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The thin filaments are organized into densely packed lattices interdigitated with myosin-based thick filaments. The crossbridge interactions between these myofilaments drive muscle contraction, and the degree of myofilament overlap is a key factor of contractile force determination. As such, the optimal length of the thin filaments is critical for efficient activity, therefore, this parameter is precisely controlled according to the workload of a given muscle. Thin filament length is thought to be regulated by two major, but only partially understood mechanisms: it is set by (i) factors that mediate the assembly of filaments from monomers and catalyze their elongation, and (ii) by factors that specify their length and uniformity. Mutations affecting these factors can alter the length of thin filaments, and in human cases, many of them are linked to debilitating diseases such as nemaline myopathy and dilated cardiomyopathy.<\/jats:p>","DOI":"10.3390\/ijms23105306","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T08:31:55Z","timestamp":1652171515000},"page":"5306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Mechanisms of Thin Filament Assembly and Length Regulation in Muscles"],"prefix":"10.3390","volume":"23","author":[{"given":"Szil\u00e1rd","family":"Szikora","sequence":"first","affiliation":[{"name":"Institute of Genetics, Biological Research Centre, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"G\u00f6r\u00f6g","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Biological Research Centre, H-6726 Szeged, Hungary"},{"name":"Doctoral School of Multidisciplinary Medical Science, Faculty of Medicine, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-2424","authenticated-orcid":false,"given":"J\u00f3zsef","family":"Mih\u00e1ly","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Biological Research Centre, H-6726 Szeged, Hungary"},{"name":"Department of Genetics, University of Szeged, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/173971a0","article-title":"Structural changes in muscle during contraction; interference microscopy of living muscle fibres","volume":"173","author":"Huxley","year":"1954","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/jphysiol.1966.sp007873","article-title":"The relation between sarcomere length and active tension in isolated semitendinosus fibres of the frog","volume":"183","author":"Edman","year":"1966","journal-title":"J. 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