{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:20:39Z","timestamp":1760232039719,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008251","name":"Internal Funding Agency of Tomas Bata University in Zl\u00edn","doi-asserted-by":"publisher","award":["IGA\/FT\/2020\/007"],"award-info":[{"award-number":["IGA\/FT\/2020\/007"]}],"id":[{"id":"10.13039\/501100008251","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>New tetrahydropyrazino[2,3-c]quinolin-5(6H)-ones were prepared from 3-chloroquinoline-2,4(1H,3H)-diones and ethylene diamine. In their reaction with HNCO, an unprecedented molecular rearrangement produced new types of hydantoin derivatives. All prepared compounds were characterized on the basis of their 1H, 13C, and 15N NMR and ESI mass spectra and some were authenticated by X-ray analysis of single crystalline material. A proposed mechanism for rearrangement is discussed in this essay. The CDK and ABL inhibition activity as well as in vitro cytotoxicity of the prepared compounds was also tested.<\/jats:p>","DOI":"10.3390\/ijms23105481","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T09:27:56Z","timestamp":1652520476000},"page":"5481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Rearrangement of Pyrazino[2,3-c]quinolin-5(6H)-ones during Their Reaction with Isocyanic Acid"],"prefix":"10.3390","volume":"23","author":[{"given":"Anton\u00edn","family":"Kl\u00e1sek","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 5669, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-5044","authenticated-orcid":false,"given":"Anton\u00edn","family":"Ly\u010dka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Hradec Kr\u00e1lov\u00e9, Rokitansk\u00e9ho 62, 530 03 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"K\u0159emen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 5669, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale\u0161","family":"R\u016f\u017ei\u010dka","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-4040","authenticated-orcid":false,"given":"Michal","family":"Rouchal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 5669, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3390\/81100793","article-title":"The Chemistry of \u03b1-Haloketones and Their Utility in Heterocyclic Synthesis","volume":"8","author":"Erian","year":"2003","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3987\/COM-02-9522","article-title":"Syntheses of 3-Aminoquionoline-2,4(1H,3H)-diones","volume":"57","author":"Kafka","year":"2002","journal-title":"Heterocycles"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0040-4020(03)00028-0","article-title":"Unprecendented reactivity of 3-amino-1H,3H-quionoline-2,4-diones with urea: An efficient synthesis of 2,6-dihydro-imidazo[1,5-c]quinazoline-3,5-diones","volume":"59","year":"2003","journal-title":"Tetrahedron"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1016\/S0040-4020(03)00785-3","article-title":"Reaction of 1-alkyl\/aryl-3amino-1H,3H-quinoline-2,4-diones with urea. 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