{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:08:22Z","timestamp":1785388102343,"version":"3.55.0"},"reference-count":108,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","award":["CAPES\u2014Finance Code 001"],"award-info":[{"award-number":["CAPES\u2014Finance Code 001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","award":["CNPq, Process no 308489\/2020-9"],"award-info":[{"award-number":["CNPq, Process no 308489\/2020-9"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","award":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"],"award-info":[{"award-number":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s (FAPEG)","award":["CAPES\u2014Finance Code 001"],"award-info":[{"award-number":["CAPES\u2014Finance Code 001"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s (FAPEG)","award":["CNPq, Process no 308489\/2020-9"],"award-info":[{"award-number":["CNPq, Process no 308489\/2020-9"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s (FAPEG)","award":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"],"award-info":[{"award-number":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["CAPES\u2014Finance Code 001"],"award-info":[{"award-number":["CAPES\u2014Finance Code 001"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["CNPq, Process no 308489\/2020-9"],"award-info":[{"award-number":["CNPq, Process no 308489\/2020-9"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"],"award-info":[{"award-number":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"]}]},{"name":"Instituto Federal Goiano","award":["CAPES\u2014Finance Code 001"],"award-info":[{"award-number":["CAPES\u2014Finance Code 001"]}]},{"name":"Instituto Federal Goiano","award":["CNPq, Process no 308489\/2020-9"],"award-info":[{"award-number":["CNPq, Process no 308489\/2020-9"]}]},{"name":"Instituto Federal Goiano","award":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"],"award-info":[{"award-number":["Process no 23218.000072.2022-21 and 23218.001874.2022-58"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Edible packaging has been developed as a biodegradable and non-toxic alternative to traditional petroleum-based food packaging. Biopolymeric edible films, in addition to their passive protective function, may also play a bioactive role as vehicles for bioactive compounds of importance to human health. In recent years, a new generation of edible food packaging has been developed to incorporate ingredients with functional potential that have beneficial effects on consumer health. Curcumin, a bioactive compound widely used as a natural dye obtained from turmeric rhizomes (Curcuma longa L.), has a broad spectrum of beneficial properties for human health, such as anti-inflammatory, anti-hypertensive, antioxidant, anti-cancer, and other activities. To demonstrate these properties, curcumin has been explored as a bioactive agent for the development of bioactive packaging, which can be referred to as functional packaging and used in food. The aim of this review was to describe the current and potential research on the development of functional-edible-films incorporating curcumin for applications such as food packaging.<\/jats:p>","DOI":"10.3390\/ijms23105638","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T11:59:37Z","timestamp":1652875177000},"page":"5638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Edible Bioactive Film with Curcumin: A Potential \u201cFunctional\u201d Packaging?"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-7128","authenticated-orcid":false,"given":"Josemar Gon\u00e7alves","family":"Oliveira Filho","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 13560-570, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-2718","authenticated-orcid":false,"given":"Mariana Buranelo","family":"Egea","sequence":"additional","affiliation":[{"name":"Goiano Federal Institute of Education, Science and Technology, Campus Rio Verde, Rio Verde 75901-970, Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1007\/s10570-021-03945-0","article-title":"Arrowroot starch-based films incorporated with a carnauba wax nanoemulsion, cellulose nanocrystals, and essential oils: A new functional material for food packaging applications","volume":"28","author":"Albiero","year":"2021","journal-title":"Cellulose"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ncube, L., Ude, A., Ogunmuyiwa, E., Na, C.-S., Zulkifli, R., and Beas, I. (2020). Environmental impact of food packaging materials: A review of contemporary development from conventional plastics to polylactic acid based materials. Materials, 13.","DOI":"10.3390\/ma13214994"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.foodhyd.2019.01.052","article-title":"Active food packaging: Alginate films with cottonseed protein hydrolysates","volume":"92","author":"Rodrigues","year":"2019","journal-title":"Food Hydrocoll."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tifs.2021.07.035","article-title":"Aloe vera gel, an excellent base material for edible films and coatings","volume":"116","author":"Maan","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.carbpol.2018.05.017","article-title":"Nanofibrillated bacterial cellulose and pectin edible films added with fruit purees","volume":"196","author":"Viana","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.eurpolymj.2010.12.011","article-title":"Natural-based plasticizers and biopolymer films: A review","volume":"47","author":"Vieira","year":"2011","journal-title":"Eur. Polym. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.foodres.2016.10.026","article-title":"Probiotics and their potential applications in active edible films and coatings","volume":"90","author":"Espitia","year":"2016","journal-title":"Food Res. Int."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"de Oliveira Filho, J.G., de Almeida, M.J., Sousa, T., de Santos, D., and Egea, M. (2021). Bioactive Compounds of Turmeric (Curcuma longa L.). Bioact. Compd. Underutilized Veg. Legumes, 297\u2013318.","DOI":"10.1007\/978-3-030-57415-4_37"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Tungmunnithum, D., Thongboonyou, A., Pholboon, A., and Yangsabai, A. (2018). Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: An overview. Medicines, 5.","DOI":"10.3390\/medicines5030093"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"112527","DOI":"10.1016\/j.lwt.2021.112527","article-title":"Natural colorants from plant pigments and their encapsulation: An emerging window for the food industry","volume":"153","author":"Ghosh","year":"2022","journal-title":"LWT"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3945\/ajcn.116.133132","article-title":"Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men","volume":"104","author":"Cassidy","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"104625","DOI":"10.1016\/j.phrs.2019.104625","article-title":"The beneficial health effects of flavonoids on the cardiovascular system: Focus on K+ channels","volume":"152","author":"Fusi","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Rees, A., Dodd, G.F., and Spencer, J.P.E. (2018). The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function. Nutrients, 10.","DOI":"10.3390\/nu10121852"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.ijbiomac.2018.10.196","article-title":"Curcumin entrapped gelatin\/ionically modified bacterial cellulose based self-healable hydrogel film: An eco-friendly sustainable synthesis method of wound healing patch","volume":"122","author":"Khamrai","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.foodhyd.2016.11.007","article-title":"Smart edible films based on gelatin and curcumin","volume":"66","author":"Musso","year":"2017","journal-title":"Food Hydrocoll."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.foodhyd.2017.04.018","article-title":"Investigation of antioxidant activity and release kinetics of curcumin from tara gum\/polyvinyl alcohol active film","volume":"70","author":"Ma","year":"2017","journal-title":"Food Hydrocoll."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108293","DOI":"10.1016\/j.lwt.2019.108293","article-title":"Characterization and antibacterial activity evaluation of curcumin loaded konjac glucomannan and zein nanofibril films","volume":"113","author":"Wang","year":"2019","journal-title":"LWT"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-41334-1_1","article-title":"Curcumin and its role in chronic diseases","volume":"Volume 928","author":"Gupta","year":"2016","journal-title":"Anti-Inflammatory Nutraceuticals and Chronic Diseases"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104392","DOI":"10.1016\/j.jff.2021.104392","article-title":"Health benefits, extraction and development of functional foods with curcuminoids","volume":"79","author":"Munekata","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1039\/C7FO01242J","article-title":"Curcumin as a functional food-derived factor: Degradation products, metabolites, bioactivity, and future perspectives","volume":"9","author":"Tsuda","year":"2018","journal-title":"Food Funct."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.indcrop.2018.12.072","article-title":"Preparation and characterization of curcumin loaded caseinate\/zein nanocomposite film using pH-driven method","volume":"130","author":"Wang","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijbiomac.2019.12.047","article-title":"Structural and physicochemical properties of ginger (Rhizoma curcumae longae) starch and resistant starch: A comparative study","volume":"144","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"131885","DOI":"10.1016\/j.foodchem.2021.131885","article-title":"Curcumin and its uses in active and smart food packaging applications-A comprehensive review","volume":"375","author":"Roy","year":"2021","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.tifs.2021.11.005","article-title":"Curcumin: A multifunctional molecule for the development of smart and active biodegradable polymer-based films","volume":"118","author":"Bertolo","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s10924-022-02372-x","article-title":"Curcumin-A Bio-based Precursor for Smart and Active Food Packaging Systems: A Review","volume":"30","author":"Tambawala","year":"2022","journal-title":"J. Polym. Environ."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1002\/fsn3.1728","article-title":"Effect of the application of an edible film with turmeric (Curcuma longa L.) on the oxidative stability of meat","volume":"8","author":"Bojorges","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1080\/10408398.2017.1393384","article-title":"Bioactive edible films for food applications: Influence of the bioactive compounds on film structure and properties","volume":"59","author":"Karbowiak","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1021\/acs.langmuir.1c00471","article-title":"Immobilization of heteroatom-doped carbon dots onto nonpolar plastics for antifogging, antioxidant, and food monitoring applications","volume":"37","author":"Das","year":"2021","journal-title":"Langmuir"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Mohamed, S.A., El-Sakhawy, M., and El-Sakhawy, M.A.-M. (2020). Polysaccharides, protein and lipid-based natural edible films in food packaging: A review. Carbohydr. Polym., 116178.","DOI":"10.1016\/j.carbpol.2020.116178"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tifs.2011.02.004","article-title":"Edible films and coatings: Structures, active functions and trends in their use","volume":"22","author":"Falguera","year":"2011","journal-title":"Trends Food Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/1541-4337.12281","article-title":"Recent advances on edible films based on fruits and vegetables\u2014A review","volume":"16","author":"Otoni","year":"2017","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Li, B., Li, C., Xu, Y., Luo, Y., Liang, D., and Huang, C. (2021). Comprehensive Review of Polysaccharide-Based Materials in Edible Packaging: A Sustainable Approach. Foods, 10.","DOI":"10.3390\/foods10081845"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100589","DOI":"10.1016\/j.fpsl.2020.100589","article-title":"New approach in the development of edible films: The use of carnauba wax micro- or nanoemulsions in arrowroot starch-based films","volume":"26","author":"Bezerra","year":"2020","journal-title":"Food Packag. Shelf Life"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"124673","DOI":"10.1016\/j.colsurfa.2020.124673","article-title":"Edible gelatin-based nanofibres loaded with oil encapsulating high-oleic palm oil emulsions","volume":"595","author":"Ricaurte","year":"2020","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tifs.2020.09.015","article-title":"Active and intelligent biodegradable packaging films using food and food waste-derived bioactive compounds: A review","volume":"105","author":"Bhargava","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.ijbiomac.2020.08.094","article-title":"Preparation of bioactive functional poly (lactic acid)\/curcumin composite film for food packaging application","volume":"162","author":"Roy","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tifs.2006.04.012","article-title":"Bioactive packaging: Turning foods into healthier foods through biomaterials","volume":"17","author":"Gavara","year":"2006","journal-title":"Trends Food Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Arroyo, B., Santos, A., de Melo, E.D.A., Campos, A., Lins, L., and Boyano-Orozco, L. (2019). Bioactive compounds and their potential use as ingredients for food and its application in food packaging. Bioactive Compounds, Elsevier.","DOI":"10.1016\/B978-0-12-814774-0.00008-6"},{"key":"ref_39","first-page":"454","article-title":"Novel food packaging technologies: Innovations and future prospective","volume":"17","author":"Majid","year":"2018","journal-title":"J. Saudi Soc. Agric. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Pavli, F., Tassou, C., Nychas, G.-J., and Chorianopoulos, N. (2018). Probiotic incorporation in edible films and coatings: Bioactive solution for functional foods. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010150"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110202","DOI":"10.1016\/j.foodres.2021.110202","article-title":"The potential of anthocyanins in smart, active, and bioactive eco-friendly polymer-based films: A review","volume":"142","author":"Braga","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ijbiomac.2020.05.066","article-title":"Development and characterization of carboxymethyl cellulose based probiotic nanocomposite film containing cellulose nanofiber and inulin for chicken fillet shelf life extension","volume":"160","author":"Zabihollahi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"109699","DOI":"10.1016\/j.lwt.2020.109699","article-title":"Bacterial cellulose\/cashew gum films as probiotic carriers","volume":"130","author":"Abreu","year":"2020","journal-title":"LWT"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"104694","DOI":"10.1016\/j.jece.2020.104694","article-title":"Antioxidant and antimicrobial poly (vinyl alcohol)-based films incorporated with grapefruit seed extract and curcumin","volume":"9","author":"Roy","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"106096","DOI":"10.1016\/j.foodhyd.2020.106096","article-title":"Physico-chemical and functional properties of rutin induced chitosan\/poly (vinyl alcohol) bioactive films for food packaging applications","volume":"109","author":"Narasagoudr","year":"2020","journal-title":"Food Hydrocoll."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106793","DOI":"10.1016\/j.jece.2021.106793","article-title":"Synergistic effect of starch\/polyvinyl alcohol\/citric acid films decorated with in-situ green-synthesized nano silver on bioactive packaging films","volume":"9","author":"Ounkaew","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.ijbiomac.2021.11.050","article-title":"Preparation and physicochemical assessment of bioactive films based on chitosan and starchy powder of white turmeric rhizomes (Curcuma Zedoaria) for green packaging applications","volume":"193","author":"Hiremani","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tifs.2021.12.004","article-title":"Food spoilage, bioactive food fresh-keeping films and functional edible coatings: Research status, existing problems and development trend","volume":"119","author":"Sun","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_49","unstructured":"Galanakis, C. (2016). Nutraceutical and Functional Food Components: Effects of Innovative Processing Techniques, Academic Press."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jtcme.2016.05.005","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives\u2013A review","volume":"7","author":"Amalraj","year":"2017","journal-title":"J. Tradit. Complementary Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10008-006-0104-4","article-title":"Electrocatalytic oxidation of glucose at a Ni-curcumin modified glassy carbon electrode","volume":"11","author":"Elahi","year":"2007","journal-title":"J. Solid State Electrochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"130485","DOI":"10.1016\/j.molstruc.2021.130485","article-title":"A novel curcumin gallium complex as photosensitizer in photodynamic therapy: Synthesis, structural and physicochemical characterization, photophysical properties and in vitro studies against breast cancer cells","volume":"1240","author":"Halevas","year":"2021","journal-title":"J. Mol. Struct."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"107343","DOI":"10.1016\/j.biotechadv.2019.01.010","article-title":"Curcumin, the golden spice in treating cardiovascular diseases","volume":"38","author":"Li","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"396708","DOI":"10.1155\/2014\/396708","article-title":"Structure-function elucidation of antioxidative and prooxidative activities of the polyphenolic compound curcumin","volume":"2014","author":"Malik","year":"2014","journal-title":"Chin. J. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0891-5849(03)00325-3","article-title":"Role of phenolic OH and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin","volume":"35","author":"Priyadarsini","year":"2003","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101678","DOI":"10.1016\/j.redox.2020.101678","article-title":"Interrelation between ROS and Ca2+ in aging and age-related diseases","volume":"36","author":"Thomas","year":"2020","journal-title":"Redox Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"105526","DOI":"10.1016\/j.phrs.2021.105526","article-title":"The hormetic dose-response mechanism: Nrf2 activation","volume":"167","author":"Calabrese","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e2000171","DOI":"10.1002\/cbdv.202000171","article-title":"Antibacterial Mechanism of Curcumin: A Review","volume":"17","author":"Zheng","year":"2020","journal-title":"Chem. Biodivers."},{"key":"ref_60","first-page":"255","article-title":"Pathogenesis of wound healing disorders in the elderly","volume":"15","author":"Makrantonaki","year":"2017","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1271\/bbb.90568","article-title":"Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents","volume":"74","author":"Dairaku","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/bph.12131","article-title":"Curcumin: An orally bioavailable blocker of TNF and other pro-inflammatory biomarkers","volume":"169","author":"Aggarwal","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_63","unstructured":"WHO (2022, January 20). Noncommunicable Diseases. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/noncommunicable-diseases."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111214","DOI":"10.1016\/j.biopha.2020.111214","article-title":"Curcumin and cardiovascular diseases: Focus on cellular targets and cascades","volume":"136","author":"Farkhondeh","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13075-021-02423-z","article-title":"A bioavailable form of curcumin, in combination with vitamin-D-and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis","volume":"23","author":"Hemshekhar","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3389\/fphar.2019.00649","article-title":"The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials","volume":"10","author":"Akbari","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/19390211.2018.1472711","article-title":"The effect of curcumin on serum copper and zinc and Zn\/Cu ratio in individuals with metabolic syndrome: A double-blind clinical trial","volume":"16","author":"Safarian","year":"2019","journal-title":"J. Diet. Suppl."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Pivari, F., Mingione, A., Brasacchio, C., and Soldati, L. (2019). Curcumin and type 2 diabetes mellitus: Prevention and treatment. Nutrients, 11.","DOI":"10.3390\/nu11081837"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fphar.2018.00472","article-title":"Curcumin, a polyphenolic curcuminoid with its protective effects and molecular mechanisms in diabetes and diabetic cardiomyopathy","volume":"9","author":"Zheng","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Assis, R., Arcaro, C., Gutierres, V., Oliveira, J., Costa, P., Baviera, A., and Brunetti, I. (2017). Combined effects of curcumin and lycopene or bixin in yoghurt on inhibition of LDL oxidation and increases in HDL and paraoxonase levels in streptozotocin-diabetic rats. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18040332"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.clnesp.2020.01.005","article-title":"Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial","volume":"36","author":"Jamilian","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Tomeh, M., Hadianamrei, R., and Zhao, X. (2019). A review of curcumin and its derivatives as anticancer agents. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051033"},{"key":"ref_73","unstructured":"CDC (2022, January 20). Mental and Chronic Diseases, Available online: https:\/\/www.cdc.gov\/chronicdisease\/index.htm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"572533","DOI":"10.3389\/fpsyt.2020.572533","article-title":"Curcumin in Depression: Potential Mechanisms of Action and Current Evidence\u2014A Narrative Review","volume":"11","author":"Ramaholimihaso","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","article-title":"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects","volume":"17","author":"Vareed","year":"2008","journal-title":"Cancer Epidemiol. Prev. Biomark."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Dei Cas, M., and Ghidoni, R. (2019). Dietary curcumin: Correlation between bioavailability and health potential. Nutrients, 11.","DOI":"10.3390\/nu11092147"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev-food-032818-121738","article-title":"Curcumin: Recent advances in the development of strategies to improve oral bioavailability","volume":"10","author":"Sanidad","year":"2019","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tifs.2017.11.009","article-title":"Recent advances in emulsion-based delivery approaches for curcumin: From encapsulation to bioaccessibility","volume":"71","author":"Akhtar","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"120534","DOI":"10.1016\/j.ijpharm.2021.120534","article-title":"Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview","volume":"604","author":"Noronha","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fphar.2020.00487","article-title":"Nanocurcumin: A promising candidate for therapeutic applications","volume":"11","author":"Karthikeyan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"16040","DOI":"10.1021\/acsami.9b02649","article-title":"Biobased cellulose nanofibril\u2013oil composite films for active edible barriers","volume":"11","author":"Valencia","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1039\/C8FO02510J","article-title":"Impact of curcumin delivery system format on bioaccessibility: Nanocrystals, nanoemulsion droplets, and natural oil bodies","volume":"10","author":"Zheng","year":"2019","journal-title":"Food Funct."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1021\/acs.jafc.7b05478","article-title":"Enhancement of curcumin bioavailability by encapsulation in sophorolipid-coated nanoparticles: An in vitro and in vivo study","volume":"66","author":"Peng","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"106253","DOI":"10.1016\/j.foodhyd.2020.106253","article-title":"Acetylated debranched starch micelles as a promising nanocarrier for curcumin","volume":"111","author":"Liu","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.foodchem.2017.04.133","article-title":"Microencapsulation structures based on protein-coated liposomes obtained through electrospraying for the stabilization and improved bioaccessibility of curcumin","volume":"233","author":"Sipoli","year":"2017","journal-title":"Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.foodchem.2014.09.131","article-title":"Co-delivery of hydrophobic curcumin and hydrophilic catechin by a water-in-oil-in-water double emulsion","volume":"173","author":"Aditya","year":"2015","journal-title":"Food Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.1021\/acs.jafc.8b03174","article-title":"Impact of delivery system type on curcumin bioaccessibility: Comparison of curcumin-loaded nanoemulsions with commercial curcumin supplements","volume":"66","author":"Zheng","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.foodchem.2011.11.039","article-title":"Nanoemulsion-and emulsion-based delivery systems for curcumin: Encapsulation and release properties","volume":"132","author":"Ahmed","year":"2012","journal-title":"Food Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.foodres.2016.08.022","article-title":"Bioaccessibility and antioxidant activity of curcumin after encapsulated by nano and Pickering emulsion based on chitosan-tripolyphosphate nanoparticles","volume":"89","author":"Shah","year":"2016","journal-title":"Food Res. Int."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1039\/C4SM00239C","article-title":"pH-driven encapsulation of curcumin in self-assembled casein nanoparticles for enhanced dispersibility and bioactivity","volume":"10","author":"Pan","year":"2014","journal-title":"Soft Matter"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1007\/s10570-019-02637-0","article-title":"Curaua cellulose sheets dip coated with micro and nano carnauba wax emulsions","volume":"26","author":"Claro","year":"2019","journal-title":"Cellulose"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"106026","DOI":"10.1016\/j.foodhyd.2020.106026","article-title":"Fabrication and investigation of physicochemical, food simulant release, and antioxidant properties of whey protein isolate-based films activated by loading with curcumin through the pH-driven method","volume":"108","author":"Kevij","year":"2020","journal-title":"Food Hydrocoll."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ijbiomac.2020.01.204","article-title":"Carboxymethyl cellulose-based antioxidant and antimicrobial active packaging film incorporated with curcumin and zinc oxide","volume":"148","author":"Roy","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"106893","DOI":"10.1016\/j.foodhyd.2021.106893","article-title":"Development of pH-responsive antioxidant soy protein isolate films incorporated with cellulose nanocrystals and curcumin nanocapsules to monitor shrimp freshness","volume":"120","author":"Xiao","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijbiomac.2019.08.261","article-title":"Development a smart edible nanocomposite based on mucilage of Melissa officinalis seed\/montmorillonite (MMT)\/curcumin","volume":"141","author":"Rostami","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/fsn3.2114","article-title":"Smart edible films based on mucilage of lallemantia iberica seed incorporated with curcumin for freshness monitoring","volume":"9","author":"Taghinia","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ijbiomac.2015.01.047","article-title":"Potential use of curcumin loaded carboxymethylated guar gum grafted gelatin film for biomedical applications","volume":"75","author":"Manna","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.carbpol.2012.03.088","article-title":"Antioxidant capacity and light-aging study of HPMC films functionalized with natural plant extract","volume":"89","author":"Akhtar","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"131121","DOI":"10.1016\/j.foodchem.2021.131121","article-title":"Development of active edible films made from banana starch and curcumin-loaded nanoemulsions","volume":"371","author":"Sanchez","year":"2022","journal-title":"Food Chem."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Rachtanapun, P., Klunklin, W., Jantrawut, P., Jantanasakulwong, K., Phimolsiripol, Y., Seesuriyachan, P., Leksawasdi, N., Chaiyaso, T., Ruksiriwanich, W., and Phongthai, S. (2021). Characterization of chitosan film incorporated with curcumin extract. Polymers, 13.","DOI":"10.3390\/polym13060963"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijbiomac.2022.02.025","article-title":"Chitosan nanoparticles embedded with curcumin and its application in pork antioxidant edible coating","volume":"204","author":"Shen","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.ijbiomac.2021.06.098","article-title":"Curcumin doped functionalized cellulose nanofibers based edible chitosan coating on kiwifruits","volume":"184","author":"Ghosh","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Bourbon, A.I., Costa, M.J., Maciel, L.C., Pastrana, L., Vicente, A.A., and Cerqueira, M.A. (2021). Active carboxymethylcellulose-based edible films: Influence of free and encapsulated curcumin on films\u2019 properties. Foods, 10.","DOI":"10.3390\/foods10071512"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Stohs, S.J., Chen, O., Ray, S.D., Ji, J., Bucci, L.R., and Preuss, H.G. (2020). Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review. Molecules, 25.","DOI":"10.3390\/molecules25061397"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1124\/pr.110.004044","article-title":"The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer","volume":"66","author":"Heger","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jfda.2016.11.004","article-title":"Food macromolecule based nanodelivery systems for enhancing the bioavailability of polyphenols","volume":"25","author":"Hu","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"101787","DOI":"10.1016\/j.jddst.2020.101787","article-title":"pH-responsive poly (lactic acid)\/sodium carboxymethyl cellulose film for enhanced delivery of curcumin in vitro","volume":"58","author":"Gunathilake","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.foodhyd.2016.02.036","article-title":"Encapsulation of curcumin in polysaccharide-based hydrogel beads: Impact of bead type on lipid digestion and curcumin bioaccessibility","volume":"58","author":"Zhang","year":"2016","journal-title":"Food Hydrocoll."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/10\/5638\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:14:10Z","timestamp":1760138050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/10\/5638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,18]]},"references-count":108,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23105638"],"URL":"https:\/\/doi.org\/10.3390\/ijms23105638","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,18]]}}}