{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:38:38Z","timestamp":1790829518887,"version":"4.1.0"},"reference-count":125,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation Leducq convention","award":["16CVD01"],"award-info":[{"award-number":["16CVD01"]}]},{"name":"Fondation Leducq convention","award":["EGID, ANR-10-LABX-0046"],"award-info":[{"award-number":["EGID, ANR-10-LABX-0046"]}]},{"name":"Fondation Leducq convention","award":["694717"],"award-info":[{"award-number":["694717"]}]},{"name":"European Genomic Institute for Diabetes","award":["16CVD01"],"award-info":[{"award-number":["16CVD01"]}]},{"name":"European Genomic Institute for Diabetes","award":["EGID, ANR-10-LABX-0046"],"award-info":[{"award-number":["EGID, ANR-10-LABX-0046"]}]},{"name":"European Genomic Institute for Diabetes","award":["694717"],"award-info":[{"award-number":["694717"]}]},{"name":"Advanced ERC Grant","award":["16CVD01"],"award-info":[{"award-number":["16CVD01"]}]},{"name":"Advanced ERC Grant","award":["EGID, ANR-10-LABX-0046"],"award-info":[{"award-number":["EGID, ANR-10-LABX-0046"]}]},{"name":"Advanced ERC Grant","award":["694717"],"award-info":[{"award-number":["694717"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Transcatheter aortic valve replacement (TAVR), as an alternative to open heart surgery, has revolutionized the treatment of severe aortic valve stenosis (AVS), the most common valvular disorder in the elderly. AVS is now considered a form of atherosclerosis and, like the latter, partly of inflammatory origin. Patients with high-grade AVS have a highly disturbed blood flow associated with high levels of shear stress. The immediate reopening of the valve during TAVR leads to a sudden restoration of a normal blood flow hemodynamic. Despite its good prognosis for patients, TAVR remains associated with bleeding or thrombotic postprocedural complications, involving mechanisms that are still poorly understood. Many studies report the close link between blood coagulation and inflammation, termed thromboinflammation, including monocytes as a major actor. The TAVR procedure represents a unique opportunity to study the influence of shear stress on human monocytes, key mediators of inflammation and hemostasis processes. The purpose of this study was to conduct a review of the literature to provide a comprehensive overview of the impact of TAVR on monocyte phenotype and subset repartition and the association of these parameters with the clinical outcomes of patients with severe AVS who underwent TAVR.<\/jats:p>","DOI":"10.3390\/ijms23105303","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T08:31:55Z","timestamp":1652171515000},"page":"5303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Circulating Monocyte Subsets and Transcatheter Aortic Valve Replacement"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0494-823X","authenticated-orcid":false,"given":"Fanny","family":"Lassalle","sequence":"first","affiliation":[{"name":"Inserm, CHU Lille, Institut Pasteur de Lille, University Lille, U1011-EGID, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Rosa","sequence":"additional","affiliation":[{"name":"Inserm, CHU Lille, Institut Pasteur de Lille, University Lille, U1011-EGID, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-1503","authenticated-orcid":false,"given":"Bart","family":"Staels","sequence":"additional","affiliation":[{"name":"Inserm, CHU Lille, Institut Pasteur de Lille, University Lille, U1011-EGID, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Van Belle","sequence":"additional","affiliation":[{"name":"Inserm, CHU Lille, Institut Pasteur de Lille, University Lille, U1011-EGID, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Susen","sequence":"additional","affiliation":[{"name":"Inserm, CHU Lille, Institut Pasteur de Lille, University Lille, U1011-EGID, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Dupont","sequence":"additional","affiliation":[{"name":"Inserm, CHU Lille, Institut Pasteur de Lille, University Lille, U1011-EGID, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/ATVBAHA.119.313067","article-title":"Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets","volume":"40","author":"Goody","year":"2020","journal-title":"Arterioscler. 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