{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:40:31Z","timestamp":1790728831836,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["2017-I2M-3-012"],"award-info":[{"award-number":["2017-I2M-3-012"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2018ZX09711001-003-010"],"award-info":[{"award-number":["2018ZX09711001-003-010"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2019-1007-19"],"award-info":[{"award-number":["2019-1007-19"]}]},{"name":"National Mega-Project for \u201cR&amp;D for Innovative drugs\u201d","award":["2017-I2M-3-012"],"award-info":[{"award-number":["2017-I2M-3-012"]}]},{"name":"National Mega-Project for \u201cR&amp;D for Innovative drugs\u201d","award":["2018ZX09711001-003-010"],"award-info":[{"award-number":["2018ZX09711001-003-010"]}]},{"name":"National Mega-Project for \u201cR&amp;D for Innovative drugs\u201d","award":["2019-1007-19"],"award-info":[{"award-number":["2019-1007-19"]}]},{"name":"Ministry of Science and Technology","award":["2017-I2M-3-012"],"award-info":[{"award-number":["2017-I2M-3-012"]}]},{"name":"Ministry of Science and Technology","award":["2018ZX09711001-003-010"],"award-info":[{"award-number":["2018ZX09711001-003-010"]}]},{"name":"Ministry of Science and Technology","award":["2019-1007-19"],"award-info":[{"award-number":["2019-1007-19"]}]},{"name":"PUMC Innovation Fund for Graduate Student","award":["2017-I2M-3-012"],"award-info":[{"award-number":["2017-I2M-3-012"]}]},{"name":"PUMC Innovation Fund for Graduate Student","award":["2018ZX09711001-003-010"],"award-info":[{"award-number":["2018ZX09711001-003-010"]}]},{"name":"PUMC Innovation Fund for Graduate Student","award":["2019-1007-19"],"award-info":[{"award-number":["2019-1007-19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and there is no specific drug to treat it. Recent results showed that 17-beta-hydroxysteroid dehydrogenase type 13 (HSD17B13) is associated with liver diseases, but these conclusions are controversial. Here, we showed that HSD17B13 was more highly expressed in the livers of NAFLD patients, and high expression was induced in the livers of murine NAFLD models and cultural hepatocytes treated using various etiologies. The high HSD17B13 expression in the hepatocytes facilitated the progression of NAFLD by directly stabilizing the intracellular lipid drops and by indirectly activating hepatic stellate cells. When HSD17B13 was overexpressed in the liver, it aggravated liver steatosis and fibrosis in mice fed with a high-fat diet, while down-regulated the high expression of HSD17B13 by short hairpin RNAs produced a therapeutic effect in the NAFLD mice. We concluded that high HSD17B13 expression is a good target for the development of drugs to treat NAFLD.<\/jats:p>","DOI":"10.3390\/ijms23105544","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T13:06:23Z","timestamp":1652706383000},"page":"5544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Down-Regulating the High Level of 17-Beta-Hydroxysteroid Dehydrogenase 13 Plays a Therapeutic Role for Non-Alcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"23","author":[{"given":"Meixi","family":"Wang","sequence":"first","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrui","family":"Li","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Li","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"},{"name":"Key Laboratory of Biotechnology of Antibiotics, The National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Dong","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"},{"name":"Key Laboratory of Biotechnology of Antibiotics, The National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, 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Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Li","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Sun","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Tang","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Yan","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3725-3258","authenticated-orcid":false,"given":"Yuhuan","family":"Li","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"},{"name":"Key Laboratory of Biotechnology of Antibiotics, The National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, 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Rev. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: Current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.gtc.2019.09.001","article-title":"Genetic Risk Factors and Disease Modifiers of Nonalcoholic Steatohepatitis","volume":"49","author":"Kozlitina","year":"2020","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41575-019-0144-8","article-title":"Past, present and future perspectives in nonalcoholic fatty liver disease","volume":"16","author":"Sanyal","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41575-020-00406-0","article-title":"Nonalcoholic fatty liver disease: Another leap forward","volume":"18","author":"Abdelmalek","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/17474124.2018.1530110","article-title":"An update on the recent advances in antifibrotic therapy","volume":"12","author":"Tacke","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1053\/j.gastro.2020.01.051","article-title":"Therapeutic Landscape for NAFLD in 2020","volume":"158","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/hep.30350","article-title":"17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease","volume":"69","author":"Ma","year":"2019","journal-title":"Hepatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa1712191","article-title":"A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease","volume":"378","author":"Cheng","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1056\/NEJMc1804027","article-title":"HSD17B13 and Chronic Liver Disease in Blacks and Hispanics","volume":"379","author":"Kozlitina","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41575-018-0016-7","article-title":"An HSD17B13 variant reduces cirrhosis risk","volume":"15","author":"Thomas","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.15403\/jgld-168","article-title":"SERPINA1 and HSD17B13 Gene Variants in Patients with Liver Fibrosis and Cirrhosis","volume":"28","author":"Skieceviciene","year":"2019","journal-title":"J. Gastrointestin Liver Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/hep.30996","article-title":"Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers","volume":"72","author":"Stickel","year":"2020","journal-title":"Hepatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.18388\/abp.2007_3289","article-title":"Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase\/reductase 9","volume":"54","author":"Liu","year":"2007","journal-title":"Acta Biochim. Pol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mce.2018.10.014","article-title":"Role of HSD17B13 in the liver physiology and pathophysiology","volume":"489","author":"Su","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mce.2018.11.012","article-title":"17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes","volume":"489","author":"Hiltunen","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbrc.2008.03.063","article-title":"17beta-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein","volume":"370","author":"Horiguchi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1073\/pnas.1410741111","article-title":"Comparative proteomic study reveals 17\u03b2-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease","volume":"111","author":"Su","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"E357","DOI":"10.1152\/ajpendo.00310.2016","article-title":"Liver X receptor \u03b1 induces 17\u03b2-hydroxysteroid dehydrogenase-13 expression through SREBP-1c","volume":"312","author":"Su","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/MPG.0000000000002573","article-title":"The rs72613567: TA Variant in the Hydroxysteroid 17-beta Dehydrogenase 13 Gene Reduces Liver Damage in Obese Children","volume":"70","author":"Umano","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/liv.14387","article-title":"Association of HSD17B13 rs72613567:TA with non-alcoholic fatty liver disease in Hispanics\/Latinos","volume":"40","author":"Kallwitz","year":"2020","journal-title":"Liver Int."},{"key":"ref_24","first-page":"8997","article-title":"HSD17B13 rs72613567 protects against liver diseases and histological progression of nonalcoholic fatty liver disease: A systematic review and meta-analysis","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1096\/fj.201700914R","article-title":"Hydroxysteroid (17\u03b2) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice","volume":"32","author":"Adam","year":"2018","journal-title":"FASEB J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.hbpd.2018.04.006","article-title":"17-beta-hydroxysteroid dehydrogenase 13 inhibits the progression and recurrence of hepatocellular carcinoma","volume":"17","author":"Chen","year":"2018","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/hep.31173","article-title":"Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of NAFLD","volume":"72","author":"Paik","year":"2020","journal-title":"Hepatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41575-018-0055-0","article-title":"The changing epidemiology of liver diseases in the Asia-Pacific region","volume":"16","author":"Wong","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_29","unstructured":"(2022, January 12). Available online: http:\/\/biogps.org\/#goto=genereport&id=243168."},{"key":"ref_30","unstructured":"(2022, January 12). Available online: http:\/\/biogps.org\/#goto=genereport&id=345275."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/hep.31517","article-title":"17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury","volume":"73","author":"Ma","year":"2020","journal-title":"Hepatology"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Khatun, M., and Ray, R.B. (2019). Mechanisms Underlying Hepatitis C Virus-Associated Hepatic Fibrosis. Cells, 8.","DOI":"10.3390\/cells8101249"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1056\/NEJMc1804638","article-title":"HCV-Associated Liver Fibrosis and HSD17B13","volume":"379","author":"About","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"546106","DOI":"10.3389\/fgene.2020.546106","article-title":"Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines","volume":"11","author":"Kawamoto","year":"2020","journal-title":"Front. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13001","DOI":"10.1128\/JVI.76.24.13001-13014.2002","article-title":"Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication","volume":"76","author":"Blight","year":"2002","journal-title":"J. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1038\/s41598-019-43335-y","article-title":"Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart","volume":"9","author":"Mardani","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ncb3166","article-title":"Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis","volume":"17","author":"Kaushik","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_38","first-page":"56","article-title":"High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase\u2013Lowering Effect of a HSD17B13 Variant","volume":"71","author":"Nordestgaard","year":"2019","journal-title":"Hepatology"},{"key":"ref_39","unstructured":"Moriles, K.E., and Azer, S.A. (2022). Alanine Amino Transferase. StatPearls, StatPearls Publishing LLC."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Motomura, T., Amirneni, S., Diaz-Aragon, R., Faccioli, L., Malizio, M., Coard, M., Kocas-Kilicarslan, Z., Frau, C., Haep, N., and Ostrowska, A. (2021). Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic Target. J. Pers. Med., 11.","DOI":"10.3390\/jpm11070619"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1194\/jlr.RA120000907","article-title":"Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity","volume":"61","author":"Ma","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.3748\/wjg.v25.i24.3009","article-title":"Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease","volume":"25","author":"Mato","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1055\/s-0033-1358521","article-title":"The Lipid Droplet as a Potential Therapeutic Target in NAFLD","volume":"33","author":"Goh","year":"2013","journal-title":"Semin. Liver Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/JLB.4MR0119-035R","article-title":"Fat, fight, and beyond: The multiple roles of lipid droplets in infections and inflammation","volume":"106","author":"Teixeira","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"114933","DOI":"10.1016\/j.bcp.2022.114933","article-title":"Targeting lipophagy as a potential therapeutic strategy for nonalcoholic fatty liver disease","volume":"197","author":"Li","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e132158","DOI":"10.1172\/jci.insight.132158","article-title":"Hydroxysteroid 17-\u03b2 dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease","volume":"5","author":"Luukkonen","year":"2020","journal-title":"JCI Insight"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1538\/expanim.18-0108","article-title":"AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: A new animal model for nonalcoholic fatty liver disease","volume":"68","author":"Komatsu","year":"2019","journal-title":"Exp. Anim."},{"key":"ref_53","first-page":"114845","article-title":"Models of nonalcoholic steatohepatitis potentiated by chemical inducers leading to hepatocellular carcinoma","volume":"195","author":"Muriel","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/hep.29881","article-title":"Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis","volume":"68","author":"Qu","year":"2018","journal-title":"Hepatology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/hep.30333","article-title":"Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis","volume":"69","author":"Farrell","year":"2018","journal-title":"Hepatology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/hep.24047","article-title":"Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells","volume":"53","author":"He","year":"2010","journal-title":"Hepatology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/hep.24160","article-title":"Host apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G is an innate defensive factor and drug target against hepatitis C virus","volume":"53","author":"Peng","year":"2011","journal-title":"Hepatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.antiviral.2019.03.005","article-title":"APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity","volume":"165","author":"Wang","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.virol.2018.11.016","article-title":"heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-\u03b1\/\u03b2","volume":"528","author":"Ma","year":"2018","journal-title":"Virology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s12250-021-00399-3","article-title":"PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression","volume":"36","author":"Yan","year":"2021","journal-title":"Virol. Sin."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/15548627.2017.1319544","article-title":"The constitutive lipid droplet protein PLIN2 regulates autophagy in liver","volume":"13","author":"Tsai","year":"2017","journal-title":"Autophagy"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/hep.30822","article-title":"Hepatocyte TNF Receptor\u2013Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6\u2013Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1","volume":"71","author":"Wang","year":"2019","journal-title":"Hepatology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1111\/jcmm.16432","article-title":"TGF-\u03b2 isoforms inhibit hepatitis C virus propagation in transforming growth factor beta\/SMAD protein signalling pathway dependent and independent manners","volume":"25","author":"Zou","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nm.4453","article-title":"The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat. Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/10\/5544\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:11:20Z","timestamp":1760137880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/10\/5544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23105544"],"URL":"https:\/\/doi.org\/10.3390\/ijms23105544","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]}}}