volume":"15","author":"Lim","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1073\/pnas.1704723114","article-title":"Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3","volume":"114","author":"Hu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40001-019-0381-x","article-title":"Identification of key genes involved in myocardial infarction","volume":"24","author":"Qiu","year":"2019","journal-title":"Eur. J. Med. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1016\/j.celrep.2019.05.039","article-title":"The RNA-binding protein YBX3 controls amino acid levels by regulating SLC mRNA abundance","volume":"27","author":"Cooke","year":"2019","journal-title":"Cell Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.isci.2019.02.023","article-title":"Loss of RNA-binding protein Sfpq causes long-gene transcriptopathy in skeletal muscle and severe muscle mass reduction with metabolic myopathy","volume":"13","author":"Hosokawa","year":"2019","journal-title":"iScience"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1080\/15476286.2020.1771944","article-title":"Regulation of the p53 expression profile by hnRNP K under stress conditions","volume":"17","author":"Swiatkowska","year":"2020","journal-title":"RNA Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1073\/pnas.95.8.4556","article-title":"Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury","volume":"95","author":"Wang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/01.CIR.0000109701.77059.E9","article-title":"Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice","volume":"109","author":"Shiomi","year":"2004","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.bbamem.2011.11.008","article-title":"Does the voltage dependent anion channel modulate cardiac ischemia-reperfusion injury?","volume":"1818","author":"Das","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41419-019-1787-7","article-title":"Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism","volume":"10","author":"Cai","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1046\/j.1432-1327.2001.02247.x","article-title":"Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle","volume":"268","author":"Thirion","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1083\/jcb.145.6.1251","article-title":"Aip1p interacts with cofilin to disassemble actin filaments","volume":"145","author":"Rodal","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/1074248420923542","article-title":"Hydrogen sulfide therapy suppresses cofilin-2 and attenuates ischemic heart failure in a mouse model of myocardial infarction","volume":"25","author":"Nguyen","year":"2020","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10974-013-9343-z","article-title":"A study of tropomyosin\u2019s role in cardiac function and disease using thin-filament reconstituted myocardium","volume":"34","author":"Bai","year":"2013","journal-title":"J. Muscle Res. Cell. Motil."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mi-Mi, L., Farman, G.P., Mayfield, R.M., Strom, J., Chu, M., Pappas, C.T., and Gregorio, C.C. (2020). In vivo elongation of thin filaments results in heart failure. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0226138"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/CIRCRESAHA.117.312117","article-title":"LncRNA ZFAS1 as a SERCA2a inhibitor to cause intracellular Ca2+ overload and contractile dysfunction in a mouse model of myocardial infarction","volume":"122","author":"Zhang","year":"2018","journal-title":"Circ. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1517\/14712590903321462","article-title":"Sarcoplasmic reticulum Ca2+ ATPase as a therapeutic target for heart failure","volume":"10","author":"Lipskaia","year":"2010","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"H259","DOI":"10.1152\/ajpheart.00766.2006","article-title":"Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein","volume":"292","author":"Boateng","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.06.029","article-title":"Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)","volume":"569","author":"Song","year":"2015","journal-title":"Gene"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.110.223925","article-title":"A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse","volume":"107","author":"Gao","year":"2010","journal-title":"Circ. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: A Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/bioinformatics\/btt019","article-title":"CluePedia Cytoscape plugin: Pathway insights using integrated experimental and in silico data","volume":"29","author":"Bindea","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Heberle, H., Meirelles, V.G., da Silva, F.R., Telles, G.P., and Minghim, R. (2015). InteractiVenn: A web-based tool for the analysis of sets through Venn diagrams. BMC Bioinform., 16.","DOI":"10.1186\/s12859-015-0611-3"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: A Hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Bai","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/5289\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:08:29Z","timestamp":1760137709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/9\/5289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,9]]},"references-count":68,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23095289"],"URL":"https:\/\/doi.org\/10.3390\/ijms23095289","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,9]]}}}