{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:06:10Z","timestamp":1770743170891,"version":"3.49.0"},"reference-count":61,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bascom Palmer Eye Institute","award":["NIH-NEI RO1EY019077"],"award-info":[{"award-number":["NIH-NEI RO1EY019077"]}]},{"name":"Bascom Palmer Eye Institute","award":["NIH-NEI RO1EY014957"],"award-info":[{"award-number":["NIH-NEI RO1EY014957"]}]},{"name":"Bascom Palmer Eye Institute","award":["NIH-NEI R24EY028785"],"award-info":[{"award-number":["NIH-NEI R24EY028785"]}]},{"name":"Bascom Palmer Eye Institute","award":["NIH-NEI P30EY014801"],"award-info":[{"award-number":["NIH-NEI P30EY014801"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The goal of neuroprotection in optic neuropathies is to prevent loss of retinal ganglion cells (RGCs) and spare their function. The ideal time window for initiating neuroprotective treatments should be the preclinical period at which RGCs start losing their functional integrity before dying. Noninvasive electrophysiological tests such as the Pattern Electroretinogram (PERG) can assess the ability of RGCs to generate electrical signals under a protracted degenerative process in both clinical conditions and experimental models, which may have both diagnostic and prognostic values and provide the rationale for early treatment. The PERG can be used to longitudinally monitor the acute and chronic effects of neuroprotective treatments. User-friendly versions of the PERG technology are now commercially available for both clinical and experimental use.<\/jats:p>","DOI":"10.3390\/ijms23105751","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T13:56:12Z","timestamp":1653054972000},"page":"5751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Using Noninvasive Electrophysiology to Determine Time Windows of Neuroprotection in Optic Neuropathies"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-3532","authenticated-orcid":false,"given":"Vittorio","family":"Porciatti","sequence":"first","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1986-6088","authenticated-orcid":false,"given":"Tsung-Han","family":"Chou","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3129\/i07-046","article-title":"Axonal loss and neuroprotection in optic neuropathies","volume":"42","author":"Levin","year":"2007","journal-title":"Can. 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